author consortium pmid date trait efo analysis source outcome exposure covariates outcome_units exposure_units methylation_array tissue further_details n n_cohorts age sex ethnicity cpg chrpos chr pos gene type beta se p details study_id Battram T GEO 30602389 2020-09-15 Tissue None EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells None DNA methylation Tissue Batch effects, cell composition (reference free) Beta Values None Illumina HumanMethylation450 Buccal cells and peripheral blood mononuclear cells None 215 1 Children Both European cg22042908 chr20:4802684 20 4802684 RASSF2 North shore -0.0545 0.00204 1.1e-66 None 30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells Yao C FHS, KORA F4, BLSA, InCHIANTI 33752734 2021-03-22 Gene expression of Affymetrix ID: 3896078 (gene symbol: SLC23A2) None Meta-analysis Table S6 DNA methylation Gene expression of Affymetrix ID: 3896078 (gene symbol: SLC23A2) Age, sex, cell composition (reference based), batch effects Beta Values None Illumina HumanMethylation450 Whole blood None 4170 1 Adults Both Unclear cg22042908 chr20:4802684 20 4802684 RASSF2 North shore None None 0.0000000000000012 None 33752734_Yao-C_gene_expression_of_affymetrix_id__3896078__gene_symbol__slc23a2__meta-analysis Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 BMI EFO_0004340 discovery None DNA methylation BMI Age,Sex,Smoking,Cell composition (reference based),Batch effects Other kg/m2 Illumina HumanMethylationEPIC Whole blood None 17304 1 Adults Both European cg22042908 chr20:4802684 20 4802684 RASSF2 North shore 0.266075 0.0383411 0.000000000004068805 None 39706196_Hannah-M.-Smith_bmi_discovery Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P18428 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P18428 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg22042908 chr20:4802684 20 4802684 RASSF2 North shore 0.0563959 0.00824343 0.000000000008157994 P18428 41361833_Josephine_Robertson_P18428_OSCA_model_1 Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 HDL cholesterol EFO_0004612 discovery None DNA methylation HDL cholesterol Age,Sex,Smoking,Cell composition (reference based),Batch effects Other mmol/L Illumina HumanMethylationEPIC Whole blood None 18225 1 Adults Both European cg22042908 chr20:4802684 20 4802684 RASSF2 North shore -0.23094 0.0372454 0.0000000005750232 None 39706196_Hannah-M.-Smith_hdl_cholesterol_discovery Demerath EW - 25935004 2015-08-01 Waist circumference EFO_0004342 Discovery Table S5 DNA methylation Waist circumference Age, sex, smoking, study centre, alcohol consumption, education, household income, physical activity, cell counts and technical covariates Beta values cm Illumina HumanMethylation450 Leukocytes Regression coefficient per 1 SD of waist circumference 2097 1 56.2 Both African cg22042908 chr20:4802684 20 4802684 RASSF2 North shore 0.0025 4e-04 0.00000000093 - 25935004_waist_circumference_discovery Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P18428 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P18428 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg22042908 chr20:4802684 20 4802684 RASSF2 North shore 0.0516404 0.00861784 0.00000000211782 P18428 41361833_Josephine_Robertson_P18428_OSCA_model_2 Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 Body fat EFO_0007800 discovery None DNA methylation Body fat Age,Sex,Smoking,Cell composition (reference based),Batch effects Other % Illumina HumanMethylationEPIC Whole blood None 17304 1 Adults Both European cg22042908 chr20:4802684 20 4802684 RASSF2 North shore 0.226152 0.0384439 0.000000004111884 None 39706196_Hannah-M.-Smith_body_fat_discovery Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg22042908 chr20:4802684 20 4802684 RASSF2 North shore -0.00081 0.00014 0.000000018 None 33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P51884 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P51884 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg22042908 chr20:4802684 20 4802684 RASSF2 North shore -0.0435153 0.00824875 0.0000001343678 P51884 41361833_Josephine_Robertson_P51884_OSCA_model_1 Robert F. Hillary Generation Scotland doi.org/10.1101/2023.11.02.23298000 Nov 3, 2023 C-reactive protein (CRP) levels None Basic model None C-reactive protein (CRP) levels DNA methylation Age, Sex, Cell composition (reference based), Batch effects mg/L Beta values Illumina HumanMethylationEPIC Whole blood None 17936 1 Adults Both European cg22042908 chr20:4802684 20 4802684 RASSF2 North shore 2 0.398 0.00000028 Basic_Model Robert-F.-Hillary_c-reactive_protein__crp__levels_basic_model Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P06727 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P06727 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg22042908 chr20:4802684 20 4802684 RASSF2 North shore -0.0396946 0.00825006 0.000001513483 P06727 41361833_Josephine_Robertson_P06727_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P18428 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P18428 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg22042908 chr20:4802684 20 4802684 RASSF2 North shore 0.040246 0.00847039 0.000002039553 P18428 41361833_Josephine_Robertson_P18428_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02647 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P02647 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg22042908 chr20:4802684 20 4802684 RASSF2 North shore -0.0410611 0.00867954 0.000002257287 P02647 41361833_Josephine_Robertson_P02647_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01024 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P01024 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg22042908 chr20:4802684 20 4802684 RASSF2 North shore 0.0393908 0.00870704 0.000006115282 P01024 41361833_Josephine_Robertson_P01024_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P06727 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P06727 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg22042908 chr20:4802684 20 4802684 RASSF2 North shore -0.0386121 0.00870663 0.000009283227 P06727 41361833_Josephine_Robertson_P06727_OSCA_model_2 Dugue P-A Melbourne Collaborative Cohort Study 31789449 2019-11-04 Alcohol consumption EFO_0004329, EFO_0007878 Previous week consumption discovery Supplementary Table 3 Alcohol consumption DNA methylation age, sex, smoking, body mass index country of birth, sample type, cell composition (reference based), batch effects g/day M Values Illumina HumanMethylation450 Whole blood None 5606 1 Adults Both Unclear cg22042908 chr20:4802684 20 4802684 RASSF2 North shore None None 0.000064 None 31789449_Dugue-P-A_alcohol_consumption_previous_week_consumption_discovery Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04004 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P04004 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg22042908 chr20:4802684 20 4802684 RASSF2 North shore 0.0327205 0.00825215 0.00007371745 P04004 41361833_Josephine_Robertson_P04004_OSCA_model_1 Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 Waist-hip ratio EFO_0004343 discovery None DNA methylation Waist-hip ratio Age,Sex,Smoking,Cell composition (reference based),Batch effects Other None Illumina HumanMethylationEPIC Whole blood None 17304 1 Adults Both European cg22042908 chr20:4802684 20 4802684 RASSF2 North shore 0.150638 0.0383474 0.00008590409 None 39706196_Hannah-M.-Smith_waist-hip_ratio_discovery Gross AM - 27105112 2016-04-21 HIV infection EFO_0000764 Discovery Table S2 DNA methylation HIV infection Age and cell counts - - Illumina HumanMethylation450 Whole blood - 181 1 46.5 Males European cg22042908 chr20:4802684 20 4802684 RASSF2 North shore 0.86072 0.2207 0.000096 - 27105112_hiv_infection_discovery