author consortium pmid date trait efo analysis source outcome exposure covariates outcome_units exposure_units methylation_array tissue further_details n n_cohorts age sex ethnicity cpg chrpos chr pos gene type beta se p details study_id Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg19693031 chr1:145441552 1 145441552 TXNIP Open sea -0.0036 0.0002 0 None 33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 2 at 6y with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg19693031 chr1:145441552 1 145441552 TXNIP Open sea 0.012 0.0013 0 None 33450751_Mulder-RH_age_model_2_at_6y_with_age_as_a_fixed_effect Sayols-Baixeras S - 28173150 2016-09-15 Serum triglycerides EFO_0004530, CHEBI_17855 Discovery and replication Table S1 Serum triglycerides DNA methylation Age, sex, smoking, cell counts and technical covariates mg/dl M values Illumina HumanMethylation450 Whole blood Triglycerides levels were log-transformed 3187 2 65.7 Both None cg19693031 chr1:145441552 1 145441552 TXNIP Open sea -0.039 0.004 0 - 28173150_serum_triglycerides_discovery_and_replication Sayols-Baixeras S - 28173150 2016-09-15 Serum triglycerides EFO_0004530, CHEBI_17855 Discovery and replication adjusted for surrogate variables Table S1 Serum triglycerides DNA methylation Age, sex, smoking, cell counts and technical covariates mg/dl M values Illumina HumanMethylation450 Whole blood Triglycerides levels were log-transformed 3187 2 65.7 Both None cg19693031 chr1:145441552 1 145441552 TXNIP Open sea -0.049 0.004 0 - 28173150_serum_triglycerides_discovery_and_replication_adjusted_for_surrogate_variables Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 Glucose EFO_0004468 sensitivity None DNA methylation Glucose Age,Sex,Smoking,Cell composition (reference based),Batch effects Other mmol/L Illumina HumanMethylationEPIC Whole blood None 17908 1 Adults Both European cg19693031 chr1:145441552 1 145441552 TXNIP Open sea -0.538279 0.027196 2.892235e-86 None 39706196_Hannah-M.-Smith_glucose_sensitivity Robert F Hillary Generation Scotland 10.1101/2023.01.10.23284387 9/6/2023 Prevalent Type 2 Diabetes (Self-report) None Basic model https://doi.org/10.5281/zenodo.8021411 DNA methylation Prevalent Type 2 Diabetes (Self-report) Age, Sex, Cell composition (reference based) M values None Illumina HumanMethylationEPIC Whole blood None 18005 1 Adults (18-65y) Both European cg19693031 chr1:145441552 1 145441552 TXNIP Open sea -0.22 0.0117 1.6000000000000002e-81 None Robert-F-Hillary_Prevalent_Type_2_Diabetes_(Self-report)_Basic_model Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 Glucose EFO_0004468 discovery None DNA methylation Glucose Age,Sex,Smoking,Cell composition (reference based),Batch effects Other mmol/L Illumina HumanMethylationEPIC Whole blood None 17908 1 Adults Both European cg19693031 chr1:145441552 1 145441552 TXNIP Open sea -0.46722 0.0254828 2.098107e-74 None 39706196_Hannah-M.-Smith_glucose_discovery Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04004 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P04004 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg19693031 chr1:145441552 1 145441552 TXNIP Open sea -0.133925 0.00818219 1.09538e-59 P04004 41361833_Josephine_Robertson_P04004_OSCA_model_1 Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 Body fat EFO_0007800 sensitivity None DNA methylation Body fat Age,Sex,Smoking,Cell composition (reference based),Batch effects Other % Illumina HumanMethylationEPIC Whole blood None 17304 1 Adults Both European cg19693031 chr1:145441552 1 145441552 TXNIP Open sea -0.435949 0.0271956 2.043124e-57 None 39706196_Hannah-M.-Smith_body_fat_sensitivity Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04004 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P04004 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg19693031 chr1:145441552 1 145441552 TXNIP Open sea -0.135113 0.00846323 6.782946999999999e-57 P04004 41361833_Josephine_Robertson_P04004_OSCA_model_2 Bonder MJ - 25282492 2014-10-04 Fetal vs adult liver UBERON_0002107, GO_0048513 - Additional file 2 DNA methylation Fetal vs adult liver Sex and technical covariates M values - Illumina HumanMethylation450 Liver - 195 2 - Missing None cg19693031 chr1:145441552 1 145441552 TXNIP Open sea 3.86482 0.10156 5.170000000000001e-56 - 25282492_fetal_vs_adult_liver Battram T GEO 30602389 2020-09-15 Tissue None EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells None DNA methylation Tissue Batch effects, cell composition (reference free) Beta Values None Illumina HumanMethylation450 Buccal cells and peripheral blood mononuclear cells None 215 1 Children Both European cg19693031 chr1:145441552 1 145441552 TXNIP Open sea -0.15415 0.00691 2.6999999999999997e-55 None 30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 BMI EFO_0004340 sensitivity None DNA methylation BMI Age,Sex,Smoking,Cell composition (reference based),Batch effects Other kg/m2 Illumina HumanMethylationEPIC Whole blood None 17304 1 Adults Both European cg19693031 chr1:145441552 1 145441552 TXNIP Open sea -0.42411 0.0270287 4.178674e-55 None 39706196_Hannah-M.-Smith_bmi_sensitivity Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02748 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation P02748 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg19693031 chr1:145441552 1 145441552 TXNIP Open sea 0.139134 0.0089918 1.392038e-53 P02748 41361833_Josephine_Robertson_P02748_OSCA_model_4 Robert F Hillary Generation Scotland 10.1101/2023.01.10.23284387 9/6/2023 Prevalent Type 2 Diabetes (Self-report) None Fully-adjusted model https://doi.org/10.5281/zenodo.8021411 DNA methylation Prevalent Type 2 Diabetes (Self-report) Age, Sex, Cell composition (reference based), Ancestry (genomic PCs), Body mass index, Socio-economic position, Education, Alcohol consumption M values None Illumina HumanMethylationEPIC Whole blood None 14350 1 Adults (18-65y) Both European cg19693031 chr1:145441552 1 145441552 TXNIP Open sea -0.19 0.0123 1.8e-53 None Robert-F-Hillary_Prevalent_Type_2_Diabetes_(Self-report)_Fully-adjusted_model Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04004 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation P04004 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg19693031 chr1:145441552 1 145441552 TXNIP Open sea -0.133733 0.00884201 2.714623e-51 P04004 41361833_Josephine_Robertson_P04004_OSCA_model_4 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01042 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation P01042 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg19693031 chr1:145441552 1 145441552 TXNIP Open sea -0.139314 0.00921875 3.280641e-51 P01042 41361833_Josephine_Robertson_P01042_OSCA_model_4 Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 Waist-hip ratio EFO_0004343 sensitivity None DNA methylation Waist-hip ratio Age,Sex,Smoking,Cell composition (reference based),Batch effects Other None Illumina HumanMethylationEPIC Whole blood None 17304 1 Adults Both European cg19693031 chr1:145441552 1 145441552 TXNIP Open sea -0.407625 0.0271208 9.782973e-51 None 39706196_Hannah-M.-Smith_waist-hip_ratio_sensitivity Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01042 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01042 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg19693031 chr1:145441552 1 145441552 TXNIP Open sea -0.123153 0.00819372 1.1105869999999998e-50 P01042 41361833_Josephine_Robertson_P01042_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02748 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P02748 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg19693031 chr1:145441552 1 145441552 TXNIP Open sea 0.117292 0.00835538 1.772635e-44 P02748 41361833_Josephine_Robertson_P02748_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04004 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P04004 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg19693031 chr1:145441552 1 145441552 TXNIP Open sea -0.114171 0.00817982 5.404042e-44 P04004 41361833_Josephine_Robertson_P04004_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01042 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P01042 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg19693031 chr1:145441552 1 145441552 TXNIP Open sea -0.117703 0.00851003 3.091741e-43 P01042 41361833_Josephine_Robertson_P01042_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01042 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P01042 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg19693031 chr1:145441552 1 145441552 TXNIP Open sea -0.117106 0.0084857 4.712555e-43 P01042 41361833_Josephine_Robertson_P01042_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02748 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P02748 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg19693031 chr1:145441552 1 145441552 TXNIP Open sea 0.11405 0.00834991 3.239402e-42 P02748 41361833_Josephine_Robertson_P02748_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01834 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01834 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg19693031 chr1:145441552 1 145441552 TXNIP Open sea 0.111453 0.00820513 8.999885999999999e-42 P01834 41361833_Josephine_Robertson_P01834_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 O75882 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation O75882 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg19693031 chr1:145441552 1 145441552 TXNIP Open sea -0.111672 0.00848246 2.330422e-39 O75882 41361833_Josephine_Robertson_O75882_OSCA_model_2 Robert F Hillary Generation Scotland 10.1101/2023.01.10.23284387 9/6/2023 Incident Type 2 Diabetes None Basic model https://doi.org/10.5281/zenodo.8021411 DNA methylation Incident Type 2 Diabetes Age, Sex, Cell composition (reference based) M values None Illumina HumanMethylationEPIC Whole blood None 17749 1 Adults (18-65y) Both European cg19693031 chr1:145441552 1 145441552 TXNIP Open sea -0.069 0.00538 8.7e-38 None Robert-F-Hillary_Incident_Type_2_Diabetes_Basic_model Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02748 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02748 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg19693031 chr1:145441552 1 145441552 TXNIP Open sea 0.105693 0.00821033 1.020019e-37 P02748 41361833_Josephine_Robertson_P02748_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01834 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P01834 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg19693031 chr1:145441552 1 145441552 TXNIP Open sea 0.10747 0.00847186 1.108082e-36 P01834 41361833_Josephine_Robertson_P01834_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P43652 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P43652 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg19693031 chr1:145441552 1 145441552 TXNIP Open sea -0.103833 0.00821194 1.86703e-36 P43652 41361833_Josephine_Robertson_P43652_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P43652 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P43652 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg19693031 chr1:145441552 1 145441552 TXNIP Open sea -0.10642 0.00851233 1.109207e-35 P43652 41361833_Josephine_Robertson_P43652_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 O75882 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation O75882 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg19693031 chr1:145441552 1 145441552 TXNIP Open sea -0.115109 0.00921833 1.335072e-35 O75882 41361833_Josephine_Robertson_O75882_OSCA_model_4 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 O75882 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation O75882 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg19693031 chr1:145441552 1 145441552 TXNIP Open sea -0.105789 0.00847858 1.506291e-35 O75882 41361833_Josephine_Robertson_O75882_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01024 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P01024 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg19693031 chr1:145441552 1 145441552 TXNIP Open sea -0.103216 0.00851383 1.1510380000000001e-33 P01024 41361833_Josephine_Robertson_P01024_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01834 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P01834 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg19693031 chr1:145441552 1 145441552 TXNIP Open sea 0.0994893 0.00841364 4.0687190000000003e-32 P01834 41361833_Josephine_Robertson_P01834_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P43652 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation P43652 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg19693031 chr1:145441552 1 145441552 TXNIP Open sea -0.106616 0.00904584 6.410527e-32 P43652 41361833_Josephine_Robertson_P43652_OSCA_model_4 Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 Body fat EFO_0007800 discovery None DNA methylation Body fat Age,Sex,Smoking,Cell composition (reference based),Batch effects Other % Illumina HumanMethylationEPIC Whole blood None 17304 1 Adults Both European cg19693031 chr1:145441552 1 145441552 TXNIP Open sea -0.300572 0.0257662 2.51002e-31 None 39706196_Hannah-M.-Smith_body_fat_discovery Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 O75882 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation O75882 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg19693031 chr1:145441552 1 145441552 TXNIP Open sea -0.0954691 0.00821886 4.68119e-31 O75882 41361833_Josephine_Robertson_O75882_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01024 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01024 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg19693031 chr1:145441552 1 145441552 TXNIP Open sea -0.0949579 0.00821926 9.672873e-31 P01024 41361833_Josephine_Robertson_P01024_OSCA_model_1 Richard MA CHARGE 29198723 2019-11-25 Systolic Blood Pressure EFO_0006335 Meta-analysis Table S4 DNA methylation Systolic Blood Pressure Age, sex, smoking, batch effects, ancestry, body mass index, blood cell counts Beta Values mmHg Illumina HumanMethylation450 Whole blood, CD4+ T cells Overall meta-analysis of discovery and replication cohorts 17010 14 Adults Both African, Admixed, European cg19693031 chr1:145441552 1 145441552 TXNIP Open sea -0.0002 None 3.0999999999999997e-29 None 29198723_Richard-MA_systolic_blood_pressure_meta-analysis Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01834 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation P01834 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg19693031 chr1:145441552 1 145441552 TXNIP Open sea 0.102055 0.00912746 6.603981e-29 P01834 41361833_Josephine_Robertson_P01834_OSCA_model_4 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 O75636 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation O75636 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg19693031 chr1:145441552 1 145441552 TXNIP Open sea -0.10303 0.0092187 6.977503e-29 O75636 41361833_Josephine_Robertson_O75636_OSCA_model_4 Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 Total cholesterol EFO_0004574 sensitivity None DNA methylation Total cholesterol Age,Sex,Smoking,Cell composition (reference based),Batch effects Other mmol/L Illumina HumanMethylationEPIC Whole blood None 18270 1 Adults Both European cg19693031 chr1:145441552 1 145441552 TXNIP Open sea -0.294752 0.0264225 8.358810000000001e-29 None 39706196_Hannah-M.-Smith_total_cholesterol_sensitivity Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P06312 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P06312 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg19693031 chr1:145441552 1 145441552 TXNIP Open sea 0.0911829 0.00822218 1.822868e-28 P06312 41361833_Josephine_Robertson_P06312_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01619 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01619 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg19693031 chr1:145441552 1 145441552 TXNIP Open sea 0.0911608 0.00822219 1.878565e-28 P01619 41361833_Josephine_Robertson_P01619_OSCA_model_1 Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 Waist-hip ratio EFO_0004343 discovery None DNA methylation Waist-hip ratio Age,Sex,Smoking,Cell composition (reference based),Batch effects Other None Illumina HumanMethylationEPIC Whole blood None 17304 1 Adults Both European cg19693031 chr1:145441552 1 145441552 TXNIP Open sea -0.284133 0.0256975 2.527458e-28 None 39706196_Hannah-M.-Smith_waist-hip_ratio_discovery Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 O75636 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation O75636 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg19693031 chr1:145441552 1 145441552 TXNIP Open sea -0.0895662 0.00822339 1.610283e-27 O75636 41361833_Josephine_Robertson_O75636_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 Q99459 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation Q99459 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg19693031 chr1:145441552 1 145441552 TXNIP Open sea 0.0894265 0.00822349 1.940061e-27 Q99459 41361833_Josephine_Robertson_Q99459_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P43652 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P43652 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg19693031 chr1:145441552 1 145441552 TXNIP Open sea -0.0893409 0.00833083 9.853221e-27 P43652 41361833_Josephine_Robertson_P43652_OSCA_model_3 Sayols-Baixeras S - 28173150 2016-09-15 Serum triglycerides EFO_0004530, CHEBI_17855 Replication adjusted for surrogate variables Table S1 Serum triglycerides DNA methylation Age, sex, smoking, cell counts and technical covariates mg/dl M values Illumina HumanMethylation450 Whole blood Triglycerides levels were log-transformed 2542 1 66.3 Both None cg19693031 chr1:145441552 1 145441552 TXNIP Open sea -0.051 0.005 5.7e-26 - 28173150_serum_triglycerides_replication_adjusted_for_surrogate_variables Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P36955 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P36955 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg19693031 chr1:145441552 1 145441552 TXNIP Open sea -0.0885791 0.00853562 3.832195e-25 P36955 41361833_Josephine_Robertson_P36955_OSCA_model_2 Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 BMI EFO_0004340 discovery None DNA methylation BMI Age,Sex,Smoking,Cell composition (reference based),Batch effects Other kg/m2 Illumina HumanMethylationEPIC Whole blood None 17304 1 Adults Both European cg19693031 chr1:145441552 1 145441552 TXNIP Open sea -0.262867 0.0257308 1.971557e-24 None 39706196_Hannah-M.-Smith_bmi_discovery Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a random effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg19693031 chr1:145441552 1 145441552 TXNIP Open sea 0.0024 None 2.5999999999999996e-24 None 33450751_Mulder-RH_age_model_1_with_age_as_a_random_effect Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 A0A0C4DH35 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation A0A0C4DH35 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg19693031 chr1:145441552 1 145441552 TXNIP Open sea 0.0837785 0.00822754 2.853298e-24 A0A0C4DH35 41361833_Josephine_Robertson_A0A0C4DH35_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P06312 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P06312 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg19693031 chr1:145441552 1 145441552 TXNIP Open sea 0.0857268 0.00850638 8.268333e-24 P06312 41361833_Josephine_Robertson_P06312_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 O75636 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation O75636 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg19693031 chr1:145441552 1 145441552 TXNIP Open sea -0.085759 0.00851746 9.084507e-24 O75636 41361833_Josephine_Robertson_O75636_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P00747 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation P00747 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg19693031 chr1:145441552 1 145441552 TXNIP Open sea -0.0917359 0.0092296 3.325043e-23 P00747 41361833_Josephine_Robertson_P00747_OSCA_model_4 Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 Total cholesterol EFO_0004574 discovery None DNA methylation Total cholesterol Age,Sex,Smoking,Cell composition (reference based) Other mmol/L Illumina HumanMethylationEPIC Whole blood None 18270 1 Adults Both European cg19693031 chr1:145441552 1 145441552 TXNIP Open sea -0.246457 0.0248275 3.644128000000001e-23 None 39706196_Hannah-M.-Smith_total_cholesterol_discovery Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01619 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P01619 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg19693031 chr1:145441552 1 145441552 TXNIP Open sea 0.0833267 0.00849766 1.247226e-22 P01619 41361833_Josephine_Robertson_P01619_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 A0A0C4DH35 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation A0A0C4DH35 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg19693031 chr1:145441552 1 145441552 TXNIP Open sea 0.0832718 0.0085085 1.502471e-22 A0A0C4DH35 41361833_Josephine_Robertson_A0A0C4DH35_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01019 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P01019 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg19693031 chr1:145441552 1 145441552 TXNIP Open sea -0.0834699 0.00853395 1.593379e-22 P01019 41361833_Josephine_Robertson_P01019_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 A0A075B7B8 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation A0A075B7B8 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg19693031 chr1:145441552 1 145441552 TXNIP Open sea 0.0830532 0.00851096 1.9873640000000002e-22 A0A075B7B8 41361833_Josephine_Robertson_A0A075B7B8_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P36955 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P36955 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg19693031 chr1:145441552 1 145441552 TXNIP Open sea -0.0802534 0.00822994 2.128103e-22 P36955 41361833_Josephine_Robertson_P36955_OSCA_model_1 Robert F Hillary Generation Scotland 10.1101/2023.01.10.23284387 9/6/2023 Incident Type 2 Diabetes None Fully-adjusted model https://doi.org/10.5281/zenodo.8021411 DNA methylation Incident Type 2 Diabetes Age, Sex, Smoking, Cell composition (reference based), Ancestry (genomic PCs), Body mass index, Socio-economic position, Education, Alcohol consumption M values None Illumina HumanMethylationEPIC Whole blood None 13971 1 Adults (18-65y) Both European cg19693031 chr1:145441552 1 145441552 TXNIP Open sea -0.056 0.00571 2.2e-22 None Robert-F-Hillary_Incident_Type_2_Diabetes_Fully-adjusted_model Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01019 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01019 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg19693031 chr1:145441552 1 145441552 TXNIP Open sea -0.0799612 0.00823013 3.017171e-22 P01019 41361833_Josephine_Robertson_P01019_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 A0A075B7B8 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation A0A075B7B8 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg19693031 chr1:145441552 1 145441552 TXNIP Open sea 0.0799156 0.00823016 3.1860320000000003e-22 A0A075B7B8 41361833_Josephine_Robertson_A0A075B7B8_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P06312 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P06312 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg19693031 chr1:145441552 1 145441552 TXNIP Open sea 0.0816816 0.00850118 8.554103000000001e-22 P06312 41361833_Josephine_Robertson_P06312_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P00747 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P00747 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg19693031 chr1:145441552 1 145441552 TXNIP Open sea -0.0789545 0.0082308 9.950842e-22 P00747 41361833_Josephine_Robertson_P00747_OSCA_model_1 Petersen A-K KORA F4 24014485 2013-09-06 M35186_1-arachidonoylglycerophosphoethanolamine* EFO_0004727, EFO_0004725 snps as covariates model Table S4 M35186_1-arachidonoylglycerophosphoethanolamine* DNA methylation Age, sex, body mass index, cell composition (reference based), genotype None Beta Values Illumina HumanMethylation450 Whole blood used three nearby snps as covariates 1760 1 Adults Both European cg19693031 chr1:145441552 1 145441552 TXNIP Open sea -1 0.25 1.1e-21 None 24014485_Petersen-A-K_m35186_1-arachidonoylglycerophosphoethanolamine__snps_as_covariates_model Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02750 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation P02750 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg19693031 chr1:145441552 1 145441552 TXNIP Open sea 0.0870239 0.00909339 1.236547e-21 P02750 41361833_Josephine_Robertson_P02750_OSCA_model_4 Dugue P-A Melbourne Collaborative Cohort Study 31789449 2019-11-04 Alcohol consumption EFO_0004329, EFO_0007878 Previous week consumption discovery Supplementary Table 3 Alcohol consumption DNA methylation age, sex, smoking, body mass index country of birth, sample type, cell composition (reference based), batch effects g/day M Values Illumina HumanMethylation450 Whole blood None 5606 1 Adults Both Unclear cg19693031 chr1:145441552 1 145441552 TXNIP Open sea None None 1.4e-21 None 31789449_Dugue-P-A_alcohol_consumption_previous_week_consumption_discovery Cardona A FHS 31506343 2019-09-10 Type II diabetes EFO_0001360 Replication in Europeans Table 3 DNA methylation Type II diabetes Age, sex, cell composition (reference based), batch effects, body mass index Beta Values None Illumina HumanMethylation450 Whole blood None 2607 1 Adults Both European cg19693031 chr1:145441552 1 145441552 TXNIP Open sea -0.026 0.0027 1.6e-21 None 31506343_Cardona-A_type_ii_diabetes_replication_in_europeans Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 Q99459 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation Q99459 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg19693031 chr1:145441552 1 145441552 TXNIP Open sea 0.0808694 0.0085007 2.130043e-21 Q99459 41361833_Josephine_Robertson_Q99459_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01019 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation P01019 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg19693031 chr1:145441552 1 145441552 TXNIP Open sea -0.0878136 0.00923308 2.181887e-21 P01019 41361833_Josephine_Robertson_P01019_OSCA_model_4 Cardona A EPIC-Norfolk 31506343 2019-09-10 Type II diabetes EFO_0001360 Discovery Table 2 Type II diabetes DNA methylation Age, sex, cell composition (reference based), batch effects None Beta Values Illumina HumanMethylation450 Whole blood None 1264 1 Adults Both European cg19693031 chr1:145441552 1 145441552 TXNIP Open sea -0.65 None 2.7e-21 None 31506343_Cardona-A_type_ii_diabetes_discovery Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 A0A0C4DH35 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation A0A0C4DH35 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg19693031 chr1:145441552 1 145441552 TXNIP Open sea 0.0805263 0.00850092 3.1373999999999996e-21 A0A0C4DH35 41361833_Josephine_Robertson_A0A0C4DH35_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P55056 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation P55056 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg19693031 chr1:145441552 1 145441552 TXNIP Open sea -0.0876166 0.00927914 4.186752e-21 P55056 41361833_Josephine_Robertson_P55056_OSCA_model_4 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P55056 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P55056 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg19693031 chr1:145441552 1 145441552 TXNIP Open sea -0.0804891 0.00853528 4.697266e-21 P55056 41361833_Josephine_Robertson_P55056_OSCA_model_2 Petersen A-K KORA F4 24014485 2013-09-06 M35186_1-arachidonoylglycerophosphoethanolamine* EFO_0004727, EFO_0004725 no snps model Table S2 M35186_1-arachidonoylglycerophosphoethanolamine* DNA methylation Age, sex, body mass index, cell composition (reference based) None Beta Values Illumina HumanMethylation450 Whole blood None 1760 1 Adults Both European cg19693031 chr1:145441552 1 145441552 TXNIP Open sea -1 0.25 8.9e-21 None 24014485_Petersen-A-K_m35186_1-arachidonoylglycerophosphoethanolamine__no_snps_model Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P55056 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P55056 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg19693031 chr1:145441552 1 145441552 TXNIP Open sea -0.0770532 0.00823202 9.095633e-21 P55056 41361833_Josephine_Robertson_P55056_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P00742 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P00742 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg19693031 chr1:145441552 1 145441552 TXNIP Open sea -0.0769976 0.00823206 9.694896e-21 P00742 41361833_Josephine_Robertson_P00742_OSCA_model_1 Sayols-Baixeras S - 28173150 2016-09-15 Serum triglycerides EFO_0004530, CHEBI_17855 Replication Table S1 Serum triglycerides DNA methylation Age, sex, smoking, cell counts and technical covariates mg/dl M values Illumina HumanMethylation450 Whole blood Triglycerides levels were log-transformed 2542 1 66.3 Both None cg19693031 chr1:145441552 1 145441552 TXNIP Open sea -0.041 0.004 1e-20 - 28173150_serum_triglycerides_replication Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P06312 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation P06312 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg19693031 chr1:145441552 1 145441552 TXNIP Open sea 0.0863648 0.00924184 1.049429e-20 P06312 41361833_Josephine_Robertson_P06312_OSCA_model_4 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P14151 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation P14151 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg19693031 chr1:145441552 1 145441552 TXNIP Open sea 0.0853942 0.00917055 1.432736e-20 P14151 41361833_Josephine_Robertson_P14151_OSCA_model_4 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 A0A075B7B8 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation A0A075B7B8 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg19693031 chr1:145441552 1 145441552 TXNIP Open sea 0.0790243 0.00849766 1.606298e-20 A0A075B7B8 41361833_Josephine_Robertson_A0A075B7B8_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01619 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P01619 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg19693031 chr1:145441552 1 145441552 TXNIP Open sea 0.0781794 0.00849851 4.084931e-20 P01619 41361833_Josephine_Robertson_P01619_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01019 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P01019 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg19693031 chr1:145441552 1 145441552 TXNIP Open sea -0.0783627 0.00852674 4.4375989999999996e-20 P01019 41361833_Josephine_Robertson_P01019_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01024 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P01024 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg19693031 chr1:145441552 1 145441552 TXNIP Open sea -0.0712177 0.0077654 5.29254e-20 P01024 41361833_Josephine_Robertson_P01024_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 O75636 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation O75636 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg19693031 chr1:145441552 1 145441552 TXNIP Open sea -0.0775974 0.00849214 7.211086e-20 O75636 41361833_Josephine_Robertson_O75636_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01024 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation P01024 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg19693031 chr1:145441552 1 145441552 TXNIP Open sea -0.0760687 0.00840757 1.641775e-19 P01024 41361833_Josephine_Robertson_P01024_OSCA_model_4 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P08603 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P08603 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg19693031 chr1:145441552 1 145441552 TXNIP Open sea -0.0739853 0.00823394 2.887532e-19 P08603 41361833_Josephine_Robertson_P08603_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P78563 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P78563 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg19693031 chr1:145441552 1 145441552 TXNIP Open sea 0.073631 0.00823416 4.2663409999999995e-19 P78563 41361833_Josephine_Robertson_P78563_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02750 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P02750 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg19693031 chr1:145441552 1 145441552 TXNIP Open sea 0.0752862 0.00842337 4.437351999999999e-19 P02750 41361833_Josephine_Robertson_P02750_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 Q99459 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation Q99459 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg19693031 chr1:145441552 1 145441552 TXNIP Open sea 0.0757443 0.00848558 4.922871e-19 Q99459 41361833_Josephine_Robertson_Q99459_OSCA_model_3 Dugue P-A Melbourne Collaborative Cohort Study 31789449 2019-11-04 Alcohol consumption EFO_0004329, EFO_0007878 Previous decade consumption discovery Supplementary Table 3 Alcohol consumption DNA methylation age, sex, smoking, body mass index country of birth, sample type, cell composition (reference based), batch effects g/day M Values Illumina HumanMethylation450 Whole blood None 5606 1 Adults Both Unclear cg19693031 chr1:145441552 1 145441552 TXNIP Open sea None None 5.2e-19 None 31789449_Dugue-P-A_alcohol_consumption_previous_decade_consumption_discovery Hedman AK - 28213390 2017-02-17 Serum triglycerides EFO_0004530, CHEBI_17855 Discovery and replication Table S5 DNA methylation Serum triglycerides Age, sex, cell counts and technical covariates Beta values mg/dl Illumina HumanMethylation450 Whole blood Inverse variance weighted fixed-effect meta-analysis 4261 5 65 Both None cg19693031 chr1:145441552 1 145441552 TXNIP Open sea -0.0141941 0.0015954 5.74e-19 - 28213390_serum_triglycerides_discovery_and_replication Robert F. Hillary Generation Scotland doi.org/10.1101/2023.11.02.23298000 Nov 3, 2023 C-reactive protein (CRP) levels None Basic model None C-reactive protein (CRP) levels DNA methylation Age, Sex, Cell composition (reference based), Batch effects mg/L Beta values Illumina HumanMethylationEPIC Whole blood None 17936 1 Adults Both European cg19693031 chr1:145441552 1 145441552 TXNIP Open sea -1.5 0.172 7.5e-19 Basic_Model Robert-F.-Hillary_c-reactive_protein__crp__levels_basic_model Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P36955 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation P36955 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg19693031 chr1:145441552 1 145441552 TXNIP Open sea -0.0806823 0.00909122 7.809827999999999e-19 P36955 41361833_Josephine_Robertson_P36955_OSCA_model_4 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 A0A0C4DH25 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation A0A0C4DH25 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg19693031 chr1:145441552 1 145441552 TXNIP Open sea 0.07301 0.00823454 8.41977e-19 A0A0C4DH25 41361833_Josephine_Robertson_A0A0C4DH25_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01619 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation P01619 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg19693031 chr1:145441552 1 145441552 TXNIP Open sea 0.0817352 0.00922787 9.11654e-19 P01619 41361833_Josephine_Robertson_P01619_OSCA_model_4 Chambers JC - 26095709 2015-07-01 Type II diabetes EFO_0001360 Meta-analysis Table 3 Type II diabetes DNA methylation Age, sex, cell counts and technical covariates - Beta values Illumina HumanMethylation450 Peripheral blood Regression coeffcient per 1 pecent increase in methylation 3805 4 53 Both European,South Asian cg19693031 chr1:145441552 1 145441552 TXNIP Open sea -0.0834 0.0095 1.5e-18 - 26095709_type_ii_diabetes_metaanalysis Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P08603 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P08603 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg19693031 chr1:145441552 1 145441552 TXNIP Open sea -0.0749323 0.00852292 1.632468e-18 P08603 41361833_Josephine_Robertson_P08603_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P00747 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P00747 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg19693031 chr1:145441552 1 145441552 TXNIP Open sea -0.0749243 0.00852766 1.718866e-18 P00747 41361833_Josephine_Robertson_P00747_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02750 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02750 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg19693031 chr1:145441552 1 145441552 TXNIP Open sea 0.0723207 0.00823495 1.778737e-18 P02750 41361833_Josephine_Robertson_P02750_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P55056 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P55056 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg19693031 chr1:145441552 1 145441552 TXNIP Open sea -0.0746227 0.00853756 2.568914e-18 P55056 41361833_Josephine_Robertson_P55056_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 A0A0C4DH35 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation A0A0C4DH35 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg19693031 chr1:145441552 1 145441552 TXNIP Open sea 0.0802881 0.00923473 3.861092e-18 A0A0C4DH35 41361833_Josephine_Robertson_A0A0C4DH35_OSCA_model_4 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P36955 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P36955 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg19693031 chr1:145441552 1 145441552 TXNIP Open sea -0.0722028 0.00836489 6.662342e-18 P36955 41361833_Josephine_Robertson_P36955_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P00742 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P00742 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg19693031 chr1:145441552 1 145441552 TXNIP Open sea -0.0732178 0.00853894 1.0929050000000001e-17 P00742 41361833_Josephine_Robertson_P00742_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 Q99459 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation Q99459 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg19693031 chr1:145441552 1 145441552 TXNIP Open sea 0.0787596 0.00921824 1.424481e-17 Q99459 41361833_Josephine_Robertson_Q99459_OSCA_model_4 Pfeiffer L - 25583993 2015-01-12 Triglycerides EFO_0004530, CHEBI_17855 Discovery Table 2 Triglycerides DNA methylation Age, sex, smoking, body mass index, alcohol consumption, physical activity, hypertension, history of MI, hemoglobin A1c, C-reactive protein, lipid-lowering drugs intake and cell counts mg/dl Beta values Illumina HumanMethylation450 Whole blood - 1776 1 61 Both European cg19693031 chr1:145441552 1 145441552 TXNIP Open sea -0.03 0.003 1.89e-17 - 25583993_triglycerides_discovery Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 A0A075B7B8 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation A0A075B7B8 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg19693031 chr1:145441552 1 145441552 TXNIP Open sea 0.0777571 0.00923101 3.991744e-17 A0A075B7B8 41361833_Josephine_Robertson_A0A075B7B8_OSCA_model_4 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P00747 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P00747 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg19693031 chr1:145441552 1 145441552 TXNIP Open sea -0.0714813 0.00852678 5.617778e-17 P00747 41361833_Josephine_Robertson_P00747_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04114 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation P04114 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg19693031 chr1:145441552 1 145441552 TXNIP Open sea -0.0760092 0.00908808 6.626241e-17 P04114 41361833_Josephine_Robertson_P04114_OSCA_model_4 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 A0A087WSY6 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation A0A087WSY6 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg19693031 chr1:145441552 1 145441552 TXNIP Open sea 0.0686948 0.00823707 8.104001e-17 A0A087WSY6 41361833_Josephine_Robertson_A0A087WSY6_OSCA_model_1 Gomez-Alonso MDC KORA F4 33413638 2021-01-07 VLDL-D EFO_0008594 Meta-analysis Table S2 DNA methylation VLDL-D Age, sex, smoking, body mass index, CRP, HbA1c, alcohol consumption, lipid-lowering drugs, hypertension, history of myocardial infarction, level of physical activity, cell composition (reference based) Beta Values nm Illumina HumanMethylation450 Whole blood Mean diameter for VLDL particles 5414 4 Adults Both European cg19693031 chr1:145441552 1 145441552 TXNIP Open sea -0.11 0.013 8.5e-17 None 33413638_Gomez-Alonso-MDC_vldl-d_meta-analysis Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02750 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P02750 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg19693031 chr1:145441552 1 145441552 TXNIP Open sea 0.0700043 0.00841288 9.477841000000001e-17 P02750 41361833_Josephine_Robertson_P02750_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 A0A0C4DH25 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation A0A0C4DH25 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg19693031 chr1:145441552 1 145441552 TXNIP Open sea 0.0709676 0.00852983 9.570849000000001e-17 A0A0C4DH25 41361833_Josephine_Robertson_A0A0C4DH25_OSCA_model_2 Gomez-Alonso MDC KORA F4 33413638 2021-01-07 S-VLDL-CE_pct None Meta-analysis Table S2 DNA methylation S-VLDL-CE_pct Age, sex, smoking, body mass index, CRP, HbA1c, alcohol consumption, lipid-lowering drugs, hypertension, history of myocardial infarction, level of physical activity, cell composition (reference based) Beta Values % Illumina HumanMethylation450 Whole blood Cholesterol esters to total lipids ratio in small VLDL 5414 4 Adults Both European cg19693031 chr1:145441552 1 145441552 TXNIP Open sea 0.65 0.079 1.9e-16 None 33413638_Gomez-Alonso-MDC_s-vldl-ce_pct_meta-analysis Gomez-Alonso MDC KORA F4 33413638 2021-01-07 XS-VLDL-TG_pct None Meta-analysis Table S2 DNA methylation XS-VLDL-TG_pct Age, sex, smoking, body mass index, CRP, HbA1c, alcohol consumption, lipid-lowering drugs, hypertension, history of myocardial infarction, level of physical activity, cell composition (reference based) Beta Values % Illumina HumanMethylation450 Whole blood Triglycerides to total lipids ratio in very small VLDL 5414 4 Adults Both European cg19693031 chr1:145441552 1 145441552 TXNIP Open sea -0.78 0.094 2e-16 None 33413638_Gomez-Alonso-MDC_xs-vldl-tg_pct_meta-analysis Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P00742 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation P00742 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg19693031 chr1:145441552 1 145441552 TXNIP Open sea -0.0761042 0.00928531 2.685327e-16 P00742 41361833_Josephine_Robertson_P00742_OSCA_model_4 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 A0A0G2JRQ6 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation A0A0G2JRQ6 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg19693031 chr1:145441552 1 145441552 TXNIP Open sea 0.066945 0.00823805 4.776489e-16 A0A0G2JRQ6 41361833_Josephine_Robertson_A0A0G2JRQ6_OSCA_model_1 Albao D. None 31691802 2019-12-15 Type II diabetes mellitus EFO_0001360 Linear regression Table 3 DNA methylation Type II diabetes mellitus Age, sex M Values None Illumina HumanMethylationEPIC Whole Blood None 365 2 Adults Both South Asian cg19693031 chr1:145441552 1 145441552 TXNIP Open sea None None 5.8e-16 Type 2 diabetes, p-value 31691802_Albao-D._type_ii_diabetes_mellitus_linear_regression Soriano-Tarraga C - 26643952 2016-02-01 HbA1c EFO_0009207 BASICMAR 1 Table 3 DNA methylation HbA1c Age, sex, smoking, hyperlipidemia, body mass index, cell counts and technical covariates M values % Illumina HumanMethylation450 Peripheral blood - 268 1 74 Both European cg19693031 chr1:145441552 1 145441552 TXNIP Open sea -0.129 0.016 7.3e-16 - 26643952_hba1c_basicmar_1 Hedman AK - 28213390 2017-02-17 Serum triglycerides EFO_0004530, CHEBI_17855 Discovery and replication adjusted for BMI Table S9 DNA methylation Serum triglycerides Age, sex, body mass index, cell counts and technical covariates Beta values mg/dl Illumina HumanMethylation450 Whole blood Inverse variance weighted fixed-effect meta-analysis 4261 5 65 Both None cg19693031 chr1:145441552 1 145441552 TXNIP Open sea -0.0134 0.0017 7.58e-16 - 28213390_serum_triglycerides_discovery_and_replication_adjusted_for_bmi Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01780 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P01780 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg19693031 chr1:145441552 1 145441552 TXNIP Open sea 0.0686427 0.00853386 9.390032e-16 P01780 41361833_Josephine_Robertson_P01780_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01780 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01780 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg19693031 chr1:145441552 1 145441552 TXNIP Open sea 0.0662423 0.00823844 9.616281e-16 P01780 41361833_Josephine_Robertson_P01780_OSCA_model_1 Gomez-Alonso MDC KORA F4 33413638 2021-01-07 S-VLDL-C_pct None Meta-analysis Table S2 DNA methylation S-VLDL-C_pct Age, sex, smoking, body mass index, CRP, HbA1c, alcohol consumption, lipid-lowering drugs, hypertension, history of myocardial infarction, level of physical activity, cell composition (reference based) Beta Values % Illumina HumanMethylation450 Whole blood Total cholesterol to total lipids ratio in small VLDL 5414 4 Adults Both European cg19693031 chr1:145441552 1 145441552 TXNIP Open sea 0.45 0.056 0.000000000000001 None 33413638_Gomez-Alonso-MDC_s-vldl-c_pct_meta-analysis Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 A0A075B6H7 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation A0A075B6H7 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg19693031 chr1:145441552 1 145441552 TXNIP Open sea 0.0661055 0.00823851 0.000000000000001100997 A0A075B6H7 41361833_Josephine_Robertson_A0A075B6H7_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 O14791 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation O14791 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg19693031 chr1:145441552 1 145441552 TXNIP Open sea -0.0742449 0.00927086 0.000000000000001249016 O14791 41361833_Josephine_Robertson_O14791_OSCA_model_4 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 O14791 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation O14791 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg19693031 chr1:145441552 1 145441552 TXNIP Open sea -0.0659692 0.00823859 0.000000000000001259632 O14791 41361833_Josephine_Robertson_O14791_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 A0A0A0MT89 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation A0A0A0MT89 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg19693031 chr1:145441552 1 145441552 TXNIP Open sea 0.0653033 0.00823895 0.000000000000002422071 A0A0A0MT89 41361833_Josephine_Robertson_A0A0A0MT89_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P00742 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P00742 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg19693031 chr1:145441552 1 145441552 TXNIP Open sea -0.0673379 0.00854063 0.000000000000003381585 P00742 41361833_Josephine_Robertson_P00742_OSCA_model_3 Justice AE ARIC study 32901515 09-09-2020 waist circumference-to-hip ratio None discovery Table 1 waist circumference-to-hip ratio DNA methylation Age, Sex, Smoking, Cell composition (reference based), Body mass index, Education cm Beta values Illumina HumanMethylation450 Whole blood None 2684 1 Adults Both African, Other cg19693031 chr1:145441552 1 145441552 TXNIP Open sea -0.15 0.019 0.0000000000000035 None 32901515_Justice-AE_waist_circumference-to-hip_ratio_discovery Gomez-Alonso MDC KORA F4 33413638 2021-01-07 L-VLDL-L None Meta-analysis Table S2 DNA methylation L-VLDL-L Age, sex, smoking, body mass index, CRP, HbA1c, alcohol consumption, lipid-lowering drugs, hypertension, history of myocardial infarction, level of physical activity, cell composition (reference based) Beta Values mmol/L Illumina HumanMethylation450 Whole blood Total lipids in large VLDL 5414 4 Adults Both European cg19693031 chr1:145441552 1 145441552 TXNIP Open sea -3.9 0.49 0.0000000000000052 None 33413638_Gomez-Alonso-MDC_l-vldl-l_meta-analysis Gomez-Alonso MDC KORA F4 33413638 2021-01-07 L-VLDL-P None Meta-analysis Table S2 DNA methylation L-VLDL-P Age, sex, smoking, body mass index, CRP, HbA1c, alcohol consumption, lipid-lowering drugs, hypertension, history of myocardial infarction, level of physical activity, cell composition (reference based) Beta Values mol/L Illumina HumanMethylation450 Whole blood Concentration of large VLDL particles 5414 4 Adults Both European cg19693031 chr1:145441552 1 145441552 TXNIP Open sea -3.9 0.5 0.000000000000006 None 33413638_Gomez-Alonso-MDC_l-vldl-p_meta-analysis Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01718 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01718 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg19693031 chr1:145441552 1 145441552 TXNIP Open sea 0.0642305 0.00823952 0.000000000000006849512 P01718 41361833_Josephine_Robertson_P01718_OSCA_model_1 Hedman AK - 28213390 2017-02-17 Serum triglycerides EFO_0004530, CHEBI_17855 Discovery Table S5 DNA methylation Serum triglycerides Age, sex, cell counts and technical covariates Beta values mg/dl Illumina HumanMethylation450 Whole blood - 2306 2 68 Both None cg19693031 chr1:145441552 1 145441552 TXNIP Open sea -0.0174243 0.0022491 0.0000000000000094 - 28213390_serum_triglycerides_discovery Cardona A LOLIPOP 31506343 2019-09-10 Type II diabetes EFO_0001360 Replication in Indians Table 3 Type II diabetes DNA methylation Cell composition (reference based), batch effects None Beta Values Illumina HumanMethylation450 Whole blood None 2664 1 Adults Both South Asian cg19693031 chr1:145441552 1 145441552 TXNIP Open sea -0.386 None 0.000000000000012 None 31506343_Cardona-A_type_ii_diabetes_replication_in_indians Dugue P-A Melbourne Collaborative Cohort Study 31789449 2019-11-04 Alcohol consumption EFO_0004329, EFO_0007878 Lifetime consumption discovery Supplementary Table 3 Alcohol consumption DNA methylation age, sex, smoking, body mass index country of birth, sample type, cell composition (reference based), batch effects g/day M Values Illumina HumanMethylation450 Whole blood None 5606 1 Adults Both Unclear cg19693031 chr1:145441552 1 145441552 TXNIP Open sea None None 0.000000000000013 None 31789449_Dugue-P-A_alcohol_consumption_lifetime_consumption_discovery Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02671 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation P02671 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg19693031 chr1:145441552 1 145441552 TXNIP Open sea 0.0713704 0.00927244 0.0000000000000148122 P02671 41361833_Josephine_Robertson_P02671_OSCA_model_4 Richard MA CHARGE 29198723 2019-11-25 Diastolic Blood Pressure EFO_0006336 Meta-analysis Table S4 DNA methylation Diastolic Blood Pressure Age, sex, smoking, batch effects, ancestry, body mass index, blood cell counts Beta Values mmHg Illumina HumanMethylation450 Whole blood, CD4+ T cells Overall meta-analysis of discovery and replication cohorts 17010 14 Adults Both African, Admixed, European cg19693031 chr1:145441552 1 145441552 TXNIP Open sea -0.0003 None 0.000000000000018 None 29198723_Richard-MA_diastolic_blood_pressure_meta-analysis Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 A0A0C4DH25 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation A0A0C4DH25 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg19693031 chr1:145441552 1 145441552 TXNIP Open sea 0.0652435 0.00852497 0.00000000000002081882 A0A0C4DH25 41361833_Josephine_Robertson_A0A0C4DH25_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04114 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P04114 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg19693031 chr1:145441552 1 145441552 TXNIP Open sea -0.063062 0.00824014 0.0000000000000208508 P04114 41361833_Josephine_Robertson_P04114_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 A0A0J9YX35 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation A0A0J9YX35 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg19693031 chr1:145441552 1 145441552 TXNIP Open sea 0.062955 0.00824019 0.00000000000002306472 A0A0J9YX35 41361833_Josephine_Robertson_A0A0J9YX35_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 A0A075B6H7 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation A0A075B6H7 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg19693031 chr1:145441552 1 145441552 TXNIP Open sea 0.0648917 0.00852941 0.00000000000002953015 A0A075B6H7 41361833_Josephine_Robertson_A0A075B6H7_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01780 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P01780 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg19693031 chr1:145441552 1 145441552 TXNIP Open sea 0.0649641 0.00854195 0.00000000000003014799 P01780 41361833_Josephine_Robertson_P01780_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 A0A087WSY6 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation A0A087WSY6 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg19693031 chr1:145441552 1 145441552 TXNIP Open sea 0.0643956 0.00852126 0.00000000000004366749 A0A087WSY6 41361833_Josephine_Robertson_A0A087WSY6_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04114 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P04114 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg19693031 chr1:145441552 1 145441552 TXNIP Open sea -0.0637185 0.00844637 0.00000000000004829261 P04114 41361833_Josephine_Robertson_P04114_OSCA_model_2 Gomez-Alonso MDC KORA F4 33413638 2021-01-07 L-VLDL-FC None Meta-analysis Table S2 DNA methylation L-VLDL-FC Age, sex, smoking, body mass index, CRP, HbA1c, alcohol consumption, lipid-lowering drugs, hypertension, history of myocardial infarction, level of physical activity, cell composition (reference based) Beta Values mmol/L Illumina HumanMethylation450 Whole blood Free cholesterol in large VLDL 5414 4 Adults Both European cg19693031 chr1:145441552 1 145441552 TXNIP Open sea -5 0.66 0.000000000000051 None 33413638_Gomez-Alonso-MDC_l-vldl-fc_meta-analysis Gomez-Alonso MDC KORA F4 33413638 2021-01-07 MUFAtoFA None Meta-analysis Table S2 DNA methylation MUFAtoFA Age, sex, smoking, body mass index, CRP, HbA1c, alcohol consumption, lipid-lowering drugs, hypertension, history of myocardial infarction, level of physical activity, cell composition (reference based) Beta Values % Illumina HumanMethylation450 Whole blood Ratio of monounsaturated fatty acids to total fatty acids 5414 4 Adults Both European cg19693031 chr1:145441552 1 145441552 TXNIP Open sea -0.32 0.042 0.000000000000065 None 33413638_Gomez-Alonso-MDC_mufatofa_meta-analysis Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 O14791 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation O14791 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg19693031 chr1:145441552 1 145441552 TXNIP Open sea -0.0641217 0.00854408 0.00000000000006504933 O14791 41361833_Josephine_Robertson_O14791_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P78563 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P78563 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg19693031 chr1:145441552 1 145441552 TXNIP Open sea 0.0639912 0.0085318 0.00000000000006731101 P78563 41361833_Josephine_Robertson_P78563_OSCA_model_2 Juvinao-Quintero DL ALSPAC, LBC1936, RSIII-1, RS-Bios 33622391 2021-02-23 Type 2 diabetes EFO_0001360 meta-analysis Table 2 DNA methylation Type 2 diabetes age, sex, batch effects, cell composition (reference based), smoking Beta Values None Illumina HumanMethylation450 Whole blood None 3428 4 Adults Both European cg19693031 chr1:145441552 1 145441552 TXNIP Open sea -0.019 0.00259 0.000000000000088 None 33622391_Juvinao-Quintero-DL_type_2_diabetes_meta-analysis Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 A0A0C4DH25 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation A0A0C4DH25 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg19693031 chr1:145441552 1 145441552 TXNIP Open sea 0.0690405 0.00926278 0.00000000000009594939 A0A0C4DH25 41361833_Josephine_Robertson_A0A0C4DH25_OSCA_model_4 Chambers JC - 26095709 2015-07-01 Type II diabetes EFO_0001360 Discovery Table 3 Type II diabetes DNA methylation Age, sex, cell counts and technical covariates - Beta values Illumina HumanMethylation450 Peripheral blood Regression coeffcient per 1 pecent increase in methylation 2664 1 50 Both South Asian cg19693031 chr1:145441552 1 145441552 TXNIP Open sea -0.08338161 0.0112 0.0000000000001 - 26095709_type_ii_diabetes_discovery Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 A0A0C4DH34 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation A0A0C4DH34 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg19693031 chr1:145441552 1 145441552 TXNIP Open sea 0.0611419 0.00824112 0.0000000000001243634 A0A0C4DH34 41361833_Josephine_Robertson_A0A0C4DH34_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 A0A0J9YX35 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation A0A0J9YX35 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg19693031 chr1:145441552 1 145441552 TXNIP Open sea 0.0630983 0.00853155 0.0000000000001480909 A0A0J9YX35 41361833_Josephine_Robertson_A0A0J9YX35_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 A0A0A0MT89 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation A0A0A0MT89 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg19693031 chr1:145441552 1 145441552 TXNIP Open sea 0.0630114 0.00853297 0.0000000000001613077 A0A0A0MT89 41361833_Josephine_Robertson_A0A0A0MT89_OSCA_model_2 Gomez-Alonso MDC KORA F4 33413638 2021-01-07 L-VLDL-TG None Meta-analysis Table S2 DNA methylation L-VLDL-TG Age, sex, smoking, body mass index, CRP, HbA1c, alcohol consumption, lipid-lowering drugs, hypertension, history of myocardial infarction, level of physical activity, cell composition (reference based) Beta Values mmol/L Illumina HumanMethylation450 Whole blood Triglycerides in large VLDL 5414 4 Adults Both European cg19693031 chr1:145441552 1 145441552 TXNIP Open sea -4.3 0.59 0.00000000000023 None 33413638_Gomez-Alonso-MDC_l-vldl-tg_meta-analysis Gomez-Alonso MDC KORA F4 33413638 2021-01-07 L-VLDL-PL None Meta-analysis Table S2 DNA methylation L-VLDL-PL Age, sex, smoking, body mass index, CRP, HbA1c, alcohol consumption, lipid-lowering drugs, hypertension, history of myocardial infarction, level of physical activity, cell composition (reference based) Beta Values mmol/L Illumina HumanMethylation450 Whole blood Phospholipids in large VLDL 5414 4 Adults Both European cg19693031 chr1:145441552 1 145441552 TXNIP Open sea -4.1 0.55 0.00000000000026 None 33413638_Gomez-Alonso-MDC_l-vldl-pl_meta-analysis Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 Q13790 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation Q13790 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg19693031 chr1:145441552 1 145441552 TXNIP Open sea 0.0622924 0.00854423 0.0000000000003243772 Q13790 41361833_Josephine_Robertson_Q13790_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 A0A0G2JRQ6 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation A0A0G2JRQ6 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg19693031 chr1:145441552 1 145441552 TXNIP Open sea 0.0618246 0.00853845 0.0000000000004684906 A0A0G2JRQ6 41361833_Josephine_Robertson_A0A0G2JRQ6_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04003 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P04003 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg19693031 chr1:145441552 1 145441552 TXNIP Open sea -0.0596016 0.00824189 0.0000000000005011644 P04003 41361833_Josephine_Robertson_P04003_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 A0A075B6H7 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation A0A075B6H7 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg19693031 chr1:145441552 1 145441552 TXNIP Open sea 0.0609717 0.00852224 0.000000000000880087 A0A075B6H7 41361833_Josephine_Robertson_A0A075B6H7_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 A0A0J9YX35 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation A0A0J9YX35 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg19693031 chr1:145441552 1 145441552 TXNIP Open sea 0.0609071 0.00854501 0.000000000001067485 A0A0J9YX35 41361833_Josephine_Robertson_A0A0J9YX35_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 A0A0C4DH34 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation A0A0C4DH34 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg19693031 chr1:145441552 1 145441552 TXNIP Open sea 0.0608059 0.00853825 0.000000000001116546 A0A0C4DH34 41361833_Josephine_Robertson_A0A0C4DH34_OSCA_model_2 Soriano-Tarraga C - 26643952 2016-02-01 Type II diabetes EFO_0001360 BASICMAR 1 Table 2 DNA methylation Type II diabetes Age, sex, smoking, hyperlipidemia, body mass index, cell counts and technical covariates M values - Illumina HumanMethylation450 Peripheral blood - 355 1 74 Both European cg19693031 chr1:145441552 1 145441552 TXNIP Open sea -0.35 0.0492 0.00000000000117 - 26643952_type_ii_diabetes_basicmar_1 Jiantao Ma FHS 30796027 Feb 22, 2019 hepatic fat EFO_0010821 Discovery Table 1 DNA methylation hepatic fat Age, Sex, Cell composition (reference based), Batch effects Beta values None Illumina HumanMethylation450 whole blood None 1496 1 Adults Both European cg19693031 chr1:145441552 1 145441552 TXNIP Open sea None None 0.0000000000013 None 30796027_Jiantao-Ma_hepatic_fat_discovery Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01602 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01602 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg19693031 chr1:145441552 1 145441552 TXNIP Open sea 0.0584104 0.00824247 0.000000000001438016 P01602 41361833_Josephine_Robertson_P01602_OSCA_model_1 Gomez-Alonso MDC KORA F4 33413638 2021-01-07 S-LDL-TG_pct None Meta-analysis Table S2 DNA methylation S-LDL-TG_pct Age, sex, smoking, body mass index, CRP, HbA1c, alcohol consumption, lipid-lowering drugs, hypertension, history of myocardial infarction, level of physical activity, cell composition (reference based) Beta Values % Illumina HumanMethylation450 Whole blood Triglycerides to total lipids ratio in small LDL 5414 4 Adults Both European cg19693031 chr1:145441552 1 145441552 TXNIP Open sea -0.76 0.11 0.0000000000015 None 33413638_Gomez-Alonso-MDC_s-ldl-tg_pct_meta-analysis Hedman AK - 28213390 2017-02-17 Serum triglycerides EFO_0004530, CHEBI_17855 Discovery adjusted for BMI Table S9 DNA methylation Serum triglycerides Age, sex, body mass index, cell counts and technical covariates Beta values mg/dl Illumina HumanMethylation450 Whole blood - 2306 2 68 Both None cg19693031 chr1:145441552 1 145441552 TXNIP Open sea -0.0165139 0.0023401 0.0000000000017 - 28213390_serum_triglycerides_discovery_adjusted_for_bmi Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 A0A0C4DH34 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation A0A0C4DH34 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg19693031 chr1:145441552 1 145441552 TXNIP Open sea 0.0602721 0.00855788 0.000000000001966852 A0A0C4DH34 41361833_Josephine_Robertson_A0A0C4DH34_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 A0A087WSY6 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation A0A087WSY6 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg19693031 chr1:145441552 1 145441552 TXNIP Open sea 0.0597273 0.00850711 0.000000000002301912 A0A087WSY6 41361833_Josephine_Robertson_A0A087WSY6_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 A0A0A0MT89 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation A0A0A0MT89 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg19693031 chr1:145441552 1 145441552 TXNIP Open sea 0.0598509 0.00854064 0.000000000002526925 A0A0A0MT89 41361833_Josephine_Robertson_A0A0A0MT89_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 A0A0B4J1V0 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation A0A0B4J1V0 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg19693031 chr1:145441552 1 145441552 TXNIP Open sea 0.057696 0.00824282 0.000000000002679334 A0A0B4J1V0 41361833_Josephine_Robertson_A0A0B4J1V0_OSCA_model_1 Gomez-Alonso MDC KORA F4 33413638 2021-01-07 IDL.TG_pct None Meta-analysis Table S2 DNA methylation IDL.TG_pct Age, sex, smoking, body mass index, CRP, HbA1c, alcohol consumption, lipid-lowering drugs, hypertension, history of myocardial infarction, level of physical activity, cell composition (reference based) Beta Values % Illumina HumanMethylation450 Whole blood Triglycerides to total lipids ratio in IDL 5414 4 Adults Both European cg19693031 chr1:145441552 1 145441552 TXNIP Open sea -0.72 0.1 0.0000000000029 None 33413638_Gomez-Alonso-MDC_idl_tg_pct_meta-analysis Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P78563 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation P78563 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg19693031 chr1:145441552 1 145441552 TXNIP Open sea 0.0645549 0.00924266 0.000000000002982948 P78563 41361833_Josephine_Robertson_P78563_OSCA_model_4 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 A0A0C4DH38 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation A0A0C4DH38 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg19693031 chr1:145441552 1 145441552 TXNIP Open sea 0.0574498 0.00824293 0.000000000003314445 A0A0C4DH38 41361833_Josephine_Robertson_A0A0C4DH38_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P78563 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P78563 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg19693031 chr1:145441552 1 145441552 TXNIP Open sea 0.05939 0.00852177 0.000000000003323233 P78563 41361833_Josephine_Robertson_P78563_OSCA_model_3 Gomez-Alonso MDC KORA F4 33413638 2021-01-07 S-HDL-TG None Meta-analysis Table S2 DNA methylation S-HDL-TG Age, sex, smoking, body mass index, CRP, HbA1c, alcohol consumption, lipid-lowering drugs, hypertension, history of myocardial infarction, level of physical activity, cell composition (reference based) Beta Values mmol/L Illumina HumanMethylation450 Whole blood Triglycerides in small HDL 5414 4 Adults Both European cg19693031 chr1:145441552 1 145441552 TXNIP Open sea -0.8 0.12 0.0000000000041 None 33413638_Gomez-Alonso-MDC_s-hdl-tg_meta-analysis Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 B1AHL2 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation B1AHL2 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg19693031 chr1:145441552 1 145441552 TXNIP Open sea 0.063681 0.00922008 0.00000000000516232 B1AHL2 41361833_Josephine_Robertson_B1AHL2_OSCA_model_4 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01780 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation P01780 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg19693031 chr1:145441552 1 145441552 TXNIP Open sea 0.0640399 0.00927646 0.000000000005283166 P01780 41361833_Josephine_Robertson_P01780_OSCA_model_4 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02743 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02743 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg19693031 chr1:145441552 1 145441552 TXNIP Open sea -0.0564964 0.00824338 0.000000000007491339 P02743 41361833_Josephine_Robertson_P02743_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01023 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01023 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg19693031 chr1:145441552 1 145441552 TXNIP Open sea 0.0563536 0.00824345 0.000000000008455158 P01023 41361833_Josephine_Robertson_P01023_OSCA_model_1 Gomez-Alonso MDC KORA F4 33413638 2021-01-07 L-VLDL-C None Meta-analysis Table S2 DNA methylation L-VLDL-C Age, sex, smoking, body mass index, CRP, HbA1c, alcohol consumption, lipid-lowering drugs, hypertension, history of myocardial infarction, level of physical activity, cell composition (reference based) Beta Values mmol/L Illumina HumanMethylation450 Whole blood Total cholesterol in large VLDL 5414 4 Adults Both European cg19693031 chr1:145441552 1 145441552 TXNIP Open sea -4.2 0.61 0.0000000000087 None 33413638_Gomez-Alonso-MDC_l-vldl-c_meta-analysis Liu C CHARGE+ 27843151 2016-12-15 Alcohol consumption per day EFO_0007878, EFO_0004329 European ancestry Table S5 DNA methylation Alcohol consumption per day Age, sex, body mass index, cell counts and technical covariates Beta values g der day Illumina HumanMethylation450 Whole blood - 9643 10 64.2 Both European cg19693031 chr1:145441552 1 145441552 TXNIP Open sea -0.00043938 6.46e-05 0.0000000000102 - 27843151_alcohol_consumption_per_day_european_ancestry Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 A0A0G2JRQ6 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation A0A0G2JRQ6 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg19693031 chr1:145441552 1 145441552 TXNIP Open sea 0.0630705 0.00928291 0.00000000001130708 A0A0G2JRQ6 41361833_Josephine_Robertson_A0A0G2JRQ6_OSCA_model_4 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 A0A0G2JRQ6 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation A0A0G2JRQ6 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg19693031 chr1:145441552 1 145441552 TXNIP Open sea 0.0577605 0.00854583 0.00000000001442761 A0A0G2JRQ6 41361833_Josephine_Robertson_A0A0G2JRQ6_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 Q13790 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation Q13790 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg19693031 chr1:145441552 1 145441552 TXNIP Open sea 0.0556926 0.00824376 0.00000000001474644 Q13790 41361833_Josephine_Robertson_Q13790_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02671 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02671 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg19693031 chr1:145441552 1 145441552 TXNIP Open sea 0.0556542 0.00824377 0.00000000001522805 P02671 41361833_Josephine_Robertson_P02671_OSCA_model_1 Justice AE ARIC study 32901515 09-09-2020 waist circumference-to-height None discovery Table 1 waist circumference-to-height DNA methylation Age, Sex, Smoking, Cell composition (reference based), Body mass index, Education cm Beta values Illumina HumanMethylation450 Whole blood None 2684 1 Adults Both African, Other cg19693031 chr1:145441552 1 145441552 TXNIP Open sea -0.084 0.012 0.000000000017 None 32901515_Justice-AE_waist_circumference-to-height_discovery Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 O14791 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation O14791 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg19693031 chr1:145441552 1 145441552 TXNIP Open sea -0.0574929 0.00853976 0.0000000000173121 O14791 41361833_Josephine_Robertson_O14791_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01700 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01700 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg19693031 chr1:145441552 1 145441552 TXNIP Open sea 0.0554454 0.00824387 0.00000000001812709 P01700 41361833_Josephine_Robertson_P01700_OSCA_model_1 Ma J FHS, RS, CARDIA, MESA 30936141 2020-05-22 Hepatic Fat EFO_0006506, EFO_0008421 Meta-analysis model 1 Table 1 DNA methylation Hepatic Fat Age, sex Beta Values Hounsfield units Illumina HumanMethylation450 Whole blood Model 1 = adjusted for sex + age 3400 4 Adults Both European cg19693031 chr1:145441552 1 145441552 TXNIP Open sea None None 0.00000000002 None 30936141_Ma-J_hepatic_fat_meta-analysis_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P29622 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation P29622 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg19693031 chr1:145441552 1 145441552 TXNIP Open sea -0.0621413 0.00926464 0.00000000002054499 P29622 41361833_Josephine_Robertson_P29622_OSCA_model_4 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P06310 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P06310 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg19693031 chr1:145441552 1 145441552 TXNIP Open sea 0.0551476 0.00824401 0.00000000002321783 P06310 41361833_Josephine_Robertson_P06310_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P08185 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation P08185 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg19693031 chr1:145441552 1 145441552 TXNIP Open sea -0.0600193 0.00900769 0.00000000002776594 P08185 41361833_Josephine_Robertson_P08185_OSCA_model_4 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 A0A0C4DH36 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation A0A0C4DH36 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg19693031 chr1:145441552 1 145441552 TXNIP Open sea 0.0567659 0.00853918 0.00000000003082235 A0A0C4DH36 41361833_Josephine_Robertson_A0A0C4DH36_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 A0A0C4DH36 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation A0A0C4DH36 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg19693031 chr1:145441552 1 145441552 TXNIP Open sea 0.0544624 0.00824432 0.00000000004082993 A0A0C4DH36 41361833_Josephine_Robertson_A0A0C4DH36_OSCA_model_1 Ma J FHS, RS, CARDIA, MESA 30936141 2020-05-22 Hepatic Fat EFO_0006506, EFO_0008421 Meta-analysis model 2 Table 1 DNA methylation Hepatic Fat Age, sex Beta Values Hounsfield units Illumina HumanMethylation450 Whole blood Model 2 = model 1 + smoking + physical activity + alcohol consumption 3400 4 Adults Both European cg19693031 chr1:145441552 1 145441552 TXNIP Open sea None None 0.000000000043 None 30936141_Ma-J_hepatic_fat_meta-analysis_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01718 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P01718 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg19693031 chr1:145441552 1 145441552 TXNIP Open sea 0.0562945 0.00854105 0.00000000004516316 P01718 41361833_Josephine_Robertson_P01718_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04003 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P04003 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg19693031 chr1:145441552 1 145441552 TXNIP Open sea -0.0559304 0.00852667 0.00000000005581193 P04003 41361833_Josephine_Robertson_P04003_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 A0A0A0MT89 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation A0A0A0MT89 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg19693031 chr1:145441552 1 145441552 TXNIP Open sea 0.0607437 0.00928007 0.00000000006122683 A0A0A0MT89 41361833_Josephine_Robertson_A0A0A0MT89_OSCA_model_4 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 A0A0A0MS14 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation A0A0A0MS14 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg19693031 chr1:145441552 1 145441552 TXNIP Open sea 0.0538213 0.0082446 0.00000000006881345 A0A0A0MS14 41361833_Josephine_Robertson_A0A0A0MS14_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 A0A0A0MS14 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation A0A0A0MS14 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg19693031 chr1:145441552 1 145441552 TXNIP Open sea 0.0557472 0.00854838 0.00000000007194748 A0A0A0MS14 41361833_Josephine_Robertson_A0A0A0MS14_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P14151 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P14151 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg19693031 chr1:145441552 1 145441552 TXNIP Open sea 0.0537059 0.00824466 0.00000000007554817 P14151 41361833_Josephine_Robertson_P14151_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 B1AHL2 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation B1AHL2 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg19693031 chr1:145441552 1 145441552 TXNIP Open sea 0.0536064 0.0082447 0.00000000008186294 B1AHL2 41361833_Josephine_Robertson_B1AHL2_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 A0A087WSY6 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation A0A087WSY6 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg19693031 chr1:145441552 1 145441552 TXNIP Open sea 0.0600002 0.00923231 0.00000000008350848 A0A087WSY6 41361833_Josephine_Robertson_A0A087WSY6_OSCA_model_4 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P00740 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P00740 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg19693031 chr1:145441552 1 145441552 TXNIP Open sea -0.0535179 0.00824474 0.00000000008791337 P00740 41361833_Josephine_Robertson_P00740_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 A0A075B6H7 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation A0A075B6H7 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg19693031 chr1:145441552 1 145441552 TXNIP Open sea 0.0599886 0.00925947 0.00000000009552336 A0A075B6H7 41361833_Josephine_Robertson_A0A075B6H7_OSCA_model_4 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01718 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P01718 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg19693031 chr1:145441552 1 145441552 TXNIP Open sea 0.0554313 0.00856348 0.00000000009913533 P01718 41361833_Josephine_Robertson_P01718_OSCA_model_3 Marttila S - 25888029 2015-03-14 Ageing GO_0007568 - Additional file 1 DNA methylation Age group Sex and cell counts Beta values - Illumina HumanMethylation450 Peripheral blood mononuclear cells Variable dispersion beta regression model 143 1 58.5 Both European cg19693031 chr1:145441552 1 145441552 TXNIP Open sea 0.67887668 0.1053 0.000000000112 - 25888029_ageing Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P08603 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation P08603 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg19693031 chr1:145441552 1 145441552 TXNIP Open sea -0.0549869 0.00852542 0.0000000001155419 P08603 41361833_Josephine_Robertson_P08603_OSCA_model_4 Gomez-Alonso MDC KORA F4 33413638 2021-01-07 VLDL-TG None Meta-analysis Table S2 DNA methylation VLDL-TG Age, sex, smoking, body mass index, CRP, HbA1c, alcohol consumption, lipid-lowering drugs, hypertension, history of myocardial infarction, level of physical activity, cell composition (reference based) Beta Values mmol/L Illumina HumanMethylation450 Whole blood Triglycerides in VLDL 5414 4 Adults Both European cg19693031 chr1:145441552 1 145441552 TXNIP Open sea -1.9 0.3 0.00000000012 None 33413638_Gomez-Alonso-MDC_vldl-tg_meta-analysis Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01602 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation P01602 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg19693031 chr1:145441552 1 145441552 TXNIP Open sea 0.0595768 0.00930183 0.0000000001551078 P01602 41361833_Josephine_Robertson_P01602_OSCA_model_4 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P08185 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P08185 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg19693031 chr1:145441552 1 145441552 TXNIP Open sea -0.0534434 0.00834437 0.0000000001552325 P08185 41361833_Josephine_Robertson_P08185_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 A0A0B4J1V0 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation A0A0B4J1V0 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg19693031 chr1:145441552 1 145441552 TXNIP Open sea 0.0546081 0.00853629 0.0000000001630839 A0A0B4J1V0 41361833_Josephine_Robertson_A0A0B4J1V0_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01602 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P01602 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg19693031 chr1:145441552 1 145441552 TXNIP Open sea 0.0545003 0.00853996 0.0000000001802829 P01602 41361833_Josephine_Robertson_P01602_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P06310 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P06310 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg19693031 chr1:145441552 1 145441552 TXNIP Open sea 0.0544651 0.00853759 0.0000000001830646 P06310 41361833_Josephine_Robertson_P06310_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02671 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P02671 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg19693031 chr1:145441552 1 145441552 TXNIP Open sea 0.0542439 0.00851605 0.0000000001951588 P02671 41361833_Josephine_Robertson_P02671_OSCA_model_2 Gomez-Alonso MDC KORA F4 33413638 2021-01-07 Serum-TG EFO_0004530 Meta-analysis Table S2 DNA methylation Serum-TG Age, sex, smoking, body mass index, CRP, HbA1c, alcohol consumption, lipid-lowering drugs, hypertension, history of myocardial infarction, level of physical activity, cell composition (reference based) Beta Values mmol/L Illumina HumanMethylation450 Whole blood Serum total triglycerides 5414 4 Adults Both European cg19693031 chr1:145441552 1 145441552 TXNIP Open sea -1.5 0.23 0.00000000023 None 33413638_Gomez-Alonso-MDC_serum-tg_meta-analysis Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P05546 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P05546 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg19693031 chr1:145441552 1 145441552 TXNIP Open sea -0.0520159 0.00824539 0.0000000002898669 P05546 41361833_Josephine_Robertson_P05546_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 A0A0C4DH36 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation A0A0C4DH36 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg19693031 chr1:145441552 1 145441552 TXNIP Open sea 0.0536346 0.00853857 0.0000000003448901 A0A0C4DH36 41361833_Josephine_Robertson_A0A0C4DH36_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04114 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P04114 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg19693031 chr1:145441552 1 145441552 TXNIP Open sea -0.0523671 0.008383 0.0000000004304617 P04114 41361833_Josephine_Robertson_P04114_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 A0A0C4DH34 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation A0A0C4DH34 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg19693031 chr1:145441552 1 145441552 TXNIP Open sea 0.0579803 0.00929934 0.0000000004645082 A0A0C4DH34 41361833_Josephine_Robertson_A0A0C4DH34_OSCA_model_4 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P06396 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation P06396 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg19693031 chr1:145441552 1 145441552 TXNIP Open sea 0.0571059 0.00918199 0.0000000005128201 P06396 41361833_Josephine_Robertson_P06396_OSCA_model_4 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P05546 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation P05546 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg19693031 chr1:145441552 1 145441552 TXNIP Open sea -0.05718 0.00919462 0.0000000005144004 P05546 41361833_Josephine_Robertson_P05546_OSCA_model_4 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 A0A0J9YX35 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation A0A0J9YX35 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg19693031 chr1:145441552 1 145441552 TXNIP Open sea 0.057448 0.009284 0.0000000006261181 A0A0J9YX35 41361833_Josephine_Robertson_A0A0J9YX35_OSCA_model_4 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 A0A0B4J1V0 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation A0A0B4J1V0 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg19693031 chr1:145441552 1 145441552 TXNIP Open sea 0.0527591 0.0085501 0.0000000006982981 A0A0B4J1V0 41361833_Josephine_Robertson_A0A0B4J1V0_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P80108 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P80108 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg19693031 chr1:145441552 1 145441552 TXNIP Open sea -0.0527561 0.00855499 0.0000000007155725 P80108 41361833_Josephine_Robertson_P80108_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02743 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P02743 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg19693031 chr1:145441552 1 145441552 TXNIP Open sea -0.0526711 0.00854512 0.0000000007284208 P02743 41361833_Josephine_Robertson_P02743_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P00740 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P00740 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg19693031 chr1:145441552 1 145441552 TXNIP Open sea -0.0524206 0.00853438 0.0000000008344574 P00740 41361833_Josephine_Robertson_P00740_OSCA_model_2 Singmann P - 26500701 2015-10-19 Sex EFO_0001271 KORA F4 Additional file 2 DNA methylation Sex Age, smoking, alcohol consumption, body mass index, triglycerides, total leucocytes, high-density lipoprotein, low-density lipoprotein, physical activity, diabetes, myocardial infarction, cell counts and technical covariates Beta values - Illumina HumanMethylation450 Whole blood - 1799 1 60 Both European cg19693031 chr1:145441552 1 145441552 TXNIP Open sea - - 0.00000000094 - 26500701_sex_kora_f4 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P06310 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P06310 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg19693031 chr1:145441552 1 145441552 TXNIP Open sea 0.0522599 0.00855604 0.000000001034641 P06310 41361833_Josephine_Robertson_P06310_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 A0A0A0MS14 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation A0A0A0MS14 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg19693031 chr1:145441552 1 145441552 TXNIP Open sea 0.0520292 0.00855821 0.000000001235896 A0A0A0MS14 41361833_Josephine_Robertson_A0A0A0MS14_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 A0A0C4DH38 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation A0A0C4DH38 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg19693031 chr1:145441552 1 145441552 TXNIP Open sea 0.0517843 0.00853926 0.000000001358164 A0A0C4DH38 41361833_Josephine_Robertson_A0A0C4DH38_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P20742 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P20742 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg19693031 chr1:145441552 1 145441552 TXNIP Open sea 0.0498918 0.00824629 0.000000001481698 P20742 41361833_Josephine_Robertson_P20742_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01700 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P01700 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg19693031 chr1:145441552 1 145441552 TXNIP Open sea 0.0515436 0.00853352 0.000000001577134 P01700 41361833_Josephine_Robertson_P01700_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P80108 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P80108 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg19693031 chr1:145441552 1 145441552 TXNIP Open sea -0.0497683 0.00824634 0.000000001625935 P80108 41361833_Josephine_Robertson_P80108_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 A0A075B6H9 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation A0A075B6H9 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg19693031 chr1:145441552 1 145441552 TXNIP Open sea 0.0515215 0.00855273 0.000000001742469 A0A075B6H9 41361833_Josephine_Robertson_A0A075B6H9_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02671 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P02671 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg19693031 chr1:145441552 1 145441552 TXNIP Open sea 0.0513698 0.00853484 0.000000001798633 P02671 41361833_Josephine_Robertson_P02671_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 A0A0A0MS15 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation A0A0A0MS15 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg19693031 chr1:145441552 1 145441552 TXNIP Open sea 0.0494778 0.00824646 0.000000002021045 A0A0A0MS15 41361833_Josephine_Robertson_A0A0A0MS15_OSCA_model_1 Gomez-Alonso MDC KORA F4 33413638 2021-01-07 UnSat None Meta-analysis Table S2 DNA methylation UnSat Age, sex, smoking, body mass index, CRP, HbA1c, alcohol consumption, lipid-lowering drugs, hypertension, history of myocardial infarction, level of physical activity, cell composition (reference based) Beta Values None Illumina HumanMethylation450 Whole blood Estimated degree of unsaturation 5414 4 Adults Both European cg19693031 chr1:145441552 1 145441552 TXNIP Open sea 0.12 0.021 0.0000000022 None 33413638_Gomez-Alonso-MDC_unsat_meta-analysis Gomez-Alonso MDC KORA F4 33413638 2021-01-07 M-VLDL-FC None Meta-analysis Table S2 DNA methylation M-VLDL-FC Age, sex, smoking, body mass index, CRP, HbA1c, alcohol consumption, lipid-lowering drugs, hypertension, history of myocardial infarction, level of physical activity, cell composition (reference based) Beta Values mmol/L Illumina HumanMethylation450 Whole blood Free cholesterol in medium VLDL 5414 4 Adults Both European cg19693031 chr1:145441552 1 145441552 TXNIP Open sea -1.9 0.32 0.0000000024 None 33413638_Gomez-Alonso-MDC_m-vldl-fc_meta-analysis Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01602 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P01602 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg19693031 chr1:145441552 1 145441552 TXNIP Open sea 0.0510944 0.00855667 0.000000002408146 P01602 41361833_Josephine_Robertson_P01602_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 Q08380 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation Q08380 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg19693031 chr1:145441552 1 145441552 TXNIP Open sea -0.0491836 0.00824658 0.000000002515996 Q08380 41361833_Josephine_Robertson_Q08380_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P07996 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P07996 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg19693031 chr1:145441552 1 145441552 TXNIP Open sea -0.0491416 0.0082466 0.000000002595668 P07996 41361833_Josephine_Robertson_P07996_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01701 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01701 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg19693031 chr1:145441552 1 145441552 TXNIP Open sea 0.0491003 0.00824661 0.000000002676438 P01701 41361833_Josephine_Robertson_P01701_OSCA_model_1 Gomez-Alonso MDC KORA F4 33413638 2021-01-07 M-VLDL-TG None Meta-analysis Table S2 DNA methylation M-VLDL-TG Age, sex, smoking, body mass index, CRP, HbA1c, alcohol consumption, lipid-lowering drugs, hypertension, history of myocardial infarction, level of physical activity, cell composition (reference based) Beta Values mmol/L Illumina HumanMethylation450 Whole blood Triglycerides in medium VLDL 5414 4 Adults Both European cg19693031 chr1:145441552 1 145441552 TXNIP Open sea -2.2 0.37 0.0000000031 None 33413638_Gomez-Alonso-MDC_m-vldl-tg_meta-analysis Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 A0A075B6H9 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation A0A075B6H9 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg19693031 chr1:145441552 1 145441552 TXNIP Open sea 0.0488061 0.00824673 0.000000003326737 A0A075B6H9 41361833_Josephine_Robertson_A0A075B6H9_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 A0A075B6J9 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation A0A075B6J9 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg19693031 chr1:145441552 1 145441552 TXNIP Open sea 0.0487712 0.00824675 0.000000003413338 A0A075B6J9 41361833_Josephine_Robertson_A0A075B6J9_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 Q08380 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation Q08380 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg19693031 chr1:145441552 1 145441552 TXNIP Open sea -0.0504864 0.00855384 0.000000003666196 Q08380 41361833_Josephine_Robertson_Q08380_OSCA_model_2 Justice AE ARIC study 32901515 09-09-2020 waist circumference None discovery Table 1 waist circumference DNA methylation Age, Sex, Smoking, Cell composition (reference based), Body mass index, Education None Beta values Illumina HumanMethylation450 Whole blood None 2684 1 Adults Both African, Other cg19693031 chr1:145441552 1 145441552 TXNIP Open sea -0.057 0.01 0.0000000041 None 32901515_Justice-AE_waist_circumference_discovery Gomez-Alonso MDC KORA F4 33413638 2021-01-07 IDL.FC_pct None Meta-analysis Table S2 DNA methylation IDL.FC_pct Age, sex, smoking, body mass index, CRP, HbA1c, alcohol consumption, lipid-lowering drugs, hypertension, history of myocardial infarction, level of physical activity, cell composition (reference based) Beta Values % Illumina HumanMethylation450 Whole blood Free cholesterol to total lipids ratio in IDL 5414 4 Adults Both European cg19693031 chr1:145441552 1 145441552 TXNIP Open sea 0.16 0.028 0.0000000049 None 33413638_Gomez-Alonso-MDC_idl_fc_pct_meta-analysis Soriano-Tarraga C - 26643952 2016-02-01 HbA1c EFO_0009207 BASICMAR 2 Table 3 DNA methylation HbA1c Age, sex, smoking, hyperlipidemia, body mass index, cell counts and technical covariates M values % Illumina HumanMethylation450 Peripheral blood - 162 1 74.8 Both European cg19693031 chr1:145441552 1 145441552 TXNIP Open sea -0.144 0.0246 0.00000000511 - 26643952_hba1c_basicmar_2 Gomez-Alonso MDC KORA F4 33413638 2021-01-07 PUFAtoFA None Meta-analysis Table S2 DNA methylation PUFAtoFA Age, sex, smoking, body mass index, CRP, HbA1c, alcohol consumption, lipid-lowering drugs, hypertension, history of myocardial infarction, level of physical activity, cell composition (reference based) Beta Values % Illumina HumanMethylation450 Whole blood Ratio of polyunsaturated fatty acids to total fatty acids 5414 4 Adults Both European cg19693031 chr1:145441552 1 145441552 TXNIP Open sea 0.29 0.05 0.0000000054 None 33413638_Gomez-Alonso-MDC_pufatofa_meta-analysis Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01709 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01709 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg19693031 chr1:145441552 1 145441552 TXNIP Open sea 0.0477706 0.00824715 0.000000007081898 P01709 41361833_Josephine_Robertson_P01709_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P20851 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P20851 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg19693031 chr1:145441552 1 145441552 TXNIP Open sea -0.0476754 0.00824718 0.000000007585082 P20851 41361833_Josephine_Robertson_P20851_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01714 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01714 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg19693031 chr1:145441552 1 145441552 TXNIP Open sea 0.0476506 0.00824719 0.000000007722096 P01714 41361833_Josephine_Robertson_P01714_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 A0A0C4DH38 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation A0A0C4DH38 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg19693031 chr1:145441552 1 145441552 TXNIP Open sea 0.049233 0.00855988 0.000000009016737 A0A0C4DH38 41361833_Josephine_Robertson_A0A0C4DH38_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P07996 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P07996 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg19693031 chr1:145441552 1 145441552 TXNIP Open sea -0.0490906 0.00855084 0.000000009596969 P07996 41361833_Josephine_Robertson_P07996_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01701 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P01701 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg19693031 chr1:145441552 1 145441552 TXNIP Open sea 0.0490869 0.00855082 0.000000009620131 P01701 41361833_Josephine_Robertson_P01701_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01718 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation P01718 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg19693031 chr1:145441552 1 145441552 TXNIP Open sea 0.053063 0.00929511 0.00000001160508 P01718 41361833_Josephine_Robertson_P01718_OSCA_model_4 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 Q13790 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation Q13790 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg19693031 chr1:145441552 1 145441552 TXNIP Open sea 0.0514407 0.00901284 0.00000001168709 Q13790 41361833_Josephine_Robertson_Q13790_OSCA_model_4 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P07996 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P07996 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg19693031 chr1:145441552 1 145441552 TXNIP Open sea -0.0488656 0.00856638 0.00000001190498 P07996 41361833_Josephine_Robertson_P07996_OSCA_model_3 Gomez-Alonso MDC KORA F4 33413638 2021-01-07 Ile EFO_0009793 Meta-analysis Table S2 DNA methylation Ile Age, sex, smoking, body mass index, CRP, HbA1c, alcohol consumption, lipid-lowering drugs, hypertension, history of myocardial infarction, level of physical activity, cell composition (reference based) Beta Values mmol/L Illumina HumanMethylation450 Whole blood Isoleucine 5414 4 Adults Both European cg19693031 chr1:145441552 1 145441552 TXNIP Open sea -0.54 0.095 0.000000013 None 33413638_Gomez-Alonso-MDC_ile_meta-analysis Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01700 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P01700 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg19693031 chr1:145441552 1 145441552 TXNIP Open sea 0.0486075 0.0085476 0.00000001320041 P01700 41361833_Josephine_Robertson_P01700_OSCA_model_3 Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 HDL cholesterol EFO_0004612 sensitivity None DNA methylation HDL cholesterol Age,Sex,Smoking,Cell composition (reference based),Batch effects Other mmol/L Illumina HumanMethylationEPIC Whole blood None 18225 1 Adults Both European cg19693031 chr1:145441552 1 145441552 TXNIP Open sea 0.148902 0.026432 0.00000001793001 None 39706196_Hannah-M.-Smith_hdl_cholesterol_sensitivity Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P14151 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P14151 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg19693031 chr1:145441552 1 145441552 TXNIP Open sea 0.0481184 0.00854405 0.00000001816173 P14151 41361833_Josephine_Robertson_P14151_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P08603 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P08603 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg19693031 chr1:145441552 1 145441552 TXNIP Open sea -0.044284 0.00786768 0.00000001850082 P08603 41361833_Josephine_Robertson_P08603_OSCA_model_3 Gomez-Alonso MDC KORA F4 33413638 2021-01-07 XS-VLDL-TG None Meta-analysis Table S2 DNA methylation XS-VLDL-TG Age, sex, smoking, body mass index, CRP, HbA1c, alcohol consumption, lipid-lowering drugs, hypertension, history of myocardial infarction, level of physical activity, cell composition (reference based) Beta Values mmol/L Illumina HumanMethylation450 Whole blood Triglycerides in very small VLDL 5414 4 Adults Both European cg19693031 chr1:145441552 1 145441552 TXNIP Open sea -1.1 0.19 0.000000021 None 33413638_Gomez-Alonso-MDC_xs-vldl-tg_meta-analysis Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P05546 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P05546 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg19693031 chr1:145441552 1 145441552 TXNIP Open sea -0.0478153 0.00853161 0.00000002126367 P05546 41361833_Josephine_Robertson_P05546_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01700 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation P01700 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg19693031 chr1:145441552 1 145441552 TXNIP Open sea 0.0518087 0.00928218 0.0000000242648 P01700 41361833_Josephine_Robertson_P01700_OSCA_model_4 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04003 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P04003 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg19693031 chr1:145441552 1 145441552 TXNIP Open sea -0.0472761 0.00849019 0.00000002617305 P04003 41361833_Josephine_Robertson_P04003_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 A0A075B6J9 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation A0A075B6J9 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg19693031 chr1:145441552 1 145441552 TXNIP Open sea 0.0475915 0.00855362 0.00000002684291 A0A075B6J9 41361833_Josephine_Robertson_A0A075B6J9_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02749 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02749 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg19693031 chr1:145441552 1 145441552 TXNIP Open sea -0.0458569 0.00824789 0.00000002747329 P02749 41361833_Josephine_Robertson_P02749_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 A0A0A0MS15 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation A0A0A0MS15 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg19693031 chr1:145441552 1 145441552 TXNIP Open sea 0.0473588 0.00855219 0.00000003118774 A0A0A0MS15 41361833_Josephine_Robertson_A0A0A0MS15_OSCA_model_2 Nicolas Fragoso-Bargas EPIPREG 36534481 Dec 19, 2022 HOMA-IR EFO:0000001 discovery Supplementary Table 2 DNA methylation HOMA-IR Smoking,Cell composition (reference based) M values None Illumina HumanMethylationEPIC Whole blood analysis in pregnancy (cross ancestry) 456 1 Adults (18-65 years) Females European,South Asian cg19693031 chr1:145441552 1 145441552 TXNIP Open sea -0.139283258 0.024383525 0.0000000314 None 36534481_Nicolas-Fragoso-Bargas_homa-ir_discovery Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P07360 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation P07360 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg19693031 chr1:145441552 1 145441552 TXNIP Open sea -0.0514161 0.00928798 0.0000000315184 P07360 41361833_Josephine_Robertson_P07360_OSCA_model_4 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P05160 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P05160 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg19693031 chr1:145441552 1 145441552 TXNIP Open sea -0.0455307 0.00824801 0.00000003443529 P05160 41361833_Josephine_Robertson_P05160_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P00740 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation P00740 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg19693031 chr1:145441552 1 145441552 TXNIP Open sea -0.0506762 0.00919011 0.00000003562832 P00740 41361833_Josephine_Robertson_P00740_OSCA_model_4 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P80108 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation P80108 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg19693031 chr1:145441552 1 145441552 TXNIP Open sea -0.0511212 0.00928095 0.00000003686523 P80108 41361833_Josephine_Robertson_P80108_OSCA_model_4 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01701 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P01701 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg19693031 chr1:145441552 1 145441552 TXNIP Open sea 0.0472136 0.00857421 0.00000003722586 P01701 41361833_Josephine_Robertson_P01701_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P29622 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P29622 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg19693031 chr1:145441552 1 145441552 TXNIP Open sea -0.0469833 0.00853869 0.00000003809305 P29622 41361833_Josephine_Robertson_P29622_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P35858 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P35858 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg19693031 chr1:145441552 1 145441552 TXNIP Open sea -0.0468317 0.00855283 0.00000004432445 P35858 41361833_Josephine_Robertson_P35858_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P18428 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P18428 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg19693031 chr1:145441552 1 145441552 TXNIP Open sea -0.0463166 0.00846455 0.0000000452714 P18428 41361833_Josephine_Robertson_P18428_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P20851 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P20851 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg19693031 chr1:145441552 1 145441552 TXNIP Open sea -0.0464988 0.00855044 0.00000005468948 P20851 41361833_Josephine_Robertson_P20851_OSCA_model_2 Gadd DA Generation Scotland 35945220 31/07/2022 SCUBE1 protein levels (SeqId = 8989-40) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 SCUBE1 protein levels (SeqId = 8989-40) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Signal peptide, CUB and EGF-like domain-containing protein 1 774 1 Adults (18-65 years) Both European cg19693031 chr1:145441552 1 145441552 TXNIP Open sea -0.73 0.134 0.000000065 None Gadd-DA_scube1_protein_levels__seqid___8989-40__somascan_protein_measurement Braun KVE - 28194238 2016-06-16 Triglycerides EFO_0004530, CHEBI_17855 Discovery and replication Table S1 DNA methylation Triglycerides Age, sex, smoking, cell counts and technical covariates Beta values mmol/l Illumina HumanMethylation450 Whole blood - 1485 2 64 Both None cg19693031 chr1:145441552 1 145441552 TXNIP Open sea -0.0133 0.0025 0.0000000672 - 28194238_triglycerides_discovery_and_replication Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 A0A075B6H9 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation A0A075B6H9 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg19693031 chr1:145441552 1 145441552 TXNIP Open sea 0.0461949 0.00855717 0.00000006829086 A0A075B6H9 41361833_Josephine_Robertson_A0A075B6H9_OSCA_model_3 Nicolas Fragoso-Bargas EPIPREG 36534481 Dec 19, 2022 HOMA-IR EFO:0000001 discovery (european) Supplementary Table 3 DNA methylation HOMA-IR Age,Smoking,Cell composition (reference based) M values None Illumina HumanMethylationEPIC Whole blood analysis in pregnancy (europeans) 294 1 Adults (18-65 years) Females European cg19693031 chr1:145441552 1 145441552 TXNIP Open sea -0.194252543 0.035343837 0.0000000768 None 36534481_Nicolas-Fragoso-Bargas_homa-ir_discovery_(european) Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 A0A0A0MS14 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation A0A0A0MS14 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg19693031 chr1:145441552 1 145441552 TXNIP Open sea 0.0498544 0.00930833 0.00000008642295 A0A0A0MS14 41361833_Josephine_Robertson_A0A0A0MS14_OSCA_model_4 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 A0A0B4J1V0 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation A0A0B4J1V0 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg19693031 chr1:145441552 1 145441552 TXNIP Open sea 0.049525 0.00927894 0.0000000957185 A0A0B4J1V0 41361833_Josephine_Robertson_A0A0B4J1V0_OSCA_model_4 Gomez-Alonso MDC KORA F4 33413638 2021-01-07 TGtoPG None Meta-analysis Table S2 DNA methylation TGtoPG Age, sex, smoking, body mass index, CRP, HbA1c, alcohol consumption, lipid-lowering drugs, hypertension, history of myocardial infarction, level of physical activity, cell composition (reference based) Beta Values None Illumina HumanMethylation450 Whole blood Ratio of triglycerides to phosphoglycerides 5414 4 Adults Both European cg19693031 chr1:145441552 1 145441552 TXNIP Open sea -0.64 0.12 0.000000097 None 33413638_Gomez-Alonso-MDC_tgtopg_meta-analysis Chung SA - 26192630 2015-07-20 Autoantibody production in systemic lupus erythematosus EFO_0004866, EFO_0002690 Combined Table S1 DNA methylation Autoantibody production in systemic lupus erythematosus Age, disease duration, cell counts and technical covariates Beta values - Illumina HumanMethylation450 Peripheral blood Wilcoxon rank sum test 326 2 46 Females European cg19693031 chr1:145441552 1 145441552 TXNIP Open sea - - 0.0000001 - 26192630_autoantibody_production_in_systemic_lupus_erythematosus_combined Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 A0A075B6J9 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation A0A075B6J9 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg19693031 chr1:145441552 1 145441552 TXNIP Open sea 0.0456223 0.00857304 0.0000001043711 A0A075B6J9 41361833_Josephine_Robertson_A0A075B6J9_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02749 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation P02749 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg19693031 chr1:145441552 1 145441552 TXNIP Open sea -0.0496178 0.00932881 0.0000001060048 P02749 41361833_Josephine_Robertson_P02749_OSCA_model_4 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02743 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation P02743 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg19693031 chr1:145441552 1 145441552 TXNIP Open sea -0.0482878 0.00908155 0.0000001069677 P02743 41361833_Josephine_Robertson_P02743_OSCA_model_4 Mamtani M - 26798409 2016-01-20 Hypertriglyceridemic waist EFO_0004342, EFO_0004530 - Table S2 Liability function of hypertriglyceridemic waist DNA methylation Age, sex, use of statin, use of anti-hypertensive, use of diabetic medications, cell counts and technical covariates Beta values - Illumina HumanMethylation450 Peripheral blood - 850 1 46.8 Both None cg19693031 chr1:145441552 1 145441552 TXNIP Open sea 0.30284438 0.05726 0.000000123 - 26798409_hypertriglyceridemic_waist Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P29622 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P29622 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg19693031 chr1:145441552 1 145441552 TXNIP Open sea -0.0434659 0.00824877 0.0000001388243 P29622 41361833_Josephine_Robertson_P29622_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 A0A0A0MS15 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation A0A0A0MS15 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg19693031 chr1:145441552 1 145441552 TXNIP Open sea 0.0450395 0.00857207 0.0000001507347 A0A0A0MS15 41361833_Josephine_Robertson_A0A0A0MS15_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 A0A075B6J9 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation A0A075B6J9 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg19693031 chr1:145441552 1 145441552 TXNIP Open sea 0.0488866 0.00932009 0.0000001582068 A0A075B6J9 41361833_Josephine_Robertson_A0A075B6J9_OSCA_model_4 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P18428 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P18428 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg19693031 chr1:145441552 1 145441552 TXNIP Open sea -0.0432489 0.00824885 0.0000001601547 P18428 41361833_Josephine_Robertson_P18428_OSCA_model_1 Ma J CARDSYA, FHS, MESA, RS 30936141 2019-02-21 Nonalcoholic fatty liver disease EFO_0003095, EFO_1001248 discovery and replication Table 1 Nonalcoholic fatty liver disease DNA methylation Age, sex, cell composition (reference based) None Beta Values Illumina HumanMethylation450 Whole Blood, Monocytes None 4525 4 Adults Both European cg19693031 chr1:145441552 1 145441552 TXNIP Open sea None None 0.00000017 None 30936141_Ma-J_nonalcoholic_fatty_liver_disease_discovery_and_replication Ma J FHS, RS, CARDIA, MESA 30936141 2020-05-22 Hepatic Fat EFO_0006506, EFO_0008421 Meta-analysis model 3 Table 1 DNA methylation Hepatic Fat Age, sex Beta Values Hounsfield units Illumina HumanMethylation450 Whole blood Model 3 = model 2 + BMI 3400 4 Adults Both European cg19693031 chr1:145441552 1 145441552 TXNIP Open sea None None 0.00000017 None 30936141_Ma-J_hepatic_fat_meta-analysis_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P80108 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P80108 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg19693031 chr1:145441552 1 145441552 TXNIP Open sea -0.0444946 0.00853399 0.0000001875157 P80108 41361833_Josephine_Robertson_P80108_OSCA_model_3 Gadd DA Generation Scotland 35945220 31/07/2022 PRSS8 protein levels (SeqId = 15513-108) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 PRSS8 protein levels (SeqId = 15513-108) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Prostasin 774 1 Adults (18-65 years) Both European cg19693031 chr1:145441552 1 145441552 TXNIP Open sea -0.7 0.134 0.00000022 None Gadd-DA_prss8_protein_levels__seqid___15513-108__somascan_protein_measurement Huang D BHS, GSH, DILGOM, ETS, EGCUT (Asthma), EGCUT (Young_O), FTC, HBCS,JHS, NTR, PREVEND, YFS, EpiGO, LACHY 32520614 2020-11-12 Systolic Blood Pressure EFO_0006335 Discovery Table 2, table 3 DNA methylation Systolic Blood Pressure age, sex, ancestry, body mass index, cell composition (reference based) Beta Values mmHg Illumina HumanMethylation450 Whole blood Includes some twins 4820 15 Adults Both European, Admixed cg19693031 chr1:145441552 1 145441552 TXNIP Open sea None None 0.00000022 None 32520614_Huang-D_systolic_blood_pressure_discovery Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 B1AHL2 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation B1AHL2 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg19693031 chr1:145441552 1 145441552 TXNIP Open sea 0.0442665 0.0085407 0.000000221231 B1AHL2 41361833_Josephine_Robertson_B1AHL2_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P35858 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P35858 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg19693031 chr1:145441552 1 145441552 TXNIP Open sea -0.0425891 0.00824908 0.0000002463444 P35858 41361833_Josephine_Robertson_P35858_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 Q13790 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation Q13790 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg19693031 chr1:145441552 1 145441552 TXNIP Open sea 0.0427594 0.00830513 0.0000002659021 Q13790 41361833_Josephine_Robertson_Q13790_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04003 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation P04003 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg19693031 chr1:145441552 1 145441552 TXNIP Open sea -0.0472383 0.00921949 0.0000003033412 P04003 41361833_Josephine_Robertson_P04003_OSCA_model_4 Ma J CHARGE 32525743 2020-08-01 Mediterranean diet EFO_0002755 European meta-analysis Table 1 DNA methylation Mediterranean diet Age, sex, energy intake, cell composition (reference based), batch effects Beta values Mediterranean-style diet score Illumina HumanMethylation450 Whole blood, CD4+ T-cells, CD14+ monocytes See supplement of paper for details on diet scores 6662 5 Adults Both European cg19693031 chr1:145441552 1 145441552 TXNIP Open sea 0.003 0.001 0.00000031 None 32525743_Ma-J_mediterranean_diet_european_meta-analysis Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02749 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P02749 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg19693031 chr1:145441552 1 145441552 TXNIP Open sea -0.0437723 0.00855718 0.0000003172362 P02749 41361833_Josephine_Robertson_P02749_OSCA_model_2 Liu J Rotterdam Study III-1, Rotterdam Study II-3 and Rotterdam Study III-2, Netherlands Twin Register, UK adult Twin registry 31197173 2013-06-19 fasting glucose EFO_0004465 Base plus BMI Supplementary Data 1 DNA methylation fasting glucose Age, sex, smoking, cell composition (reference based), batch effects, body mass index Beta Values mmol/L Illumina HumanMethylation450 whole blood None 4808 4 Adults Both European cg19693031 chr1:145441552 1 145441552 TXNIP Open sea -0.95 0.19 0.00000033 4805 31197173_Liu-J_fasting_glucose_base_plus_bmi Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 O43866 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation O43866 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg19693031 chr1:145441552 1 145441552 TXNIP Open sea 0.0420772 0.00824926 0.0000003425702 O43866 41361833_Josephine_Robertson_O43866_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 A0A0C4DH29 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation A0A0C4DH29 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg19693031 chr1:145441552 1 145441552 TXNIP Open sea 0.0420763 0.00824926 0.000000342777 A0A0C4DH29 41361833_Josephine_Robertson_A0A0C4DH29_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01743 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01743 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg19693031 chr1:145441552 1 145441552 TXNIP Open sea 0.0419334 0.00824931 0.0000003755749 P01743 41361833_Josephine_Robertson_P01743_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P43251 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation P43251 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg19693031 chr1:145441552 1 145441552 TXNIP Open sea -0.0471583 0.00932662 0.0000004326117 P43251 41361833_Josephine_Robertson_P43251_OSCA_model_4 Florath I - 26433941 2016-01-01 Type II diabetes EFO_0001360 Discovery adjusted for leucocyte composition Table 2 DNA methylation Type II diabetes Age, sex, smoking, body mass index, leucocyte composition and technical covariates Beta values - Illumina HumanMethylation450 Whole blood - 988 1 63 Both European cg19693031 chr1:145441552 1 145441552 TXNIP Open sea -0.029 0.0057 0.00000045 - 26433941_type_ii_diabetes_discovery_adjusted_for_leucocyte_composition Florath I - 26433941 2016-01-01 Type II diabetes EFO_0001360 Replication Table 2 DNA methylation Type II diabetes Age, sex, smoking, body mass index and technical covariates Beta values - Illumina HumanMethylation450 Whole blood - 527 1 63 Both European cg19693031 chr1:145441552 1 145441552 TXNIP Open sea -0.036 0.0072 0.00000048 - 26433941_type_ii_diabetes_replication Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P06396 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P06396 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg19693031 chr1:145441552 1 145441552 TXNIP Open sea 0.0429828 0.00854362 0.0000004937578 P06396 41361833_Josephine_Robertson_P06396_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02649 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation P02649 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg19693031 chr1:145441552 1 145441552 TXNIP Open sea -0.0468827 0.00933195 0.0000005123298 P02649 41361833_Josephine_Robertson_P02649_OSCA_model_4 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P29622 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P29622 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg19693031 chr1:145441552 1 145441552 TXNIP Open sea -0.0425566 0.0085275 0.0000006090981 P29622 41361833_Josephine_Robertson_P29622_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P07360 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P07360 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg19693031 chr1:145441552 1 145441552 TXNIP Open sea -0.0410971 0.0082496 0.0000006374123 P07360 41361833_Josephine_Robertson_P07360_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P06396 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P06396 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg19693031 chr1:145441552 1 145441552 TXNIP Open sea 0.0410658 0.00824961 0.0000006500563 P06396 41361833_Josephine_Robertson_P06396_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01709 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P01709 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg19693031 chr1:145441552 1 145441552 TXNIP Open sea 0.0425517 0.00854918 0.000000652158 P01709 41361833_Josephine_Robertson_P01709_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 Q08380 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation Q08380 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg19693031 chr1:145441552 1 145441552 TXNIP Open sea -0.0456658 0.00922902 0.0000007578698 Q08380 41361833_Josephine_Robertson_Q08380_OSCA_model_4 Liu J Rotterdam Study III-1, Rotterdam Study II-3 and Rotterdam Study III-2, Netherlands Twin Register, UK adult Twin registry 31197173 2013-06-19 fasting glucose EFO_0004465 Base Supplementary Data 1 DNA methylation fasting glucose Age, sex, smoking, cell composition (reference based), batch effects Beta Values mmol/L Illumina HumanMethylation450 whole blood None 4808 4 Adults Both European cg19693031 chr1:145441552 1 145441552 TXNIP Open sea -0.95 0.19 0.00000076 4805 31197173_Liu-J_fasting_glucose_base Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01023 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation P01023 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg19693031 chr1:145441552 1 145441552 TXNIP Open sea 0.0439626 0.00889187 0.0000007733136 P01023 41361833_Josephine_Robertson_P01023_OSCA_model_4 Joubert BR PACE 27040690 2016-04-07 Maternal smoking in pregnancy EFO_0006527, EFO_0005671, EFO_0004318, EFO_0002950 Any maternal smoking in pregnancy effect on newborns Table S3 DNA methylation Maternal smoking in pregnancy Maternal age, maternal education, parity and technical covariates Beta values - Illumina HumanMethylation450 Cord blood - 6685 13 0 Missing European,East Asian,African,Admixed,Other cg19693031 chr1:145441552 1 145441552 TXNIP Open sea -0.006 0.001 0.000000795 - 27040690_maternal_smoking_in_pregnancy_any_maternal_smoking_in_pregnancy_effect_on_newborns Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P05160 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation P05160 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg19693031 chr1:145441552 1 145441552 TXNIP Open sea -0.0460663 0.00932871 0.0000007974741 P05160 41361833_Josephine_Robertson_P05160_OSCA_model_4 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 A0A0C4DH36 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation A0A0C4DH36 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg19693031 chr1:145441552 1 145441552 TXNIP Open sea 0.0457202 0.0092758 0.0000008356684 A0A0C4DH36 41361833_Josephine_Robertson_A0A0C4DH36_OSCA_model_4 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 A0A0C4DH38 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation A0A0C4DH38 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg19693031 chr1:145441552 1 145441552 TXNIP Open sea 0.0458166 0.0092979 0.000000841464 A0A0C4DH38 41361833_Josephine_Robertson_A0A0C4DH38_OSCA_model_4 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01705 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01705 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg19693031 chr1:145441552 1 145441552 TXNIP Open sea 0.0403921 0.00824983 0.0000009879336 P01705 41361833_Josephine_Robertson_P01705_OSCA_model_1 Gadd DA Generation Scotland 35945220 31/07/2022 OXT protein levels (SeqId = 8356-88) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 OXT protein levels (SeqId = 8356-88) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Oxytocin-neurophysin 1 774 1 Adults (18-65 years) Both European cg19693031 chr1:145441552 1 145441552 TXNIP Open sea -0.66 0.134 0.000001 None Gadd-DA_oxt_protein_levels__seqid___8356-88__somascan_protein_measurement Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02749 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P02749 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg19693031 chr1:145441552 1 145441552 TXNIP Open sea -0.0418063 0.00857928 0.000001111007 P02749 41361833_Josephine_Robertson_P02749_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02649 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02649 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg19693031 chr1:145441552 1 145441552 TXNIP Open sea -0.0401689 0.00824991 0.000001133266 P02649 41361833_Josephine_Robertson_P02649_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P06310 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation P06310 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg19693031 chr1:145441552 1 145441552 TXNIP Open sea 0.0451692 0.00929536 0.000001190022 P06310 41361833_Josephine_Robertson_P06310_OSCA_model_4 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01714 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P01714 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg19693031 chr1:145441552 1 145441552 TXNIP Open sea 0.0414088 0.00854401 0.000001269265 P01714 41361833_Josephine_Robertson_P01714_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P08185 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P08185 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg19693031 chr1:145441552 1 145441552 TXNIP Open sea -0.0399573 0.00824998 0.000001289911 P08185 41361833_Josephine_Robertson_P08185_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P35858 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P35858 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg19693031 chr1:145441552 1 145441552 TXNIP Open sea -0.0413907 0.00854871 0.00000130015 P35858 41361833_Josephine_Robertson_P35858_OSCA_model_2 Hedman AK - 28213390 2017-02-17 Serum triglycerides EFO_0004530, CHEBI_17855 Replication Table S5 DNA methylation Serum triglycerides Age, sex, cell counts and technical covariates Beta values mg/dl Illumina HumanMethylation450 Whole blood - 1955 3 61 Both None cg19693031 chr1:145441552 1 145441552 TXNIP Open sea -0.0109322 0.0022625 0.00000135 - 28213390_serum_triglycerides_replication Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P07360 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P07360 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg19693031 chr1:145441552 1 145441552 TXNIP Open sea -0.0413462 0.00855637 0.00000136392 P07360 41361833_Josephine_Robertson_P07360_OSCA_model_2 Soriano-Tarraga C - 26643952 2016-02-01 Type II diabetes EFO_0001360 BASICMAR 2 Table 2 DNA methylation Type II diabetes Age, sex, smoking, hyperlipidemia, body mass index, cell counts and technical covariates M values - Illumina HumanMethylation450 Peripheral blood - 167 1 74.8 Both European cg19693031 chr1:145441552 1 145441552 TXNIP Open sea -0.3 0.0621 0.00000137 - 26643952_type_ii_diabetes_basicmar_2 Florath I - 26433941 2016-01-01 Type II diabetes EFO_0001360 Discovery Table 2 DNA methylation Type II diabetes Age, sex, smoking, body mass index and technical covariates Beta values - Illumina HumanMethylation450 Whole blood - 988 1 63 Both European cg19693031 chr1:145441552 1 145441552 TXNIP Open sea -0.03 0.0062 0.0000015 - 26433941_type_ii_diabetes_discovery Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01709 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation P01709 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg19693031 chr1:145441552 1 145441552 TXNIP Open sea 0.0445701 0.00930698 0.000001693459 P01709 41361833_Josephine_Robertson_P01709_OSCA_model_4 Sayols-Baixeras S - 28173150 2016-09-15 Serum triglycerides EFO_0004530, CHEBI_17855 Discovery adjusted for surrogate variables Table S1 Serum triglycerides DNA methylation Age, sex, smoking, cell counts and technical covariates mg/dl M values Illumina HumanMethylation450 Whole blood Triglycerides levels were log-transformed 645 1 63.2 Both None cg19693031 chr1:145441552 1 145441552 TXNIP Open sea -0.043 0.009 0.0000017 - 28173150_serum_triglycerides_discovery_adjusted_for_surrogate_variables Gadd DA Generation Scotland 35945220 31/07/2022 ALDOB protein levels (SeqId = 18185-118) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 ALDOB protein levels (SeqId = 18185-118) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Fructose-bisphosphate aldolase B 774 1 Adults (18-65 years) Both European cg19693031 chr1:145441552 1 145441552 TXNIP Open sea -0.64 0.134 0.0000018 None Gadd-DA_aldob_protein_levels__seqid___18185-118__somascan_protein_measurement Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P00740 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P00740 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg19693031 chr1:145441552 1 145441552 TXNIP Open sea -0.0403807 0.0084597 0.000001829809 P00740 41361833_Josephine_Robertson_P00740_OSCA_model_3 Joubert BR PACE 27040690 2016-04-07 Maternal smoking in pregnancy EFO_0006527, EFO_0005671, EFO_0004318, EFO_0002950 Sustained maternal smoking in pregnancy effect on newborns Table S3 DNA methylation Maternal smoking in pregnancy Maternal age, maternal education, parity and technical covariates Beta values - Illumina HumanMethylation450 Cord blood - 5647 9 0 Missing European,African,Admixed,Other cg19693031 chr1:145441552 1 145441552 TXNIP Open sea -0.008 0.002 0.00000188 - 27040690_maternal_smoking_in_pregnancy_sustained_maternal_smoking_in_pregnancy_effect_on_newborns Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01023 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P01023 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg19693031 chr1:145441552 1 145441552 TXNIP Open sea 0.0405376 0.00852119 0.000001981043 P01023 41361833_Josephine_Robertson_P01023_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01766 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01766 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg19693031 chr1:145441552 1 145441552 TXNIP Open sea 0.039097 0.00825026 0.000002169135 P01766 41361833_Josephine_Robertson_P01766_OSCA_model_1 Gadd DA Generation Scotland 35945220 31/07/2022 ACY1 protein levels (SeqId = 3343-1) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 ACY1 protein levels (SeqId = 3343-1) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Aminoacylase-1 774 1 Adults (18-65 years) Both European cg19693031 chr1:145441552 1 145441552 TXNIP Open sea -0.63 0.134 0.0000023 None Gadd-DA_acy1_protein_levels__seqid___3343-1__somascan_protein_measurement Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01709 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P01709 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg19693031 chr1:145441552 1 145441552 TXNIP Open sea 0.0402871 0.00856499 0.0000025782 P01709 41361833_Josephine_Robertson_P01709_OSCA_model_3 Battram T GEO 23334450 2020-09-15 Rheumatoid arthritis EFO_0000685 EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE42861 None DNA methylation Rheumatoid arthritis Batch effects, cell composition (reference free) Beta Values None Illumina HumanMethylation450 Whole blood None 689 1 Adults Both European cg19693031 chr1:145441552 1 145441552 TXNIP Open sea 0.0204 0.00432 0.0000029 None 23334450_Battram-T_rheumatoid_arthritis_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse42861 Gadd DA Generation Scotland 35945220 31/07/2022 APOC3 protein levels (SeqId = 6461-54) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 APOC3 protein levels (SeqId = 6461-54) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Apolipoprotein C-III 774 1 Adults (18-65 years) Both European cg19693031 chr1:145441552 1 145441552 TXNIP Open sea -0.63 0.134 0.0000032 None Gadd-DA_apoc3_protein_levels__seqid___6461-54__somascan_protein_measurement Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 Q9Y5Y7 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation Q9Y5Y7 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg19693031 chr1:145441552 1 145441552 TXNIP Open sea 0.0433744 0.00932393 0.000003317059 Q9Y5Y7 41361833_Josephine_Robertson_Q9Y5Y7_OSCA_model_4 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P14151 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P14151 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg19693031 chr1:145441552 1 145441552 TXNIP Open sea 0.0395687 0.00851204 0.000003371699 P14151 41361833_Josephine_Robertson_P14151_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02751 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02751 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg19693031 chr1:145441552 1 145441552 TXNIP Open sea -0.0382843 0.00825052 0.000003510389 P02751 41361833_Josephine_Robertson_P02751_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01743 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P01743 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg19693031 chr1:145441552 1 145441552 TXNIP Open sea 0.0396538 0.0085502 0.000003552516 P01743 41361833_Josephine_Robertson_P01743_OSCA_model_2 Gomez-Alonso MDC KORA F4 33413638 2021-01-07 M-VLDL-P None Meta-analysis Table S2 DNA methylation M-VLDL-P Age, sex, smoking, body mass index, CRP, HbA1c, alcohol consumption, lipid-lowering drugs, hypertension, history of myocardial infarction, level of physical activity, cell composition (reference based) Beta Values mol/L Illumina HumanMethylation450 Whole blood Concentration of medium VLDL particles 5414 4 Adults Both European cg19693031 chr1:145441552 1 145441552 TXNIP Open sea -1.8 0.38 0.0000037 None 33413638_Gomez-Alonso-MDC_m-vldl-p_meta-analysis Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02751 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P02751 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg19693031 chr1:145441552 1 145441552 TXNIP Open sea -0.0394095 0.00854198 0.000003990599 P02751 41361833_Josephine_Robertson_P02751_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 A0A075B6H9 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation A0A075B6H9 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg19693031 chr1:145441552 1 145441552 TXNIP Open sea 0.0428572 0.00929958 0.000004089839 A0A075B6H9 41361833_Josephine_Robertson_A0A075B6H9_OSCA_model_4 Gomez-Alonso MDC KORA F4 33413638 2021-01-07 M-VLDL-L None Meta-analysis Table S2 DNA methylation M-VLDL-L Age, sex, smoking, body mass index, CRP, HbA1c, alcohol consumption, lipid-lowering drugs, hypertension, history of myocardial infarction, level of physical activity, cell composition (reference based) Beta Values mmol/L Illumina HumanMethylation450 Whole blood Total lipids in medium VLDL 5414 4 Adults Both European cg19693031 chr1:145441552 1 145441552 TXNIP Open sea -1.7 0.37 0.0000044 None 33413638_Gomez-Alonso-MDC_m-vldl-l_meta-analysis Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02649 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P02649 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg19693031 chr1:145441552 1 145441552 TXNIP Open sea -0.0392347 0.0085531 0.000004529614 P02649 41361833_Josephine_Robertson_P02649_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 Q08380 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation Q08380 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg19693031 chr1:145441552 1 145441552 TXNIP Open sea -0.0389207 0.00848803 0.000004569545 Q08380 41361833_Josephine_Robertson_Q08380_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01701 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation P01701 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg19693031 chr1:145441552 1 145441552 TXNIP Open sea 0.0426994 0.00931921 0.000004646533 P01701 41361833_Josephine_Robertson_P01701_OSCA_model_4 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01705 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P01705 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg19693031 chr1:145441552 1 145441552 TXNIP Open sea 0.0390809 0.00855447 0.000004952745 P01705 41361833_Josephine_Robertson_P01705_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02649 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P02649 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg19693031 chr1:145441552 1 145441552 TXNIP Open sea -0.0391864 0.00857809 0.000004959548 P02649 41361833_Josephine_Robertson_P02649_OSCA_model_3 Gadd DA Generation Scotland 35945220 31/07/2022 PRSS2 protein levels (SeqId = 5034-79) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 PRSS2 protein levels (SeqId = 5034-79) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Trypsin-2 774 1 Adults (18-65 years) Both European cg19693031 chr1:145441552 1 145441552 TXNIP Open sea -0.61 0.134 0.0000052 None Gadd-DA_prss2_protein_levels__seqid___5034-79__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 PSAT1 protein levels (SeqId = 18342-2) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 PSAT1 protein levels (SeqId = 18342-2) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Phosphoserine aminotransferase 774 1 Adults (18-65 years) Both European cg19693031 chr1:145441552 1 145441552 TXNIP Open sea -0.61 0.134 0.0000054 None Gadd-DA_psat1_protein_levels__seqid___18342-2__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 GLTPD2 protein levels (SeqId = 7948-129) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 GLTPD2 protein levels (SeqId = 7948-129) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Glycolipid transfer protein domain-containing protein 2 774 1 Adults (18-65 years) Both European cg19693031 chr1:145441552 1 145441552 TXNIP Open sea -0.61 0.13 0.0000055 None Gadd-DA_gltpd2_protein_levels__seqid___7948-129__somascan_protein_measurement Battram T ARIES None 2020-08-20 Total lipids in small HDL EFO_0004529 None None DNA methylation Total lipids in small HDL Batch effects, cell composition (reference free), ancestry (genomic PCs) Beta Values mmol/l Illumina HumanMethylation450 Whole blood None 685 1 Adults Females European cg19693031 chr1:145441552 1 145441552 TXNIP Open sea -1.29 0.28 0.0000056 None Battram-T_total_lipids_in_small_hdl Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P05160 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P05160 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg19693031 chr1:145441552 1 145441552 TXNIP Open sea -0.0387222 0.00855388 0.000006033794 P05160 41361833_Josephine_Robertson_P05160_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01705 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P01705 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg19693031 chr1:145441552 1 145441552 TXNIP Open sea 0.0387678 0.00857965 0.000006274279 P01705 41361833_Josephine_Robertson_P01705_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04430 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P04430 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg19693031 chr1:145441552 1 145441552 TXNIP Open sea 0.0372721 0.00825083 0.000006310069 P04430 41361833_Josephine_Robertson_P04430_OSCA_model_1 Joubert BR PACE 27040690 2016-04-07 Maternal smoking in pregnancy EFO_0006527, EFO_0005671, EFO_0004318, EFO_0002950 Sustained maternal smoking in pregnancy effect on newborns adjusted for cell counts Table S3 DNA methylation Maternal smoking in pregnancy Maternal age, maternal education, parity, white blood cell counts and technical covariates Beta values - Illumina HumanMethylation450 Cord blood - 5647 9 0 Missing European,African,Admixed,Other cg19693031 chr1:145441552 1 145441552 TXNIP Open sea -0.006 0.001 0.00000696 - 27040690_maternal_smoking_in_pregnancy_sustained_maternal_smoking_in_pregnancy_effect_on_newborns_adjusted_for_cell_counts Sikdar S PACE 31536415 2019-09-19 Prenatal smoke exposure EFO_0009115, EFO_0008361, EFO_0006527, EFO_0004318 Inverse varience-weighted fixed-effects meta-analysis Table S1 DNA methylation Prenatal smoke exposure Maternal age, socioeconomic position, cell composition (reference based), batch effects Beta Values None Illumina HumanMethylation450 Cord blood, whole blood None 5648 9 Infants Both European, African, Unclear cg19693031 chr1:145441552 1 145441552 TXNIP Open sea -0.0058 0.0013 0.000007 None 31536415_Sikdar-S_prenatal_smoke_exposure_inverse_varience-weighted_fixed-effects_meta-analysis Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01714 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P01714 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg19693031 chr1:145441552 1 145441552 TXNIP Open sea 0.038419 0.00856271 0.00000728549 P01714 41361833_Josephine_Robertson_P01714_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P43251 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P43251 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg19693031 chr1:145441552 1 145441552 TXNIP Open sea -0.0370063 0.00825092 0.000007343013 P43251 41361833_Josephine_Robertson_P43251_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 A0A0A0MS15 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation A0A0A0MS15 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg19693031 chr1:145441552 1 145441552 TXNIP Open sea 0.0415544 0.00931776 0.000008268601 A0A0A0MS15 41361833_Josephine_Robertson_A0A0A0MS15_OSCA_model_4 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P05160 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P05160 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg19693031 chr1:145441552 1 145441552 TXNIP Open sea -0.0381361 0.00857885 0.000008838552 P05160 41361833_Josephine_Robertson_P05160_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P20851 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P20851 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg19693031 chr1:145441552 1 145441552 TXNIP Open sea -0.0378645 0.00852024 0.000008891906 P20851 41361833_Josephine_Robertson_P20851_OSCA_model_3 Tobi EW PACE, PREciSE None 2021-12-10 maternal glucose CHEBI_17234, EFO_0004468 fasting glucose meta-EWAS https://doi.org/10.5281/zenodo.5886997 DNA methylation maternal glucose Sex, Cell composition (reference based), Batch effects, Gestational age, gestational age at glycemic measurement, parity, maternal age Beta values mmol/L Illumina HumanMethylation450, Illumina HumanMethylationEPIC cord blood meta-EWAS of exposure in utero 2404 7 Infants Both European, South Asian, Other cg19693031 chr1:145441552 1 145441552 TXNIP Open sea -0.0047 0.0011 0.0000094 - | - | - | - | - | - | + | 2404 Tobi-EW_maternal_glucose_fasting_glucose_meta-ewas Gadd DA Generation Scotland 35945220 31/07/2022 RBP5 protein levels (SeqId = 19241-31) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 RBP5 protein levels (SeqId = 19241-31) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Retinol-binding protein 5 774 1 Adults (18-65 years) Both European cg19693031 chr1:145441552 1 145441552 TXNIP Open sea -0.59 0.134 0.00001 None Gadd-DA_rbp5_protein_levels__seqid___19241-31__somascan_protein_measurement Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01703 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01703 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg19693031 chr1:145441552 1 145441552 TXNIP Open sea 0.0363754 0.00825111 0.00001048034 P01703 41361833_Josephine_Robertson_P01703_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P05546 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P05546 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg19693031 chr1:145441552 1 145441552 TXNIP Open sea -0.0371982 0.00846628 0.00001122255 P05546 41361833_Josephine_Robertson_P05546_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P20742 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation P20742 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg19693031 chr1:145441552 1 145441552 TXNIP Open sea 0.0394445 0.00898807 0.00001149121 P20742 41361833_Josephine_Robertson_P20742_OSCA_model_4 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01743 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P01743 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg19693031 chr1:145441552 1 145441552 TXNIP Open sea 0.0375498 0.00856944 0.00001185099 P01743 41361833_Josephine_Robertson_P01743_OSCA_model_3 Gomez-Alonso MDC KORA F4 33413638 2021-01-07 FAw6toFA None Meta-analysis Table S2 DNA methylation FAw6toFA Age, sex, smoking, body mass index, CRP, HbA1c, alcohol consumption, lipid-lowering drugs, hypertension, history of myocardial infarction, level of physical activity, cell composition (reference based) Beta Values % Illumina HumanMethylation450 Whole blood Omega-6 fatty acids 5414 4 Adults Both European cg19693031 chr1:145441552 1 145441552 TXNIP Open sea 0.28 0.064 0.000012 None 33413638_Gomez-Alonso-MDC_faw6tofa_meta-analysis Battram T ARIES None 2020-08-20 Concentration of small HDL particles EFO_0004612 None None DNA methylation Concentration of small HDL particles Batch effects, cell composition (reference free), ancestry (genomic PCs) Beta Values mol/l Illumina HumanMethylation450 Whole blood None 684 1 Adults Females European cg19693031 chr1:145441552 1 145441552 TXNIP Open sea None None 0.000012 None Battram-T_concentration_of_small_hdl_particles Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01743 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation P01743 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg19693031 chr1:145441552 1 145441552 TXNIP Open sea 0.0406579 0.00931919 0.0000129278 P01743 41361833_Josephine_Robertson_P01743_OSCA_model_4 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P20851 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation P20851 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg19693031 chr1:145441552 1 145441552 TXNIP Open sea -0.0404074 0.00926195 0.00001293265 P20851 41361833_Josephine_Robertson_P20851_OSCA_model_4 Gadd DA Generation Scotland 35945220 31/07/2022 CPM protein levels (SeqId = 9416-77) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 CPM protein levels (SeqId = 9416-77) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Carboxypeptidase M 774 1 Adults (18-65 years) Both European cg19693031 chr1:145441552 1 145441552 TXNIP Open sea -0.59 0.134 0.000013 None Gadd-DA_cpm_protein_levels__seqid___9416-77__somascan_protein_measurement Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 A0A0B4J1U7 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation A0A0B4J1U7 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg19693031 chr1:145441552 1 145441552 TXNIP Open sea 0.0358818 0.00825125 0.00001378996 A0A0B4J1U7 41361833_Josephine_Robertson_A0A0B4J1U7_OSCA_model_1 Hedman AK - 28213390 2017-02-17 Serum triglycerides EFO_0004530, CHEBI_17855 Replication adjusted for BMI Table S9 DNA methylation Serum triglycerides Age, sex, body mass index, cell counts and technical covariates Beta values mg/dl Illumina HumanMethylation450 Whole blood - 1955 3 61 Both None cg19693031 chr1:145441552 1 145441552 TXNIP Open sea -0.01027 0.002376 0.0000154 - 28213390_serum_triglycerides_replication_adjusted_for_bmi Gadd DA Generation Scotland 35945220 31/07/2022 PYY protein levels (SeqId = 3727-35) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 PYY protein levels (SeqId = 3727-35) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Peptide YY 774 1 Adults (18-65 years) Both European cg19693031 chr1:145441552 1 145441552 TXNIP Open sea -0.58 0.134 0.000016 None Gadd-DA_pyy_protein_levels__seqid___3727-35__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 C9 protein levels (SeqId = 3060-43) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 C9 protein levels (SeqId = 3060-43) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Complement component C9 774 1 Adults (18-65 years) Both European cg19693031 chr1:145441552 1 145441552 TXNIP Open sea 0.57 0.132 0.000016 None Gadd-DA_c9_protein_levels__seqid___3060-43__somascan_protein_measurement Liu C CHARGE+ 27843151 2016-11-15 Alcohol consumption per day EFO_0007878, EFO_0004329 CD14+ monocytes Table S7 DNA methylation Alcohol consumption per day Age, sex, body mass index, cell counts and technical covariates Beta values g per day Illumina HumanMethylation450 CD14+ monocytes - 1251 1 60 Both European,African,Admixed cg19693031 chr1:145441552 1 145441552 TXNIP Open sea -0.000496 0.000115 0.0000168 - 27843151_alcohol_consumption_per_day_cd14_monocytes Gadd DA Generation Scotland 35945220 31/07/2022 GPD1 protein levels (SeqId = 13697-51) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 GPD1 protein levels (SeqId = 13697-51) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Glycerol-3-phosphate dehydrogenase [NAD(+)], cytoplasmic 774 1 Adults (18-65 years) Both European cg19693031 chr1:145441552 1 145441552 TXNIP Open sea -0.58 0.134 0.000018 None Gadd-DA_gpd1_protein_levels__seqid___13697-51__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 CES1 protein levels (SeqId = 15487-164) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 CES1 protein levels (SeqId = 15487-164) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Liver carboxylesterase 1 774 1 Adults (18-65 years) Both European cg19693031 chr1:145441552 1 145441552 TXNIP Open sea -0.57 0.134 0.000018 None Gadd-DA_ces1_protein_levels__seqid___15487-164__somascan_protein_measurement Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P08185 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P08185 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg19693031 chr1:145441552 1 145441552 TXNIP Open sea -0.036555 0.00853523 0.00001856964 P08185 41361833_Josephine_Robertson_P08185_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01766 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P01766 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg19693031 chr1:145441552 1 145441552 TXNIP Open sea 0.0366846 0.00857342 0.00001890311 P01766 41361833_Josephine_Robertson_P01766_OSCA_model_3 Gomez-Alonso MDC KORA F4 33413638 2021-01-07 M-VLDL-PL None Meta-analysis Table S2 DNA methylation M-VLDL-PL Age, sex, smoking, body mass index, CRP, HbA1c, alcohol consumption, lipid-lowering drugs, hypertension, history of myocardial infarction, level of physical activity, cell composition (reference based) Beta Values mmol/L Illumina HumanMethylation450 Whole blood Phospholipids in medium VLDL 5414 4 Adults Both European cg19693031 chr1:145441552 1 145441552 TXNIP Open sea -1.6 0.37 0.000019 None 33413638_Gomez-Alonso-MDC_m-vldl-pl_meta-analysis Florath I - 26433941 2016-01-01 Type II diabetes EFO_0001360 Replication adjusted for leucocyte composition Table 2 DNA methylation Type II diabetes Age, sex, smoking, body mass index, leucocyte composition and technical covariates Beta values - Illumina HumanMethylation450 Whole blood - 527 1 63 Both European cg19693031 chr1:145441552 1 145441552 TXNIP Open sea -0.031 0.0072 0.000019 - 26433941_type_ii_diabetes_replication_adjusted_for_leucocyte_composition Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P20742 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P20742 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg19693031 chr1:145441552 1 145441552 TXNIP Open sea 0.0365102 0.00853628 0.00001905808 P20742 41361833_Josephine_Robertson_P20742_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 A0A075B6I0 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation A0A075B6I0 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg19693031 chr1:145441552 1 145441552 TXNIP Open sea 0.0352424 0.00825144 0.00001957744 A0A075B6I0 41361833_Josephine_Robertson_A0A075B6I0_OSCA_model_1 Gadd DA Generation Scotland 35945220 31/07/2022 KRT1 protein levels (SeqId = 9931-20) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 KRT1 protein levels (SeqId = 9931-20) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Keratin, type II cytoskeletal 1 774 1 Adults (18-65 years) Both European cg19693031 chr1:145441552 1 145441552 TXNIP Open sea -0.57 0.134 0.00002 None Gadd-DA_krt1_protein_levels__seqid___9931-20__somascan_protein_measurement Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P35858 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation P35858 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg19693031 chr1:145441552 1 145441552 TXNIP Open sea -0.0394328 0.00926598 0.0000209738 P35858 41361833_Josephine_Robertson_P35858_OSCA_model_4 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 A0A075B6I0 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation A0A075B6I0 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg19693031 chr1:145441552 1 145441552 TXNIP Open sea 0.0363948 0.00855283 0.00002100717 A0A075B6I0 41361833_Josephine_Robertson_A0A075B6I0_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P43251 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P43251 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg19693031 chr1:145441552 1 145441552 TXNIP Open sea -0.0362308 0.00855734 0.00002310854 P43251 41361833_Josephine_Robertson_P43251_OSCA_model_2 Battram T ARIES None 2020-08-20 Phospholipids in small HDL EFO_0004639 None None DNA methylation Phospholipids in small HDL Batch effects, cell composition (reference free), ancestry (genomic PCs) Beta Values mmol/l Illumina HumanMethylation450 Whole blood None 684 1 Adults Females European cg19693031 chr1:145441552 1 145441552 TXNIP Open sea -1.93 0.45 0.000024 None Battram-T_phospholipids_in_small_hdl Chambers JC - 26095709 2015-07-01 Type II diabetes EFO_0001360 Replication Table 3 Type II diabetes DNA methylation Age, sex, cell counts and technical covariates - Beta values Illumina HumanMethylation450 Peripheral blood Regression coeffcient per 1 pecent increase in methylation 1141 3 59 Both European cg19693031 chr1:145441552 1 145441552 TXNIP Open sea -0.0408 0.0097 0.000025 - 26095709_type_ii_diabetes_replication Battram T ARIES None 2020-08-20 Free cholesterol in small HDL EFO_0008591 None None DNA methylation Free cholesterol in small HDL Batch effects, cell composition (reference free), ancestry (genomic PCs) Beta Values mmol/l Illumina HumanMethylation450 Whole blood None 684 1 Adults Females European cg19693031 chr1:145441552 1 145441552 TXNIP Open sea -11.3 2.7 0.000026 None Battram-T_free_cholesterol_in_small_hdl Gomez-Alonso MDC KORA F4 33413638 2021-01-07 MUFA EFO_0006823 Meta-analysis Table S2 DNA methylation MUFA Age, sex, smoking, body mass index, CRP, HbA1c, alcohol consumption, lipid-lowering drugs, hypertension, history of myocardial infarction, level of physical activity, cell composition (reference based) Beta Values mmol/L Illumina HumanMethylation450 Whole blood Monounsaturated fatty acids 16:1, 18:1 5414 4 Adults Both European cg19693031 chr1:145441552 1 145441552 TXNIP Open sea -0.89 0.21 0.000027 None 33413638_Gomez-Alonso-MDC_mufa_meta-analysis Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02743 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P02743 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg19693031 chr1:145441552 1 145441552 TXNIP Open sea -0.0349997 0.00835431 0.0000281314 P02743 41361833_Josephine_Robertson_P02743_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01705 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation P01705 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg19693031 chr1:145441552 1 145441552 TXNIP Open sea 0.0390173 0.00933086 0.00002912319 P01705 41361833_Josephine_Robertson_P01705_OSCA_model_4 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02765 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02765 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg19693031 chr1:145441552 1 145441552 TXNIP Open sea -0.0345026 0.00825166 0.00002915378 P02765 41361833_Josephine_Robertson_P02765_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01766 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P01766 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg19693031 chr1:145441552 1 145441552 TXNIP Open sea 0.035723 0.00855081 0.00002961279 P01766 41361833_Josephine_Robertson_P01766_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 B1AHL2 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation B1AHL2 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg19693031 chr1:145441552 1 145441552 TXNIP Open sea 0.0354522 0.00850615 0.00003092696 B1AHL2 41361833_Josephine_Robertson_B1AHL2_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02765 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P02765 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg19693031 chr1:145441552 1 145441552 TXNIP Open sea -0.0356236 0.008559 0.00003170994 P02765 41361833_Josephine_Robertson_P02765_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01706 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01706 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg19693031 chr1:145441552 1 145441552 TXNIP Open sea 0.0343442 0.0082517 0.00003171606 P01706 41361833_Josephine_Robertson_P01706_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P07996 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation P07996 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg19693031 chr1:145441552 1 145441552 TXNIP Open sea -0.0386187 0.00929853 0.00003297064 P07996 41361833_Josephine_Robertson_P07996_OSCA_model_4 Singmann P - 26500701 2015-10-19 Sex EFO_0001271 Meta-analysis Additional file 2 DNA methylation Sex Age, smoking, alcohol consumption, body mass index, triglycerides, total leucocytes, high-density lipoprotein, low-density lipoprotein, physical activity, diabetes, myocardial infarction, cell counts and technical covariates Beta values - Illumina HumanMethylation450 Whole blood - 1999 3 35.7 Both European cg19693031 chr1:145441552 1 145441552 TXNIP Open sea - - 0.0000332 - 26500701_sex_metaanalysis Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 O43866 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation O43866 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg19693031 chr1:145441552 1 145441552 TXNIP Open sea 0.0382836 0.00927079 0.00003655904 O43866 41361833_Josephine_Robertson_O43866_OSCA_model_4 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 A0A0B4J1U7 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation A0A0B4J1U7 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg19693031 chr1:145441552 1 145441552 TXNIP Open sea 0.0352885 0.0085481 0.0000367602 A0A0B4J1U7 41361833_Josephine_Robertson_A0A0B4J1U7_OSCA_model_2 Gadd DA Generation Scotland 35945220 31/07/2022 HMGCS1 protein levels (SeqId = 13496-19) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 HMGCS1 protein levels (SeqId = 13496-19) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Hydroxymethylglutaryl-CoA synthase, cytoplasmic 774 1 Adults (18-65 years) Both European cg19693031 chr1:145441552 1 145441552 TXNIP Open sea -0.55 0.134 0.000038 None Gadd-DA_hmgcs1_protein_levels__seqid___13496-19__somascan_protein_measurement Cronjé HT Prospective Urban and Rural Epidemiology study 31910897 2020-01-07 Triglycerides EFO_0004530 None Additional file 2e DNA methylation Triglycerides Age, body mass index, cell composition (reference based), batch effects Beta Values log mg/dL Illumina HumanMethylationEPIC Whole blood None 117 1 Adults Males African cg19693031 chr1:145441552 1 145441552 TXNIP Open sea -0.0477 0.0109 0.000039 None 31910897_Cronjé-HT_triglycerides Gomez-Alonso MDC KORA F4 33413638 2021-01-07 L-LDL-FC_pct None Meta-analysis Table S2 DNA methylation L-LDL-FC_pct Age, sex, smoking, body mass index, CRP, HbA1c, alcohol consumption, lipid-lowering drugs, hypertension, history of myocardial infarction, level of physical activity, cell composition (reference based) Beta Values % Illumina HumanMethylation450 Whole blood Free cholesterol to total lipids ratio in large LDL 5414 4 Adults Both European cg19693031 chr1:145441552 1 145441552 TXNIP Open sea 0.17 0.041 0.000039 None 33413638_Gomez-Alonso-MDC_l-ldl-fc_pct_meta-analysis Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 A0A0B4J1U7 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation A0A0B4J1U7 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg19693031 chr1:145441552 1 145441552 TXNIP Open sea 0.0351921 0.00856386 0.00003988865 A0A0B4J1U7 41361833_Josephine_Robertson_A0A0B4J1U7_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01714 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation P01714 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg19693031 chr1:145441552 1 145441552 TXNIP Open sea 0.0382109 0.00930055 0.0000400482 P01714 41361833_Josephine_Robertson_P01714_OSCA_model_4 Robert F. Hillary Generation Scotland doi.org/10.1101/2023.11.02.23298000 Nov 3, 2023 C-reactive protein (CRP) levels None Fully-adjusted model None C-reactive protein (CRP) levels DNA methylation Age, Sex, Smoking, Cell composition (reference based), Batch effects, Ancestry (genomic PCs), Body mass index, Socio-economic position, Education, Alcohol consumption mg/L Beta values Illumina HumanMethylationEPIC Whole blood None 14040 1 Adults Both European cg19693031 chr1:145441552 1 145441552 TXNIP Open sea -0.72 0.176 0.000041 Fully_Adjusted_Model Robert-F.-Hillary_c-reactive_protein__crp__levels_fully-adjusted_model Gadd DA Generation Scotland 35945220 31/07/2022 PCSK7 protein levels (SeqId = 4459-68) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 PCSK7 protein levels (SeqId = 4459-68) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Proprotein convertase subtilisin/kexin type 7 774 1 Adults (18-65 years) Both European cg19693031 chr1:145441552 1 145441552 TXNIP Open sea -0.55 0.134 0.000041 None Gadd-DA_pcsk7_protein_levels__seqid___4459-68__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 ALDH1A1 protein levels (SeqId = 11265-8) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 ALDH1A1 protein levels (SeqId = 11265-8) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Retinal dehydrogenase 1 774 1 Adults (18-65 years) Both European cg19693031 chr1:145441552 1 145441552 TXNIP Open sea -0.55 0.134 0.000042 None Gadd-DA_aldh1a1_protein_levels__seqid___11265-8__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 SHBG protein levels (SeqId = 4929-55) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 SHBG protein levels (SeqId = 4929-55) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Sex hormone-binding globulin 774 1 Adults (18-65 years) Both European cg19693031 chr1:145441552 1 145441552 TXNIP Open sea 0.55 0.134 0.000043 None Gadd-DA_shbg_protein_levels__seqid___4929-55__somascan_protein_measurement Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01344 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation P01344 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg19693031 chr1:145441552 1 145441552 TXNIP Open sea -0.0380355 0.00931912 0.00004499266 P01344 41361833_Josephine_Robertson_P01344_OSCA_model_4 Huang D BHS, GSH, DILGOM, ETS, EGCUT (Asthma), EGCUT (Young_O), FTC, HBCS,JHS, NTR, PREVEND, YFS, EpiGO, LACHY 32520614 2020-11-12 Diastolic Blood Pressure EFO_0006336 Discovery Table 2, table 3 DNA methylation Diastolic Blood Pressure age, sex, ancestry, body mass index, cell composition (reference based) Beta Values mmHg Illumina HumanMethylation450 Whole blood Includes some twins 4820 15 Adults Both European, Admixed cg19693031 chr1:145441552 1 145441552 TXNIP Open sea None None 0.000046 None 32520614_Huang-D_diastolic_blood_pressure_discovery Gadd DA Generation Scotland 35945220 31/07/2022 MGAT4B protein levels (SeqId = 7141-21) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 MGAT4B protein levels (SeqId = 7141-21) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase B 774 1 Adults (18-65 years) Both European cg19693031 chr1:145441552 1 145441552 TXNIP Open sea -0.545 0.134 0.000048 None Gadd-DA_mgat4b_protein_levels__seqid___7141-21__somascan_protein_measurement Battram T ARIES None 2020-08-20 Leucine EFO_0009770 None None DNA methylation Leucine Batch effects, cell composition (reference free), ancestry (genomic PCs) Beta Values mmol/l Illumina HumanMethylation450 Whole blood None 684 1 Adults Females European cg19693031 chr1:145441552 1 145441552 TXNIP Open sea -16 3.9 0.000052 None Battram-T_leucine Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01344 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01344 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg19693031 chr1:145441552 1 145441552 TXNIP Open sea -0.0333393 0.00825198 0.00005368876 P01344 41361833_Josephine_Robertson_P01344_OSCA_model_1 Battram T ARIES None 2020-08-20 Glucose EFO_0004465 fasting None DNA methylation Glucose Batch effects, cell composition (reference free), ancestry (genomic PCs) Beta Values mmol/l Illumina HumanMethylation450 Whole blood None 682 1 Adults Females European cg19693031 chr1:145441552 1 145441552 TXNIP Open sea -0.31 0.077 0.000056 None Battram-T_glucose_fasting Gadd DA Generation Scotland 35945220 31/07/2022 PTK7 protein levels (SeqId = 9525-1) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 PTK7 protein levels (SeqId = 9525-1) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Inactive tyrosine-protein kinase 7 774 1 Adults (18-65 years) Both European cg19693031 chr1:145441552 1 145441552 TXNIP Open sea -0.54 0.134 0.000057 None Gadd-DA_ptk7_protein_levels__seqid___9525-1__somascan_protein_measurement Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 O43866 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation O43866 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg19693031 chr1:145441552 1 145441552 TXNIP Open sea 0.0343747 0.00853996 0.00005722384 O43866 41361833_Josephine_Robertson_O43866_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02747 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation P02747 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg19693031 chr1:145441552 1 145441552 TXNIP Open sea 0.0374585 0.00931142 0.00005778441 P02747 41361833_Josephine_Robertson_P02747_OSCA_model_4 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 A0A075B6I0 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation A0A075B6I0 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg19693031 chr1:145441552 1 145441552 TXNIP Open sea 0.0344105 0.00856167 0.00005870446 A0A075B6I0 41361833_Josephine_Robertson_A0A075B6I0_OSCA_model_3 Gadd DA Generation Scotland 35945220 31/07/2022 ALDOC protein levels (SeqId = 9876-20) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 ALDOC protein levels (SeqId = 9876-20) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Fructose-bisphosphate aldolase C 774 1 Adults (18-65 years) Both European cg19693031 chr1:145441552 1 145441552 TXNIP Open sea -0.539 0.134 0.000059 None Gadd-DA_aldoc_protein_levels__seqid___9876-20__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 AKR1D1 protein levels (SeqId = 18398-1) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 AKR1D1 protein levels (SeqId = 18398-1) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: 3-oxo-5-beta-steroid 4-dehydrogenase 774 1 Adults (18-65 years) Both European cg19693031 chr1:145441552 1 145441552 TXNIP Open sea -0.54 0.134 0.000064 None Gadd-DA_akr1d1_protein_levels__seqid___18398-1__somascan_protein_measurement Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P07360 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P07360 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg19693031 chr1:145441552 1 145441552 TXNIP Open sea -0.0341614 0.00854479 0.00006421442 P07360 41361833_Josephine_Robertson_P07360_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P00748 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P00748 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg19693031 chr1:145441552 1 145441552 TXNIP Open sea -0.0329089 0.0082521 0.00006697219 P00748 41361833_Josephine_Robertson_P00748_OSCA_model_1 Nuotio ML FINRISK, NFBC1966 33239708 2020-12-14 Metabolic Sydnrome EFO_0000195 Discovery Supplmentary table 1 DNA methylation Metabolic Sydnrome age, sex, smoking, alcohol consumption, cell composition (reference based), batch effects, ancestry (genomic PCs) M Values None Illumina HumanMethylation450 Whole blood No CpGs replicated 517 1 Adults Both European cg19693031 chr1:145441552 1 145441552 TXNIP Open sea -0.12444 0.031 0.00007 None 33239708_Nuotio-ML_metabolic_sydnrome_discovery Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02765 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation P02765 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg19693031 chr1:145441552 1 145441552 TXNIP Open sea -0.0368857 0.00931808 0.00007577669 P02765 41361833_Josephine_Robertson_P02765_OSCA_model_4 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01009 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation P01009 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg19693031 chr1:145441552 1 145441552 TXNIP Open sea 0.0367781 0.0093113 0.00007856953 P01009 41361833_Josephine_Robertson_P01009_OSCA_model_4 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P06396 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P06396 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg19693031 chr1:145441552 1 145441552 TXNIP Open sea 0.0335365 0.00849472 0.0000792015 P06396 41361833_Josephine_Robertson_P06396_OSCA_model_3 Gadd DA Generation Scotland 35945220 31/07/2022 SERPINA3 protein levels (SeqId = 4153-11) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 SERPINA3 protein levels (SeqId = 4153-11) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Alpha-1-antichymotrypsin 774 1 Adults (18-65 years) Both European cg19693031 chr1:145441552 1 145441552 TXNIP Open sea 0.53 0.134 0.000081 None Gadd-DA_serpina3_protein_levels__seqid___4153-11__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 KLB protein levels (SeqId = 19557-3) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 KLB protein levels (SeqId = 19557-3) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Beta-klotho 774 1 Adults (18-65 years) Both European cg19693031 chr1:145441552 1 145441552 TXNIP Open sea -0.527 0.134 0.000081 None Gadd-DA_klb_protein_levels__seqid___19557-3__somascan_protein_measurement Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01703 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation P01703 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg19693031 chr1:145441552 1 145441552 TXNIP Open sea 0.0366621 0.00931503 0.00008330489 P01703 41361833_Josephine_Robertson_P01703_OSCA_model_4 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04430 None OSCA model 4 10.5281/zenodo.16924748 DNA methylation P04430 Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg19693031 chr1:145441552 1 145441552 TXNIP Open sea 0.0366828 0.00932251 0.00008363035 P04430 41361833_Josephine_Robertson_P04430_OSCA_model_4 Gadd DA Generation Scotland 35945220 31/07/2022 ADH1C protein levels (SeqId = 15525-294) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 ADH1C protein levels (SeqId = 15525-294) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Alcohol dehydrogenase 1C 774 1 Adults (18-65 years) Both European cg19693031 chr1:145441552 1 145441552 TXNIP Open sea -0.53 0.134 0.000084 None Gadd-DA_adh1c_protein_levels__seqid___15525-294__somascan_protein_measurement Gadd DA Generation Scotland 35945220 31/07/2022 AKR7A3 protein levels (SeqId = 18173-11) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 AKR7A3 protein levels (SeqId = 18173-11) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Aflatoxin B1 aldehyde reductase member 3 774 1 Adults (18-65 years) Both European cg19693031 chr1:145441552 1 145441552 TXNIP Open sea -0.52 0.134 0.000095 None Gadd-DA_akr7a3_protein_levels__seqid___18173-11__somascan_protein_measurement