author	consortium	pmid	date	trait	efo	analysis	source	outcome	exposure	covariates	outcome_units	exposure_units	methylation_array	tissue	further_details	n	n_cohorts	age	sex	ethnicity	cpg	chrpos	chr	pos	gene	type	beta	se	p	details	study_id
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg19789466	chr12:113344923	12	113344923	OAS1	Open sea	-0.01	0.00026	0	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 2 at 6y with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg19789466	chr12:113344923	12	113344923	OAS1	Open sea	0.037	0.0012	0	None	33450751_Mulder-RH_age_model_2_at_6y_with_age_as_a_fixed_effect
Xu CJ	-	28056824	2017-01-05	Age 4 vs age 0	EFO_0000246	-	Additional file 3	DNA methylation	Age 4 vs age 0	Sex, cell counts and technical covariates	Beta values	-	Illumina HumanMethylation450	Whole blood and cord blood	-	269	2	-	Both	European	cg19789466	chr12:113344923	12	113344923	OAS1	Open sea	-	-	3.6599999999999998e-149	-	28056824_age_4_vs_age_0
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg19789466	chr12:113344923	12	113344923	OAS1	Open sea	0.09481	0.00252	6.6e-91	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Wozniak MB	-	23526956	2013-03-05	Clear cell renal carcinoma	EFO_0000349, EFO_0000681	-	Table S6	DNA methylation	Clear cell renal carcinoma	-	M values	-	Illumina HumanMethylation450	Clear cell renal carcinoma tumour cells and adjacent healthy cells	-	129	1	63	Both	European	cg19789466	chr12:113344923	12	113344923	OAS1	Open sea	-	-	6.45e-81	-	23526956_clear_cell_renal_carcinoma
Yao C	FHS, KORA F4, BLSA, InCHIANTI	33752734	2021-03-22	Gene expression of Affymetrix ID: 3432467 (gene symbol: OAS3)	None	Meta-analysis	Table S6	DNA methylation	Gene expression of Affymetrix ID: 3432467 (gene symbol: OAS3)	Age, sex, cell composition (reference based), batch effects	Beta Values	None	Illumina HumanMethylation450	Whole blood	None	4170	1	Adults	Both	Unclear	cg19789466	chr12:113344923	12	113344923	OAS1	Open sea	None	None	3.5e-20	None	33752734_Yao-C_gene_expression_of_affymetrix_id__3432467__gene_symbol__oas3__meta-analysis
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A075B7B8	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	A0A075B7B8	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg19789466	chr12:113344923	12	113344923	OAS1	Open sea	-0.0597896	0.00828174	0.0000000000005476447	A0A075B7B8	41361833_Josephine_Robertson_A0A075B7B8_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A075B7B8	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	A0A075B7B8	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg19789466	chr12:113344923	12	113344923	OAS1	Open sea	-0.0637505	0.00885243	0.0000000000006246673	A0A075B7B8	41361833_Josephine_Robertson_A0A075B7B8_OSCA_model_4
Chung SA	-	26192630	2015-07-20	Autoantibody production in systemic lupus erythematosus	EFO_0004866, EFO_0002690	Combined	Table S1	DNA methylation	Autoantibody production in systemic lupus erythematosus	Age, disease duration, cell counts and technical covariates	Beta values	-	Illumina HumanMethylation450	Peripheral blood	Wilcoxon rank sum test	326	2	46	Females	European	cg19789466	chr12:113344923	12	113344923	OAS1	Open sea	-	-	0.00000000000067	-	26192630_autoantibody_production_in_systemic_lupus_erythematosus_combined
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A075B7B8	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	A0A075B7B8	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg19789466	chr12:113344923	12	113344923	OAS1	Open sea	-0.0573465	0.00824298	0.000000000003622817	A0A075B7B8	41361833_Josephine_Robertson_A0A075B7B8_OSCA_model_1
Battram T	GEO	23177740	2020-09-15	Age	EFO_0000246	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE40279	None	DNA methylation	Age	Batch effects, cell composition (reference free)	Beta Values	Years	Illumina HumanMethylation450	Whole blood	None	656	1	Adults	Both	Unclear	cg19789466	chr12:113344923	12	113344923	OAS1	Open sea	-0.00035	0.00005	0.0000000000083	None	23177740_Battram-T_age_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse40279
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A075B7B8	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	A0A075B7B8	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg19789466	chr12:113344923	12	113344923	OAS1	Open sea	-0.056027	0.00825204	0.00000000001168723	A0A075B7B8	41361833_Josephine_Robertson_A0A075B7B8_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0C4DH35	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	A0A0C4DH35	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg19789466	chr12:113344923	12	113344923	OAS1	Open sea	-0.0574541	0.00886035	0.00000000009194184	A0A0C4DH35	41361833_Josephine_Robertson_A0A0C4DH35_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01714	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P01714	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg19789466	chr12:113344923	12	113344923	OAS1	Open sea	-0.0574948	0.0089058	0.0000000001109754	P01714	41361833_Josephine_Robertson_P01714_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01834	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P01834	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg19789466	chr12:113344923	12	113344923	OAS1	Open sea	-0.0532825	0.008265	0.0000000001178379	P01834	41361833_Josephine_Robertson_P01834_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0C4DH35	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	A0A0C4DH35	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg19789466	chr12:113344923	12	113344923	OAS1	Open sea	-0.0532688	0.00828253	0.0000000001303019	A0A0C4DH35	41361833_Josephine_Robertson_A0A0C4DH35_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01714	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P01714	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg19789466	chr12:113344923	12	113344923	OAS1	Open sea	-0.053266	0.00829675	0.0000000001403658	P01714	41361833_Josephine_Robertson_P01714_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A075B6H9	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	A0A075B6H9	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg19789466	chr12:113344923	12	113344923	OAS1	Open sea	-0.0571174	0.00890636	0.0000000001469637	A0A075B6H9	41361833_Josephine_Robertson_A0A075B6H9_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01834	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P01834	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg19789466	chr12:113344923	12	113344923	OAS1	Open sea	-0.0555731	0.00877269	0.0000000002446263	P01834	41361833_Josephine_Robertson_P01834_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01714	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P01714	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg19789466	chr12:113344923	12	113344923	OAS1	Open sea	-0.0524886	0.0082982	0.0000000002600839	P01714	41361833_Josephine_Robertson_P01714_OSCA_model_3
Chung SA	-	26192630	2015-07-20	Autoantibody production in systemic lupus erythematosus	EFO_0004866, EFO_0002690	Linear regression model	Table 2	DNA methylation	Autoantibody production in systemic lupus erythematosus	Age, ethnicity, cell counts and technical covariates	Beta values	-	Illumina HumanMethylation450	Peripheral blood	-	326	2	46	Females	European	cg19789466	chr12:113344923	12	113344923	OAS1	Open sea	-0.012	0.0019	0.00000000072	-	26192630_autoantibody_production_in_systemic_lupus_erythematosus_linear_regression_model
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01700	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P01700	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg19789466	chr12:113344923	12	113344923	OAS1	Open sea	-0.050515	0.00829138	0.000000001139623	P01700	41361833_Josephine_Robertson_P01700_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01700	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P01700	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg19789466	chr12:113344923	12	113344923	OAS1	Open sea	-0.053864	0.00889405	0.00000000142796	P01700	41361833_Josephine_Robertson_P01700_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0C4DH35	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	A0A0C4DH35	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg19789466	chr12:113344923	12	113344923	OAS1	Open sea	-0.0495564	0.00825896	0.000000002015638	A0A0C4DH35	41361833_Josephine_Robertson_A0A0C4DH35_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01714	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01714	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg19789466	chr12:113344923	12	113344923	OAS1	Open sea	-0.0493621	0.00824651	0.000000002203206	P01714	41361833_Josephine_Robertson_P01714_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01834	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P01834	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg19789466	chr12:113344923	12	113344923	OAS1	Open sea	-0.0485647	0.00818826	0.000000003078439	P01834	41361833_Josephine_Robertson_P01834_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A075B6H9	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	A0A075B6H9	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg19789466	chr12:113344923	12	113344923	OAS1	Open sea	-0.0491559	0.0083106	0.000000003395782	A0A075B6H9	41361833_Josephine_Robertson_A0A075B6H9_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01700	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P01700	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg19789466	chr12:113344923	12	113344923	OAS1	Open sea	-0.048772	0.00828853	0.000000004085141	P01700	41361833_Josephine_Robertson_P01700_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A075B6H9	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	A0A075B6H9	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg19789466	chr12:113344923	12	113344923	OAS1	Open sea	-0.0484628	0.00824687	0.000000004281004	A0A075B6H9	41361833_Josephine_Robertson_A0A075B6H9_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0C4DH35	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	A0A0C4DH35	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg19789466	chr12:113344923	12	113344923	OAS1	Open sea	-0.0483045	0.00824693	0.000000004806011	A0A0C4DH35	41361833_Josephine_Robertson_A0A0C4DH35_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01834	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01834	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg19789466	chr12:113344923	12	113344923	OAS1	Open sea	-0.0481295	0.008247	0.000000005459628	P01834	41361833_Josephine_Robertson_P01834_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01700	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01700	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg19789466	chr12:113344923	12	113344923	OAS1	Open sea	-0.0481189	0.00824701	0.000000005501915	P01700	41361833_Josephine_Robertson_P01700_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A075B6I0	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	A0A075B6I0	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg19789466	chr12:113344923	12	113344923	OAS1	Open sea	-0.0517842	0.00891965	0.00000000654526	A0A075B6I0	41361833_Josephine_Robertson_A0A075B6I0_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A075B6H9	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	A0A075B6H9	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg19789466	chr12:113344923	12	113344923	OAS1	Open sea	-0.0479193	0.00829726	0.000000007836493	A0A075B6H9	41361833_Josephine_Robertson_A0A075B6H9_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A075B6I0	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	A0A075B6I0	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg19789466	chr12:113344923	12	113344923	OAS1	Open sea	-0.047363	0.00830625	0.00000001206287	A0A075B6I0	41361833_Josephine_Robertson_A0A075B6I0_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0J9YX35	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	A0A0J9YX35	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg19789466	chr12:113344923	12	113344923	OAS1	Open sea	-0.0504823	0.00889932	0.00000001432981	A0A0J9YX35	41361833_Josephine_Robertson_A0A0J9YX35_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01619	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P01619	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg19789466	chr12:113344923	12	113344923	OAS1	Open sea	-0.0497983	0.00885778	0.00000001922249	P01619	41361833_Josephine_Robertson_P01619_OSCA_model_4
Chung SA	-	26192630	2015-07-20	Autoantibody production in systemic lupus erythematosus	EFO_0004866, EFO_0002690	Discovery	Table 2	DNA methylation	Autoantibody production in systemic lupus erythematosus	Technical covariates	Beta values	-	Illumina HumanMethylation450	Peripheral blood	Wilcoxon rank sum test	186	1	46	Females	European	cg19789466	chr12:113344923	12	113344923	OAS1	Open sea	-	-	0.000000023	-	26192630_autoantibody_production_in_systemic_lupus_erythematosus_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01602	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P01602	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg19789466	chr12:113344923	12	113344923	OAS1	Open sea	-0.0497608	0.00891755	0.00000002446458	P01602	41361833_Josephine_Robertson_P01602_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O75636	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	O75636	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg19789466	chr12:113344923	12	113344923	OAS1	Open sea	-0.0493115	0.00886312	0.00000002687921	O75636	41361833_Josephine_Robertson_O75636_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01709	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P01709	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg19789466	chr12:113344923	12	113344923	OAS1	Open sea	-0.0493195	0.00891716	0.00000003241441	P01709	41361833_Josephine_Robertson_P01709_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01023	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P01023	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg19789466	chr12:113344923	12	113344923	OAS1	Open sea	0.0467761	0.00852001	0.00000004082748	P01023	41361833_Josephine_Robertson_P01023_OSCA_model_4
Gadd DA	Generation Scotland	35945220	31/07/2022	MX1 protein levels (SeqId = 17460-51)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	MX1 protein levels (SeqId = 17460-51)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Interferon-induced GTP-binding protein Mx1	774	1	Adults (18-65 years)	Both	European	cg19789466	chr12:113344923	12	113344923	OAS1	Open sea	-1	0.182	0.000000046	None	Gadd-DA_mx1_protein_levels__seqid___17460-51__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A075B6I0	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	A0A075B6I0	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg19789466	chr12:113344923	12	113344923	OAS1	Open sea	-0.0447325	0.00829916	0.000000071548	A0A075B6I0	41361833_Josephine_Robertson_A0A075B6I0_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06727	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P06727	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg19789466	chr12:113344923	12	113344923	OAS1	Open sea	0.0445318	0.00830503	0.00000008353858	P06727	41361833_Josephine_Robertson_P06727_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0J9YX35	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	A0A0J9YX35	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg19789466	chr12:113344923	12	113344923	OAS1	Open sea	-0.0444111	0.008297	0.00000008797088	A0A0J9YX35	41361833_Josephine_Robertson_A0A0J9YX35_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0C4DH25	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	A0A0C4DH25	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg19789466	chr12:113344923	12	113344923	OAS1	Open sea	-0.0475479	0.00888527	0.00000008862976	A0A0C4DH25	41361833_Josephine_Robertson_A0A0C4DH25_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A075B6I0	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	A0A075B6I0	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg19789466	chr12:113344923	12	113344923	OAS1	Open sea	-0.0440392	0.00824856	0.00000009484544	A0A075B6I0	41361833_Josephine_Robertson_A0A075B6I0_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01602	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P01602	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg19789466	chr12:113344923	12	113344923	OAS1	Open sea	-0.0441755	0.00830132	0.0000001044286	P01602	41361833_Josephine_Robertson_P01602_OSCA_model_2
Gadd DA	Generation Scotland	35945220	31/07/2022	ISG15 protein levels (SeqId = 14151-4)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	ISG15 protein levels (SeqId = 14151-4)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Ubiquitin-like protein ISG15	774	1	Adults (18-65 years)	Both	European	cg19789466	chr12:113344923	12	113344923	OAS1	Open sea	-0.97	0.182	0.00000011	None	Gadd-DA_isg15_protein_levels__seqid___14151-4__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06727	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P06727	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg19789466	chr12:113344923	12	113344923	OAS1	Open sea	0.0435195	0.00824875	0.0000001339934	P06727	41361833_Josephine_Robertson_P06727_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01780	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P01780	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg19789466	chr12:113344923	12	113344923	OAS1	Open sea	-0.0467028	0.00889633	0.0000001545047	P01780	41361833_Josephine_Robertson_P01780_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06727	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P06727	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg19789466	chr12:113344923	12	113344923	OAS1	Open sea	0.0430414	0.00822798	0.0000001708241	P06727	41361833_Josephine_Robertson_P06727_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01602	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P01602	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg19789466	chr12:113344923	12	113344923	OAS1	Open sea	-0.0432961	0.00830035	0.0000001851339	P01602	41361833_Josephine_Robertson_P01602_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0C4DH25	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	A0A0C4DH25	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg19789466	chr12:113344923	12	113344923	OAS1	Open sea	-0.0429883	0.00829993	0.0000002255955	A0A0C4DH25	41361833_Josephine_Robertson_A0A0C4DH25_OSCA_model_2
Bohlin J	-	27717397	2016-10-07	Gestational age	EFO_0005112	Ultrasound-estimated gestational age	Table S1	DNA methylation	Gestational age	Offspring sex, maternal age, maternal smoking, study design, caesarean section and cell counts	Beta values	days	Illumina HumanMethylation450	Cord blood	-	1068	1	0	Both	European	cg19789466	chr12:113344923	12	113344923	OAS1	Open sea	-0.00062267	0.00012049	0.000000283	-	27717397_gestational_age_ultrasoundestimated_gestational_age
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O75636	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	O75636	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg19789466	chr12:113344923	12	113344923	OAS1	Open sea	-0.0422072	0.00824921	0.0000003151711	O75636	41361833_Josephine_Robertson_O75636_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01619	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P01619	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg19789466	chr12:113344923	12	113344923	OAS1	Open sea	-0.0423125	0.00827637	0.0000003220296	P01619	41361833_Josephine_Robertson_P01619_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0J9YX35	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	A0A0J9YX35	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg19789466	chr12:113344923	12	113344923	OAS1	Open sea	-0.0422893	0.00829365	0.0000003457262	A0A0J9YX35	41361833_Josephine_Robertson_A0A0J9YX35_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A075B6H7	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	A0A075B6H7	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg19789466	chr12:113344923	12	113344923	OAS1	Open sea	-0.0421695	0.00829661	0.0000003766097	A0A075B6H7	41361833_Josephine_Robertson_A0A075B6H7_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A075B6H7	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	A0A075B6H7	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg19789466	chr12:113344923	12	113344923	OAS1	Open sea	-0.0449585	0.0088789	0.0000004165756	A0A075B6H7	41361833_Josephine_Robertson_A0A075B6H7_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P36955	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P36955	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg19789466	chr12:113344923	12	113344923	OAS1	Open sea	0.0411371	0.00812547	0.0000004182994	P36955	41361833_Josephine_Robertson_P36955_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01023	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01023	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg19789466	chr12:113344923	12	113344923	OAS1	Open sea	0.0417426	0.00824938	0.0000004241117	P01023	41361833_Josephine_Robertson_P01023_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0C4DH25	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	A0A0C4DH25	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg19789466	chr12:113344923	12	113344923	OAS1	Open sea	-0.0407344	0.00827688	0.000000868289	A0A0C4DH25	41361833_Josephine_Robertson_A0A0C4DH25_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O75636	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	O75636	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg19789466	chr12:113344923	12	113344923	OAS1	Open sea	-0.0405327	0.00825201	0.0000009118982	O75636	41361833_Josephine_Robertson_O75636_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O75882	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	O75882	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg19789466	chr12:113344923	12	113344923	OAS1	Open sea	0.0433002	0.00887424	0.000001075752	O75882	41361833_Josephine_Robertson_O75882_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01619	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P01619	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg19789466	chr12:113344923	12	113344923	OAS1	Open sea	-0.0402921	0.00825862	0.000001078582	P01619	41361833_Josephine_Robertson_P01619_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01602	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01602	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg19789466	chr12:113344923	12	113344923	OAS1	Open sea	-0.0395135	0.00825012	0.000001688835	P01602	41361833_Josephine_Robertson_P01602_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P36955	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P36955	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg19789466	chr12:113344923	12	113344923	OAS1	Open sea	0.0396647	0.00831755	0.000001871192	P36955	41361833_Josephine_Robertson_P36955_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A075B6H7	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	A0A075B6H7	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg19789466	chr12:113344923	12	113344923	OAS1	Open sea	-0.0393076	0.00825019	0.000001911892	A0A075B6H7	41361833_Josephine_Robertson_A0A075B6H7_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0J9YX35	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	A0A0J9YX35	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg19789466	chr12:113344923	12	113344923	OAS1	Open sea	-0.039222	0.00825022	0.000002012695	A0A0J9YX35	41361833_Josephine_Robertson_A0A0J9YX35_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0C4DH36	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	A0A0C4DH36	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg19789466	chr12:113344923	12	113344923	OAS1	Open sea	-0.0422097	0.00889014	0.000002074595	A0A0C4DH36	41361833_Josephine_Robertson_A0A0C4DH36_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0C4DH25	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	A0A0C4DH25	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg19789466	chr12:113344923	12	113344923	OAS1	Open sea	-0.0391325	0.00825025	0.000002123539	A0A0C4DH25	41361833_Josephine_Robertson_A0A0C4DH25_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0C4DH36	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	A0A0C4DH36	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg19789466	chr12:113344923	12	113344923	OAS1	Open sea	-0.0393466	0.0083032	0.000002170882	A0A0C4DH36	41361833_Josephine_Robertson_A0A0C4DH36_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A075B6H7	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	A0A075B6H7	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg19789466	chr12:113344923	12	113344923	OAS1	Open sea	-0.0387525	0.0082728	0.000002834104	A0A075B6H7	41361833_Josephine_Robertson_A0A075B6H7_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01023	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P01023	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg19789466	chr12:113344923	12	113344923	OAS1	Open sea	0.0373227	0.00797145	0.000002865789	P01023	41361833_Josephine_Robertson_P01023_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01709	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P01709	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg19789466	chr12:113344923	12	113344923	OAS1	Open sea	-0.0386501	0.00830766	0.000003310609	P01709	41361833_Josephine_Robertson_P01709_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01023	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P01023	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg19789466	chr12:113344923	12	113344923	OAS1	Open sea	0.0385087	0.00827987	0.000003334014	P01023	41361833_Josephine_Robertson_P01023_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06727	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P06727	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg19789466	chr12:113344923	12	113344923	OAS1	Open sea	0.040849	0.00881317	0.000003600221	P06727	41361833_Josephine_Robertson_P06727_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P36955	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P36955	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg19789466	chr12:113344923	12	113344923	OAS1	Open sea	0.038226	0.00825054	0.000003632301	P36955	41361833_Josephine_Robertson_P36955_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01701	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P01701	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg19789466	chr12:113344923	12	113344923	OAS1	Open sea	-0.0413123	0.00893109	0.000003765883	P01701	41361833_Josephine_Robertson_P01701_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P36955	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P36955	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg19789466	chr12:113344923	12	113344923	OAS1	Open sea	0.0403501	0.00872975	0.000003830551	P36955	41361833_Josephine_Robertson_P36955_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O75636	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	O75636	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg19789466	chr12:113344923	12	113344923	OAS1	Open sea	-0.0383223	0.00829848	0.000003907636	O75636	41361833_Josephine_Robertson_O75636_OSCA_model_2
Chung SA	-	26192630	2015-07-20	Autoantibody production in systemic lupus erythematosus	EFO_0004866, EFO_0002690	Replication	Table 2	DNA methylation	Autoantibody production in systemic lupus erythematosus	Technical covariates	Beta values	-	Illumina HumanMethylation450	Peripheral blood	Wilcoxon rank sum test	140	1	46	Females	European	cg19789466	chr12:113344923	12	113344923	OAS1	Open sea	-	-	0.0000046	-	26192630_autoantibody_production_in_systemic_lupus_erythematosus_replication
Gadd DA	Generation Scotland	35945220	31/07/2022	EPHB2 protein levels (SeqId = 8225-86)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	EPHB2 protein levels (SeqId = 8225-86)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Ephrin type-B receptor 2	774	1	Adults (18-65 years)	Both	European	cg19789466	chr12:113344923	12	113344923	OAS1	Open sea	-0.82	0.182	0.0000062	None	Gadd-DA_ephb2_protein_levels__seqid___8225-86__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01780	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P01780	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg19789466	chr12:113344923	12	113344923	OAS1	Open sea	-0.0373137	0.00830445	0.000007069023	P01780	41361833_Josephine_Robertson_P01780_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P20742	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P20742	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg19789466	chr12:113344923	12	113344923	OAS1	Open sea	0.0385545	0.00861363	0.000007663291	P20742	41361833_Josephine_Robertson_P20742_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01619	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01619	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg19789466	chr12:113344923	12	113344923	OAS1	Open sea	-0.0366869	0.00825101	0.000008798254	P01619	41361833_Josephine_Robertson_P01619_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01709	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P01709	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg19789466	chr12:113344923	12	113344923	OAS1	Open sea	-0.0368276	0.00830673	0.000009340216	P01709	41361833_Josephine_Robertson_P01709_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P20742	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P20742	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg19789466	chr12:113344923	12	113344923	OAS1	Open sea	0.0364168	0.00825109	0.00001024056	P20742	41361833_Josephine_Robertson_P20742_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O75882	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	O75882	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg19789466	chr12:113344923	12	113344923	OAS1	Open sea	0.0361956	0.00825116	0.00001158729	O75882	41361833_Josephine_Robertson_O75882_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0C4DH36	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	A0A0C4DH36	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg19789466	chr12:113344923	12	113344923	OAS1	Open sea	-0.0361756	0.00828616	0.00001275341	A0A0C4DH36	41361833_Josephine_Robertson_A0A0C4DH36_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0C4DH36	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	A0A0C4DH36	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg19789466	chr12:113344923	12	113344923	OAS1	Open sea	-0.0359325	0.00825124	0.00001340947	A0A0C4DH36	41361833_Josephine_Robertson_A0A0C4DH36_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0A0MS15	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	A0A0A0MS15	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg19789466	chr12:113344923	12	113344923	OAS1	Open sea	-0.0387608	0.00893014	0.00001431477	A0A0A0MS15	41361833_Josephine_Robertson_A0A0A0MS15_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O75882	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	O75882	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg19789466	chr12:113344923	12	113344923	OAS1	Open sea	0.0355789	0.00826055	0.00001664946	O75882	41361833_Josephine_Robertson_O75882_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01743	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P01743	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg19789466	chr12:113344923	12	113344923	OAS1	Open sea	-0.0382331	0.00893141	0.00001874508	P01743	41361833_Josephine_Robertson_P01743_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A087WSY6	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	A0A087WSY6	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg19789466	chr12:113344923	12	113344923	OAS1	Open sea	-0.0351786	0.00829067	0.00002217476	A0A087WSY6	41361833_Josephine_Robertson_A0A087WSY6_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01780	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P01780	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg19789466	chr12:113344923	12	113344923	OAS1	Open sea	-0.0351521	0.00829494	0.00002271278	P01780	41361833_Josephine_Robertson_P01780_OSCA_model_3
Gross AM	-	27105112	2016-04-21	HIV infection	EFO_0000764	Discovery	Table S2	DNA methylation	HIV infection	Age and cell counts	-	-	Illumina HumanMethylation450	Whole blood	-	181	1	46.5	Males	European	cg19789466	chr12:113344923	12	113344923	OAS1	Open sea	-1.038326	0.2452	0.000023	-	27105112_hiv_infection_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0A0MT89	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	A0A0A0MT89	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg19789466	chr12:113344923	12	113344923	OAS1	Open sea	-0.034807	0.00830146	0.00002770586	A0A0A0MT89	41361833_Josephine_Robertson_A0A0A0MT89_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01780	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01780	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg19789466	chr12:113344923	12	113344923	OAS1	Open sea	-0.0342964	0.00825171	0.00003253142	P01780	41361833_Josephine_Robertson_P01780_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0C4DH38	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	A0A0C4DH38	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg19789466	chr12:113344923	12	113344923	OAS1	Open sea	-0.0369535	0.00891295	0.00003401701	A0A0C4DH38	41361833_Josephine_Robertson_A0A0C4DH38_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O75882	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	O75882	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg19789466	chr12:113344923	12	113344923	OAS1	Open sea	0.0342558	0.00828569	0.00003579676	O75882	41361833_Josephine_Robertson_O75882_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06312	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P06312	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg19789466	chr12:113344923	12	113344923	OAS1	Open sea	-0.0365852	0.00887829	0.00003797264	P06312	41361833_Josephine_Robertson_P06312_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01743	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P01743	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg19789466	chr12:113344923	12	113344923	OAS1	Open sea	-0.0342246	0.00830905	0.00003826788	P01743	41361833_Josephine_Robertson_P01743_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	Q99459	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	Q99459	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg19789466	chr12:113344923	12	113344923	OAS1	Open sea	-0.0340521	0.00828035	0.00003937032	Q99459	41361833_Josephine_Robertson_Q99459_OSCA_model_2
Bohlin J	-	27717397	2016-10-07	Gestational age	EFO_0005112	Last menstrual period-estimated gestational age	Table S2	DNA methylation	Gestational age	Offspring sex, maternal age, maternal smoking, study design, caesarean section and cell counts	Beta values	days	Illumina HumanMethylation450	Cord blood	-	1068	1	0	Both	European	cg19789466	chr12:113344923	12	113344923	OAS1	Open sea	-0.00043021	0.00010459	0.000042	-	27717397_gestational_age_last_menstrual_periodestimated_gestational_age
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P20742	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P20742	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg19789466	chr12:113344923	12	113344923	OAS1	Open sea	0.0337746	0.00829473	0.00004689301	P20742	41361833_Josephine_Robertson_P20742_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01709	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01709	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg19789466	chr12:113344923	12	113344923	OAS1	Open sea	-0.0335851	0.00825191	0.00004726336	P01709	41361833_Josephine_Robertson_P01709_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0A0MS15	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	A0A0A0MS15	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg19789466	chr12:113344923	12	113344923	OAS1	Open sea	-0.0334907	0.00831379	0.00005645706	A0A0A0MS15	41361833_Josephine_Robertson_A0A0A0MS15_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P20742	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P20742	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg19789466	chr12:113344923	12	113344923	OAS1	Open sea	0.0323779	0.00804406	0.00005724444	P20742	41361833_Josephine_Robertson_P20742_OSCA_model_3
Gadd DA	Generation Scotland	35945220	31/07/2022	IFNB1 protein levels (SeqId = 14127-240)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	IFNB1 protein levels (SeqId = 14127-240)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Interferon beta	774	1	Adults (18-65 years)	Both	European	cg19789466	chr12:113344923	12	113344923	OAS1	Open sea	-0.73	0.182	0.000066	None	Gadd-DA_ifnb1_protein_levels__seqid___14127-240__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0A0MT89	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	A0A0A0MT89	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg19789466	chr12:113344923	12	113344923	OAS1	Open sea	-0.0354117	0.00890189	0.00006983358	A0A0A0MT89	41361833_Josephine_Robertson_A0A0A0MT89_OSCA_model_4
Gadd DA	Generation Scotland	35945220	31/07/2022	CLEC4C protein levels (SeqId = 9094-5)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	CLEC4C protein levels (SeqId = 9094-5)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: C-type lectin domain family 4 member C	774	1	Adults (18-65 years)	Both	European	cg19789466	chr12:113344923	12	113344923	OAS1	Open sea	-0.72	0.182	0.000072	None	Gadd-DA_clec4c_protein_levels__seqid___9094-5__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01743	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P01743	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg19789466	chr12:113344923	12	113344923	OAS1	Open sea	-0.0328613	0.00831136	0.00007728621	P01743	41361833_Josephine_Robertson_P01743_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01743	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01743	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg19789466	chr12:113344923	12	113344923	OAS1	Open sea	-0.0323433	0.00825225	0.00008919745	P01743	41361833_Josephine_Robertson_P01743_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0A0MT89	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	A0A0A0MT89	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg19789466	chr12:113344923	12	113344923	OAS1	Open sea	-0.0323639	0.00829197	0.00009541789	A0A0A0MT89	41361833_Josephine_Robertson_A0A0A0MT89_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04211	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P04211	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg19789466	chr12:113344923	12	113344923	OAS1	Open sea	-0.0324321	0.00831706	0.00009683452	P04211	41361833_Josephine_Robertson_P04211_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0A0MS15	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	A0A0A0MS15	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg19789466	chr12:113344923	12	113344923	OAS1	Open sea	-0.0323676	0.00831642	0.00009985834	A0A0A0MS15	41361833_Josephine_Robertson_A0A0A0MS15_OSCA_model_3
Liu C	CHARGE+	27843151	2016-11-15	Alcohol consumption per day	EFO_0007878, EFO_0004329	African ancestry	Table S6	DNA methylation	Alcohol consumption per day	Age, sex, body mass index, cell counts and technical covariates	Beta values	g per day	Illumina HumanMethylation450	Whole blood	-	2423	3	56	Both	African	cg19789466	chr12:113344923	12	113344923	OAS1	Open sea	-8.74e-06	2.25e-06	0.0000999	-	27843151_alcohol_consumption_per_day_african_ancestry