author consortium pmid date trait efo analysis source outcome exposure covariates outcome_units exposure_units methylation_array tissue further_details n n_cohorts age sex ethnicity cpg chrpos chr pos gene type beta se p details study_id Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg19584674 chr14:24898818 14 24898818 KHNYN;CBLN3 Island -0.0031 0.0002 0 None 33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect Battram T GEO 30602389 2020-09-15 Tissue None EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells None DNA methylation Tissue Batch effects, cell composition (reference free) Beta Values None Illumina HumanMethylation450 Buccal cells and peripheral blood mononuclear cells None 215 1 Children Both European cg19584674 chr14:24898818 14 24898818 KHNYN;CBLN3 Island 0.16341 0.00619 5.000000000000001e-66 None 30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells Xu CJ - 28056824 2017-01-05 Age 4 vs age 0 EFO_0000246 - Additional file 3 DNA methylation Age 4 vs age 0 Sex, cell counts and technical covariates Beta values - Illumina HumanMethylation450 Whole blood and cord blood - 269 2 - Both European cg19584674 chr14:24898818 14 24898818 KHNYN;CBLN3 Island - - 5.2e-55 - 28056824_age_4_vs_age_0 Wozniak MB - 23526956 2013-03-05 Clear cell renal carcinoma EFO_0000349, EFO_0000681 - Table S6 DNA methylation Clear cell renal carcinoma - M values - Illumina HumanMethylation450 Clear cell renal carcinoma tumour cells and adjacent healthy cells - 129 1 63 Both European cg19584674 chr14:24898818 14 24898818 KHNYN;CBLN3 Island - - 1.47e-39 - 23526956_clear_cell_renal_carcinoma Yao C FHS, KORA F4, BLSA, InCHIANTI 33752734 2021-03-22 Gene expression of Affymetrix ID: 3558270 (gene symbol: CBLN3) None Meta-analysis Table S6 DNA methylation Gene expression of Affymetrix ID: 3558270 (gene symbol: CBLN3) Age, sex, cell composition (reference based), batch effects Beta Values None Illumina HumanMethylation450 Whole blood None 4170 1 Adults Both Unclear cg19584674 chr14:24898818 14 24898818 KHNYN;CBLN3 Island None None 0.000000000000017 None 33752734_Yao-C_gene_expression_of_affymetrix_id__3558270__gene_symbol__cbln3__meta-analysis Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 2 at 6y with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg19584674 chr14:24898818 14 24898818 KHNYN;CBLN3 Island 0.0085 0.0013 0.000000000029 None 33450751_Mulder-RH_age_model_2_at_6y_with_age_as_a_fixed_effect Mulder RH ALSPAC,Generation R 33450751 25/01/2021 sex PATO_0000047 Discovery http://epidelta.mrcieu.ac.uk/ DNA methylation sex gestational age,cohort,cell composition (reference based),batch effects Beta Values None Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg19584674 chr14:24898818 14 24898818 KHNYN;CBLN3 Island -0.014 0.0026 0.000000027 None 33450751_Mulder-RH_sex_discovery Spiers H - 25650246 2015-02-03 Gestational age EFO_0005112, EFO_0000246 - Additional file 1 DNA methylation Gestational age Sex and technical covariates Beta values days Illumina HumanMethylation450 Fetal brain - 179 1 - Both None cg19584674 chr14:24898818 14 24898818 KHNYN;CBLN3 Island -0.09301 0.0173 0.0000000823 - 25650246_gestational_age Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01042 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P01042 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg19584674 chr14:24898818 14 24898818 KHNYN;CBLN3 Island -0.0357148 0.00823505 0.00001454559 P01042 41361833_Josephine_Robertson_P01042_OSCA_model_2 Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 BMI EFO_0004340 discovery None DNA methylation BMI Age,Sex,Smoking,Cell composition (reference based),Batch effects Other kg/m2 Illumina HumanMethylationEPIC Whole blood None 17304 1 Adults Both European cg19584674 chr14:24898818 14 24898818 KHNYN;CBLN3 Island -0.0929687 0.0215793 0.00001654681 None 39706196_Hannah-M.-Smith_bmi_discovery Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01042 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P01042 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg19584674 chr14:24898818 14 24898818 KHNYN;CBLN3 Island -0.0352071 0.00824558 0.00001968694 P01042 41361833_Josephine_Robertson_P01042_OSCA_model_3 Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 2 at 9y with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg19584674 chr14:24898818 14 24898818 KHNYN;CBLN3 Island 0.0051 0.0012 0.000021 None 33450751_Mulder-RH_age_model_2_at_9y_with_age_as_a_fixed_effect Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01042 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01042 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg19584674 chr14:24898818 14 24898818 KHNYN;CBLN3 Island -0.0348844 0.00825155 0.00002376059 P01042 41361833_Josephine_Robertson_P01042_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P08185 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P08185 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg19584674 chr14:24898818 14 24898818 KHNYN;CBLN3 Island -0.0330977 0.00804441 0.00003903553 P08185 41361833_Josephine_Robertson_P08185_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02748 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation P02748 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg19584674 chr14:24898818 14 24898818 KHNYN;CBLN3 Island 0.0372508 0.0090581 0.0000393653 P02748 41361833_Josephine_Robertson_P02748_OSCA_model_4 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01042 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation P01042 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg19584674 chr14:24898818 14 24898818 KHNYN;CBLN3 Island -0.0377038 0.0092834 0.00004902853 P01042 41361833_Josephine_Robertson_P01042_OSCA_model_4 Dugue P-A Melbourne Collaborative Cohort Study 31789449 2019-11-04 Alcohol consumption EFO_0004329, EFO_0007878 Previous week consumption discovery Supplementary Table 3 Alcohol consumption DNA methylation age, sex, smoking, body mass index country of birth, sample type, cell composition (reference based), batch effects g/day M Values Illumina HumanMethylation450 Whole blood None 5606 1 Adults Both Unclear cg19584674 chr14:24898818 14 24898818 KHNYN;CBLN3 Island None None 0.000058 None 31789449_Dugue-P-A_alcohol_consumption_previous_week_consumption_discovery