author	consortium	pmid	date	trait	efo	analysis	source	outcome	exposure	covariates	outcome_units	exposure_units	methylation_array	tissue	further_details	n	n_cohorts	age	sex	ethnicity	cpg	chrpos	chr	pos	gene	type	beta	se	p	details	study_id
Sikdar S	CHARGE	31536415	2019-09-19	Smoking	EFO_0009115, EFO_0006527, EFO_0004318	random effects meta-analysis	Table S2	DNA methylation	Smoking	Age, sex, cell composition (reference based), batch effects	Beta Values	None	Illumina HumanMethylation450	Whole blood, CD4+ T cells, CD14+ monocytes	None	15907	16	Adults	Both	European, African, Other	cg21161138	chr5:399360	5	399360	AHRR	Open sea	-0.05089	0.00104	0	None	31536415_Sikdar-S_smoking_random_effects_meta-analysis
Robert F Hillary	Generation Scotland	10.1101/2023.01.10.23284387	9/6/2023	Incident COPD	None	Basic model	https://doi.org/10.5281/zenodo.8021411	DNA methylation	Incident COPD	Age, Sex, Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	None	17902	1	Adults (18-65y)	Both	European	cg21161138	chr5:399360	5	399360	AHRR	Open sea	-0.14	0.00522	1.1000000000000002e-165	None	Robert-F-Hillary_Incident_COPD_Basic_model
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Current vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	1851	1	Adults	Both	European	cg21161138	chr5:399360	5	399360	AHRR	Open sea	-0.52	0.021	6.699999999999999e-135	None	31552803_Dugue-PA_smoking_current_vs_never_smoking
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg21161138	chr5:399360	5	399360	AHRR	Open sea	0.32364	0.00531	6e-128	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01742	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P01742	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21161138	chr5:399360	5	399360	AHRR	Open sea	-0.168069	0.00816348	7.2209470000000005e-93	P01742	41361833_Josephine_Robertson_P01742_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01742	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01742	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21161138	chr5:399360	5	399360	AHRR	Open sea	-0.160359	0.00814972	4.268913e-85	P01742	41361833_Josephine_Robertson_P01742_OSCA_model_1
Zeilinger S	-	23691101	2013-05-17	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking discovery	Table S1	DNA methylation	Smoking	Age, sex, body mass index, alcohol consumption and cell counts	M values	-	Illumina HumanMethylation450	Whole blood	-	1011	1	60.8	Both	European	cg21161138	chr5:399360	5	399360	AHRR	Open sea	-	-	8.58e-81	-	23691101_smoking_current_vs_never_smoking_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01834	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01834	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21161138	chr5:399360	5	399360	AHRR	Open sea	0.153421	0.00815882	5.735191e-78	P01834	41361833_Josephine_Robertson_P01834_OSCA_model_1
Dogan MV	-	28686328	2017-07-07	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	-	Table S1	DNA methylation	Smoking	Age, sex and technical covariates	M values	-	Illumina HumanMethylation450	Peripheral blood	-	1597	1	67	Both	European	cg21161138	chr5:399360	5	399360	AHRR	Open sea	-1.63455233	0.0891	4.1999999999999997e-75	-	28686328_smoking
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01834	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P01834	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21161138	chr5:399360	5	399360	AHRR	Open sea	0.150377	0.00819117	1.926048e-74	P01834	41361833_Josephine_Robertson_P01834_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01742	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P01742	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21161138	chr5:399360	5	399360	AHRR	Open sea	-0.154224	0.00903783	1.1508259999999999e-64	P01742	41361833_Josephine_Robertson_P01742_OSCA_model_3
Sikdar S	PACE	31536415	2019-09-19	Prenatal smoke exposure	EFO_0009115, EFO_0008361, EFO_0006527, EFO_0004318	Inverse varience-weighted fixed-effects meta-analysis	Table S1	DNA methylation	Prenatal smoke exposure	Maternal age, socioeconomic position, cell composition (reference based), batch effects	Beta Values	None	Illumina HumanMethylation450	Cord blood, whole blood	None	5648	9	Infants	Both	European, African, Unclear	cg21161138	chr5:399360	5	399360	AHRR	Open sea	-0.0213	0.0013	6.6000000000000005e-59	None	31536415_Sikdar-S_prenatal_smoke_exposure_inverse_varience-weighted_fixed-effects_meta-analysis
Joubert BR	PACE	27040690	2016-04-07	Maternal smoking in pregnancy	EFO_0006527, EFO_0005671, EFO_0004318, EFO_0002950	Sustained maternal smoking in pregnancy effect on newborns adjusted for cell counts	Table S3	DNA methylation	Maternal smoking in pregnancy	Maternal age, maternal education, parity, white blood cell counts and technical covariates	Beta values	-	Illumina HumanMethylation450	Cord blood	-	5647	9	0	Missing	European,African,Admixed,Other	cg21161138	chr5:399360	5	399360	AHRR	Open sea	-0.021	0.001	6.61e-59	-	27040690_maternal_smoking_in_pregnancy_sustained_maternal_smoking_in_pregnancy_effect_on_newborns_adjusted_for_cell_counts
Guida F	-	25556184	2015-04-15	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Whole blood	-	582	2	54	Females	European	cg21161138	chr5:399360	5	399360	AHRR	Open sea	-0.46	0.029	8.510000000000001e-57	-	25556184_smoking_current_vs_never_smoking
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01834	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P01834	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21161138	chr5:399360	5	399360	AHRR	Open sea	0.155558	0.00988452	2.375511e-55	P01834	41361833_Josephine_Robertson_P01834_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01742	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P01742	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21161138	chr5:399360	5	399360	AHRR	Open sea	-0.153525	0.00976163	2.7794800000000002e-55	P01742	41361833_Josephine_Robertson_P01742_OSCA_model_4
Joubert BR	PACE	27040690	2016-04-07	Maternal smoking in pregnancy	EFO_0006527, EFO_0005671, EFO_0004318, EFO_0002950	Sustained maternal smoking in pregnancy effect on newborns	Table S3	DNA methylation	Maternal smoking in pregnancy	Maternal age, maternal education, parity and technical covariates	Beta values	-	Illumina HumanMethylation450	Cord blood	-	5647	9	0	Missing	European,African,Admixed,Other	cg21161138	chr5:399360	5	399360	AHRR	Open sea	-0.022	0.001	1.7799999999999998e-54	-	27040690_maternal_smoking_in_pregnancy_sustained_maternal_smoking_in_pregnancy_effect_on_newborns
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06312	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P06312	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21161138	chr5:399360	5	399360	AHRR	Open sea	0.12772	0.00818895	2.0997580000000002e-54	P06312	41361833_Josephine_Robertson_P06312_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0C4DH35	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	A0A0C4DH35	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21161138	chr5:399360	5	399360	AHRR	Open sea	0.127022	0.00818969	7.945545e-54	A0A0C4DH35	41361833_Josephine_Robertson_A0A0C4DH35_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06312	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P06312	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21161138	chr5:399360	5	399360	AHRR	Open sea	0.1258	0.0082366	2.906997e-52	P06312	41361833_Josephine_Robertson_P06312_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	Q99459	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	Q99459	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21161138	chr5:399360	5	399360	AHRR	Open sea	0.124222	0.00819262	1.5349329999999998e-51	Q99459	41361833_Josephine_Robertson_Q99459_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0C4DH35	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	A0A0C4DH35	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21161138	chr5:399360	5	399360	AHRR	Open sea	0.123333	0.00823959	2.7769719999999996e-50	A0A0C4DH35	41361833_Josephine_Robertson_A0A0C4DH35_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	Q99459	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	Q99459	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21161138	chr5:399360	5	399360	AHRR	Open sea	0.120408	0.00823338	4.2826109999999997e-48	Q99459	41361833_Josephine_Robertson_Q99459_OSCA_model_2
Ambatipudi S	-	26864933	2016-05-01	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Age, breast cancer status, menopausal status, use of contraceptive pill, use of hormone replacement therapy and technical covariates	M values	-	Illumina HumanMethylation450	Peripheral blood	-	721	1	52.6	Females	European	cg21161138	chr5:399360	5	399360	AHRR	Open sea	-	-	3.19e-47	-	26864933_smoking_current_vs_never_smoking
Robert F. Hillary	Generation Scotland	doi.org/10.1101/2023.11.02.23298000	Nov 3, 2023	C-reactive protein (CRP) levels	None	Basic model	None	C-reactive protein (CRP) levels	DNA methylation	Age, Sex, Cell composition (reference based), Batch effects	mg/L	Beta values	Illumina HumanMethylationEPIC	Whole blood	None	17936	1	Adults	Both	European	cg21161138	chr5:399360	5	399360	AHRR	Open sea	-2.7	0.192	2.4e-45	Basic_Model	Robert-F.-Hillary_c-reactive_protein__crp__levels_basic_model
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21161138	chr5:399360	5	399360	AHRR	Open sea	-0.114256	0.00811792	1.0635609999999999e-44	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A075B7B8	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	A0A075B7B8	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21161138	chr5:399360	5	399360	AHRR	Open sea	0.115283	0.00820152	1.37287e-44	A0A075B7B8	41361833_Josephine_Robertson_A0A075B7B8_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	B1AHL2	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	B1AHL2	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21161138	chr5:399360	5	399360	AHRR	Open sea	0.11398	0.00820276	1.2773080000000001e-43	B1AHL2	41361833_Josephine_Robertson_B1AHL2_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01834	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P01834	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21161138	chr5:399360	5	399360	AHRR	Open sea	0.125944	0.00912448	4.551168e-43	P01834	41361833_Josephine_Robertson_P01834_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P05546	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P05546	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21161138	chr5:399360	5	399360	AHRR	Open sea	-0.112818	0.00820386	9.152256e-43	P05546	41361833_Josephine_Robertson_P05546_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06312	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P06312	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21161138	chr5:399360	5	399360	AHRR	Open sea	0.136516	0.0100165	4.849787e-42	P06312	41361833_Josephine_Robertson_P06312_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	B1AHL2	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	B1AHL2	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21161138	chr5:399360	5	399360	AHRR	Open sea	0.112067	0.00826257	1.179246e-41	B1AHL2	41361833_Josephine_Robertson_B1AHL2_OSCA_model_2
Joubert BR	PACE	27040690	2016-04-07	Maternal smoking in pregnancy	EFO_0006527, EFO_0005671, EFO_0004318, EFO_0002950	Any maternal smoking in pregnancy effect on newborns	Table S3	DNA methylation	Maternal smoking in pregnancy	Maternal age, maternal education, parity and technical covariates	Beta values	-	Illumina HumanMethylation450	Cord blood	-	6685	13	0	Missing	European,East Asian,African,Admixed,Other	cg21161138	chr5:399360	5	399360	AHRR	Open sea	-0.014	0.001	1.46e-41	-	27040690_maternal_smoking_in_pregnancy_any_maternal_smoking_in_pregnancy_effect_on_newborns
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P05546	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P05546	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21161138	chr5:399360	5	399360	AHRR	Open sea	-0.111657	0.00825534	1.961601e-41	P05546	41361833_Josephine_Robertson_P05546_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A075B7B8	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	A0A075B7B8	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21161138	chr5:399360	5	399360	AHRR	Open sea	0.111411	0.00825342	2.806189e-41	A0A075B7B8	41361833_Josephine_Robertson_A0A075B7B8_OSCA_model_2
Robert F Hillary	Generation Scotland	10.1101/2023.01.10.23284387	9/6/2023	Incident Lung Cancer	None	Basic model	https://doi.org/10.5281/zenodo.8021411	DNA methylation	Incident Lung Cancer	Age, Sex, Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	None	18364	1	Adults (18-65y)	Both	European	cg21161138	chr5:399360	5	399360	AHRR	Open sea	-0.038	0.00282	8.199999999999999e-41	None	Robert-F-Hillary_Incident_Lung_Cancer_Basic_model
Zeilinger S	-	23691101	2013-05-17	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking replication	Table S2	DNA methylation	Smoking	Age, sex, body mass index, alcohol consumption and cell counts	M values	-	Illumina HumanMethylation450	Whole blood	-	468	1	53	Both	European	cg21161138	chr5:399360	5	399360	AHRR	Open sea	-	-	1.19e-40	-	23691101_smoking_current_vs_never_smoking_replication
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A087WSY6	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	A0A087WSY6	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21161138	chr5:399360	5	399360	AHRR	Open sea	0.109421	0.00820699	2.5650500000000003e-40	A0A087WSY6	41361833_Josephine_Robertson_A0A087WSY6_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0C4DH36	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	A0A0C4DH36	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21161138	chr5:399360	5	399360	AHRR	Open sea	0.107542	0.00820869	5.378518e-39	A0A0C4DH36	41361833_Josephine_Robertson_A0A0C4DH36_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A087WSY6	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	A0A087WSY6	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21161138	chr5:399360	5	399360	AHRR	Open sea	0.107813	0.00825598	9.319866000000001e-39	A0A087WSY6	41361833_Josephine_Robertson_A0A087WSY6_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	Q99459	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	Q99459	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21161138	chr5:399360	5	399360	AHRR	Open sea	0.129038	0.00999242	6.07562e-38	Q99459	41361833_Josephine_Robertson_Q99459_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0C4DH35	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	A0A0C4DH35	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21161138	chr5:399360	5	399360	AHRR	Open sea	0.127543	0.0100127	5.704589e-37	A0A0C4DH35	41361833_Josephine_Robertson_A0A0C4DH35_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0C4DH36	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	A0A0C4DH36	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21161138	chr5:399360	5	399360	AHRR	Open sea	0.105259	0.00827212	6.763358e-37	A0A0C4DH36	41361833_Josephine_Robertson_A0A0C4DH36_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06312	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P06312	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21161138	chr5:399360	5	399360	AHRR	Open sea	0.115195	0.00921524	1.127615e-35	P06312	41361833_Josephine_Robertson_P06312_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21161138	chr5:399360	5	399360	AHRR	Open sea	-0.100679	0.00821462	2.294045e-34	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_1
Battram T	GEO	25424692	2020-09-15	Smoking	EFO_0004318, EFO_0005671, EFO_0006527	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE50660. Never vs current smokers	None	DNA methylation	Smoking	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Whole blood	None	201	1	Adults	Both	European	cg21161138	chr5:399360	5	399360	AHRR	Open sea	0.0823	0.0054	3.6e-34	None	25424692_Battram-T_smoking_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse50660__never_vs_current_smokers
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21161138	chr5:399360	5	399360	AHRR	Open sea	-0.110824	0.00909164	5.1527829999999995e-34	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02763	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P02763	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21161138	chr5:399360	5	399360	AHRR	Open sea	-0.100145	0.00826855	1.327927e-33	P02763	41361833_Josephine_Robertson_P02763_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A075B6H7	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	A0A075B6H7	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21161138	chr5:399360	5	399360	AHRR	Open sea	0.0987771	0.00821619	3.8856570000000005e-33	A0A075B6H7	41361833_Josephine_Robertson_A0A075B6H7_OSCA_model_1
Zhang Y	-	26826776	2016-04-01	Serum cotinine	EFO_0007813	Replication	Table 2	DNA methylation	Serum cotinine	Age, sex, body mass index, physical activity, total cholesterol, systolic blood pressure, prevalence of cardiovascular disease, diabetes, cancer, leukocyte, cell counts and technical covariates	Beta values	ng/ml	Illumina HumanMethylation450	Whole blood	-	500	1	62	Both	European	cg21161138	chr5:399360	5	399360	AHRR	Open sea	-9e-04	7.5e-05	9.01e-33	-	26826776_serum_cotinine_replication
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01780	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01780	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21161138	chr5:399360	5	399360	AHRR	Open sea	0.0969071	0.00821771	5.950127e-32	P01780	41361833_Josephine_Robertson_P01780_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	B1AHL2	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	B1AHL2	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21161138	chr5:399360	5	399360	AHRR	Open sea	0.10806	0.00920288	1.076158e-31	B1AHL2	41361833_Josephine_Robertson_B1AHL2_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A075B6H7	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	A0A075B6H7	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21161138	chr5:399360	5	399360	AHRR	Open sea	0.0970652	0.00827327	1.204553e-31	A0A075B6H7	41361833_Josephine_Robertson_A0A075B6H7_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A075B7B8	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	A0A075B7B8	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21161138	chr5:399360	5	399360	AHRR	Open sea	0.117273	0.0100156	1.582791e-31	A0A075B7B8	41361833_Josephine_Robertson_A0A075B7B8_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02750	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P02750	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21161138	chr5:399360	5	399360	AHRR	Open sea	-0.0952315	0.00817707	3.29342e-31	P02750	41361833_Josephine_Robertson_P02750_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02763	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02763	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21161138	chr5:399360	5	399360	AHRR	Open sea	-0.0953558	0.00821895	5.499947e-31	P02763	41361833_Josephine_Robertson_P02763_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0C4DH35	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	A0A0C4DH35	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21161138	chr5:399360	5	399360	AHRR	Open sea	0.10602	0.00922164	1.846591e-30	A0A0C4DH35	41361833_Josephine_Robertson_A0A0C4DH35_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06396	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P06396	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21161138	chr5:399360	5	399360	AHRR	Open sea	0.0951466	0.00827944	1.955774e-30	P06396	41361833_Josephine_Robertson_P06396_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01780	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P01780	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21161138	chr5:399360	5	399360	AHRR	Open sea	0.0948651	0.0082813	2.973128e-30	P01780	41361833_Josephine_Robertson_P01780_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	Q99459	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	Q99459	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21161138	chr5:399360	5	399360	AHRR	Open sea	0.10449	0.00920288	9.428446999999999e-30	Q99459	41361833_Josephine_Robertson_Q99459_OSCA_model_3
Imboden M	Aging Lungs in European Cohorts project	31073081	2019-07-01	FEV1 / FVC	EFO_0004713	Meta-analysis	Supplementary table 3	DNA methylation	FEV1 / FVC	Batch effects, age, age squared, height, squared deviation from the mean height, sex, education, body mass index, cell composition (reference based)	Beta Values	None	Illumina HumanMethylation450	Whole blood	Meta-analyses were conducted across time points	5370	8	Adults	Both	European	cg21161138	chr5:399360	5	399360	AHRR	Open sea	0.243	0.021	9.700000000000001e-30	None	31073081_Imboden-M_fev1___fvc_meta-analysis
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P78563	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P78563	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21161138	chr5:399360	5	399360	AHRR	Open sea	0.0932968	0.00822056	9.956612e-30	P78563	41361833_Josephine_Robertson_P78563_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21161138	chr5:399360	5	399360	AHRR	Open sea	-0.110422	0.00981527	3.053339e-29	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0J9YX35	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	A0A0J9YX35	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21161138	chr5:399360	5	399360	AHRR	Open sea	0.0919954	0.00822156	6.009814e-29	A0A0J9YX35	41361833_Josephine_Robertson_A0A0J9YX35_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P78563	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P78563	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21161138	chr5:399360	5	399360	AHRR	Open sea	0.0922985	0.00827886	9.481829e-29	P78563	41361833_Josephine_Robertson_P78563_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06310	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P06310	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21161138	chr5:399360	5	399360	AHRR	Open sea	0.111323	0.0100743	2.829229e-28	P06310	41361833_Josephine_Robertson_P06310_OSCA_model_4
Domingo-Relloso A	Strong Heart Study	32484362	2020-06-02	Smoking	EFO_0004318, EFO_0005671, EFO_0006527	Current vs never	Table S2	DNA methylation	Smoking	Age, sex, batch effects, body mass index, cell composition (reference based), ancestry (genomic PCs)	M Values	None	Illumina HumanMethylationEPIC	Whole blood	None	2325	1	Adults	Both	Unclear	cg21161138	chr5:399360	5	399360	AHRR	Open sea	-0.152	0.0138	3.8000000000000005e-28	None	32484362_Domingo-Relloso-A_smoking_current_vs_never
Ambatipudi S	-	26864933	2016-05-01	Smoking	EFO_0005671, EFO_0004318	Former vs never smoking	Table S2	DNA methylation	Smoking	Age, breast cancer status, menopausal status, use of contraceptive pill, use of hormone replacement therapy and technical covariates	M values	-	Illumina HumanMethylation450	Peripheral blood	-	717	1	53.4	Females	European	cg21161138	chr5:399360	5	399360	AHRR	Open sea	-	-	3.9899999999999997e-28	-	26864933_smoking_former_vs_never_smoking
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06396	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P06396	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21161138	chr5:399360	5	399360	AHRR	Open sea	0.0902382	0.00822289	6.541086e-28	P06396	41361833_Josephine_Robertson_P06396_OSCA_model_1
Imboden M	Aging Lungs in European Cohorts project	31073081	2019-07-01	FEV1	EFO_0004314	Meta-analysis	Supplementary table 4	DNA methylation	FEV1	Batch effects, age, age squared, height, squared deviation from the mean height, sex, education, body mass index, cell composition (reference based)	Beta Values	L	Illumina HumanMethylation450	Whole blood	Meta-analyses were conducted across time points	5370	8	Adults	Both	European	cg21161138	chr5:399360	5	399360	AHRR	Open sea	1.56	0.143	8.9e-28	None	31073081_Imboden-M_fev1_meta-analysis
Robert F Hillary	Generation Scotland	10.1101/2023.01.10.23284387	9/6/2023	Prevalent Chronic Pain (Self-report)	None	Basic model	https://doi.org/10.5281/zenodo.8021411	DNA methylation	Prevalent Chronic Pain (Self-report)	Age, Sex, Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	Fully-adjusted model	18413	1	Adults (18-65y)	Both	European	cg21161138	chr5:399360	5	399360	AHRR	Open sea	-0.34	0.0315	1.5e-27	None	Robert-F-Hillary_Prevalent_Chronic_Pain_(Self-report)_Basic_model
Sayols-Baixeras S	-	26829059	2015-01-01	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking adjusted for cell counts	Table S1	DNA methylation	Smoking	Age, sex, physical activity, cell counts and technical covariates	M values	-	Illumina HumanMethylation450	Peripheral blood	-	449	1	63.1	Both	European	cg21161138	chr5:399360	5	399360	AHRR	Open sea	-	-	2.3800000000000002e-27	-	26829059_smoking_current_vs_never_smoking_adjusted_for_cell_counts
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0B4J1V0	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	A0A0B4J1V0	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21161138	chr5:399360	5	399360	AHRR	Open sea	0.0890041	0.0082238	3.403199e-27	A0A0B4J1V0	41361833_Josephine_Robertson_A0A0B4J1V0_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0C4DH36	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	A0A0C4DH36	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21161138	chr5:399360	5	399360	AHRR	Open sea	0.10834	0.0100554	5.745449e-27	A0A0C4DH36	41361833_Josephine_Robertson_A0A0C4DH36_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0C4DH25	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	A0A0C4DH25	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21161138	chr5:399360	5	399360	AHRR	Open sea	0.0881603	0.00822442	1.037274e-26	A0A0C4DH25	41361833_Josephine_Robertson_A0A0C4DH25_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0J9YX35	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	A0A0J9YX35	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21161138	chr5:399360	5	399360	AHRR	Open sea	0.0886683	0.00828089	1.176596e-26	A0A0J9YX35	41361833_Josephine_Robertson_A0A0J9YX35_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P05546	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P05546	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21161138	chr5:399360	5	399360	AHRR	Open sea	-0.0968763	0.00916847	5.299171e-26	P05546	41361833_Josephine_Robertson_P05546_OSCA_model_3
Markunas CA	-	24906187	2014-10-01	Maternal smoking during pregnancy	EFO_0006527, EFO_0005671, EFO_0004318, EFO_0002950	Model 1	Table S2	DNA methylation	Maternal smoking during pregnancy	Offspring sex, offspring cleft status and technical covariates	Beta values	-	Illumina HumanMethylation450	Whole blood	-	889	1	0	Both	European	cg21161138	chr5:399360	5	399360	AHRR	Open sea	-0.019	0.0018	5.51e-26	-	24906187_maternal_smoking_during_pregnancy_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02763	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P02763	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21161138	chr5:399360	5	399360	AHRR	Open sea	-0.0958624	0.00919567	2.344723e-25	P02763	41361833_Josephine_Robertson_P02763_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06310	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P06310	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21161138	chr5:399360	5	399360	AHRR	Open sea	0.0856541	0.00822623	2.66877e-25	P06310	41361833_Josephine_Robertson_P06310_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0C4DH25	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	A0A0C4DH25	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21161138	chr5:399360	5	399360	AHRR	Open sea	0.0861755	0.00828511	2.9954960000000003e-25	A0A0C4DH25	41361833_Josephine_Robertson_A0A0C4DH25_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0B4J1V0	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	A0A0B4J1V0	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21161138	chr5:399360	5	399360	AHRR	Open sea	0.0856054	0.00828381	6.019349e-25	A0A0B4J1V0	41361833_Josephine_Robertson_A0A0B4J1V0_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A087WSY6	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	A0A087WSY6	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21161138	chr5:399360	5	399360	AHRR	Open sea	0.103092	0.0100178	9.412371e-25	A0A087WSY6	41361833_Josephine_Robertson_A0A087WSY6_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01780	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P01780	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21161138	chr5:399360	5	399360	AHRR	Open sea	0.103278	0.0100678	1.316788e-24	P01780	41361833_Josephine_Robertson_P01780_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01619	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01619	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21161138	chr5:399360	5	399360	AHRR	Open sea	0.0843376	0.00822716	1.415758e-24	P01619	41361833_Josephine_Robertson_P01619_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04004	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P04004	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21161138	chr5:399360	5	399360	AHRR	Open sea	-0.0846204	0.00827305	1.786927e-24	P04004	41361833_Josephine_Robertson_P04004_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P05546	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P05546	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21161138	chr5:399360	5	399360	AHRR	Open sea	-0.101234	0.00997671	4.104103e-24	P05546	41361833_Josephine_Robertson_P05546_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04004	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04004	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21161138	chr5:399360	5	399360	AHRR	Open sea	-0.0825409	0.0082284	1.3240290000000002e-23	P04004	41361833_Josephine_Robertson_P04004_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06310	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P06310	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21161138	chr5:399360	5	399360	AHRR	Open sea	0.0828521	0.00828693	1.850059e-23	P06310	41361833_Josephine_Robertson_P06310_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02763	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P02763	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21161138	chr5:399360	5	399360	AHRR	Open sea	-0.0997913	0.00998874	1.995933e-23	P02763	41361833_Josephine_Robertson_P02763_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02750	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P02750	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21161138	chr5:399360	5	399360	AHRR	Open sea	-0.0904208	0.00913033	4.755385e-23	P02750	41361833_Josephine_Robertson_P02750_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0J9YX35	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	A0A0J9YX35	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21161138	chr5:399360	5	399360	AHRR	Open sea	0.0995872	0.0100753	5.750031e-23	A0A0J9YX35	41361833_Josephine_Robertson_A0A0J9YX35_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A075B6H7	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	A0A075B6H7	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21161138	chr5:399360	5	399360	AHRR	Open sea	0.0993044	0.01005	5.936853e-23	A0A075B6H7	41361833_Josephine_Robertson_A0A075B6H7_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01619	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P01619	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21161138	chr5:399360	5	399360	AHRR	Open sea	0.0813596	0.00826456	8.52743e-23	P01619	41361833_Josephine_Robertson_P01619_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02750	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02750	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21161138	chr5:399360	5	399360	AHRR	Open sea	-0.0809842	0.00822945	8.837628000000001e-23	P02750	41361833_Josephine_Robertson_P02750_OSCA_model_1
Sayols-Baixeras S	-	26829059	2015-01-01	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S1	DNA methylation	Smoking	Age, sex, physical activity and technical covariates	M values	-	Illumina HumanMethylation450	Peripheral blood	-	449	1	63.1	Both	European	cg21161138	chr5:399360	5	399360	AHRR	Open sea	-	-	9.28e-23	-	26829059_smoking_current_vs_never_smoking
Petersen A-K	KORA F4	24014485	2013-09-06	M36098_4-vinylphenol_sulfate	EFO_0004727, EFO_0004725	no snps model	Table S2	M36098_4-vinylphenol_sulfate	DNA methylation	Age, sex, body mass index, cell composition (reference based)	None	Beta Values	Illumina HumanMethylation450	Whole blood	None	1760	1	Adults	Both	European	cg21161138	chr5:399360	5	399360	AHRR	Open sea	-0.98	0.17	1.7000000000000002e-22	None	24014485_Petersen-A-K_m36098_4-vinylphenol_sulfate_no_snps_model
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0C4DH36	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	A0A0C4DH36	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21161138	chr5:399360	5	399360	AHRR	Open sea	0.0904216	0.00925821	1.8329410000000002e-22	A0A0C4DH36	41361833_Josephine_Robertson_A0A0C4DH36_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A075B7B8	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	A0A075B7B8	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21161138	chr5:399360	5	399360	AHRR	Open sea	0.0899286	0.00922871	2.278234e-22	A0A075B7B8	41361833_Josephine_Robertson_A0A075B7B8_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	B1AHL2	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	B1AHL2	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21161138	chr5:399360	5	399360	AHRR	Open sea	0.0974796	0.0100102	2.425303e-22	B1AHL2	41361833_Josephine_Robertson_B1AHL2_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01780	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P01780	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21161138	chr5:399360	5	399360	AHRR	Open sea	0.0899277	0.00926805	3.414713e-22	P01780	41361833_Josephine_Robertson_P01780_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0B4J1U7	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	A0A0B4J1U7	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21161138	chr5:399360	5	399360	AHRR	Open sea	0.0791516	0.00823067	7.886807e-22	A0A0B4J1U7	41361833_Josephine_Robertson_A0A0B4J1U7_OSCA_model_1
Tsaprouni LG	CARDIOGENICS	25424692	2014-10-31	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	-	Table S2	DNA methylation	Smoking	Age, sex, disease status, centre and technical covariates	Beta values	-	Illumina HumanMethylation450	Whole blood	-	464	1	55.4	Both	European	cg21161138	chr5:399360	5	399360	AHRR	Open sea	-	-	9.29e-22	-	25424692_smoking
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04114	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04114	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21161138	chr5:399360	5	399360	AHRR	Open sea	-0.0789429	0.0082308	1.008759e-21	P04114	41361833_Josephine_Robertson_P04114_OSCA_model_1
Sayols-Baixeras S	-	26829059	2015-01-01	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Smoking status	Table S1	DNA methylation	Smoking	Age, sex, physical activity and technical covariates	M values	-	Illumina HumanMethylation450	Peripheral blood	-	645	1	63.2	Both	European	cg21161138	chr5:399360	5	399360	AHRR	Open sea	-	-	1.9600000000000003e-21	-	26829059_smoking_smoking_status
Markunas CA	-	24906187	2014-10-01	Maternal smoking during pregnancy	EFO_0006527, EFO_0005671, EFO_0004318, EFO_0002950	Model 2	Table S2	DNA methylation	Maternal smoking during pregnancy	Offspring sex, offspring cleft status, birth weight, maternal age, maternal alcohol consumption, maternal education, maternal folic acid, supplement use, cell counts and technical covariates	Beta values	-	Illumina HumanMethylation450	Whole blood	-	889	1	0	Both	European	cg21161138	chr5:399360	5	399360	AHRR	Open sea	-0.0181	0.0019	2e-21	-	24906187_maternal_smoking_during_pregnancy_model_2
Petersen A-K	KORA F4	24014485	2013-09-06	M36098_4-vinylphenol_sulfate	EFO_0004727, EFO_0004725	snps as covariates model	Table S4	M36098_4-vinylphenol_sulfate	DNA methylation	Age, sex, body mass index, cell composition (reference based), genotype	None	Beta Values	Illumina HumanMethylation450	Whole blood	used three nearby snps as covariates	1760	1	Adults	Both	European	cg21161138	chr5:399360	5	399360	AHRR	Open sea	-0.98	0.172	2.5e-21	None	24014485_Petersen-A-K_m36098_4-vinylphenol_sulfate_snps_as_covariates_model
Robert F Hillary	Generation Scotland	10.1101/2023.01.10.23284387	9/6/2023	Prevalent COPD (Self-report)	None	Basic model	https://doi.org/10.5281/zenodo.8021411	DNA methylation	Prevalent COPD (Self-report)	Age, Sex, Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	None	18078	1	Adults (18-65y)	Both	European	cg21161138	chr5:399360	5	399360	AHRR	Open sea	-0.088	0.00929	2.8e-21	None	Robert-F-Hillary_Prevalent_COPD_(Self-report)_Basic_model
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A087WSY6	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	A0A087WSY6	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21161138	chr5:399360	5	399360	AHRR	Open sea	0.0872751	0.00922905	3.656255e-21	A0A087WSY6	41361833_Josephine_Robertson_A0A087WSY6_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0G2JRQ6	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	A0A0G2JRQ6	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21161138	chr5:399360	5	399360	AHRR	Open sea	0.0777689	0.00823157	3.979271e-21	A0A0G2JRQ6	41361833_Josephine_Robertson_A0A0G2JRQ6_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0B4J1V0	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	A0A0B4J1V0	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21161138	chr5:399360	5	399360	AHRR	Open sea	0.0942846	0.0100699	8.860285999999999e-21	A0A0B4J1V0	41361833_Josephine_Robertson_A0A0B4J1V0_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A075B6I0	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	A0A075B6I0	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21161138	chr5:399360	5	399360	AHRR	Open sea	0.0769993	0.00823206	9.676867e-21	A0A075B6I0	41361833_Josephine_Robertson_A0A075B6I0_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0B4J1U7	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	A0A0B4J1U7	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21161138	chr5:399360	5	399360	AHRR	Open sea	0.0775465	0.00829397	1.003318e-20	A0A0B4J1U7	41361833_Josephine_Robertson_A0A0B4J1U7_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0G2JRQ6	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	A0A0G2JRQ6	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21161138	chr5:399360	5	399360	AHRR	Open sea	0.0767877	0.00829508	2.388339e-20	A0A0G2JRQ6	41361833_Josephine_Robertson_A0A0G2JRQ6_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01619	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P01619	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21161138	chr5:399360	5	399360	AHRR	Open sea	0.0916019	0.010033	7.727400999999999e-20	P01619	41361833_Josephine_Robertson_P01619_OSCA_model_4
Marzi SJ	E-Risk	29325449	2018-01-12	Smoking	EFO_0006526	None	S2	DNA methylation	Smoking	sex, cell composition (reference based), batch effects	Beta Values	Pack years	Illumina HumanMethylation450	Whole blood	Analysis of twins	1658	1	Adults	Both	Unclear	cg21161138	chr5:399360	5	399360	AHRR	Open sea	-0.012	None	1e-19	None	29325449_Marzi-SJ_smoking
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06310	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P06310	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21161138	chr5:399360	5	399360	AHRR	Open sea	0.0842087	0.00928058	1.295064e-19	P06310	41361833_Josephine_Robertson_P06310_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A075B6I0	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	A0A075B6I0	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21161138	chr5:399360	5	399360	AHRR	Open sea	0.0747619	0.00830064	2.3796269999999998e-19	A0A075B6I0	41361833_Josephine_Robertson_A0A075B6I0_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0C4DH25	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	A0A0C4DH25	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21161138	chr5:399360	5	399360	AHRR	Open sea	0.090627	0.0100639	2.415064e-19	A0A0C4DH25	41361833_Josephine_Robertson_A0A0C4DH25_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P78563	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P78563	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21161138	chr5:399360	5	399360	AHRR	Open sea	0.0903127	0.0100398	2.636568e-19	P78563	41361833_Josephine_Robertson_P78563_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0J9YX35	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	A0A0J9YX35	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21161138	chr5:399360	5	399360	AHRR	Open sea	0.0828679	0.00927365	4.515498e-19	A0A0J9YX35	41361833_Josephine_Robertson_A0A0J9YX35_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0G2JMB2	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	A0A0G2JMB2	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21161138	chr5:399360	5	399360	AHRR	Open sea	-0.0734601	0.00823426	5.146753999999999e-19	A0A0G2JMB2	41361833_Josephine_Robertson_A0A0G2JMB2_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0G2JMB2	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	A0A0G2JMB2	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21161138	chr5:399360	5	399360	AHRR	Open sea	-0.0735768	0.00830705	9.13796e-19	A0A0G2JMB2	41361833_Josephine_Robertson_A0A0G2JMB2_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P14151	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P14151	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21161138	chr5:399360	5	399360	AHRR	Open sea	0.072208	0.00829747	3.590801e-18	P14151	41361833_Josephine_Robertson_P14151_OSCA_model_2
van Dongen J	BIOS	30631468	2018-03-23	Educational attainment	EFO_0004784	model 1	Table S2	DNA methylation	Educational attainment	Sex, age, batch effects, cell composition (reference based)	Beta Values	None	Illumina HumanMethylation450	Whole blood	None	4152	4	Adults	Both	European	cg21161138	chr5:399360	5	399360	AHRR	Open sea	0.021	0.002	4.5e-18	None	30631468_van-Dongen-J_educational_attainment_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0G2JRQ6	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	A0A0G2JRQ6	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21161138	chr5:399360	5	399360	AHRR	Open sea	0.0874512	0.0100846	4.695586e-18	A0A0G2JRQ6	41361833_Josephine_Robertson_A0A0G2JRQ6_OSCA_model_4
Sun Y-Q	HUNT study	33729499	17/03/21	smoking	EFO_0004318, EFO_0005671, EFO_0009115, EFO_0006526	None	Table 1	DNA methylation	smoking	Age, sex, cell composition (reference based), batch effects	Beta Values	None	Illumina HumanMethylationEPIC	Whole blood	None	128	1	Adults	Both	European	cg21161138	chr5:399360	5	399360	AHRR	Open sea	-0.015	0.00149	6.5e-18	None	33729499_Sun-Y-Q_smoking
Dugue PA	Melbourne Collaborative Cohort Study	31552803	2019-09-25	Smoking	EFO_0006527, EFO_0004318	Former vs never smoking	Supplementary table 1	DNA methylation	Smoking	Sex, country of birth, age, alcohol consumption, cell composition (reference based), batch effects	M Values	None	Illumina HumanMethylation450	Whole blood	None	156	1	Adults	Both	European	cg21161138	chr5:399360	5	399360	AHRR	Open sea	-0.12	0.014	1.2e-17	None	31552803_Dugue-PA_smoking_former_vs_never_smoking
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04114	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P04114	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21161138	chr5:399360	5	399360	AHRR	Open sea	-0.0844956	0.00988161	1.3421690000000002e-17	P04114	41361833_Josephine_Robertson_P04114_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02750	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P02750	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21161138	chr5:399360	5	399360	AHRR	Open sea	-0.0845392	0.00989468	1.4243470000000002e-17	P02750	41361833_Josephine_Robertson_P02750_OSCA_model_4
Zhu X	-	26756918	2016-07-01	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	-	Table S1	DNA methylation	Smoking	Age, sex, alcohol consumption, body mass index and technical covariates	Beta values	-	Illumina HumanMethylation450	Whole blood	Regression coefficients are for inverse normally transformed DNA methylation	596	4	53.9	Both	European	cg21161138	chr5:399360	5	399360	AHRR	Open sea	-0.397	0.046765	2.08e-17	-	26756918_smoking
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0B4J1V0	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	A0A0B4J1V0	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21161138	chr5:399360	5	399360	AHRR	Open sea	0.0785646	0.00927772	2.7288250000000003e-17	A0A0B4J1V0	41361833_Josephine_Robertson_A0A0B4J1V0_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0A0MT89	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	A0A0A0MT89	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21161138	chr5:399360	5	399360	AHRR	Open sea	0.0696448	0.00823652	3.035621e-17	A0A0A0MT89	41361833_Josephine_Robertson_A0A0A0MT89_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06396	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P06396	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21161138	chr5:399360	5	399360	AHRR	Open sea	0.077579	0.00921081	4.0207160000000004e-17	P06396	41361833_Josephine_Robertson_P06396_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O75636	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	O75636	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21161138	chr5:399360	5	399360	AHRR	Open sea	-0.0688761	0.00823696	6.725637000000001e-17	O75636	41361833_Josephine_Robertson_O75636_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0C4DH25	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	A0A0C4DH25	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21161138	chr5:399360	5	399360	AHRR	Open sea	0.0771856	0.00925758	8.252653e-17	A0A0C4DH25	41361833_Josephine_Robertson_A0A0C4DH25_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A075B6H7	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	A0A075B6H7	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21161138	chr5:399360	5	399360	AHRR	Open sea	0.0767621	0.00925252	1.166329e-16	A0A075B6H7	41361833_Josephine_Robertson_A0A075B6H7_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P14151	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P14151	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21161138	chr5:399360	5	399360	AHRR	Open sea	0.0682898	0.0082373	1.226748e-16	P14151	41361833_Josephine_Robertson_P14151_OSCA_model_1
Joehanes R	-	27651444	2016-10-01	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Current vs never smoking	Table S2	DNA methylation	Current versus never smoking	Age, sex, cell counts and technical covariates	Beta values	-	Illumina HumanMethylation450	Whole blood, CD4+ T cells or monocytes	-	9389	16	60.3	Both	European,African	cg21161138	chr5:399360	5	399360	AHRR	Open sea	-0.053	0.0065	4.4e-16	-	27651444_smoking_current_vs_never_smoking
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01700	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01700	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21161138	chr5:399360	5	399360	AHRR	Open sea	0.0663554	0.00823837	8.596256e-16	P01700	41361833_Josephine_Robertson_P01700_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01619	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P01619	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21161138	chr5:399360	5	399360	AHRR	Open sea	0.0742194	0.00923858	0.000000000000001017932	P01619	41361833_Josephine_Robertson_P01619_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0A0MT89	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	A0A0A0MT89	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21161138	chr5:399360	5	399360	AHRR	Open sea	0.0665929	0.00829633	0.000000000000001076013	A0A0A0MT89	41361833_Josephine_Robertson_A0A0A0MT89_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	Q9Y5Y7	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	Q9Y5Y7	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21161138	chr5:399360	5	399360	AHRR	Open sea	0.0661179	0.0082385	0.000000000000001087611	Q9Y5Y7	41361833_Josephine_Robertson_Q9Y5Y7_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P35858	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P35858	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21161138	chr5:399360	5	399360	AHRR	Open sea	0.0662764	0.00830305	0.000000000000001543816	P35858	41361833_Josephine_Robertson_P35858_OSCA_model_2
Karlsson Linner R	-	29086770	2017-10-31	Educational attainment	EFO_0004784	Basic model	Table S1.6b	DNA methylation	Educational attainment	Age, sex, cell counts and technical covariates	Beta values	years of schooling	Illumina HumanMethylation450	Whole blood	-	10767	27	57	Both	None	cg21161138	chr5:399360	5	399360	AHRR	Open sea	-	-	0.00000000000000208	-	29086770_educational_attainment_basic_model
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04114	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P04114	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21161138	chr5:399360	5	399360	AHRR	Open sea	-0.0650994	0.00821324	0.000000000000002422369	P04114	41361833_Josephine_Robertson_P04114_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01709	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01709	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21161138	chr5:399360	5	399360	AHRR	Open sea	0.0646203	0.00823931	0.000000000000004703849	P01709	41361833_Josephine_Robertson_P01709_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P35858	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P35858	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21161138	chr5:399360	5	399360	AHRR	Open sea	0.064595	0.00823933	0.000000000000004820561	P35858	41361833_Josephine_Robertson_P35858_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0B4J1U7	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	A0A0B4J1U7	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21161138	chr5:399360	5	399360	AHRR	Open sea	0.079137	0.0101075	0.000000000000005230006	A0A0B4J1U7	41361833_Josephine_Robertson_A0A0B4J1U7_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01700	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P01700	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21161138	chr5:399360	5	399360	AHRR	Open sea	0.0787124	0.0100835	0.000000000000006298814	P01700	41361833_Josephine_Robertson_P01700_OSCA_model_4
Zhang Y	-	26826776	2016-04-01	Serum cotinine	EFO_0007813	Discovery	Table 2	DNA methylation	Serum cotinine	Age, sex and technical covariates	Beta values	ng/ml	Illumina HumanMethylation450	Whole blood	-	500	1	62	Both	European	cg21161138	chr5:399360	5	399360	AHRR	Open sea	-7e-04	9e-05	0.00000000000000754	-	26826776_serum_cotinine_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	Q9Y5Y7	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	Q9Y5Y7	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21161138	chr5:399360	5	399360	AHRR	Open sea	0.0645498	0.00831098	0.000000000000008580011	Q9Y5Y7	41361833_Josephine_Robertson_Q9Y5Y7_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P27169	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P27169	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21161138	chr5:399360	5	399360	AHRR	Open sea	0.064403	0.00829314	0.000000000000008646832	P27169	41361833_Josephine_Robertson_P27169_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04004	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P04004	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21161138	chr5:399360	5	399360	AHRR	Open sea	-0.069029	0.00892674	0.00000000000001119966	P04004	41361833_Josephine_Robertson_P04004_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01700	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P01700	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21161138	chr5:399360	5	399360	AHRR	Open sea	0.0640468	0.00829312	0.00000000000001210615	P01700	41361833_Josephine_Robertson_P01700_OSCA_model_2
Joehanes R	-	27651444	2016-10-01	Smoking	EFO_0005671, EFO_0004318	Former vs never smoking	Table S5	DNA methylation	Former versus never smoking	Age, sex, cell counts and technical covariates	Beta values	-	Illumina HumanMethylation450	Whole blood, CD4+ T cells or monocytes	-	13474	16	62.9	Both	European,African	cg21161138	chr5:399360	5	399360	AHRR	Open sea	-0.0087	0.0011	0.000000000000016	-	27651444_smoking_former_vs_never_smoking
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P78563	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P78563	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21161138	chr5:399360	5	399360	AHRR	Open sea	0.0710942	0.00925427	0.0000000000000166097	P78563	41361833_Josephine_Robertson_P78563_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01743	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01743	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21161138	chr5:399360	5	399360	AHRR	Open sea	0.0632174	0.00824006	0.00000000000001800207	P01743	41361833_Josephine_Robertson_P01743_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A075B6H9	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	A0A075B6H9	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21161138	chr5:399360	5	399360	AHRR	Open sea	0.0633046	0.0083122	0.00000000000002778898	A0A075B6H9	41361833_Josephine_Robertson_A0A075B6H9_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A075B6H9	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	A0A075B6H9	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21161138	chr5:399360	5	399360	AHRR	Open sea	0.06252	0.00824042	0.00000000000003470706	A0A075B6H9	41361833_Josephine_Robertson_A0A075B6H9_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A075B6H9	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	A0A075B6H9	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21161138	chr5:399360	5	399360	AHRR	Open sea	0.076431	0.0101003	0.00000000000004039517	A0A075B6H9	41361833_Josephine_Robertson_A0A075B6H9_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O75636	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	O75636	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21161138	chr5:399360	5	399360	AHRR	Open sea	-0.0626185	0.00829651	0.00000000000004695476	O75636	41361833_Josephine_Robertson_O75636_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04114	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P04114	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21161138	chr5:399360	5	399360	AHRR	Open sea	-0.0684916	0.00910135	0.00000000000005559547	P04114	41361833_Josephine_Robertson_P04114_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00740	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P00740	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21161138	chr5:399360	5	399360	AHRR	Open sea	-0.0624071	0.00829516	0.00000000000005650408	P00740	41361833_Josephine_Robertson_P00740_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0B4J1U7	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	A0A0B4J1U7	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21161138	chr5:399360	5	399360	AHRR	Open sea	0.069765	0.00929078	0.00000000000006298727	A0A0B4J1U7	41361833_Josephine_Robertson_A0A0B4J1U7_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01743	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P01743	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21161138	chr5:399360	5	399360	AHRR	Open sea	0.061941	0.00830623	0.00000000000009335196	P01743	41361833_Josephine_Robertson_P01743_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P27169	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P27169	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21161138	chr5:399360	5	399360	AHRR	Open sea	0.0614438	0.00824097	0.00000000000009424803	P27169	41361833_Josephine_Robertson_P27169_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A075B6I0	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	A0A075B6I0	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21161138	chr5:399360	5	399360	AHRR	Open sea	0.0753315	0.0101134	0.00000000000009953429	A0A075B6I0	41361833_Josephine_Robertson_A0A075B6I0_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P27169	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P27169	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21161138	chr5:399360	5	399360	AHRR	Open sea	0.0687374	0.00924304	0.0000000000001089758	P27169	41361833_Josephine_Robertson_P27169_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0G2JRQ6	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	A0A0G2JRQ6	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21161138	chr5:399360	5	399360	AHRR	Open sea	0.0688784	0.00928072	0.0000000000001220142	A0A0G2JRQ6	41361833_Josephine_Robertson_A0A0G2JRQ6_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01709	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P01709	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21161138	chr5:399360	5	399360	AHRR	Open sea	0.0614901	0.00830639	0.0000000000001406475	P01709	41361833_Josephine_Robertson_P01709_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0A0MT89	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	A0A0A0MT89	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21161138	chr5:399360	5	399360	AHRR	Open sea	0.074546	0.0100874	0.0000000000001547608	A0A0A0MT89	41361833_Josephine_Robertson_A0A0A0MT89_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0A0MS15	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	A0A0A0MS15	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21161138	chr5:399360	5	399360	AHRR	Open sea	0.0745716	0.0101206	0.0000000000001820194	A0A0A0MS15	41361833_Josephine_Robertson_A0A0A0MS15_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0C4DH34	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	A0A0C4DH34	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21161138	chr5:399360	5	399360	AHRR	Open sea	0.0735985	0.0101075	0.000000000000346812	A0A0C4DH34	41361833_Josephine_Robertson_A0A0C4DH34_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01743	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P01743	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21161138	chr5:399360	5	399360	AHRR	Open sea	0.0736203	0.0101223	0.0000000000003691948	P01743	41361833_Josephine_Robertson_P01743_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0A0MS14	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	A0A0A0MS14	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21161138	chr5:399360	5	399360	AHRR	Open sea	0.0599274	0.00824173	0.0000000000003742645	A0A0A0MS14	41361833_Josephine_Robertson_A0A0A0MS14_OSCA_model_1
van Dongen J	ALSPAC, Dunedin, E-risk, FinnTwin12, GS:SFHS, GLAKU, HELIX, LLD, NFBC1996, NFBC1986, NTR, SATSA, YFS	33420481	2021-01-08	Aggressive behaviour	EFO_0003015	Meta-analysis in whole blood	eTable 6	DNA methylation	Aggressive behaviour	age, sex, cell compostion (reference based), cell composition (reference free), batch effects	Beta Values	None	Illumina HumanMethylation450, Illumina HumanMethylationEPIC	Whole blood	Age range from 7 - 70	14434	13	Adults	Both	Unclear	cg21161138	chr5:399360	5	399360	AHRR	Open sea	None	None	0.00000000000047	None	33420481_van-Dongen-J_aggressive_behaviour_meta-analysis_in_whole_blood
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00740	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P00740	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21161138	chr5:399360	5	399360	AHRR	Open sea	-0.0596114	0.00824189	0.0000000000004967828	P00740	41361833_Josephine_Robertson_P00740_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P35858	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P35858	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21161138	chr5:399360	5	399360	AHRR	Open sea	0.0670945	0.00928427	0.0000000000005193312	P35858	41361833_Josephine_Robertson_P35858_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P15169	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P15169	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21161138	chr5:399360	5	399360	AHRR	Open sea	0.058915	0.00824223	0.0000000000009224649	P15169	41361833_Josephine_Robertson_P15169_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06727	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P06727	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21161138	chr5:399360	5	399360	AHRR	Open sea	-0.0588794	0.00824225	0.0000000000009519214	P06727	41361833_Josephine_Robertson_P06727_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0C4DH34	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	A0A0C4DH34	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21161138	chr5:399360	5	399360	AHRR	Open sea	0.0586801	0.00824234	0.000000000001134745	A0A0C4DH34	41361833_Josephine_Robertson_A0A0C4DH34_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0A0MS14	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	A0A0A0MS14	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21161138	chr5:399360	5	399360	AHRR	Open sea	0.0587794	0.00831199	0.000000000001600388	A0A0A0MS14	41361833_Josephine_Robertson_A0A0A0MS14_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0A0MS15	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	A0A0A0MS15	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21161138	chr5:399360	5	399360	AHRR	Open sea	0.0582686	0.00824254	0.000000000001628092	A0A0A0MS15	41361833_Josephine_Robertson_A0A0A0MS15_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06727	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P06727	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21161138	chr5:399360	5	399360	AHRR	Open sea	-0.0704882	0.00999044	0.000000000001796112	P06727	41361833_Josephine_Robertson_P06727_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P18428	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P18428	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21161138	chr5:399360	5	399360	AHRR	Open sea	-0.0575752	0.00822725	0.000000000002706856	P18428	41361833_Josephine_Robertson_P18428_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P15169	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P15169	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21161138	chr5:399360	5	399360	AHRR	Open sea	0.0580943	0.00831501	0.000000000002936081	P15169	41361833_Josephine_Robertson_P15169_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P07996	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P07996	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21161138	chr5:399360	5	399360	AHRR	Open sea	-0.0576264	0.00831222	0.000000000004300493	P07996	41361833_Josephine_Robertson_P07996_OSCA_model_2
Dogan MV	-	24559495	2014-02-22	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	-	Table 2	DNA methylation	Smoking	Cell counts and technical covariates	Beta values	-	Illumina HumanMethylation450	Peripheral Blood	-	111	1	48.4	Females	African	cg21161138	chr5:399360	5	399360	AHRR	Open sea	-	-	0.00000000000464	-	24559495_smoking
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01706	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P01706	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21161138	chr5:399360	5	399360	AHRR	Open sea	0.0574269	0.00831441	0.00000000000515708	P01706	41361833_Josephine_Robertson_P01706_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O43866	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	O43866	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21161138	chr5:399360	5	399360	AHRR	Open sea	0.056823	0.00824323	0.000000000005674261	O43866	41361833_Josephine_Robertson_O43866_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P08571	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P08571	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21161138	chr5:399360	5	399360	AHRR	Open sea	-0.0571237	0.00830212	0.000000000006200639	P08571	41361833_Josephine_Robertson_P08571_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01706	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01706	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21161138	chr5:399360	5	399360	AHRR	Open sea	0.0567132	0.00824328	0.00000000000623096	P01706	41361833_Josephine_Robertson_P01706_OSCA_model_1
Karabegovic I	Airwave, ALSPAC, ESTHER, FHS, KORA, Rotterdam Study, Twins UK, ARIC, CHS, EPIC	33990564	05-14-2021	Coffee and tea consumption	None	Meta-analysis	Table 2	DNA methylation	Coffee and tea consumption	Age, Sex, Smoking, Cell composition (reference based), Batch effects, Alcohol consumption	Beta values	None	Illumina HumanMethylation450	Whole blood	None	15789	15	Adults	Both	European, African	cg21161138	chr5:399360	5	399360	AHRR	Open sea	-0.0011	0.0002	0.0000000000067	None	33990564_Karabegovic-I_coffee_and_tea_consumption_meta-analysis
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P07996	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P07996	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21161138	chr5:399360	5	399360	AHRR	Open sea	-0.0564091	0.00824342	0.000000000008067153	P07996	41361833_Josephine_Robertson_P07996_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0C4DH34	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	A0A0C4DH34	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21161138	chr5:399360	5	399360	AHRR	Open sea	0.056568	0.00830547	0.00000000001007444	A0A0C4DH34	41361833_Josephine_Robertson_A0A0C4DH34_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06727	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P06727	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21161138	chr5:399360	5	399360	AHRR	Open sea	-0.0563106	0.00830827	0.00000000001268054	P06727	41361833_Josephine_Robertson_P06727_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P27169	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P27169	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21161138	chr5:399360	5	399360	AHRR	Open sea	0.0677203	0.0100101	0.00000000001381857	P27169	41361833_Josephine_Robertson_P27169_OSCA_model_4
Wiklund P.	Northern Finland Birth, IoW Birth Cohort, ALSPAC	31262328	2019-07-01	Maternal smoking	EFO_0006527	Meta-analysis	Table 1	DNA methylation	Maternal smoking	Sex, body mass index, smoking, socioeconomic position, ancestry (genomic PCs), age, maternal age	Beta Values	None	Illumina HumanMethylation450	Whole Blood	Some study specific covariates	2821	3	Adults	Both	European	cg21161138	chr5:399360	5	399360	AHRR	Open sea	-0.013	0.002	0.000000000015	None	31262328_Wiklund-P._maternal_smoking_meta-analysis
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0A0MS15	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	A0A0A0MS15	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21161138	chr5:399360	5	399360	AHRR	Open sea	0.0561432	0.00831358	0.00000000001500753	A0A0A0MS15	41361833_Josephine_Robertson_A0A0A0MS15_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01602	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P01602	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21161138	chr5:399360	5	399360	AHRR	Open sea	0.0676263	0.0101138	0.00000000002368334	P01602	41361833_Josephine_Robertson_P01602_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04004	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P04004	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21161138	chr5:399360	5	399360	AHRR	Open sea	-0.0644225	0.00967527	0.00000000002865557	P04004	41361833_Josephine_Robertson_P04004_OSCA_model_4
Sun Y-Q	HUNT study	33729499	17/03/21	lung cancer	MONDO_0008903	None	Table 3	lung cancer	DNA methylation	Age, sex, cell composition (reference based)	None	Beta Values	Illumina HumanMethylationEPIC	Whole blood	Potentially adjusted for batch effects, but it wasn't clear	276	1	Adults	Both	European	cg21161138	chr5:399360	5	399360	AHRR	Open sea	-25.8	3.9	0.000000000034	None	33729499_Sun-Y-Q_lung_cancer
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P23142	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P23142	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21161138	chr5:399360	5	399360	AHRR	Open sea	0.0546551	0.00824423	0.00000000003485904	P23142	41361833_Josephine_Robertson_P23142_OSCA_model_1
Robert F Hillary	Generation Scotland	10.1101/2023.01.10.23284387	9/6/2023	Incident Stroke	None	Basic model	https://doi.org/10.5281/zenodo.8021411	DNA methylation	Incident Stroke	Age, Sex, Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	None	18023	1	Adults (18-65y)	Both	European	cg21161138	chr5:399360	5	399360	AHRR	Open sea	-0.034	0.00512	0.000000000035	None	Robert-F-Hillary_Incident_Stroke_Basic_model
van Dongen J	BIOS	30631468	2018-03-23	Educational attainment	EFO_0004784	model 3	Table S2	DNA methylation	Educational attainment	Sex, age, batch effects, cell composition (reference based), smoking, body mass index	Beta Values	None	Illumina HumanMethylation450	Whole blood	None	4152	4	Adults	Both	European	cg21161138	chr5:399360	5	399360	AHRR	Open sea	0.013	0.002	0.000000000037	None	30631468_van-Dongen-J_educational_attainment_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P08571	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P08571	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21161138	chr5:399360	5	399360	AHRR	Open sea	-0.0543531	0.00824437	0.00000000004464892	P08571	41361833_Josephine_Robertson_P08571_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A075B6H9	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	A0A075B6H9	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21161138	chr5:399360	5	399360	AHRR	Open sea	0.0612217	0.0092915	0.00000000004578982	A0A075B6H9	41361833_Josephine_Robertson_A0A075B6H9_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01602	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01602	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21161138	chr5:399360	5	399360	AHRR	Open sea	0.0534983	0.00824475	0.0000000000893133	P01602	41361833_Josephine_Robertson_P01602_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P23142	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P23142	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21161138	chr5:399360	5	399360	AHRR	Open sea	0.0534978	0.00831334	0.0000000001271642	P23142	41361833_Josephine_Robertson_P23142_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O43866	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	O43866	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21161138	chr5:399360	5	399360	AHRR	Open sea	0.0531898	0.00829888	0.0000000001506852	O43866	41361833_Josephine_Robertson_O43866_OSCA_model_2
Wahl A	TwinsUK, EGCUT	29055820	2017-10-18	IgG glycosylation measure - IGP72	EFO_0005193	None	Table S3	IgG glycosylation measure - IGP72	DNA methylation	Age, sex, body mass index, cell composition (reference based), batch effects	None	Beta Values	Illumina HumanMethylation450	Whole blood	Glycans measured using UPLC - 76 glycan traits assessed in total	757	2	Adults	Both	Unclear	cg21161138	chr5:399360	5	399360	AHRR	Open sea	7.4	1.16	0.00000000017	None	29055820_Wahl-A_igg_glycosylation_measure_-_igp72
Wahl A	TwinsUK, EGCUT	29055820	2017-10-18	IgG glycosylation measure - IGP62	EFO_0005193	None	Table S3	IgG glycosylation measure - IGP62	DNA methylation	Age, sex, body mass index, cell composition (reference based), batch effects	None	Beta Values	Illumina HumanMethylation450	Whole blood	Glycans measured using UPLC - 76 glycan traits assessed in total	757	2	Adults	Both	Unclear	cg21161138	chr5:399360	5	399360	AHRR	Open sea	7.5	1.18	0.00000000018	None	29055820_Wahl-A_igg_glycosylation_measure_-_igp62
Wahl A	TwinsUK, EGCUT	29055820	2017-10-18	IgG glycosylation measure - IGP70	EFO_0005193	None	Table S3	IgG glycosylation measure - IGP70	DNA methylation	Age, sex, body mass index, cell composition (reference based), batch effects	None	Beta Values	Illumina HumanMethylation450	Whole blood	Glycans measured using UPLC - 76 glycan traits assessed in total	757	2	Adults	Both	Unclear	cg21161138	chr5:399360	5	399360	AHRR	Open sea	-7.4	1.17	0.00000000018	None	29055820_Wahl-A_igg_glycosylation_measure_-_igp70
Wahl A	TwinsUK, EGCUT	29055820	2017-10-18	IgG glycosylation measure - IGP71	EFO_0005193	None	Table S3	IgG glycosylation measure - IGP71	DNA methylation	Age, sex, body mass index, cell composition (reference based), batch effects	None	Beta Values	Illumina HumanMethylation450	Whole blood	Glycans measured using UPLC - 76 glycan traits assessed in total	757	2	Adults	Both	Unclear	cg21161138	chr5:399360	5	399360	AHRR	Open sea	-7.4	1.17	0.00000000018	None	29055820_Wahl-A_igg_glycosylation_measure_-_igp71
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01743	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P01743	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21161138	chr5:399360	5	399360	AHRR	Open sea	0.0591572	0.00930261	0.0000000002088102	P01743	41361833_Josephine_Robertson_P01743_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A075B6I0	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	A0A075B6I0	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21161138	chr5:399360	5	399360	AHRR	Open sea	0.0590558	0.00929322	0.0000000002149841	A0A075B6I0	41361833_Josephine_Robertson_A0A075B6I0_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P08603	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P08603	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21161138	chr5:399360	5	399360	AHRR	Open sea	-0.0541717	0.00854451	0.0000000002365695	P08603	41361833_Josephine_Robertson_P08603_OSCA_model_3
Priyanka Choudhary	PACE	38052982	Dec 5, 2023	Maternal education at the time of pregnancy	None	Model1_Cord_All	None	DNA methylation	Maternal education at the time of pregnancy	Sex, Cell composition (reference based), Batch effects	Beta values	years of schooling	Illumina HumanMethylation450	Cord blood	Illumina HumanMethylationEPIC was also used for some cohorts	9881	None	Infants	Both	Admixed	cg21161138	chr5:399360	5	399360	AHRR	Open sea	0.00053	0.000084	0.00000000026	None	38052982_Priyanka-Choudhary_maternal_education_at_the_time_of_pregnancy_model1_cord_all
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P07360	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P07360	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21161138	chr5:399360	5	399360	AHRR	Open sea	-0.0518768	0.00824545	0.0000000003232098	P07360	41361833_Josephine_Robertson_P07360_OSCA_model_1
Domingo-Relloso A	Strong Heart Study	32484362	2020-06-02	Smoking	EFO_0004318, EFO_0005671, EFO_0006526	Pack years	Table S4	DNA methylation	Smoking	Age, sex, batch effects, body mass index, cell composition (reference based), ancestry (genomic PCs)	M Values	pack-years	Illumina HumanMethylationEPIC	Whole blood	None	2325	1	Adults	Both	Unclear	cg21161138	chr5:399360	5	399360	AHRR	Open sea	-0.00195	0.0003	0.00000000033	None	32484362_Domingo-Relloso-A_smoking_pack_years
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01602	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P01602	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21161138	chr5:399360	5	399360	AHRR	Open sea	0.0521173	0.0083063	0.0000000003607639	P01602	41361833_Josephine_Robertson_P01602_OSCA_model_2
Smith AK	Psychiatric Genomics Consortium (PGC) PTSD Epigenetics Workgroup	33235198	2020-11-24	post-traumatic stress disorder	EFO_0001358	Meta-analysis	Supplementary data 2	DNA methylation	post-traumatic stress disorder	Age, sex, smoking, cell composition (reference based), batch effects, ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylation450	Whole blood	Controls had been exposed to trauma but did not have a current diagnosis of PTSD or a prior history of PTSD	1896	10	Adults	Both	European, African	cg21161138	chr5:399360	5	399360	AHRR	Open sea	-0.092	0.0145	0.00000000039	None	33235198_Smith-AK_post-traumatic_stress_disorder_meta-analysis
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01706	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P01706	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21161138	chr5:399360	5	399360	AHRR	Open sea	0.0633242	0.0101251	0.0000000004107701	P01706	41361833_Josephine_Robertson_P01706_OSCA_model_4
Battram T	GEO	25424692	2020-09-15	Smoking	EFO_0004318, EFO_0005671, EFO_0006527	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE50660. Former vs current smokers	None	DNA methylation	Smoking	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Whole blood	None	285	1	Adults	Both	European	cg21161138	chr5:399360	5	399360	AHRR	Open sea	0.0554	0.00856	0.00000000045	None	25424692_Battram-T_smoking_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse50660__former_vs_current_smokers
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01019	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P01019	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21161138	chr5:399360	5	399360	AHRR	Open sea	0.0578962	0.00928868	0.0000000004701518	P01019	41361833_Josephine_Robertson_P01019_OSCA_model_3
van Dongen J	BIOS	30631468	2018-03-23	Educational attainment	EFO_0004784	model 2	Table S2	DNA methylation	Educational attainment	Sex, age, batch effects, cell composition (reference based), smoking	Beta Values	None	Illumina HumanMethylation450	Whole blood	None	4152	4	Adults	Both	European	cg21161138	chr5:399360	5	399360	AHRR	Open sea	0.013	0.002	0.0000000005	None	30631468_van-Dongen-J_educational_attainment_model_2
Xu R	Boston Birth Cohort	33663600	2021-03-04	maternal smoking	EFO_0004318, EFO_0006527, EFO_0005671, EFO_0002950	Discovery, black only	Table S2	DNA methylation	maternal smoking	gestational age, sex, maternal age, maternal education, race, maternal BMI, maternal alcohol consumption, maternal diabetes, cell composition (reference based), batch effects	Beta Values	None	Illumina HumanMethylationEPIC	Cord blood	None	679	1	Infants	Both	African	cg21161138	chr5:399360	5	399360	AHRR	Open sea	-0.55	0.087	0.00000000055	None	33663600_Xu-R_maternal_smoking_discovery__black_only
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P14151	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P14151	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21161138	chr5:399360	5	399360	AHRR	Open sea	0.0573012	0.00924168	0.000000000578655	P14151	41361833_Josephine_Robertson_P14151_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P08603	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P08603	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21161138	chr5:399360	5	399360	AHRR	Open sea	-0.0574661	0.00927182	0.0000000005874148	P08603	41361833_Josephine_Robertson_P08603_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	Q15848	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	Q15848	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21161138	chr5:399360	5	399360	AHRR	Open sea	0.0507033	0.00824595	0.0000000008005898	Q15848	41361833_Josephine_Robertson_Q15848_OSCA_model_1
Wahl A	TwinsUK, EGCUT	29055820	2017-10-18	IgG glycosylation measure - IGP66	EFO_0005193	None	Table S3	IgG glycosylation measure - IGP66	DNA methylation	Age, sex, body mass index, cell composition (reference based), batch effects	None	Beta Values	Illumina HumanMethylation450	Whole blood	Glycans measured using UPLC - 76 glycan traits assessed in total	757	2	Adults	Both	Unclear	cg21161138	chr5:399360	5	399360	AHRR	Open sea	-7.4	1.21	0.000000001	None	29055820_Wahl-A_igg_glycosylation_measure_-_igp66
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P35858	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P35858	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21161138	chr5:399360	5	399360	AHRR	Open sea	0.0615132	0.0100695	0.000000001028971	P35858	41361833_Josephine_Robertson_P35858_OSCA_model_4
Wahl A	TwinsUK, EGCUT	29055820	2017-10-18	IgG glycosylation measure - GP10	EFO_0005193	None	Table S3	IgG glycosylation measure - GP10	DNA methylation	Age, sex, body mass index, cell composition (reference based), batch effects	None	Beta Values	Illumina HumanMethylation450	Whole blood	Glycans measured using UPLC - 76 glycan traits assessed in total	757	2	Adults	Both	Unclear	cg21161138	chr5:399360	5	399360	AHRR	Open sea	-7.3	1.2	0.0000000012	None	29055820_Wahl-A_igg_glycosylation_measure_-_gp10
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0A0MS14	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	A0A0A0MS14	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21161138	chr5:399360	5	399360	AHRR	Open sea	0.0615435	0.0101193	0.000000001218049	A0A0A0MS14	41361833_Josephine_Robertson_A0A0A0MS14_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01700	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P01700	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21161138	chr5:399360	5	399360	AHRR	Open sea	0.0563902	0.00928418	0.000000001280098	P01700	41361833_Josephine_Robertson_P01700_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P07360	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P07360	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21161138	chr5:399360	5	399360	AHRR	Open sea	-0.0504065	0.00831809	0.000000001395674	P07360	41361833_Josephine_Robertson_P07360_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00740	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P00740	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21161138	chr5:399360	5	399360	AHRR	Open sea	-0.0554793	0.00918584	0.0000000015818	P00740	41361833_Josephine_Robertson_P00740_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	Q15848	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	Q15848	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21161138	chr5:399360	5	399360	AHRR	Open sea	0.050213	0.00831583	0.000000001595604	Q15848	41361833_Josephine_Robertson_Q15848_OSCA_model_2
Karabegovic I	Airwave, ALSPAC, ESTHER, FHS, KORA, Rotterdam Study, Twins UK	33990564	05-14-2021	Coffee and tea consumption	None	Discovery	Table 2	DNA methylation	Coffee and tea consumption	Age, Sex, Smoking, Cell composition (reference based), Batch effects, Body mass index, Alcohol consumption	Beta values	None	Illumina HumanMethylation450	Whole blood	None	9612	7	Adults	Both	European	cg21161138	chr5:399360	5	399360	AHRR	Open sea	-0.0011	0.0002	0.0000000018	None	33990564_Karabegovic-I_coffee_and_tea_consumption_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01706	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P01706	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21161138	chr5:399360	5	399360	AHRR	Open sea	0.0558829	0.00930184	0.000000001925924	P01706	41361833_Josephine_Robertson_P01706_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O43866	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	O43866	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21161138	chr5:399360	5	399360	AHRR	Open sea	0.0603992	0.0100749	0.000000002082179	O43866	41361833_Josephine_Robertson_O43866_OSCA_model_4
Robert F Hillary	Generation Scotland	10.1101/2023.01.10.23284387	9/6/2023	Incident Chronic Pain	None	Basic model	https://doi.org/10.5281/zenodo.8021411	DNA methylation	Incident Chronic Pain	Age, Sex, Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	None	11591	1	Adults (18-65y)	Both	European	cg21161138	chr5:399360	5	399360	AHRR	Open sea	-0.093	0.0155	0.0000000021	None	Robert-F-Hillary_Incident_Chronic_Pain_Basic_model
Robert F Hillary	Generation Scotland	10.1101/2023.01.10.23284387	9/6/2023	Prevalent Ischemic Heart Disease (Self-report)	None	Basic model	https://doi.org/10.5281/zenodo.8021411	DNA methylation	Prevalent Ischemic Heart Disease (Self-report)	Age, Sex, Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	None	18059	1	Adults (18-65y)	Both	European	cg21161138	chr5:399360	5	399360	AHRR	Open sea	-0.089	0.0149	0.0000000024	None	Robert-F-Hillary_Prevalent_Ischemic_Heart_Disease_(Self-report)_Basic_model
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	Q16610	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	Q16610	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21161138	chr5:399360	5	399360	AHRR	Open sea	0.0494501	0.00832044	0.00000000285835	Q16610	41361833_Josephine_Robertson_Q16610_OSCA_model_2
Wahl A	TwinsUK, EGCUT	29055820	2017-10-18	IgG glycosylation measure - IGP49	EFO_0005193	None	Table S3	IgG glycosylation measure - IGP49	DNA methylation	Age, sex, body mass index, cell composition (reference based), batch effects	None	Beta Values	Illumina HumanMethylation450	Whole blood	Glycans measured using UPLC - 76 glycan traits assessed in total	757	2	Adults	Both	Unclear	cg21161138	chr5:399360	5	399360	AHRR	Open sea	-7.4	1.25	0.0000000034	None	29055820_Wahl-A_igg_glycosylation_measure_-_igp49
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	Total cholesterol	EFO_0004574	sensitivity	None	DNA methylation	Total cholesterol	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	mmol/L	Illumina HumanMethylationEPIC	Whole blood	None	18270	1	Adults	Both	European	cg21161138	chr5:399360	5	399360	AHRR	Open sea	-0.295459	0.049984	0.000000003459227	None	39706196_Hannah-M.-Smith_total_cholesterol_sensitivity
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0A0MS15	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	A0A0A0MS15	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21161138	chr5:399360	5	399360	AHRR	Open sea	0.0548446	0.00930994	0.000000003923377	A0A0A0MS15	41361833_Josephine_Robertson_A0A0A0MS15_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01019	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P01019	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21161138	chr5:399360	5	399360	AHRR	Open sea	0.0592175	0.0100594	0.00000000402416	P01019	41361833_Josephine_Robertson_P01019_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	Q96PD5	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	Q96PD5	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21161138	chr5:399360	5	399360	AHRR	Open sea	-0.048543	0.00824684	0.000000004036526	Q96PD5	41361833_Josephine_Robertson_Q96PD5_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01718	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P01718	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21161138	chr5:399360	5	399360	AHRR	Open sea	0.0594278	0.0101071	0.000000004197097	P01718	41361833_Josephine_Robertson_P01718_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00742	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P00742	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21161138	chr5:399360	5	399360	AHRR	Open sea	-0.0483954	0.0082469	0.000000004497447	P00742	41361833_Josephine_Robertson_P00742_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02775	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P02775	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21161138	chr5:399360	5	399360	AHRR	Open sea	-0.0484357	0.00829908	0.000000005450852	P02775	41361833_Josephine_Robertson_P02775_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06727	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P06727	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21161138	chr5:399360	5	399360	AHRR	Open sea	-0.0536573	0.00921502	0.000000005907657	P06727	41361833_Josephine_Robertson_P06727_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P18428	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P18428	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21161138	chr5:399360	5	399360	AHRR	Open sea	-0.0526362	0.00904399	0.000000006007105	P18428	41361833_Josephine_Robertson_P18428_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A075B6J9	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	A0A075B6J9	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21161138	chr5:399360	5	399360	AHRR	Open sea	0.0479487	0.00824707	0.000000006225631	A0A075B6J9	41361833_Josephine_Robertson_A0A075B6J9_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02751	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P02751	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21161138	chr5:399360	5	399360	AHRR	Open sea	0.0482529	0.00830435	0.000000006355874	P02751	41361833_Josephine_Robertson_P02751_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01766	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P01766	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21161138	chr5:399360	5	399360	AHRR	Open sea	0.0587268	0.0101289	0.000000006850363	P01766	41361833_Josephine_Robertson_P01766_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P18428	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P18428	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21161138	chr5:399360	5	399360	AHRR	Open sea	-0.0476078	0.00824721	0.000000007963558	P18428	41361833_Josephine_Robertson_P18428_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P15169	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P15169	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21161138	chr5:399360	5	399360	AHRR	Open sea	0.0533619	0.00931508	0.00000001032806	P15169	41361833_Josephine_Robertson_P15169_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O75636	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	O75636	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21161138	chr5:399360	5	399360	AHRR	Open sea	-0.0575707	0.0100561	0.00000001055033	O75636	41361833_Josephine_Robertson_O75636_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01709	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P01709	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21161138	chr5:399360	5	399360	AHRR	Open sea	0.0578527	0.0101173	0.00000001097757	P01709	41361833_Josephine_Robertson_P01709_OSCA_model_4
Wahl A	TwinsUK, EGCUT	29055820	2017-10-18	IgG glycosylation measure - IGP63	EFO_0005193	None	Table S3	IgG glycosylation measure - IGP63	DNA methylation	Age, sex, body mass index, cell composition (reference based), batch effects	None	Beta Values	Illumina HumanMethylation450	Whole blood	Glycans measured using UPLC - 76 glycan traits assessed in total	757	2	Adults	Both	Unclear	cg21161138	chr5:399360	5	399360	AHRR	Open sea	7	1.22	0.000000011	None	29055820_Wahl-A_igg_glycosylation_measure_-_igp63
Priyanka Choudhary	PACE	38052982	Dec 5, 2023	Maternal education at the time of pregnancy	None	Model1_Cord_European	None	DNA methylation	Maternal education at the time of pregnancy	Sex, Cell composition (reference based), Batch effects	Beta values	years of schooling	Illumina HumanMethylation450	Cord blood	Illumina HumanMethylationEPIC was also used for some cohorts	9501	None	Infants	Both	European	cg21161138	chr5:399360	5	399360	AHRR	Open sea	0.0005	0.000088	0.000000013	None	38052982_Priyanka-Choudhary_maternal_education_at_the_time_of_pregnancy_model1_cord_european
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01709	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P01709	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21161138	chr5:399360	5	399360	AHRR	Open sea	0.0526743	0.00930135	0.00000001514724	P01709	41361833_Josephine_Robertson_P01709_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P05160	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P05160	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21161138	chr5:399360	5	399360	AHRR	Open sea	-0.0573824	0.0101417	0.00000001559586	P05160	41361833_Josephine_Robertson_P05160_OSCA_model_4
Xu R	Boston Birth Cohort	33663600	2021-03-04	maternal smoking	EFO_0004318, EFO_0006527, EFO_0005671, EFO_0002950	Discovery	Table S1	DNA methylation	maternal smoking	gestational age, sex, maternal age, maternal education, race, maternal BMI, maternal alcohol consumption, maternal diabetes, cell composition (reference based), batch effects	Beta Values	None	Illumina HumanMethylationEPIC	Cord blood	None	954	1	Infants	Both	Admixed	cg21161138	chr5:399360	5	399360	AHRR	Open sea	-0.41	0.072	0.000000016	None	33663600_Xu-R_maternal_smoking_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O43866	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	O43866	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21161138	chr5:399360	5	399360	AHRR	Open sea	0.0523327	0.00926359	0.00000001641133	O43866	41361833_Josephine_Robertson_O43866_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01602	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P01602	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21161138	chr5:399360	5	399360	AHRR	Open sea	0.0522854	0.00929673	0.00000001899217	P01602	41361833_Josephine_Robertson_P01602_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	Q96PD5	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	Q96PD5	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21161138	chr5:399360	5	399360	AHRR	Open sea	-0.0568676	0.0101309	0.00000002021288	Q96PD5	41361833_Josephine_Robertson_Q96PD5_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	Q96PD5	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	Q96PD5	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21161138	chr5:399360	5	399360	AHRR	Open sea	-0.0466916	0.00831977	0.00000002034788	Q96PD5	41361833_Josephine_Robertson_Q96PD5_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	Q9Y5Y7	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	Q9Y5Y7	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21161138	chr5:399360	5	399360	AHRR	Open sea	0.0522296	0.00930779	0.00000002043528	Q9Y5Y7	41361833_Josephine_Robertson_Q9Y5Y7_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00742	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P00742	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21161138	chr5:399360	5	399360	AHRR	Open sea	-0.046529	0.00831684	0.00000002251411	P00742	41361833_Josephine_Robertson_P00742_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P07996	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P07996	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21161138	chr5:399360	5	399360	AHRR	Open sea	-0.0564746	0.0101067	0.00000002340182	P07996	41361833_Josephine_Robertson_P07996_OSCA_model_4
Kyung WK	None	32795589	08-11-2020	eosinophilia	HP_0001880	discovery	Table E4	DNA methylation	eosinophilia	None	Beta values	None	Illumina HumanMethylationEPIC	nasal polyp	None	129	1	Adults	Both	East Asian	cg21161138	chr5:399360	5	399360	AHRR	Open sea	-0.024	0.00396	0.000000025	None	32795589_Kyung-WK_eosinophilia_discovery
Wahl A	TwinsUK, EGCUT	29055820	2017-10-18	IgG glycosylation measure - IGP67	EFO_0005193	None	Table S3	IgG glycosylation measure - IGP67	DNA methylation	Age, sex, body mass index, cell composition (reference based), batch effects	None	Beta Values	Illumina HumanMethylation450	Whole blood	Glycans measured using UPLC - 76 glycan traits assessed in total	757	2	Adults	Both	Unclear	cg21161138	chr5:399360	5	399360	AHRR	Open sea	-6.8	1.22	0.000000027	None	29055820_Wahl-A_igg_glycosylation_measure_-_igp67
Wahl A	TwinsUK, EGCUT	29055820	2017-10-18	IgG glycosylation measure - IGP40	EFO_0005193	None	Table S3	IgG glycosylation measure - IGP40	DNA methylation	Age, sex, body mass index, cell composition (reference based), batch effects	None	Beta Values	Illumina HumanMethylation450	Whole blood	Glycans measured using UPLC - 76 glycan traits assessed in total	757	2	Adults	Both	Unclear	cg21161138	chr5:399360	5	399360	AHRR	Open sea	-6.3	1.14	0.000000028	None	29055820_Wahl-A_igg_glycosylation_measure_-_igp40
Wahl A	TwinsUK, EGCUT	29055820	2017-10-18	IgG glycosylation measure - IGP39	EFO_0005193	None	Table S3	IgG glycosylation measure - IGP39	DNA methylation	Age, sex, body mass index, cell composition (reference based), batch effects	None	Beta Values	Illumina HumanMethylation450	Whole blood	Glycans measured using UPLC - 76 glycan traits assessed in total	757	2	Adults	Both	Unclear	cg21161138	chr5:399360	5	399360	AHRR	Open sea	-6.3	1.14	0.000000028	None	29055820_Wahl-A_igg_glycosylation_measure_-_igp39
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	Q16610	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	Q16610	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21161138	chr5:399360	5	399360	AHRR	Open sea	0.0513809	0.00931672	0.00000003548586	Q16610	41361833_Josephine_Robertson_Q16610_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0A0MT89	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	A0A0A0MT89	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21161138	chr5:399360	5	399360	AHRR	Open sea	0.0511246	0.00928398	0.00000003716506	A0A0A0MT89	41361833_Josephine_Robertson_A0A0A0MT89_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A075B6J9	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	A0A075B6J9	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21161138	chr5:399360	5	399360	AHRR	Open sea	0.045717	0.00831941	0.00000003967201	A0A075B6J9	41361833_Josephine_Robertson_A0A075B6J9_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	Q16610	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	Q16610	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21161138	chr5:399360	5	399360	AHRR	Open sea	0.0452928	0.0082481	0.00000004056106	Q16610	41361833_Josephine_Robertson_Q16610_OSCA_model_1
Fasanelli F	-	26667048	2015-12-15	Lung cancer	EFO_0001071	-	Table 1	Lung cancer	DNA methylation	Cell counts and technical covariates	-	Beta values	Illumina HumanMethylation450	Whole blood	Regression coefficients are per 1-SD of DNA methylation	250	1	47	Females	European	cg21161138	chr5:399360	5	399360	AHRR	Open sea	-0.7765	0.1425	0.0000000501	-	26667048_lung_cancer
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01714	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P01714	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21161138	chr5:399360	5	399360	AHRR	Open sea	0.0545788	0.0101095	0.00000006814358	P01714	41361833_Josephine_Robertson_P01714_OSCA_model_4
Karlsson Linner R	-	29086770	2017-10-31	Educational attainment	EFO_0004784	Adjusted model	Table S1.7b	DNA methylation	Educational attainment	Age, sex, smoking, body mass index, cell counts and technical covariates	Beta values	years of schooling	Illumina HumanMethylation450	Whole blood	-	10767	27	57	Both	None	cg21161138	chr5:399360	5	399360	AHRR	Open sea	-	-	0.0000000739	-	29086770_educational_attainment_adjusted_model
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01019	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01019	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21161138	chr5:399360	5	399360	AHRR	Open sea	0.0442492	0.00824848	0.00000008239277	P01019	41361833_Josephine_Robertson_P01019_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O75636	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	O75636	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21161138	chr5:399360	5	399360	AHRR	Open sea	-0.049565	0.00924253	0.00000008322629	O75636	41361833_Josephine_Robertson_O75636_OSCA_model_3
Shenker NS	-	23175441	2013-03-01	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Breast cancer cohort	Table S3	DNA methylation	Smoking	Age, case-control status and technical covariates	Beta values	-	Illumina HumanMethylation450	Peripheral blood	-	184	1	50.5	Females	European	cg21161138	chr5:399360	5	399360	AHRR	Open sea	-	-	0.000000086	-	23175441_smoking_breast_cancer_cohort
Battram T	GEO	25424692	2020-09-15	Smoking	EFO_0004318, EFO_0005671, EFO_0006527	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE50660. Never vs former smokers	None	DNA methylation	Smoking	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Whole blood	None	442	1	Adults	Both	European	cg21161138	chr5:399360	5	399360	AHRR	Open sea	0.019	0.00349	0.000000091	None	25424692_Battram-T_smoking_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse50660__never_vs_former_smokers
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P05160	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P05160	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21161138	chr5:399360	5	399360	AHRR	Open sea	-0.0440613	0.00824855	0.00000009345412	P05160	41361833_Josephine_Robertson_P05160_OSCA_model_1
Philibert RA	-	24120260	2013-10-11	Smoking	EFO_0006527, EFO_0004318	-	Table 2	DNA methylation	Smoking	Technical covariates	Beta values	-	Illumina HumanMethylation450	Lymphocytes	-	101	1	22	Males	African	cg21161138	chr5:399360	5	399360	AHRR	Open sea	-	-	0.000000118	-	24120260_smoking
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0C4DH34	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	A0A0C4DH34	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21161138	chr5:399360	5	399360	AHRR	Open sea	0.0491398	0.00930365	0.0000001297685	A0A0C4DH34	41361833_Josephine_Robertson_A0A0C4DH34_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01019	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P01019	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21161138	chr5:399360	5	399360	AHRR	Open sea	0.0438335	0.00830902	0.0000001343382	P01019	41361833_Josephine_Robertson_P01019_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01766	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01766	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21161138	chr5:399360	5	399360	AHRR	Open sea	0.0431959	0.00824886	0.0000001658332	P01766	41361833_Josephine_Robertson_P01766_OSCA_model_1
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	Total cholesterol	EFO_0004574	discovery	None	DNA methylation	Total cholesterol	Age,Sex,Smoking,Cell composition (reference based)	Other	mmol/L	Illumina HumanMethylationEPIC	Whole blood	None	18270	1	Adults	Both	European	cg21161138	chr5:399360	5	399360	AHRR	Open sea	-0.248926	0.0478037	0.0000001937358	None	39706196_Hannah-M.-Smith_total_cholesterol_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P08603	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P08603	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21161138	chr5:399360	5	399360	AHRR	Open sea	-0.0428531	0.00824899	0.0000002075077	P08603	41361833_Josephine_Robertson_P08603_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02775	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02775	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21161138	chr5:399360	5	399360	AHRR	Open sea	-0.042565	0.00824909	0.0000002502153	P02775	41361833_Josephine_Robertson_P02775_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	Q15848	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	Q15848	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21161138	chr5:399360	5	399360	AHRR	Open sea	0.04772	0.0092627	0.0000002612747	Q15848	41361833_Josephine_Robertson_Q15848_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02647	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02647	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21161138	chr5:399360	5	399360	AHRR	Open sea	0.0424542	0.00824913	0.0000002687995	P02647	41361833_Josephine_Robertson_P02647_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01718	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01718	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21161138	chr5:399360	5	399360	AHRR	Open sea	0.0422609	0.0082492	0.0000003044816	P01718	41361833_Josephine_Robertson_P01718_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0A0MS14	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	A0A0A0MS14	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21161138	chr5:399360	5	399360	AHRR	Open sea	0.0475988	0.00930054	0.0000003129495	A0A0A0MS14	41361833_Josephine_Robertson_A0A0A0MS14_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P22792	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P22792	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21161138	chr5:399360	5	399360	AHRR	Open sea	0.0420171	0.00824928	0.0000003560003	P22792	41361833_Josephine_Robertson_P22792_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	Q13790	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	Q13790	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21161138	chr5:399360	5	399360	AHRR	Open sea	0.0420014	0.00824929	0.000000359606	Q13790	41361833_Josephine_Robertson_Q13790_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P08571	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P08571	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21161138	chr5:399360	5	399360	AHRR	Open sea	-0.0471822	0.00927179	0.000000364819	P08571	41361833_Josephine_Robertson_P08571_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04180	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P04180	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21161138	chr5:399360	5	399360	AHRR	Open sea	0.041983	0.00832336	0.0000004613493	P04180	41361833_Josephine_Robertson_P04180_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02751	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02751	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21161138	chr5:399360	5	399360	AHRR	Open sea	0.041497	0.00824946	0.0000004955656	P02751	41361833_Josephine_Robertson_P02751_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P22792	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P22792	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21161138	chr5:399360	5	399360	AHRR	Open sea	0.0418007	0.00831751	0.0000005077059	P22792	41361833_Josephine_Robertson_P22792_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00747	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P00747	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21161138	chr5:399360	5	399360	AHRR	Open sea	-0.0415573	0.00830586	0.0000005698703	P00747	41361833_Josephine_Robertson_P00747_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06396	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P06396	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21161138	chr5:399360	5	399360	AHRR	Open sea	0.0498953	0.00998947	0.000000595772	P06396	41361833_Josephine_Robertson_P06396_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	Q96PD5	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	Q96PD5	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21161138	chr5:399360	5	399360	AHRR	Open sea	-0.0463572	0.00931156	0.0000006481936	Q96PD5	41361833_Josephine_Robertson_Q96PD5_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P05160	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P05160	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21161138	chr5:399360	5	399360	AHRR	Open sea	-0.0414063	0.00831824	0.0000006504991	P05160	41361833_Josephine_Robertson_P05160_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01718	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P01718	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21161138	chr5:399360	5	399360	AHRR	Open sea	0.0413171	0.00831227	0.000000674913	P01718	41361833_Josephine_Robertson_P01718_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04180	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04180	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21161138	chr5:399360	5	399360	AHRR	Open sea	0.04096	0.00824964	0.000000694481	P04180	41361833_Josephine_Robertson_P04180_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P08603	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P08603	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21161138	chr5:399360	5	399360	AHRR	Open sea	-0.0411886	0.00830419	0.0000007129098	P08603	41361833_Josephine_Robertson_P08603_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	Q9Y5Y7	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	Q9Y5Y7	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21161138	chr5:399360	5	399360	AHRR	Open sea	0.050272	0.0101381	0.0000007175842	Q9Y5Y7	41361833_Josephine_Robertson_Q9Y5Y7_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02749	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02749	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21161138	chr5:399360	5	399360	AHRR	Open sea	-0.0408085	0.00824969	0.0000007633221	P02749	41361833_Josephine_Robertson_P02749_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00742	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P00742	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21161138	chr5:399360	5	399360	AHRR	Open sea	-0.0454681	0.0092901	0.000000997291	P00742	41361833_Josephine_Robertson_P00742_OSCA_model_3
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	HDL cholesterol	EFO_0004612	sensitivity	None	DNA methylation	HDL cholesterol	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	mmol/L	Illumina HumanMethylationEPIC	Whole blood	None	18225	1	Adults	Both	European	cg21161138	chr5:399360	5	399360	AHRR	Open sea	0.243488	0.0498064	0.000001023712	None	39706196_Hannah-M.-Smith_hdl_cholesterol_sensitivity
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00740	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P00740	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21161138	chr5:399360	5	399360	AHRR	Open sea	-0.0486788	0.0099959	0.00000112833	P00740	41361833_Josephine_Robertson_P00740_OSCA_model_4
Battram T	GEO	24559495	2020-09-15	Smoking	EFO_0004318, EFO_0005671, EFO_0006527	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE53045	None	DNA methylation	Smoking	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Peripheral blood mononuclear cells	None	111	1	Adults	Females	African	cg21161138	chr5:399360	5	399360	AHRR	Open sea	-0.047	0.009	0.0000012	None	24559495_Battram-T_smoking_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse53045
Marzi C	-	27824951	2016-11-08	C-reactive protein	EFO_0004458	KORA F4 discovery	Table SB	C-reactive protein	DNA methylation	Age, sex, smoking, body mass index, fasting status, cell counts and technical covariates	mg/l	Beta values	Illumina HumanMethylation450	Peripheral blood	-	1741	1	60.9	Both	European	cg21161138	chr5:399360	5	399360	AHRR	Open sea	-0.021	0.004	0.00000122	-	27824951_creactive_protein_kora_f4_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01766	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P01766	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21161138	chr5:399360	5	399360	AHRR	Open sea	0.040107	0.00831482	0.000001424335	P01766	41361833_Josephine_Robertson_P01766_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01714	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01714	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21161138	chr5:399360	5	399360	AHRR	Open sea	0.0397021	0.00825006	0.000001506591	P01714	41361833_Josephine_Robertson_P01714_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02751	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P02751	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21161138	chr5:399360	5	399360	AHRR	Open sea	0.0441402	0.0091899	0.00000157759	P02751	41361833_Josephine_Robertson_P02751_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00747	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P00747	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21161138	chr5:399360	5	399360	AHRR	Open sea	-0.0396237	0.00825009	0.000001579897	P00747	41361833_Josephine_Robertson_P00747_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02647	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P02647	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21161138	chr5:399360	5	399360	AHRR	Open sea	0.0424392	0.00886742	0.000001718274	P02647	41361833_Josephine_Robertson_P02647_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02749	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P02749	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21161138	chr5:399360	5	399360	AHRR	Open sea	-0.0397795	0.0083236	0.000001777769	P02749	41361833_Josephine_Robertson_P02749_OSCA_model_2
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	HDL cholesterol	EFO_0004612	discovery	None	DNA methylation	HDL cholesterol	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	mmol/L	Illumina HumanMethylationEPIC	Whole blood	None	18225	1	Adults	Both	European	cg21161138	chr5:399360	5	399360	AHRR	Open sea	0.22883	0.0479499	0.000001835634	None	39706196_Hannah-M.-Smith_hdl_cholesterol_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P05160	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P05160	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21161138	chr5:399360	5	399360	AHRR	Open sea	-0.0444341	0.00931861	0.000001875552	P05160	41361833_Josephine_Robertson_P05160_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P07996	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P07996	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21161138	chr5:399360	5	399360	AHRR	Open sea	-0.0442803	0.00930916	0.000001987152	P07996	41361833_Josephine_Robertson_P07996_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P55056	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P55056	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21161138	chr5:399360	5	399360	AHRR	Open sea	-0.0390106	0.00825029	0.000002284057	P55056	41361833_Josephine_Robertson_P55056_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0C4DH29	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	A0A0C4DH29	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21161138	chr5:399360	5	399360	AHRR	Open sea	0.0389376	0.00825031	0.000002385746	A0A0C4DH29	41361833_Josephine_Robertson_A0A0C4DH29_OSCA_model_1
Robert F Hillary	Generation Scotland	10.1101/2023.01.10.23284387	9/6/2023	Incident Ischemic Heart Disease	None	Basic model	https://doi.org/10.5281/zenodo.8021411	DNA methylation	Incident Ischemic Heart Disease	Age, Sex, Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	None	17483	1	Adults (18-65y)	Both	European	cg21161138	chr5:399360	5	399360	AHRR	Open sea	-0.028	0.00598	0.0000024	None	Robert-F-Hillary_Incident_Ischemic_Heart_Disease_Basic_model
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02775	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P02775	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21161138	chr5:399360	5	399360	AHRR	Open sea	-0.0474533	0.0100855	0.000002560896	P02775	41361833_Josephine_Robertson_P02775_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	Q13790	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	Q13790	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21161138	chr5:399360	5	399360	AHRR	Open sea	0.0391343	0.00831883	0.000002570609	Q13790	41361833_Josephine_Robertson_Q13790_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A075B6J9	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	A0A075B6J9	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21161138	chr5:399360	5	399360	AHRR	Open sea	0.0476257	0.0101368	0.000002647463	A0A075B6J9	41361833_Josephine_Robertson_A0A075B6J9_OSCA_model_4
Zeilinger S	-	23691101	2013-05-17	Smoking	EFO_0005671, EFO_0004318	Former vs never smoking	Table S1	DNA methylation	Smoking	Age, sex, body mass index, alcohol consumption and cell counts	M values	-	Illumina HumanMethylation450	Whole blood	-	1531	1	61.5	Both	European	cg21161138	chr5:399360	5	399360	AHRR	Open sea	-	-	0.00000292	-	23691101_smoking_former_vs_never_smoking
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02647	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P02647	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21161138	chr5:399360	5	399360	AHRR	Open sea	0.038746	0.00828998	0.000002982627	P02647	41361833_Josephine_Robertson_P02647_OSCA_model_2
Robert F Hillary	Generation Scotland	10.1101/2023.01.10.23284387	9/6/2023	Prevalent Stroke (Self-report)	None	Basic model	https://doi.org/10.5281/zenodo.8021411	DNA methylation	Prevalent Stroke (Self-report)	Age, Sex, Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	None	18056	1	Adults (18-65y)	Both	European	cg21161138	chr5:399360	5	399360	AHRR	Open sea	-0.048	0.01033	0.0000034	None	Robert-F-Hillary_Prevalent_Stroke_(Self-report)_Basic_model
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	Q16610	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	Q16610	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21161138	chr5:399360	5	399360	AHRR	Open sea	0.0471097	0.0101467	0.000003466445	Q16610	41361833_Josephine_Robertson_Q16610_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01714	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P01714	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21161138	chr5:399360	5	399360	AHRR	Open sea	0.0385322	0.00831042	0.000003572219	P01714	41361833_Josephine_Robertson_P01714_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01701	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P01701	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21161138	chr5:399360	5	399360	AHRR	Open sea	0.0467857	0.0101339	0.000003931142	P01701	41361833_Josephine_Robertson_P01701_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	Q13790	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	Q13790	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21161138	chr5:399360	5	399360	AHRR	Open sea	0.0416368	0.0090238	0.000003981364	Q13790	41361833_Josephine_Robertson_Q13790_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P07360	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P07360	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21161138	chr5:399360	5	399360	AHRR	Open sea	-0.0425262	0.00928098	0.000004641588	P07360	41361833_Josephine_Robertson_P07360_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P23142	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P23142	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21161138	chr5:399360	5	399360	AHRR	Open sea	0.0422484	0.00929027	0.000005469652	P23142	41361833_Josephine_Robertson_P23142_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	Q15848	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	Q15848	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21161138	chr5:399360	5	399360	AHRR	Open sea	0.0454394	0.0100839	0.000006652687	Q15848	41361833_Josephine_Robertson_Q15848_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02760	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02760	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21161138	chr5:399360	5	399360	AHRR	Open sea	0.0370349	0.00825091	0.000007224213	P02760	41361833_Josephine_Robertson_P02760_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01024	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01024	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21161138	chr5:399360	5	399360	AHRR	Open sea	0.0370196	0.00825091	0.000007287568	P01024	41361833_Josephine_Robertson_P01024_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0C4DH29	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	A0A0C4DH29	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21161138	chr5:399360	5	399360	AHRR	Open sea	0.037283	0.00831709	0.000007426611	A0A0C4DH29	41361833_Josephine_Robertson_A0A0C4DH29_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02775	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P02775	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21161138	chr5:399360	5	399360	AHRR	Open sea	-0.0416683	0.0092966	0.000007446983	P02775	41361833_Josephine_Robertson_P02775_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04217	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P04217	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21161138	chr5:399360	5	399360	AHRR	Open sea	-0.0369542	0.00830431	0.000008650187	P04217	41361833_Josephine_Robertson_P04217_OSCA_model_2
Shenker NS	-	23175441	2013-03-01	Smoking	EFO_0006527, EFO_0005671, EFO_0004318	Colon cancer cohort	Table S3	DNA methylation	Smoking	Age, case-control status and technical covariates	Beta values	-	Illumina HumanMethylation450	Peripheral blood	-	190	1	55	Both	European	cg21161138	chr5:399360	5	399360	AHRR	Open sea	-	-	0.00000887	-	23175441_smoking_colon_cancer_cohort
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P55056	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P55056	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21161138	chr5:399360	5	399360	AHRR	Open sea	-0.0443423	0.0101145	0.00001173076	P55056	41361833_Josephine_Robertson_P55056_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02760	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P02760	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21161138	chr5:399360	5	399360	AHRR	Open sea	0.0363495	0.00831975	0.00001256344	P02760	41361833_Josephine_Robertson_P02760_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01024	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P01024	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21161138	chr5:399360	5	399360	AHRR	Open sea	0.0362035	0.00831652	0.00001350735	P01024	41361833_Josephine_Robertson_P01024_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01031	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P01031	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21161138	chr5:399360	5	399360	AHRR	Open sea	-0.0401292	0.00922452	0.00001368819	P01031	41361833_Josephine_Robertson_P01031_OSCA_model_3
Robert F Hillary	Generation Scotland	10.1101/2023.01.10.23284387	9/6/2023	Incident Liver Cirrhosis	None	Basic model	https://doi.org/10.5281/zenodo.8021411	DNA methylation	Incident Liver Cirrhosis	Age, Sex, Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	None	18325	1	Adults (18-65y)	Both	European	cg21161138	chr5:399360	5	399360	AHRR	Open sea	-0.009	0.00207	0.000014	None	Robert-F-Hillary_Incident_Liver_Cirrhosis_Basic_model
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P15169	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P15169	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21161138	chr5:399360	5	399360	AHRR	Open sea	0.0434346	0.0101339	0.00001830204	P15169	41361833_Josephine_Robertson_P15169_OSCA_model_4
Robert F Hillary	Generation Scotland	10.1101/2023.01.10.23284387	9/6/2023	Incident Chronic Kidney Disease	None	Basic model	https://doi.org/10.5281/zenodo.8021411	DNA methylation	Incident Chronic Kidney Disease	Age, Sex, Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	None	18000	1	Adults (18-65y)	Both	European	cg21161138	chr5:399360	5	399360	AHRR	Open sea	-0.014	0.00332	0.000019	None	Robert-F-Hillary_Incident_Chronic_Kidney_Disease_Basic_model
Robert F Hillary	Generation Scotland	10.1101/2023.01.10.23284387	9/6/2023	Prevalent Rheumatoid Arthritis (Self-report)	None	Basic model	https://doi.org/10.5281/zenodo.8021411	DNA methylation	Prevalent Rheumatoid Arthritis (Self-report)	Age, Sex, Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	None	18055	1	Adults (18-65y)	Both	European	cg21161138	chr5:399360	5	399360	AHRR	Open sea	-0.049	0.0115	0.000019	None	Robert-F-Hillary_Prevalent_Rheumatoid_Arthritis_(Self-report)_Basic_model
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02647	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P02647	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21161138	chr5:399360	5	399360	AHRR	Open sea	0.0406264	0.00960022	0.00002332257	P02647	41361833_Josephine_Robertson_P02647_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04430	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04430	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21161138	chr5:399360	5	399360	AHRR	Open sea	0.0349007	0.00825154	0.00002355357	P04430	41361833_Josephine_Robertson_P04430_OSCA_model_1
Rebecca Richmond	SEE-Cigs	34583751	Sep 28, 2021	Smoking	EFO_0004318	smoking (vs. non-smoking)	Supplementary Table 2	DNA methylation	Smoking	Age, Sex, Body mass index, Education, household smoking, recreational drug use, 20 surrogate variables	Beta values	None	Illumina HumanMethylationEPIC	Saliva	None	231	1	Adults (18-65 years)	Both	Admixed	cg21161138	chr5:399360	5	399360	AHRR	Open sea	-0.0558	0.01292	0.000024	None	34583751_Rebecca-Richmond_smoking_smoking__vs__non-smoking_
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02749	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P02749	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21161138	chr5:399360	5	399360	AHRR	Open sea	-0.0427426	0.0101481	0.00002547611	P02749	41361833_Josephine_Robertson_P02749_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P55056	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P55056	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21161138	chr5:399360	5	399360	AHRR	Open sea	-0.0348096	0.00832153	0.00002892677	P55056	41361833_Josephine_Robertson_P55056_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02760	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P02760	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21161138	chr5:399360	5	399360	AHRR	Open sea	0.0385778	0.00924716	0.00003038733	P02760	41361833_Josephine_Robertson_P02760_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P23142	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P23142	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21161138	chr5:399360	5	399360	AHRR	Open sea	0.0420802	0.0101147	0.0000319655	P23142	41361833_Josephine_Robertson_P23142_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04003	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P04003	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21161138	chr5:399360	5	399360	AHRR	Open sea	-0.0416369	0.0100286	0.00003317499	P04003	41361833_Josephine_Robertson_P04003_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02790	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P02790	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21161138	chr5:399360	5	399360	AHRR	Open sea	-0.0383521	0.00923883	0.00003326249	P02790	41361833_Josephine_Robertson_P02790_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02749	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P02749	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21161138	chr5:399360	5	399360	AHRR	Open sea	-0.0386454	0.00932211	0.00003408776	P02749	41361833_Josephine_Robertson_P02749_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P08571	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P08571	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21161138	chr5:399360	5	399360	AHRR	Open sea	-0.0417308	0.0100856	0.00003527964	P08571	41361833_Josephine_Robertson_P08571_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04211	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P04211	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21161138	chr5:399360	5	399360	AHRR	Open sea	0.041928	0.0101476	0.00003619128	P04211	41361833_Josephine_Robertson_P04211_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P22792	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P22792	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21161138	chr5:399360	5	399360	AHRR	Open sea	0.0384769	0.00931352	0.00003627301	P22792	41361833_Josephine_Robertson_P22792_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A075B6J9	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	A0A075B6J9	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21161138	chr5:399360	5	399360	AHRR	Open sea	0.038422	0.00931684	0.00003745182	A0A075B6J9	41361833_Josephine_Robertson_A0A075B6J9_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00742	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P00742	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21161138	chr5:399360	5	399360	AHRR	Open sea	-0.0415333	0.0101145	0.00004041713	P00742	41361833_Josephine_Robertson_P00742_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P18428	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P18428	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21161138	chr5:399360	5	399360	AHRR	Open sea	-0.0400158	0.00978736	0.00004364477	P18428	41361833_Josephine_Robertson_P18428_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04430	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P04430	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21161138	chr5:399360	5	399360	AHRR	Open sea	0.0338877	0.00831878	0.00004652894	P04430	41361833_Josephine_Robertson_P04430_OSCA_model_2
Robert F Hillary	Generation Scotland	10.1101/2023.01.10.23284387	9/6/2023	Prevalent Chronic Kidney Disease (Estimated)	None	Fully-adjusted Model	https://doi.org/10.5281/zenodo.8021411	DNA methylation	Prevalent Chronic Kidney Disease (Estimated)	Age, Sex, Cell composition (reference based), Ancestry (genomic PCs), Body mass index, Socio-economic position, Education, Alcohol consumption	M values	None	Illumina HumanMethylationEPIC	Whole blood	Fully-adjusted model	14315	1	Adults (18-65y)	Both	European	cg21161138	chr5:399360	5	399360	AHRR	Open sea	-0.07	0.01735	0.000052	None	Robert-F-Hillary_Prevalent_Chronic_Kidney_Disease_(Estimated)_Fully-adjusted_Model
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04211	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04211	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21161138	chr5:399360	5	399360	AHRR	Open sea	0.0333112	0.00825199	0.00005447332	P04211	41361833_Josephine_Robertson_P04211_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01766	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P01766	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21161138	chr5:399360	5	399360	AHRR	Open sea	0.0373393	0.00931438	0.00006133363	P01766	41361833_Josephine_Robertson_P01766_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04217	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P04217	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21161138	chr5:399360	5	399360	AHRR	Open sea	-0.0370215	0.00930112	0.0000691516	P04217	41361833_Josephine_Robertson_P04217_OSCA_model_3
Robert F Hillary	Generation Scotland	10.1101/2023.01.10.23284387	9/6/2023	Incident Rheumatoid Arthritis	None	Basic model	https://doi.org/10.5281/zenodo.8021411	DNA methylation	Incident Rheumatoid Arthritis	Age, Sex, Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	None	18027	1	Adults (18-65y)	Both	European	cg21161138	chr5:399360	5	399360	AHRR	Open sea	-0.0097	0.00244	0.000073	None	Robert-F-Hillary_Incident_Rheumatoid_Arthritis_Basic_model
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	Q13790	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	Q13790	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21161138	chr5:399360	5	399360	AHRR	Open sea	0.038545	0.00980657	0.00008514805	Q13790	41361833_Josephine_Robertson_Q13790_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01714	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P01714	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg21161138	chr5:399360	5	399360	AHRR	Open sea	0.0364137	0.00930355	0.00009120515	P01714	41361833_Josephine_Robertson_P01714_OSCA_model_3
Gross AM	-	27105112	2016-04-21	HIV infection	EFO_0000764	Neutrophils	Table S2	DNA methylation	HIV infection	Age	-	-	Illumina HumanMethylation450	Neutrophils	-	60	1	46.5	Males	European	cg21161138	chr5:399360	5	399360	AHRR	Open sea	-0.30386	0.0779	0.0000964	-	27105112_hiv_infection_neutrophils