author	consortium	pmid	date	trait	efo	analysis	source	outcome	exposure	covariates	outcome_units	exposure_units	methylation_array	tissue	further_details	n	n_cohorts	age	sex	ethnicity	cpg	chrpos	chr	pos	gene	type	beta	se	p	details	study_id
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 2 at 6y with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg22930808	chr3:122281881	3	122281881	PARP9;DTX3L	North shore	0.029	0.0017	0	None	33450751_Mulder-RH_age_model_2_at_6y_with_age_as_a_fixed_effect
Battram T	GEO	30602389	2020-09-15	Tissue	None	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells	None	DNA methylation	Tissue	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Buccal cells and peripheral blood mononuclear cells	None	215	1	Children	Both	European	cg22930808	chr3:122281881	3	122281881	PARP9;DTX3L	North shore	0.21501	0.00722	4.500000000000001e-74	None	30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg22930808	chr3:122281881	3	122281881	PARP9;DTX3L	North shore	-0.144309	0.00817015	4.1969760000000003e-69	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_1
Imgenberg-Kreuz J	-	26857698	2016-11-01	Primary Sjogrens syndrome	EFO_0000699	Whole blood	Table S1	DNA methylation	Primary Sjogrens syndrome	Age, sex and cell counts	Beta values	-	Illumina HumanMethylation450	Whole blood	-	500	1	-	Both	European	cg22930808	chr3:122281881	3	122281881	PARP9;DTX3L	North shore	-	-	2.4e-55	-	26857698_primary_sjogrens_syndrome_whole_blood
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O75882	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	O75882	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg22930808	chr3:122281881	3	122281881	PARP9;DTX3L	North shore	0.117941	0.00819895	1.3346120000000001e-46	O75882	41361833_Josephine_Robertson_O75882_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02750	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02750	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg22930808	chr3:122281881	3	122281881	PARP9;DTX3L	North shore	-0.115486	0.00820133	9.669085000000001e-45	P02750	41361833_Josephine_Robertson_P02750_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P18428	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P18428	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg22930808	chr3:122281881	3	122281881	PARP9;DTX3L	North shore	-0.109281	0.00820712	3.225602e-40	P18428	41361833_Josephine_Robertson_P18428_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01742	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01742	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg22930808	chr3:122281881	3	122281881	PARP9;DTX3L	North shore	-0.108139	0.00820815	2.0565770000000003e-39	P01742	41361833_Josephine_Robertson_P01742_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O75882	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	O75882	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg22930808	chr3:122281881	3	122281881	PARP9;DTX3L	North shore	0.120452	0.00954579	2.58622e-36	O75882	41361833_Josephine_Robertson_O75882_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O75882	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	O75882	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg22930808	chr3:122281881	3	122281881	PARP9;DTX3L	North shore	0.105922	0.00866614	3.4569279999999997e-34	O75882	41361833_Josephine_Robertson_O75882_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01714	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P01714	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg22930808	chr3:122281881	3	122281881	PARP9;DTX3L	North shore	-0.116953	0.00958896	4.741208e-34	P01714	41361833_Josephine_Robertson_P01714_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01714	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P01714	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg22930808	chr3:122281881	3	122281881	PARP9;DTX3L	North shore	-0.104952	0.00868583	1.870414e-33	P01714	41361833_Josephine_Robertson_P01714_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O75636	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	O75636	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg22930808	chr3:122281881	3	122281881	PARP9;DTX3L	North shore	-0.114811	0.0095408	3.39187e-33	O75636	41361833_Josephine_Robertson_O75636_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01714	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P01714	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg22930808	chr3:122281881	3	122281881	PARP9;DTX3L	North shore	-0.104269	0.0086966	5.7424680000000004e-33	P01714	41361833_Josephine_Robertson_P01714_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01703	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P01703	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg22930808	chr3:122281881	3	122281881	PARP9;DTX3L	North shore	-0.114355	0.00960573	1.5769440000000002e-32	P01703	41361833_Josephine_Robertson_P01703_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O75882	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	O75882	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg22930808	chr3:122281881	3	122281881	PARP9;DTX3L	North shore	0.100759	0.00865321	3.371779e-31	O75882	41361833_Josephine_Robertson_O75882_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P27169	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P27169	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg22930808	chr3:122281881	3	122281881	PARP9;DTX3L	North shore	0.0924413	0.00822122	3.255587e-29	P27169	41361833_Josephine_Robertson_P27169_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01703	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01703	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg22930808	chr3:122281881	3	122281881	PARP9;DTX3L	North shore	-0.0911703	0.00822219	1.854382e-28	P01703	41361833_Josephine_Robertson_P01703_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01703	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P01703	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg22930808	chr3:122281881	3	122281881	PARP9;DTX3L	North shore	-0.0955015	0.00869275	5.715281e-28	P01703	41361833_Josephine_Robertson_P01703_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01703	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P01703	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg22930808	chr3:122281881	3	122281881	PARP9;DTX3L	North shore	-0.0946439	0.00871028	2.1341060000000003e-27	P01703	41361833_Josephine_Robertson_P01703_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O75636	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	O75636	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg22930808	chr3:122281881	3	122281881	PARP9;DTX3L	North shore	-0.0930984	0.00865169	6.649443e-27	O75636	41361833_Josephine_Robertson_O75636_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg22930808	chr3:122281881	3	122281881	PARP9;DTX3L	North shore	-0.091729	0.00854439	8.712119000000001e-27	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg22930808	chr3:122281881	3	122281881	PARP9;DTX3L	North shore	-0.0909624	0.00854581	2.3188639999999998e-26	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0C4DH38	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	A0A0C4DH38	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg22930808	chr3:122281881	3	122281881	PARP9;DTX3L	North shore	-0.10165	0.00960056	4.211965e-26	A0A0C4DH38	41361833_Josephine_Robertson_A0A0C4DH38_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01714	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01714	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg22930808	chr3:122281881	3	122281881	PARP9;DTX3L	North shore	-0.0870512	0.00822523	4.4164639999999996e-26	P01714	41361833_Josephine_Robertson_P01714_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O75636	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	O75636	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg22930808	chr3:122281881	3	122281881	PARP9;DTX3L	North shore	-0.0894935	0.00869353	9.080626e-25	O75636	41361833_Josephine_Robertson_O75636_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04196	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04196	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg22930808	chr3:122281881	3	122281881	PARP9;DTX3L	North shore	0.0838331	0.00822751	2.664951e-24	P04196	41361833_Josephine_Robertson_P04196_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0C4DH38	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	A0A0C4DH38	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg22930808	chr3:122281881	3	122281881	PARP9;DTX3L	North shore	-0.0883413	0.00869751	3.704836e-24	A0A0C4DH38	41361833_Josephine_Robertson_A0A0C4DH38_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg22930808	chr3:122281881	3	122281881	PARP9;DTX3L	North shore	-0.094678	0.00935542	5.394972e-24	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01742	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P01742	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg22930808	chr3:122281881	3	122281881	PARP9;DTX3L	North shore	-0.085966	0.00853949	9.245284e-24	P01742	41361833_Josephine_Robertson_P01742_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0C4DH38	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	A0A0C4DH38	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg22930808	chr3:122281881	3	122281881	PARP9;DTX3L	North shore	-0.0864082	0.00871092	4.0486580000000004e-23	A0A0C4DH38	41361833_Josephine_Robertson_A0A0C4DH38_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02647	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P02647	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg22930808	chr3:122281881	3	122281881	PARP9;DTX3L	North shore	0.0899393	0.00911831	7.055051e-23	P02647	41361833_Josephine_Robertson_P02647_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01700	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P01700	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg22930808	chr3:122281881	3	122281881	PARP9;DTX3L	North shore	-0.0941893	0.00959166	1.086098e-22	P01700	41361833_Josephine_Robertson_P01700_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01700	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P01700	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg22930808	chr3:122281881	3	122281881	PARP9;DTX3L	North shore	-0.0849602	0.00869909	1.834449e-22	P01700	41361833_Josephine_Robertson_P01700_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01700	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P01700	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg22930808	chr3:122281881	3	122281881	PARP9;DTX3L	North shore	-0.0846741	0.00869403	2.394709e-22	P01700	41361833_Josephine_Robertson_P01700_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P27169	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P27169	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg22930808	chr3:122281881	3	122281881	PARP9;DTX3L	North shore	0.0841993	0.00866626	3.014859e-22	P27169	41361833_Josephine_Robertson_P27169_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01742	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P01742	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg22930808	chr3:122281881	3	122281881	PARP9;DTX3L	North shore	-0.0906704	0.0093449	3.4257360000000003e-22	P01742	41361833_Josephine_Robertson_P01742_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P29622	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P29622	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg22930808	chr3:122281881	3	122281881	PARP9;DTX3L	North shore	0.0793208	0.00823056	6.456947e-22	P29622	41361833_Josephine_Robertson_P29622_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02763	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02763	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg22930808	chr3:122281881	3	122281881	PARP9;DTX3L	North shore	-0.0787672	0.00823092	1.240293e-21	P02763	41361833_Josephine_Robertson_P02763_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01742	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P01742	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg22930808	chr3:122281881	3	122281881	PARP9;DTX3L	North shore	-0.0820593	0.00866485	3.206367e-21	P01742	41361833_Josephine_Robertson_P01742_OSCA_model_2
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	HDL cholesterol	EFO_0004612	discovery	None	DNA methylation	HDL cholesterol	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	mmol/L	Illumina HumanMethylationEPIC	Whole blood	None	18225	1	Adults	Both	European	cg22930808	chr3:122281881	3	122281881	PARP9;DTX3L	North shore	0.228534	0.0241474	3.311286e-21	None	39706196_Hannah-M.-Smith_hdl_cholesterol_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P18428	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P18428	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg22930808	chr3:122281881	3	122281881	PARP9;DTX3L	North shore	-0.0796591	0.0084752	6.303007e-21	P18428	41361833_Josephine_Robertson_P18428_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0C4DH38	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	A0A0C4DH38	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg22930808	chr3:122281881	3	122281881	PARP9;DTX3L	North shore	-0.0772567	0.00823189	7.195799999999999e-21	A0A0C4DH38	41361833_Josephine_Robertson_A0A0C4DH38_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02647	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P02647	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg22930808	chr3:122281881	3	122281881	PARP9;DTX3L	North shore	0.0777904	0.00830681	8.720707e-21	P02647	41361833_Josephine_Robertson_P02647_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00734	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P00734	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg22930808	chr3:122281881	3	122281881	PARP9;DTX3L	North shore	0.0759966	0.00823269	3.0395339999999996e-20	P00734	41361833_Josephine_Robertson_P00734_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P27169	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P27169	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg22930808	chr3:122281881	3	122281881	PARP9;DTX3L	North shore	0.0794609	0.0086976	7.318586e-20	P27169	41361833_Josephine_Robertson_P27169_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P27169	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P27169	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg22930808	chr3:122281881	3	122281881	PARP9;DTX3L	North shore	0.0869137	0.00952117	7.840529999999999e-20	P27169	41361833_Josephine_Robertson_P27169_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P08571	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P08571	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg22930808	chr3:122281881	3	122281881	PARP9;DTX3L	North shore	-0.07499	0.00823332	9.448296999999999e-20	P08571	41361833_Josephine_Robertson_P08571_OSCA_model_1
Gadd DA	Generation Scotland	35945220	31/07/2022	MX1 protein levels (SeqId = 17460-51)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	MX1 protein levels (SeqId = 17460-51)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Interferon-induced GTP-binding protein Mx1	774	1	Adults (18-65 years)	Both	European	cg22930808	chr3:122281881	3	122281881	PARP9;DTX3L	North shore	-1.13	0.124	9.8e-20	None	Gadd-DA_mx1_protein_levels__seqid___17460-51__somascan_protein_measurement
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	Total cholesterol	EFO_0004574	sensitivity	None	DNA methylation	Total cholesterol	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	mmol/L	Illumina HumanMethylationEPIC	Whole blood	None	18270	1	Adults	Both	European	cg22930808	chr3:122281881	3	122281881	PARP9;DTX3L	North shore	0.23213	0.0257461	2.137896e-19	None	39706196_Hannah-M.-Smith_total_cholesterol_sensitivity
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01700	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01700	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg22930808	chr3:122281881	3	122281881	PARP9;DTX3L	North shore	-0.0721569	0.00823505	2.122438e-18	P01700	41361833_Josephine_Robertson_P01700_OSCA_model_1
Gadd DA	Generation Scotland	35945220	31/07/2022	GBP1 protein levels (SeqId = 15326-64)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	GBP1 protein levels (SeqId = 15326-64)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Guanylate-binding protein 1	774	1	Adults (18-65 years)	Both	European	cg22930808	chr3:122281881	3	122281881	PARP9;DTX3L	North shore	-1.06	0.122	3.3e-18	None	Gadd-DA_gbp1_protein_levels__seqid___15326-64__somascan_protein_measurement
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	HDL cholesterol	EFO_0004612	sensitivity	None	DNA methylation	HDL cholesterol	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	mmol/L	Illumina HumanMethylationEPIC	Whole blood	None	18225	1	Adults	Both	European	cg22930808	chr3:122281881	3	122281881	PARP9;DTX3L	North shore	0.221436	0.0256391	6.259098e-18	None	39706196_Hannah-M.-Smith_hdl_cholesterol_sensitivity
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04196	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P04196	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg22930808	chr3:122281881	3	122281881	PARP9;DTX3L	North shore	0.0752894	0.00872229	6.651335e-18	P04196	41361833_Josephine_Robertson_P04196_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04196	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P04196	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg22930808	chr3:122281881	3	122281881	PARP9;DTX3L	North shore	0.0743673	0.0087097	1.4926530000000002e-17	P04196	41361833_Josephine_Robertson_P04196_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04196	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P04196	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg22930808	chr3:122281881	3	122281881	PARP9;DTX3L	North shore	0.0816041	0.0096174	2.3608650000000003e-17	P04196	41361833_Josephine_Robertson_P04196_OSCA_model_4
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	Total cholesterol	EFO_0004574	discovery	None	DNA methylation	Total cholesterol	Age,Sex,Smoking,Cell composition (reference based)	Other	mmol/L	Illumina HumanMethylationEPIC	Whole blood	None	18270	1	Adults	Both	European	cg22930808	chr3:122281881	3	122281881	PARP9;DTX3L	North shore	0.200886	0.0240966	8.174766000000001e-17	None	39706196_Hannah-M.-Smith_total_cholesterol_discovery
Gadd DA	Generation Scotland	35945220	31/07/2022	ISG15 protein levels (SeqId = 14151-4)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	ISG15 protein levels (SeqId = 14151-4)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Ubiquitin-like protein ISG15	774	1	Adults (18-65 years)	Both	European	cg22930808	chr3:122281881	3	122281881	PARP9;DTX3L	North shore	-1.03	0.124	9.9e-17	None	Gadd-DA_isg15_protein_levels__seqid___14151-4__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02647	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02647	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg22930808	chr3:122281881	3	122281881	PARP9;DTX3L	North shore	0.0683943	0.00823724	1.102517e-16	P02647	41361833_Josephine_Robertson_P02647_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02750	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P02750	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg22930808	chr3:122281881	3	122281881	PARP9;DTX3L	North shore	-0.0709218	0.0086023	1.798053e-16	P02750	41361833_Josephine_Robertson_P02750_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P18428	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P18428	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg22930808	chr3:122281881	3	122281881	PARP9;DTX3L	North shore	-0.0765167	0.00930505	2.147929e-16	P18428	41361833_Josephine_Robertson_P18428_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P18428	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P18428	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg22930808	chr3:122281881	3	122281881	PARP9;DTX3L	North shore	-0.0707832	0.00862992	2.557633e-16	P18428	41361833_Josephine_Robertson_P18428_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0C4DH34	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	A0A0C4DH34	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg22930808	chr3:122281881	3	122281881	PARP9;DTX3L	North shore	-0.0783397	0.00962177	4.202005e-16	A0A0C4DH34	41361833_Josephine_Robertson_A0A0C4DH34_OSCA_model_4
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	BMI	EFO_0004340	sensitivity	None	DNA methylation	BMI	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	kg/m2	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg22930808	chr3:122281881	3	122281881	PARP9;DTX3L	North shore	0.212677	0.0262281	5.454004e-16	None	39706196_Hannah-M.-Smith_bmi_sensitivity
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	Q08380	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	Q08380	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg22930808	chr3:122281881	3	122281881	PARP9;DTX3L	North shore	-0.0769229	0.00954477	8.271564e-16	Q08380	41361833_Josephine_Robertson_Q08380_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O75636	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	O75636	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg22930808	chr3:122281881	3	122281881	PARP9;DTX3L	North shore	-0.0662729	0.00823842	9.328569e-16	O75636	41361833_Josephine_Robertson_O75636_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01619	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P01619	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg22930808	chr3:122281881	3	122281881	PARP9;DTX3L	North shore	-0.075834	0.00956179	0.000000000000002331317	P01619	41361833_Josephine_Robertson_P01619_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	Q08380	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	Q08380	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg22930808	chr3:122281881	3	122281881	PARP9;DTX3L	North shore	-0.0679044	0.00864502	0.000000000000004282591	Q08380	41361833_Josephine_Robertson_Q08380_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P29622	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P29622	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg22930808	chr3:122281881	3	122281881	PARP9;DTX3L	North shore	0.0676047	0.00869973	0.00000000000000830889	P29622	41361833_Josephine_Robertson_P29622_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02763	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P02763	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg22930808	chr3:122281881	3	122281881	PARP9;DTX3L	North shore	-0.0737439	0.00952587	0.0000000000000104713	P02763	41361833_Josephine_Robertson_P02763_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0C4DH34	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	A0A0C4DH34	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg22930808	chr3:122281881	3	122281881	PARP9;DTX3L	North shore	-0.067527	0.00872517	0.00000000000001064453	A0A0C4DH34	41361833_Josephine_Robertson_A0A0C4DH34_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P43652	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P43652	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg22930808	chr3:122281881	3	122281881	PARP9;DTX3L	North shore	0.0634695	0.00823992	0.0000000000000141739	P43652	41361833_Josephine_Robertson_P43652_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01619	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P01619	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg22930808	chr3:122281881	3	122281881	PARP9;DTX3L	North shore	-0.06675	0.00868559	0.00000000000001624949	P01619	41361833_Josephine_Robertson_P01619_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02763	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P02763	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg22930808	chr3:122281881	3	122281881	PARP9;DTX3L	North shore	-0.0660296	0.00864805	0.00000000000002393638	P02763	41361833_Josephine_Robertson_P02763_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04114	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04114	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg22930808	chr3:122281881	3	122281881	PARP9;DTX3L	North shore	0.0628869	0.00824023	0.00000000000002459277	P04114	41361833_Josephine_Robertson_P04114_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01619	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P01619	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg22930808	chr3:122281881	3	122281881	PARP9;DTX3L	North shore	-0.065704	0.0086757	0.00000000000003854166	P01619	41361833_Josephine_Robertson_P01619_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P08571	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P08571	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg22930808	chr3:122281881	3	122281881	PARP9;DTX3L	North shore	-0.0659277	0.00871092	0.00000000000004003215	P08571	41361833_Josephine_Robertson_P08571_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0C4DH34	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	A0A0C4DH34	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg22930808	chr3:122281881	3	122281881	PARP9;DTX3L	North shore	-0.065938	0.00871417	0.00000000000004053743	A0A0C4DH34	41361833_Josephine_Robertson_A0A0C4DH34_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02750	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P02750	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg22930808	chr3:122281881	3	122281881	PARP9;DTX3L	North shore	-0.06484	0.00858388	0.0000000000000448049	P02750	41361833_Josephine_Robertson_P02750_OSCA_model_3
Chung SA	-	26192630	2015-07-20	Autoantibody production in systemic lupus erythematosus	EFO_0004866, EFO_0002690	Combined	Table S1	DNA methylation	Autoantibody production in systemic lupus erythematosus	Age, disease duration, cell counts and technical covariates	Beta values	-	Illumina HumanMethylation450	Peripheral blood	Wilcoxon rank sum test	326	2	46	Females	European	cg22930808	chr3:122281881	3	122281881	PARP9;DTX3L	North shore	-	-	0.000000000000086	-	26192630_autoantibody_production_in_systemic_lupus_erythematosus_combined
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01766	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P01766	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg22930808	chr3:122281881	3	122281881	PARP9;DTX3L	North shore	-0.0647313	0.00873318	0.0000000000001310947	P01766	41361833_Josephine_Robertson_P01766_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06396	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P06396	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg22930808	chr3:122281881	3	122281881	PARP9;DTX3L	North shore	0.0609654	0.00824121	0.0000000000001461479	P06396	41361833_Josephine_Robertson_P06396_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P29622	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P29622	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg22930808	chr3:122281881	3	122281881	PARP9;DTX3L	North shore	0.0640952	0.00869643	0.0000000000001793535	P29622	41361833_Josephine_Robertson_P29622_OSCA_model_2
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 2 at 9y with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg22930808	chr3:122281881	3	122281881	PARP9;DTX3L	North shore	-0.012	0.0017	0.00000000000045	None	33450751_Mulder-RH_age_model_2_at_9y_with_age_as_a_fixed_effect
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02751	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02751	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg22930808	chr3:122281881	3	122281881	PARP9;DTX3L	North shore	0.0597147	0.00824184	0.0000000000004529153	P02751	41361833_Josephine_Robertson_P02751_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02760	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P02760	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg22930808	chr3:122281881	3	122281881	PARP9;DTX3L	North shore	0.0689717	0.00956311	0.0000000000005772674	P02760	41361833_Josephine_Robertson_P02760_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01766	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P01766	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg22930808	chr3:122281881	3	122281881	PARP9;DTX3L	North shore	-0.062835	0.00871869	0.0000000000006002017	P01766	41361833_Josephine_Robertson_P01766_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	Q08380	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	Q08380	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg22930808	chr3:122281881	3	122281881	PARP9;DTX3L	North shore	-0.0592264	0.00824208	0.0000000000007000803	Q08380	41361833_Josephine_Robertson_Q08380_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02647	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P02647	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg22930808	chr3:122281881	3	122281881	PARP9;DTX3L	North shore	0.0623779	0.00869235	0.0000000000007512256	P02647	41361833_Josephine_Robertson_P02647_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04275	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04275	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg22930808	chr3:122281881	3	122281881	PARP9;DTX3L	North shore	-0.0588249	0.00824227	0.0000000000009988093	P04275	41361833_Josephine_Robertson_P04275_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01766	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P01766	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg22930808	chr3:122281881	3	122281881	PARP9;DTX3L	North shore	-0.0684441	0.0096409	0.000000000001311166	P01766	41361833_Josephine_Robertson_P01766_OSCA_model_4
Gadd DA	Generation Scotland	35945220	31/07/2022	DDX58 protein levels (SeqId = 12382-2)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	DDX58 protein levels (SeqId = 12382-2)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Probable ATP-dependent RNA helicase DDX58	774	1	Adults (18-65 years)	Both	European	cg22930808	chr3:122281881	3	122281881	PARP9;DTX3L	North shore	-0.88	0.124	0.0000000000014	None	Gadd-DA_ddx58_protein_levels__seqid___12382-2__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02763	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P02763	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg22930808	chr3:122281881	3	122281881	PARP9;DTX3L	North shore	-0.0616855	0.00870705	0.00000000000145855	P02763	41361833_Josephine_Robertson_P02763_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01602	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P01602	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg22930808	chr3:122281881	3	122281881	PARP9;DTX3L	North shore	-0.0680159	0.00963042	0.000000000001707733	P01602	41361833_Josephine_Robertson_P01602_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01602	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P01602	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg22930808	chr3:122281881	3	122281881	PARP9;DTX3L	North shore	-0.061261	0.00871528	0.000000000002169653	P01602	41361833_Josephine_Robertson_P01602_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02760	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P02760	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg22930808	chr3:122281881	3	122281881	PARP9;DTX3L	North shore	0.0608711	0.00867223	0.000000000002331337	P02760	41361833_Josephine_Robertson_P02760_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00734	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P00734	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg22930808	chr3:122281881	3	122281881	PARP9;DTX3L	North shore	0.0608139	0.00870132	0.00000000000288705	P00734	41361833_Josephine_Robertson_P00734_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0C4DH34	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	A0A0C4DH34	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg22930808	chr3:122281881	3	122281881	PARP9;DTX3L	North shore	-0.0573783	0.00824297	0.000000000003524952	A0A0C4DH34	41361833_Josephine_Robertson_A0A0C4DH34_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00734	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P00734	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg22930808	chr3:122281881	3	122281881	PARP9;DTX3L	North shore	0.0606248	0.00871455	0.00000000000363013	P00734	41361833_Josephine_Robertson_P00734_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P08571	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P08571	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg22930808	chr3:122281881	3	122281881	PARP9;DTX3L	North shore	-0.060331	0.00869818	0.000000000004201005	P08571	41361833_Josephine_Robertson_P08571_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	Q08380	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	Q08380	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg22930808	chr3:122281881	3	122281881	PARP9;DTX3L	North shore	-0.0602329	0.00872823	0.00000000000537787	Q08380	41361833_Josephine_Robertson_Q08380_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01602	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P01602	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg22930808	chr3:122281881	3	122281881	PARP9;DTX3L	North shore	-0.0601739	0.00872344	0.000000000005491845	P01602	41361833_Josephine_Robertson_P01602_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A075B6I1	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	A0A075B6I1	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg22930808	chr3:122281881	3	122281881	PARP9;DTX3L	North shore	-0.0567566	0.00824326	0.000000000006004826	A0A075B6I1	41361833_Josephine_Robertson_A0A075B6I1_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02787	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P02787	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg22930808	chr3:122281881	3	122281881	PARP9;DTX3L	North shore	0.0658039	0.00955802	0.000000000006027343	P02787	41361833_Josephine_Robertson_P02787_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02787	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P02787	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg22930808	chr3:122281881	3	122281881	PARP9;DTX3L	North shore	0.0591165	0.00869349	0.00000000001085997	P02787	41361833_Josephine_Robertson_P02787_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02760	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02760	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg22930808	chr3:122281881	3	122281881	PARP9;DTX3L	North shore	0.055564	0.00824382	0.00000000001642039	P02760	41361833_Josephine_Robertson_P02760_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01762	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01762	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg22930808	chr3:122281881	3	122281881	PARP9;DTX3L	North shore	-0.0555505	0.00824382	0.0000000000166063	P01762	41361833_Josephine_Robertson_P01762_OSCA_model_1
Gadd DA	Generation Scotland	35945220	31/07/2022	CXCL11 protein levels (SeqId = 3038-9)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	CXCL11 protein levels (SeqId = 3038-9)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: C-X-C motif chemokine 11	774	1	Adults (18-65 years)	Both	European	cg22930808	chr3:122281881	3	122281881	PARP9;DTX3L	North shore	-0.83	0.124	0.000000000017	None	Gadd-DA_cxcl11_protein_levels__seqid___3038-9__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P29622	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P29622	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg22930808	chr3:122281881	3	122281881	PARP9;DTX3L	North shore	0.0646194	0.0095947	0.00000000001701511	P29622	41361833_Josephine_Robertson_P29622_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P43652	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P43652	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg22930808	chr3:122281881	3	122281881	PARP9;DTX3L	North shore	0.0584422	0.00872249	0.00000000002157542	P43652	41361833_Josephine_Robertson_P43652_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01701	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P01701	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg22930808	chr3:122281881	3	122281881	PARP9;DTX3L	North shore	-0.0645737	0.00964349	0.00000000002218625	P01701	41361833_Josephine_Robertson_P01701_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P08571	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P08571	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg22930808	chr3:122281881	3	122281881	PARP9;DTX3L	North shore	-0.0641529	0.00959617	0.00000000002388619	P08571	41361833_Josephine_Robertson_P08571_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02750	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P02750	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg22930808	chr3:122281881	3	122281881	PARP9;DTX3L	North shore	-0.0630527	0.00943248	0.00000000002398786	P02750	41361833_Josephine_Robertson_P02750_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P55056	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P55056	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg22930808	chr3:122281881	3	122281881	PARP9;DTX3L	North shore	0.0547126	0.0082442	0.00000000003325133	P55056	41361833_Josephine_Robertson_P55056_OSCA_model_1
Robert F. Hillary	Generation Scotland	doi.org/10.1101/2023.11.02.23298000	Nov 3, 2023	C-reactive protein (CRP) levels	None	Fully-adjusted model	None	C-reactive protein (CRP) levels	DNA methylation	Age, Sex, Smoking, Cell composition (reference based), Batch effects, Ancestry (genomic PCs), Body mass index, Socio-economic position, Education, Alcohol consumption	mg/L	Beta values	Illumina HumanMethylationEPIC	Whole blood	None	14040	1	Adults	Both	European	cg22930808	chr3:122281881	3	122281881	PARP9;DTX3L	North shore	-1.1	0.167	0.000000000052	Fully_Adjusted_Model	Robert-F.-Hillary_c-reactive_protein__crp__levels_fully-adjusted_model
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01766	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01766	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg22930808	chr3:122281881	3	122281881	PARP9;DTX3L	North shore	-0.054036	0.00824451	0.00000000005781754	P01766	41361833_Josephine_Robertson_P01766_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02749	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P02749	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg22930808	chr3:122281881	3	122281881	PARP9;DTX3L	North shore	0.0565936	0.00873072	0.00000000009333427	P02749	41361833_Josephine_Robertson_P02749_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01762	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P01762	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg22930808	chr3:122281881	3	122281881	PARP9;DTX3L	North shore	-0.0563043	0.00872521	0.0000000001130526	P01762	41361833_Josephine_Robertson_P01762_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02749	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P02749	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg22930808	chr3:122281881	3	122281881	PARP9;DTX3L	North shore	0.0563287	0.00874476	0.0000000001220439	P02749	41361833_Josephine_Robertson_P02749_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02749	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P02749	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg22930808	chr3:122281881	3	122281881	PARP9;DTX3L	North shore	0.0619039	0.00965706	0.0000000001497542	P02749	41361833_Josephine_Robertson_P02749_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01834	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P01834	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg22930808	chr3:122281881	3	122281881	PARP9;DTX3L	North shore	-0.0603328	0.00947991	0.0000000002020504	P01834	41361833_Josephine_Robertson_P01834_OSCA_model_4
Imgenberg-Kreuz J	-	26857698	2016-11-01	Primary Sjogrens syndrome	EFO_0000699	CD19+ B cells	Table S6	DNA methylation	Primary Sjogrens syndrome	Age, sex and cell counts	Beta values	-	Illumina HumanMethylation450	CD19+ B cells	-	71	1	-	Both	European	cg22930808	chr3:122281881	3	122281881	PARP9;DTX3L	North shore	-	-	0.00000000024	-	26857698_primary_sjogrens_syndrome_cd19_b_cells
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A075B6H9	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	A0A075B6H9	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg22930808	chr3:122281881	3	122281881	PARP9;DTX3L	North shore	-0.0604943	0.00962501	0.0000000003368883	A0A075B6H9	41361833_Josephine_Robertson_A0A075B6H9_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01762	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P01762	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg22930808	chr3:122281881	3	122281881	PARP9;DTX3L	North shore	-0.0548282	0.00873929	0.000000000362339	P01762	41361833_Josephine_Robertson_P01762_OSCA_model_3
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	BMI	EFO_0004340	discovery	None	DNA methylation	BMI	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	kg/m2	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg22930808	chr3:122281881	3	122281881	PARP9;DTX3L	North shore	0.156171	0.0249072	0.0000000003693365	None	39706196_Hannah-M.-Smith_bmi_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02760	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P02760	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg22930808	chr3:122281881	3	122281881	PARP9;DTX3L	North shore	0.0545612	0.00872643	0.0000000004153679	P02760	41361833_Josephine_Robertson_P02760_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00734	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P00734	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg22930808	chr3:122281881	3	122281881	PARP9;DTX3L	North shore	0.0597528	0.00961504	0.0000000005287803	P00734	41361833_Josephine_Robertson_P00734_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01619	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01619	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg22930808	chr3:122281881	3	122281881	PARP9;DTX3L	North shore	-0.051208	0.00824574	0.0000000005433156	P01619	41361833_Josephine_Robertson_P01619_OSCA_model_1
Mendelson MM	FHS	29740313	2018-04-24	Soluble tumor necrosis factor receptor 2	EFO_0008384, NCIT_C117749	None	Table S1	DNA methylation	Soluble tumor necrosis factor receptor 2	Age, sex, body mass index, smoking, batch effects	Beta Values	pg/ml	Illumina HumanMethylation450	Whole blood	None	2468	1	Adults	Both	Unclear	cg22930808	chr3:122281881	3	122281881	PARP9;DTX3L	North shore	-0.0203	0.00326	0.00000000061	None	29740313_Mendelson-MM_soluble_tumor_necrosis_factor_receptor_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A075B7B8	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	A0A075B7B8	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg22930808	chr3:122281881	3	122281881	PARP9;DTX3L	North shore	-0.0590085	0.0095707	0.0000000007209205	A0A075B7B8	41361833_Josephine_Robertson_A0A075B7B8_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02671	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02671	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg22930808	chr3:122281881	3	122281881	PARP9;DTX3L	North shore	-0.0507915	0.00824591	0.0000000007483331	P02671	41361833_Josephine_Robertson_P02671_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02787	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P02787	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg22930808	chr3:122281881	3	122281881	PARP9;DTX3L	North shore	0.0534945	0.00873112	0.0000000009191707	P02787	41361833_Josephine_Robertson_P02787_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A075B7B8	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	A0A075B7B8	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg22930808	chr3:122281881	3	122281881	PARP9;DTX3L	North shore	-0.0526778	0.00868143	0.000000001328065	A0A075B7B8	41361833_Josephine_Robertson_A0A075B7B8_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04430	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P04430	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg22930808	chr3:122281881	3	122281881	PARP9;DTX3L	North shore	-0.0527771	0.00874108	0.00000000159984	P04430	41361833_Josephine_Robertson_P04430_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A075B6H9	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	A0A075B6H9	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg22930808	chr3:122281881	3	122281881	PARP9;DTX3L	North shore	-0.0524064	0.00873097	0.000000001990562	A0A075B6H9	41361833_Josephine_Robertson_A0A075B6H9_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01701	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P01701	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg22930808	chr3:122281881	3	122281881	PARP9;DTX3L	North shore	-0.052276	0.00872807	0.000000002155297	P01701	41361833_Josephine_Robertson_P01701_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04430	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P04430	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg22930808	chr3:122281881	3	122281881	PARP9;DTX3L	North shore	-0.0577333	0.00964806	0.00000000222902	P04430	41361833_Josephine_Robertson_P04430_OSCA_model_4
Robert F. Hillary	Generation Scotland	doi.org/10.1101/2023.11.02.23298000	Nov 3, 2023	C-reactive protein (CRP) levels	None	Basic model	None	C-reactive protein (CRP) levels	DNA methylation	Age, Sex, Cell composition (reference based), Batch effects	mg/L	Beta values	Illumina HumanMethylationEPIC	Whole blood	None	17936	1	Adults	Both	European	cg22930808	chr3:122281881	3	122281881	PARP9;DTX3L	North shore	-0.97	0.162	0.0000000024	Basic_Model	Robert-F.-Hillary_c-reactive_protein__crp__levels_basic_model
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0A0MT89	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	A0A0A0MT89	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg22930808	chr3:122281881	3	122281881	PARP9;DTX3L	North shore	-0.0519025	0.00871467	0.000000002647881	A0A0A0MT89	41361833_Josephine_Robertson_A0A0A0MT89_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00450	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P00450	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg22930808	chr3:122281881	3	122281881	PARP9;DTX3L	North shore	-0.049043	0.00824664	0.000000002792509	P00450	41361833_Josephine_Robertson_P00450_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04430	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P04430	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg22930808	chr3:122281881	3	122281881	PARP9;DTX3L	North shore	-0.0516061	0.0087259	0.000000003410545	P04430	41361833_Josephine_Robertson_P04430_OSCA_model_2
Gadd DA	Generation Scotland	35945220	31/07/2022	IFIT3 protein levels (SeqId = 13642-90)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	IFIT3 protein levels (SeqId = 13642-90)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Interferon-induced protein with tetratricopeptide repeats 3	774	1	Adults (18-65 years)	Both	European	cg22930808	chr3:122281881	3	122281881	PARP9;DTX3L	North shore	-0.73	0.124	0.0000000037	None	Gadd-DA_ifit3_protein_levels__seqid___13642-90__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01834	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P01834	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg22930808	chr3:122281881	3	122281881	PARP9;DTX3L	North shore	-0.0506741	0.00861177	0.000000004084949	P01834	41361833_Josephine_Robertson_P01834_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0A0MT89	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	A0A0A0MT89	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg22930808	chr3:122281881	3	122281881	PARP9;DTX3L	North shore	-0.0512061	0.00871665	0.00000000433259	A0A0A0MT89	41361833_Josephine_Robertson_A0A0A0MT89_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01701	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P01701	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg22930808	chr3:122281881	3	122281881	PARP9;DTX3L	North shore	-0.0513583	0.00874363	0.000000004351536	P01701	41361833_Josephine_Robertson_P01701_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A075B7B8	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	A0A075B7B8	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg22930808	chr3:122281881	3	122281881	PARP9;DTX3L	North shore	-0.0511112	0.00870619	0.000000004433871	A0A075B7B8	41361833_Josephine_Robertson_A0A075B7B8_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01344	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01344	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg22930808	chr3:122281881	3	122281881	PARP9;DTX3L	North shore	0.0483085	0.00824693	0.00000000479215	P01344	41361833_Josephine_Robertson_P01344_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01709	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P01709	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg22930808	chr3:122281881	3	122281881	PARP9;DTX3L	North shore	-0.0563378	0.00963497	0.000000005104986	P01709	41361833_Josephine_Robertson_P01709_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P20851	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P20851	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg22930808	chr3:122281881	3	122281881	PARP9;DTX3L	North shore	-0.0560283	0.00958708	0.000000005200011	P20851	41361833_Josephine_Robertson_P20851_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0A0MS15	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	A0A0A0MS15	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg22930808	chr3:122281881	3	122281881	PARP9;DTX3L	North shore	-0.0563321	0.00964515	0.000000005316326	A0A0A0MS15	41361833_Josephine_Robertson_A0A0A0MS15_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01834	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P01834	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg22930808	chr3:122281881	3	122281881	PARP9;DTX3L	North shore	-0.0507129	0.00868557	0.000000005370662	P01834	41361833_Josephine_Robertson_P01834_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02749	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02749	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg22930808	chr3:122281881	3	122281881	PARP9;DTX3L	North shore	0.0481442	0.008247	0.000000005401839	P02749	41361833_Josephine_Robertson_P02749_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0A0MT89	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	A0A0A0MT89	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg22930808	chr3:122281881	3	122281881	PARP9;DTX3L	North shore	-0.0560235	0.0096137	0.000000005745963	A0A0A0MT89	41361833_Josephine_Robertson_A0A0A0MT89_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02751	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P02751	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg22930808	chr3:122281881	3	122281881	PARP9;DTX3L	North shore	0.0507822	0.00871615	0.000000005788931	P02751	41361833_Josephine_Robertson_P02751_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01718	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P01718	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg22930808	chr3:122281881	3	122281881	PARP9;DTX3L	North shore	-0.0507541	0.00873635	0.000000006394669	P01718	41361833_Josephine_Robertson_P01718_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A075B6H9	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	A0A075B6H9	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg22930808	chr3:122281881	3	122281881	PARP9;DTX3L	North shore	-0.0504606	0.00872622	0.000000007503176	A0A075B6H9	41361833_Josephine_Robertson_A0A075B6H9_OSCA_model_3
Gadd DA	Generation Scotland	35945220	31/07/2022	STAT1 protein levels (SeqId = 10370-21)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	STAT1 protein levels (SeqId = 10370-21)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Signal transducer and activator of transcription 1-alpha/beta	774	1	Adults (18-65 years)	Both	European	cg22930808	chr3:122281881	3	122281881	PARP9;DTX3L	North shore	-0.71	0.124	0.0000000078	None	Gadd-DA_stat1_protein_levels__seqid___10370-21__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04275	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P04275	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg22930808	chr3:122281881	3	122281881	PARP9;DTX3L	North shore	-0.055692	0.00964812	0.000000007976949	P04275	41361833_Josephine_Robertson_P04275_OSCA_model_4
Gadd DA	Generation Scotland	35945220	31/07/2022	LAG3 protein levels (SeqId = 9950-229)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	LAG3 protein levels (SeqId = 9950-229)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Lymphocyte activation gene 3 protein	774	1	Adults (18-65 years)	Both	European	cg22930808	chr3:122281881	3	122281881	PARP9;DTX3L	North shore	-0.71	0.124	0.0000000085	None	Gadd-DA_lag3_protein_levels__seqid___9950-229__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01042	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01042	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg22930808	chr3:122281881	3	122281881	PARP9;DTX3L	North shore	0.0473191	0.00824732	0.000000009797771	P01042	41361833_Josephine_Robertson_P01042_OSCA_model_1
Gadd DA	Generation Scotland	35945220	31/07/2022	COLEC12 protein levels (SeqId = 5457-5)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	COLEC12 protein levels (SeqId = 5457-5)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Collectin-12	774	1	Adults (18-65 years)	Both	European	cg22930808	chr3:122281881	3	122281881	PARP9;DTX3L	North shore	0.71	0.124	0.00000001	None	Gadd-DA_colec12_protein_levels__seqid___5457-5__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01718	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P01718	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg22930808	chr3:122281881	3	122281881	PARP9;DTX3L	North shore	-0.0499735	0.00872211	0.00000001026952	P01718	41361833_Josephine_Robertson_P01718_OSCA_model_2
Gadd DA	Generation Scotland	35945220	31/07/2022	CD48 protein levels (SeqId = 3292-75)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	CD48 protein levels (SeqId = 3292-75)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: CD48 antigen	774	1	Adults (18-65 years)	Both	European	cg22930808	chr3:122281881	3	122281881	PARP9;DTX3L	North shore	-0.71	0.124	0.000000011	None	Gadd-DA_cd48_protein_levels__seqid___3292-75__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06396	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P06396	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg22930808	chr3:122281881	3	122281881	PARP9;DTX3L	North shore	0.0494856	0.00865876	0.000000011178	P06396	41361833_Josephine_Robertson_P06396_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0C4DH29	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	A0A0C4DH29	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg22930808	chr3:122281881	3	122281881	PARP9;DTX3L	North shore	-0.0551281	0.00965224	0.00000001142097	A0A0C4DH29	41361833_Josephine_Robertson_A0A0C4DH29_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01705	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P01705	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg22930808	chr3:122281881	3	122281881	PARP9;DTX3L	North shore	-0.0550833	0.00965844	0.00000001199038	P01705	41361833_Josephine_Robertson_P01705_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0B4J1V2	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	A0A0B4J1V2	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg22930808	chr3:122281881	3	122281881	PARP9;DTX3L	North shore	-0.0470294	0.00824744	0.00000001204769	A0A0B4J1V2	41361833_Josephine_Robertson_A0A0B4J1V2_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01718	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01718	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg22930808	chr3:122281881	3	122281881	PARP9;DTX3L	North shore	-0.0469552	0.00824746	0.00000001269973	P01718	41361833_Josephine_Robertson_P01718_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P55056	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P55056	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg22930808	chr3:122281881	3	122281881	PARP9;DTX3L	North shore	0.049644	0.00872984	0.00000001319861	P55056	41361833_Josephine_Robertson_P55056_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01718	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P01718	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg22930808	chr3:122281881	3	122281881	PARP9;DTX3L	North shore	-0.0545381	0.00962653	0.00000001494496	P01718	41361833_Josephine_Robertson_P01718_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01602	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01602	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg22930808	chr3:122281881	3	122281881	PARP9;DTX3L	North shore	-0.0465218	0.00824763	0.00000001725572	P01602	41361833_Josephine_Robertson_P01602_OSCA_model_1
Gadd DA	Generation Scotland	35945220	31/07/2022	B2M protein levels (SeqId = 3485-28)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	B2M protein levels (SeqId = 3485-28)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Beta-2-microglobulin	774	1	Adults (18-65 years)	Both	European	cg22930808	chr3:122281881	3	122281881	PARP9;DTX3L	North shore	-0.69	0.124	0.000000029	None	Gadd-DA_b2m_protein_levels__seqid___3485-28__somascan_protein_measurement
Sikdar S	CHARGE	31536415	2019-09-19	Smoking	EFO_0009115, EFO_0006527, EFO_0004318	random effects meta-analysis	Table S2	DNA methylation	Smoking	Age, sex, cell composition (reference based), batch effects	Beta Values	None	Illumina HumanMethylation450	Whole blood, CD4+ T cells, CD14+ monocytes	None	15907	16	Adults	Both	European, African, Other	cg22930808	chr3:122281881	3	122281881	PARP9;DTX3L	North shore	-0.00751	0.00136	0.000000033	None	31536415_Sikdar-S_smoking_random_effects_meta-analysis
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02787	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02787	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg22930808	chr3:122281881	3	122281881	PARP9;DTX3L	North shore	0.0454658	0.00824803	0.00000003601044	P02787	41361833_Josephine_Robertson_P02787_OSCA_model_1
Gadd DA	Generation Scotland	35945220	31/07/2022	NMI protein levels (SeqId = 17512-2)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	NMI protein levels (SeqId = 17512-2)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: N-myc-interactor	774	1	Adults (18-65 years)	Both	European	cg22930808	chr3:122281881	3	122281881	PARP9;DTX3L	North shore	-0.68	0.124	0.000000037	None	Gadd-DA_nmi_protein_levels__seqid___17512-2__somascan_protein_measurement
Gross AM	-	27105112	2016-04-21	HIV infection	EFO_0000764	CD4+ T-cells	Table S2	DNA methylation	HIV infection	Age	-	-	Illumina HumanMethylation450	CD4+ T-cells	-	60	1	46.5	Males	European	cg22930808	chr3:122281881	3	122281881	PARP9;DTX3L	North shore	-0.384122	0.0698	0.0000000381	None	27105112_hiv_infection_cd4_tcells
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0A0MS14	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	A0A0A0MS14	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg22930808	chr3:122281881	3	122281881	PARP9;DTX3L	North shore	-0.0530082	0.00963955	0.0000000388284	A0A0A0MS14	41361833_Josephine_Robertson_A0A0A0MS14_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01705	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P01705	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg22930808	chr3:122281881	3	122281881	PARP9;DTX3L	North shore	-0.0480695	0.0087475	0.00000003967117	P01705	41361833_Josephine_Robertson_P01705_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P36955	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P36955	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg22930808	chr3:122281881	3	122281881	PARP9;DTX3L	North shore	0.0479204	0.0087364	0.00000004199769	P36955	41361833_Josephine_Robertson_P36955_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P43652	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P43652	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg22930808	chr3:122281881	3	122281881	PARP9;DTX3L	North shore	0.046557	0.00852124	0.00000004740614	P43652	41361833_Josephine_Robertson_P43652_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01705	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P01705	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg22930808	chr3:122281881	3	122281881	PARP9;DTX3L	North shore	-0.0476229	0.00873002	0.00000004974492	P01705	41361833_Josephine_Robertson_P01705_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0A0MS15	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	A0A0A0MS15	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg22930808	chr3:122281881	3	122281881	PARP9;DTX3L	North shore	-0.0476073	0.00873061	0.00000005035184	A0A0A0MS15	41361833_Josephine_Robertson_A0A0A0MS15_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06727	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P06727	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg22930808	chr3:122281881	3	122281881	PARP9;DTX3L	North shore	0.0517829	0.00952114	0.00000005452219	P06727	41361833_Josephine_Robertson_P06727_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A075B6I1	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	A0A075B6I1	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg22930808	chr3:122281881	3	122281881	PARP9;DTX3L	North shore	-0.0475126	0.00874456	0.00000005617379	A0A075B6I1	41361833_Josephine_Robertson_A0A075B6I1_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04275	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P04275	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg22930808	chr3:122281881	3	122281881	PARP9;DTX3L	North shore	-0.0473207	0.00871638	0.00000005759166	P04275	41361833_Josephine_Robertson_P04275_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0A0MS15	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	A0A0A0MS15	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg22930808	chr3:122281881	3	122281881	PARP9;DTX3L	North shore	-0.0474362	0.00874214	0.00000005849636	A0A0A0MS15	41361833_Josephine_Robertson_A0A0A0MS15_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A075B6I1	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	A0A075B6I1	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg22930808	chr3:122281881	3	122281881	PARP9;DTX3L	North shore	-0.0471989	0.00872795	0.00000006480616	A0A075B6I1	41361833_Josephine_Robertson_A0A075B6I1_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04275	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P04275	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg22930808	chr3:122281881	3	122281881	PARP9;DTX3L	North shore	-0.0471939	0.00873441	0.00000006648127	P04275	41361833_Josephine_Robertson_P04275_OSCA_model_3
Aslibekyan S	CHARGE	29617535	2018-04-04	Tumour necrosis factor-alpha	EFO_0003271	Meta-analysis model 3	Table 2	DNA methylation	Tumour necrosis factor-alpha	Age, sex, batch effects, cell composition (reference based), smoking, body mass index	Beta Values	pg/ml	Illumina HumanMethylation450	Whole blood	Some associations replicated - see paper	4163	5	Adults	Both	European	cg22930808	chr3:122281881	3	122281881	PARP9;DTX3L	North shore	-0.01	0.002	0.000000069	None	29617535_Aslibekyan-S_tumour_necrosis_factor-alpha_meta-analysis_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01705	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01705	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg22930808	chr3:122281881	3	122281881	PARP9;DTX3L	North shore	-0.044481	0.0082484	0.00000007048977	P01705	41361833_Josephine_Robertson_P01705_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01743	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P01743	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg22930808	chr3:122281881	3	122281881	PARP9;DTX3L	North shore	-0.0469422	0.00873714	0.00000007874155	P01743	41361833_Josephine_Robertson_P01743_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01743	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P01743	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg22930808	chr3:122281881	3	122281881	PARP9;DTX3L	North shore	-0.0466833	0.00872619	0.00000008937754	P01743	41361833_Josephine_Robertson_P01743_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06396	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P06396	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg22930808	chr3:122281881	3	122281881	PARP9;DTX3L	North shore	0.0464903	0.00872067	0.0000000990934	P06396	41361833_Josephine_Robertson_P06396_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04211	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04211	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg22930808	chr3:122281881	3	122281881	PARP9;DTX3L	North shore	-0.0439672	0.00824859	0.00000009951889	P04211	41361833_Josephine_Robertson_P04211_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P55056	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P55056	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg22930808	chr3:122281881	3	122281881	PARP9;DTX3L	North shore	0.0463974	0.00872174	0.0000001054433	P55056	41361833_Josephine_Robertson_P55056_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A075B6I1	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	A0A075B6I1	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg22930808	chr3:122281881	3	122281881	PARP9;DTX3L	North shore	-0.051271	0.0096517	0.0000001099452	A0A075B6I1	41361833_Josephine_Robertson_A0A075B6I1_OSCA_model_4
Gadd DA	Generation Scotland	35945220	31/07/2022	MDGA2 protein levels (SeqId = 19372-7)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	MDGA2 protein levels (SeqId = 19372-7)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: MAM domain-containing glycosylphosphatidylinositol anchor protein 2	774	1	Adults (18-65 years)	Both	European	cg22930808	chr3:122281881	3	122281881	PARP9;DTX3L	North shore	0.65	0.124	0.00000015	None	Gadd-DA_mdga2_protein_levels__seqid___19372-7__somascan_protein_measurement
Robert F Hillary	Generation Scotland	10.1101/2023.01.10.23284387	9/6/2023	Incident COPD	None	Basic model	https://doi.org/10.5281/zenodo.8021411	DNA methylation	Incident COPD	Age, Sex, Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	None	17902	1	Adults (18-65y)	Both	European	cg22930808	chr3:122281881	3	122281881	PARP9;DTX3L	North shore	-0.023	0.00433	0.00000015	None	Robert-F-Hillary_Incident_COPD_Basic_model
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0B4J1V2	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	A0A0B4J1V2	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg22930808	chr3:122281881	3	122281881	PARP9;DTX3L	North shore	-0.04586	0.00873241	0.0000001528071	A0A0B4J1V2	41361833_Josephine_Robertson_A0A0B4J1V2_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01743	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P01743	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg22930808	chr3:122281881	3	122281881	PARP9;DTX3L	North shore	-0.0505936	0.00964852	0.0000001596073	P01743	41361833_Josephine_Robertson_P01743_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P43251	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P43251	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg22930808	chr3:122281881	3	122281881	PARP9;DTX3L	North shore	0.0432019	0.00824886	0.0000001651762	P43251	41361833_Josephine_Robertson_P43251_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06727	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P06727	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg22930808	chr3:122281881	3	122281881	PARP9;DTX3L	North shore	0.0431833	0.00824887	0.0000001672127	P06727	41361833_Josephine_Robertson_P06727_OSCA_model_1
Gadd DA	Generation Scotland	35945220	31/07/2022	CXCL10 protein levels (SeqId = 4141-79)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	CXCL10 protein levels (SeqId = 4141-79)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: C-X-C motif chemokine 10	774	1	Adults (18-65 years)	Both	European	cg22930808	chr3:122281881	3	122281881	PARP9;DTX3L	North shore	-0.65	0.124	0.00000018	None	Gadd-DA_cxcl10_protein_levels__seqid___4141-79__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P43652	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P43652	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg22930808	chr3:122281881	3	122281881	PARP9;DTX3L	North shore	0.0490808	0.00940381	0.0000001821003	P43652	41361833_Josephine_Robertson_P43652_OSCA_model_4
Aslibekyan S	CHARGE	29617535	2018-04-04	Tumour necrosis factor-alpha	EFO_0003271	Meta-analysis base model	eTable 3	DNA methylation	Tumour necrosis factor-alpha	Age, sex, batch effects	Beta Values	pg/ml	Illumina HumanMethylation450	Whole blood	None	4163	5	Adults	Both	European	cg22930808	chr3:122281881	3	122281881	PARP9;DTX3L	North shore	-0.01	0.002	0.0000002	None	29617535_Aslibekyan-S_tumour_necrosis_factor-alpha_meta-analysis_base_model
Aslibekyan S	CHARGE	29617535	2018-04-04	Tumour necrosis factor-alpha	EFO_0003271	Meta-analysis model 2	eTable 3	DNA methylation	Tumour necrosis factor-alpha	Age, sex, batch effects, cell composition (reference based)	Beta Values	pg/ml	Illumina HumanMethylation450	Whole blood	None	4163	5	Adults	Both	European	cg22930808	chr3:122281881	3	122281881	PARP9;DTX3L	North shore	-0.01	0.002	0.00000021	None	29617535_Aslibekyan-S_tumour_necrosis_factor-alpha_meta-analysis_model_2
Gadd DA	Generation Scotland	35945220	31/07/2022	FOLR2 protein levels (SeqId = 15587-20)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	FOLR2 protein levels (SeqId = 15587-20)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Folate receptor beta	774	1	Adults (18-65 years)	Both	European	cg22930808	chr3:122281881	3	122281881	PARP9;DTX3L	North shore	-0.64	0.124	0.00000022	None	Gadd-DA_folr2_protein_levels__seqid___15587-20__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0B4J1V2	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	A0A0B4J1V2	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg22930808	chr3:122281881	3	122281881	PARP9;DTX3L	North shore	-0.0449726	0.00874776	0.0000002767452	A0A0B4J1V2	41361833_Josephine_Robertson_A0A0B4J1V2_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A075B6H7	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	A0A075B6H7	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg22930808	chr3:122281881	3	122281881	PARP9;DTX3L	North shore	-0.049292	0.00959455	0.0000002819954	A0A075B6H7	41361833_Josephine_Robertson_A0A075B6H7_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0A0MS15	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	A0A0A0MS15	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg22930808	chr3:122281881	3	122281881	PARP9;DTX3L	North shore	-0.0423277	0.00824917	0.0000002916538	A0A0A0MS15	41361833_Josephine_Robertson_A0A0A0MS15_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0B4J1V2	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	A0A0B4J1V2	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg22930808	chr3:122281881	3	122281881	PARP9;DTX3L	North shore	-0.049502	0.00965757	0.0000003001765	A0A0B4J1V2	41361833_Josephine_Robertson_A0A0B4J1V2_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01701	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01701	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg22930808	chr3:122281881	3	122281881	PARP9;DTX3L	North shore	-0.0422487	0.0082492	0.0000003068814	P01701	41361833_Josephine_Robertson_P01701_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0C4DH29	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	A0A0C4DH29	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg22930808	chr3:122281881	3	122281881	PARP9;DTX3L	North shore	-0.0447188	0.00874039	0.0000003154595	A0A0C4DH29	41361833_Josephine_Robertson_A0A0C4DH29_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P20851	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P20851	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg22930808	chr3:122281881	3	122281881	PARP9;DTX3L	North shore	-0.0443599	0.00868796	0.0000003333399	P20851	41361833_Josephine_Robertson_P20851_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06727	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P06727	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg22930808	chr3:122281881	3	122281881	PARP9;DTX3L	North shore	0.0441838	0.00865376	0.0000003336421	P06727	41361833_Josephine_Robertson_P06727_OSCA_model_3
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	Body fat	EFO_0007800	sensitivity	None	DNA methylation	Body fat	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	%	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg22930808	chr3:122281881	3	122281881	PARP9;DTX3L	North shore	0.134432	0.0264285	0.0000003682847	None	39706196_Hannah-M.-Smith_body_fat_sensitivity
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04211	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P04211	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg22930808	chr3:122281881	3	122281881	PARP9;DTX3L	North shore	-0.0490164	0.00966142	0.0000003955248	P04211	41361833_Josephine_Robertson_P04211_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01762	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P01762	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg22930808	chr3:122281881	3	122281881	PARP9;DTX3L	North shore	-0.0489586	0.00965078	0.0000003963488	P01762	41361833_Josephine_Robertson_P01762_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0C4DH29	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	A0A0C4DH29	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg22930808	chr3:122281881	3	122281881	PARP9;DTX3L	North shore	-0.044275	0.00872791	0.0000003967854	A0A0C4DH29	41361833_Josephine_Robertson_A0A0C4DH29_OSCA_model_2
Gadd DA	Generation Scotland	35945220	31/07/2022	CD5L protein levels (SeqId = 3293-2)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	CD5L protein levels (SeqId = 3293-2)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: CD5 antigen-like	774	1	Adults (18-65 years)	Both	European	cg22930808	chr3:122281881	3	122281881	PARP9;DTX3L	North shore	-0.62	0.123	0.00000046	None	Gadd-DA_cd5l_protein_levels__seqid___3293-2__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0C4DH29	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	A0A0C4DH29	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg22930808	chr3:122281881	3	122281881	PARP9;DTX3L	North shore	-0.041329	0.00824952	0.0000005510077	A0A0C4DH29	41361833_Josephine_Robertson_A0A0C4DH29_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01344	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P01344	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg22930808	chr3:122281881	3	122281881	PARP9;DTX3L	North shore	0.0482952	0.00964847	0.0000005637099	P01344	41361833_Josephine_Robertson_P01344_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04211	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P04211	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg22930808	chr3:122281881	3	122281881	PARP9;DTX3L	North shore	-0.0432754	0.00873529	0.0000007348061	P04211	41361833_Josephine_Robertson_P04211_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01344	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P01344	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg22930808	chr3:122281881	3	122281881	PARP9;DTX3L	North shore	0.0432104	0.00874772	0.0000007913744	P01344	41361833_Josephine_Robertson_P01344_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P19827	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P19827	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg22930808	chr3:122281881	3	122281881	PARP9;DTX3L	North shore	0.0477071	0.00967002	0.0000008165105	P19827	41361833_Josephine_Robertson_P19827_OSCA_model_4
Gadd DA	Generation Scotland	35945220	31/07/2022	CHST12 protein levels (SeqId = 6626-81)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	CHST12 protein levels (SeqId = 6626-81)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Carbohydrate sulfotransferase 12	774	1	Adults (18-65 years)	Both	European	cg22930808	chr3:122281881	3	122281881	PARP9;DTX3L	North shore	-0.61	0.124	0.00000084	None	Gadd-DA_chst12_protein_levels__seqid___6626-81__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01743	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01743	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg22930808	chr3:122281881	3	122281881	PARP9;DTX3L	North shore	-0.0406434	0.00824975	0.0000008457412	P01743	41361833_Josephine_Robertson_P01743_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A075B6H9	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	A0A075B6H9	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg22930808	chr3:122281881	3	122281881	PARP9;DTX3L	North shore	-0.0404892	0.0082498	0.0000009304376	A0A075B6H9	41361833_Josephine_Robertson_A0A075B6H9_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A075B7B8	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	A0A075B7B8	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg22930808	chr3:122281881	3	122281881	PARP9;DTX3L	North shore	-0.0404402	0.00824982	0.0000009590663	A0A075B7B8	41361833_Josephine_Robertson_A0A075B7B8_OSCA_model_1
Gadd DA	Generation Scotland	35945220	31/07/2022	CECR1 protein levels (SeqId = 6077-63)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	CECR1 protein levels (SeqId = 6077-63)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Adenosine deaminase 2	774	1	Adults (18-65 years)	Both	European	cg22930808	chr3:122281881	3	122281881	PARP9;DTX3L	North shore	-0.61	0.124	0.000001	None	Gadd-DA_cecr1_protein_levels__seqid___6077-63__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	IFI16 protein levels (SeqId = 13940-19)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	IFI16 protein levels (SeqId = 13940-19)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Gamma-interferon-inducible protein 16	774	1	Adults (18-65 years)	Both	European	cg22930808	chr3:122281881	3	122281881	PARP9;DTX3L	North shore	-0.61	0.124	0.000001	None	Gadd-DA_ifi16_protein_levels__seqid___13940-19__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0A0MS14	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	A0A0A0MS14	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg22930808	chr3:122281881	3	122281881	PARP9;DTX3L	North shore	-0.0425052	0.00873204	0.00000114065	A0A0A0MS14	41361833_Josephine_Robertson_A0A0A0MS14_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04211	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P04211	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg22930808	chr3:122281881	3	122281881	PARP9;DTX3L	North shore	-0.0425241	0.00874828	0.000001180931	P04211	41361833_Josephine_Robertson_P04211_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01344	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P01344	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg22930808	chr3:122281881	3	122281881	PARP9;DTX3L	North shore	0.0424071	0.00873094	0.000001203451	P01344	41361833_Josephine_Robertson_P01344_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0A0MS14	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	A0A0A0MS14	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg22930808	chr3:122281881	3	122281881	PARP9;DTX3L	North shore	-0.0422721	0.00873257	0.000001306718	A0A0A0MS14	41361833_Josephine_Robertson_A0A0A0MS14_OSCA_model_3
Battram T	GEO	29921915	2020-09-15	Multiple sclerosis	EFO_0003885	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE106648	None	DNA methylation	Multiple sclerosis	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Whole blood	None	279	1	Young adults	Both	Unclear	cg22930808	chr3:122281881	3	122281881	PARP9;DTX3L	North shore	-0.0514	0.0104	0.0000014	None	29921915_Battram-T_multiple_sclerosis_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse106648
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02751	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P02751	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg22930808	chr3:122281881	3	122281881	PARP9;DTX3L	North shore	0.041576	0.00862783	0.000001458489	P02751	41361833_Josephine_Robertson_P02751_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A075B6H7	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	A0A075B6H7	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg22930808	chr3:122281881	3	122281881	PARP9;DTX3L	North shore	-0.0417947	0.00870018	0.000001571554	A0A075B6H7	41361833_Josephine_Robertson_A0A075B6H7_OSCA_model_3
Gadd DA	Generation Scotland	35945220	31/07/2022	CXCL9 protein levels (SeqId = 9188-119)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	CXCL9 protein levels (SeqId = 9188-119)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: C-X-C motif chemokine 9	774	1	Adults (18-65 years)	Both	European	cg22930808	chr3:122281881	3	122281881	PARP9;DTX3L	North shore	-0.59	0.124	0.0000016	None	Gadd-DA_cxcl9_protein_levels__seqid___9188-119__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04114	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P04114	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg22930808	chr3:122281881	3	122281881	PARP9;DTX3L	North shore	0.041413	0.00863226	0.000001622648	P04114	41361833_Josephine_Robertson_P04114_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P55056	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P55056	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg22930808	chr3:122281881	3	122281881	PARP9;DTX3L	North shore	0.046157	0.0096315	0.000001665018	P55056	41361833_Josephine_Robertson_P55056_OSCA_model_4
Gadd DA	Generation Scotland	35945220	31/07/2022	DTX3L protein levels (SeqId = 11643-73)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	DTX3L protein levels (SeqId = 11643-73)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: E3 ubiquitin-protein ligase DTX3L	774	1	Adults (18-65 years)	Both	European	cg22930808	chr3:122281881	3	122281881	PARP9;DTX3L	North shore	-0.59	0.124	0.0000017	None	Gadd-DA_dtx3l_protein_levels__seqid___11643-73__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0A0MT89	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	A0A0A0MT89	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg22930808	chr3:122281881	3	122281881	PARP9;DTX3L	North shore	-0.0394301	0.00825015	0.000001775949	A0A0A0MT89	41361833_Josephine_Robertson_A0A0A0MT89_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06396	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P06396	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg22930808	chr3:122281881	3	122281881	PARP9;DTX3L	North shore	0.0452724	0.00951442	0.000001971025	P06396	41361833_Josephine_Robertson_P06396_OSCA_model_4
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age*sex	PATO_0000047,EFO_0000246	Discovery	http://epidelta.mrcieu.ac.uk/	DNA methylation	age*sex	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg22930808	chr3:122281881	3	122281881	PARP9;DTX3L	North shore	0.0014	0.00029	0.000002	None	33450751_Mulder-RH_age_sex_discovery
Dugue P-A	Melbourne Collaborative Cohort Study	31789449	2019-11-04	Alcohol consumption	EFO_0004329, EFO_0007878	Previous week consumption discovery	Supplementary Table 3	Alcohol consumption	DNA methylation	age, sex, smoking, body mass index  country of birth, sample type, cell composition (reference based),  batch effects	g/day	M Values	Illumina HumanMethylation450	Whole blood	None	5606	1	Adults	Both	Unclear	cg22930808	chr3:122281881	3	122281881	PARP9;DTX3L	North shore	None	None	0.000002	None	31789449_Dugue-P-A_alcohol_consumption_previous_week_consumption_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01709	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P01709	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg22930808	chr3:122281881	3	122281881	PARP9;DTX3L	North shore	-0.0414888	0.00873534	0.000002058136	P01709	41361833_Josephine_Robertson_P01709_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P05160	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P05160	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg22930808	chr3:122281881	3	122281881	PARP9;DTX3L	North shore	0.0391822	0.00825023	0.000002061297	P05160	41361833_Josephine_Robertson_P05160_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P36955	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P36955	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg22930808	chr3:122281881	3	122281881	PARP9;DTX3L	North shore	0.0391557	0.00825024	0.000002094345	P36955	41361833_Josephine_Robertson_P36955_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P10643	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P10643	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg22930808	chr3:122281881	3	122281881	PARP9;DTX3L	North shore	-0.0390115	0.00825029	0.000002282898	P10643	41361833_Josephine_Robertson_P10643_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04430	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04430	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg22930808	chr3:122281881	3	122281881	PARP9;DTX3L	North shore	-0.0388688	0.00825033	0.00000248548	P04430	41361833_Josephine_Robertson_P04430_OSCA_model_1
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	Glucose	EFO_0004468	sensitivity	None	DNA methylation	Glucose	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	mmol/L	Illumina HumanMethylationEPIC	Whole blood	None	17908	1	Adults	Both	European	cg22930808	chr3:122281881	3	122281881	PARP9;DTX3L	North shore	0.123203	0.0262904	0.000002803621	None	39706196_Hannah-M.-Smith_glucose_sensitivity
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01042	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P01042	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg22930808	chr3:122281881	3	122281881	PARP9;DTX3L	North shore	0.045037	0.00961426	0.000002833141	P01042	41361833_Josephine_Robertson_P01042_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01709	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P01709	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg22930808	chr3:122281881	3	122281881	PARP9;DTX3L	North shore	-0.0408535	0.00872811	0.00000288486	P01709	41361833_Josephine_Robertson_P01709_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P13671	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P13671	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg22930808	chr3:122281881	3	122281881	PARP9;DTX3L	North shore	-0.0386145	0.00825041	0.000002890027	P13671	41361833_Josephine_Robertson_P13671_OSCA_model_1
Gadd DA	Generation Scotland	35945220	31/07/2022	CBLN4 protein levels (SeqId = 5688-65)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	CBLN4 protein levels (SeqId = 5688-65)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Cerebellin-4	774	1	Adults (18-65 years)	Both	European	cg22930808	chr3:122281881	3	122281881	PARP9;DTX3L	North shore	0.58	0.124	0.0000029	None	Gadd-DA_cbln4_protein_levels__seqid___5688-65__somascan_protein_measurement
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	Glucose	EFO_0004468	discovery	None	DNA methylation	Glucose	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	mmol/L	Illumina HumanMethylationEPIC	Whole blood	None	17908	1	Adults	Both	European	cg22930808	chr3:122281881	3	122281881	PARP9;DTX3L	North shore	0.114816	0.0245843	0.000003029594	None	39706196_Hannah-M.-Smith_glucose_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P05543	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P05543	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg22930808	chr3:122281881	3	122281881	PARP9;DTX3L	North shore	-0.0384874	0.00825045	0.00000311514	P05543	41361833_Josephine_Robertson_P05543_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A075B6H7	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	A0A075B6H7	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg22930808	chr3:122281881	3	122281881	PARP9;DTX3L	North shore	-0.040551	0.00871782	0.000003324051	A0A075B6H7	41361833_Josephine_Robertson_A0A075B6H7_OSCA_model_2
Gross AM	-	27105112	2016-04-21	HIV infection	EFO_0000764	Discovery	Table S2	DNA methylation	HIV infection	Age and cell counts	-	-	Illumina HumanMethylation450	Whole blood	-	181	1	46.5	Males	European	cg22930808	chr3:122281881	3	122281881	PARP9;DTX3L	North shore	-1.728723	0.3727	0.00000352	-	27105112_hiv_infection_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01031	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01031	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg22930808	chr3:122281881	3	122281881	PARP9;DTX3L	North shore	-0.0381521	0.00825056	0.000003792786	P01031	41361833_Josephine_Robertson_P01031_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01024	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P01024	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg22930808	chr3:122281881	3	122281881	PARP9;DTX3L	North shore	0.0403161	0.00872827	0.000003888338	P01024	41361833_Josephine_Robertson_P01024_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00740	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P00740	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg22930808	chr3:122281881	3	122281881	PARP9;DTX3L	North shore	-0.0378835	0.00825064	0.000004435451	P00740	41361833_Josephine_Robertson_P00740_OSCA_model_1
Gadd DA	Generation Scotland	35945220	31/07/2022	ATP1B1 protein levels (SeqId = 13392-13)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	ATP1B1 protein levels (SeqId = 13392-13)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Sodium/potassium-transporting ATPase subunit beta-1	774	1	Adults (18-65 years)	Both	European	cg22930808	chr3:122281881	3	122281881	PARP9;DTX3L	North shore	0.569	0.124	0.0000045	None	Gadd-DA_atp1b1_protein_levels__seqid___13392-13__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	NTRK2 protein levels (SeqId = 4866-59)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	NTRK2 protein levels (SeqId = 4866-59)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: BDNF/NT-3 growth factors receptor	774	1	Adults (18-65 years)	Both	European	cg22930808	chr3:122281881	3	122281881	PARP9;DTX3L	North shore	0.57	0.124	0.0000048	None	Gadd-DA_ntrk2_protein_levels__seqid___4866-59__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P05160	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P05160	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg22930808	chr3:122281881	3	122281881	PARP9;DTX3L	North shore	0.0437648	0.00966244	0.000005962721	P05160	41361833_Josephine_Robertson_P05160_OSCA_model_4
Colicino E	CHARGE	32697766	07-22-2020	All cause mortality	EFO_0004352	basic model	Table S2	All cause mortality	DNA methylation	Age, Sex, Cell composition (reference based), Batch effects	None	M values	Illumina HumanMethylation450	Whole blood	Effect estimates represent hazard ratio per 10% increase in DNA methylation.	12300	12	Adults	Both	European, African	cg22930808	chr3:122281881	3	122281881	PARP9;DTX3L	North shore	0.94	None	0.0000061	None	32697766_Colicino-E_all_cause_mortality_basic_model
Gadd DA	Generation Scotland	35945220	31/07/2022	UBLCP1 protein levels (SeqId = 19124-9)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	UBLCP1 protein levels (SeqId = 19124-9)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Ubiquitin-like domain-containing CTD phosphatase 1	774	1	Adults (18-65 years)	Both	European	cg22930808	chr3:122281881	3	122281881	PARP9;DTX3L	North shore	-0.56	0.124	0.0000068	None	Gadd-DA_ublcp1_protein_levels__seqid___19124-9__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P05160	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P05160	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg22930808	chr3:122281881	3	122281881	PARP9;DTX3L	North shore	0.0393597	0.00874946	0.000006895009	P05160	41361833_Josephine_Robertson_P05160_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P05160	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P05160	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg22930808	chr3:122281881	3	122281881	PARP9;DTX3L	North shore	0.0390838	0.0087322	0.0000076689	P05160	41361833_Josephine_Robertson_P05160_OSCA_model_2
Battram T	GEO	27886173	2020-09-15	Crohn's disease	EFO_0000384	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE87640	None	DNA methylation	Crohn's disease	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Whole blood	None	161	1	Adults	Both	European	cg22930808	chr3:122281881	3	122281881	PARP9;DTX3L	North shore	0.0284	0.00615	0.0000087	None	27886173_Battram-T_crohn_s_disease_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse87640
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01042	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P01042	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg22930808	chr3:122281881	3	122281881	PARP9;DTX3L	North shore	0.0386737	0.00873002	0.000009492747	P01042	41361833_Josephine_Robertson_P01042_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	Q9Y5Y7	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	Q9Y5Y7	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg22930808	chr3:122281881	3	122281881	PARP9;DTX3L	North shore	0.0427773	0.00965688	0.000009503939	Q9Y5Y7	41361833_Josephine_Robertson_Q9Y5Y7_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P14151	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P14151	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg22930808	chr3:122281881	3	122281881	PARP9;DTX3L	North shore	-0.0364741	0.00825108	0.000009916551	P14151	41361833_Josephine_Robertson_P14151_OSCA_model_1
Gadd DA	Generation Scotland	35945220	31/07/2022	IL15RA protein levels (SeqId = 14054-17)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	IL15RA protein levels (SeqId = 14054-17)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Interleukin-15 receptor subunit alpha	774	1	Adults (18-65 years)	Both	European	cg22930808	chr3:122281881	3	122281881	PARP9;DTX3L	North shore	-0.55	0.124	0.000011	None	Gadd-DA_il15ra_protein_levels__seqid___14054-17__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01834	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01834	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg22930808	chr3:122281881	3	122281881	PARP9;DTX3L	North shore	-0.0358378	0.00825127	0.00001412972	P01834	41361833_Josephine_Robertson_P01834_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01042	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P01042	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg22930808	chr3:122281881	3	122281881	PARP9;DTX3L	North shore	0.037812	0.00871294	0.00001435989	P01042	41361833_Josephine_Robertson_P01042_OSCA_model_2
Gadd DA	Generation Scotland	35945220	31/07/2022	C1QC protein levels (SeqId = 14100-63)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	C1QC protein levels (SeqId = 14100-63)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Complement C1q subcomponent subunit C	774	1	Adults (18-65 years)	Both	European	cg22930808	chr3:122281881	3	122281881	PARP9;DTX3L	North shore	-0.54	0.124	0.000015	None	Gadd-DA_c1qc_protein_levels__seqid___14100-63__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01709	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01709	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg22930808	chr3:122281881	3	122281881	PARP9;DTX3L	North shore	-0.0355842	0.00825134	0.00001624481	P01709	41361833_Josephine_Robertson_P01709_OSCA_model_1
Liu C	CHARGE+	27843151	2016-12-15	Alcohol consumption per day	EFO_0007878, EFO_0004329	European ancestry	Table S5	DNA methylation	Alcohol consumption per day	Age, sex, body mass index, cell counts and technical covariates	Beta values	g der day	Illumina HumanMethylation450	Whole blood	-	9643	10	64.2	Both	European	cg22930808	chr3:122281881	3	122281881	PARP9;DTX3L	North shore	-0.00018544	4.31e-05	0.0000172	-	27843151_alcohol_consumption_per_day_european_ancestry
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0A0MS14	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	A0A0A0MS14	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg22930808	chr3:122281881	3	122281881	PARP9;DTX3L	North shore	-0.0354116	0.00825139	0.00001785401	A0A0A0MS14	41361833_Josephine_Robertson_A0A0A0MS14_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P20851	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P20851	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg22930808	chr3:122281881	3	122281881	PARP9;DTX3L	North shore	-0.037311	0.00873191	0.00001941201	P20851	41361833_Josephine_Robertson_P20851_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P43251	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P43251	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg22930808	chr3:122281881	3	122281881	PARP9;DTX3L	North shore	0.0373056	0.0087355	0.00001961966	P43251	41361833_Josephine_Robertson_P43251_OSCA_model_2
Gadd DA	Generation Scotland	35945220	31/07/2022	LTA protein levels (SeqId = 3505-6)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	LTA protein levels (SeqId = 3505-6)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Lymphotoxin-alpha|Lymphotoxin-beta	774	1	Adults (18-65 years)	Both	European	cg22930808	chr3:122281881	3	122281881	PARP9;DTX3L	North shore	-0.53	0.124	0.000021	None	Gadd-DA_lta_protein_levels__seqid___3505-6__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	SLAMF6 protein levels (SeqId = 5128-53)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	SLAMF6 protein levels (SeqId = 5128-53)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: SLAM family member 6	774	1	Adults (18-65 years)	Both	European	cg22930808	chr3:122281881	3	122281881	PARP9;DTX3L	North shore	-0.53	0.124	0.000022	None	Gadd-DA_slamf6_protein_levels__seqid___5128-53__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	CASC4 protein levels (SeqId = 10613-33)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	CASC4 protein levels (SeqId = 10613-33)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Protein CASC4	774	1	Adults (18-65 years)	Both	European	cg22930808	chr3:122281881	3	122281881	PARP9;DTX3L	North shore	-0.52	0.124	0.000024	None	Gadd-DA_casc4_protein_levels__seqid___10613-33__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0C4DH35	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	A0A0C4DH35	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg22930808	chr3:122281881	3	122281881	PARP9;DTX3L	North shore	-0.0403366	0.0095827	0.00002576796	A0A0C4DH35	41361833_Josephine_Robertson_A0A0C4DH35_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P08185	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P08185	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg22930808	chr3:122281881	3	122281881	PARP9;DTX3L	North shore	0.0347132	0.0082516	0.00002604927	P08185	41361833_Josephine_Robertson_P08185_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P14151	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P14151	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg22930808	chr3:122281881	3	122281881	PARP9;DTX3L	North shore	-0.0365949	0.00872622	0.00002760847	P14151	41361833_Josephine_Robertson_P14151_OSCA_model_2
Robert F Hillary	Generation Scotland	10.1101/2023.01.10.23284387	9/6/2023	Prevalent Rheumatoid Arthritis (Self-report)	None	Basic model	https://doi.org/10.5281/zenodo.8021411	DNA methylation	Prevalent Rheumatoid Arthritis (Self-report)	Age, Sex, Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	None	18055	1	Adults (18-65y)	Both	European	cg22930808	chr3:122281881	3	122281881	PARP9;DTX3L	North shore	-0.039	0.0094	0.000029	None	Robert-F-Hillary_Prevalent_Rheumatoid_Arthritis_(Self-report)_Basic_model
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P36955	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P36955	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg22930808	chr3:122281881	3	122281881	PARP9;DTX3L	North shore	0.0356951	0.00854796	0.00002985777	P36955	41361833_Josephine_Robertson_P36955_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P19827	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P19827	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg22930808	chr3:122281881	3	122281881	PARP9;DTX3L	North shore	0.0363826	0.00874075	0.00003167063	P19827	41361833_Josephine_Robertson_P19827_OSCA_model_2
Gadd DA	Generation Scotland	35945220	31/07/2022	RNASET2 protein levels (SeqId = 16913-8)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	RNASET2 protein levels (SeqId = 16913-8)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Ribonuclease T2	774	1	Adults (18-65 years)	Both	European	cg22930808	chr3:122281881	3	122281881	PARP9;DTX3L	North shore	-0.515	0.124	0.000032	None	Gadd-DA_rnaset2_protein_levels__seqid___16913-8__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	LGALS9 protein levels (SeqId = 9197-4)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	LGALS9 protein levels (SeqId = 9197-4)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Galectin-9	774	1	Adults (18-65 years)	Both	European	cg22930808	chr3:122281881	3	122281881	PARP9;DTX3L	North shore	-0.51	0.124	0.000035	None	Gadd-DA_lgals9_protein_levels__seqid___9197-4__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	FCGR3B protein levels (SeqId = 3311-27)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	FCGR3B protein levels (SeqId = 3311-27)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Low affinity immunoglobulin gamma Fc region receptor III-B	774	1	Adults (18-65 years)	Both	European	cg22930808	chr3:122281881	3	122281881	PARP9;DTX3L	North shore	-0.512	0.124	0.000035	None	Gadd-DA_fcgr3b_protein_levels__seqid___3311-27__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	GDNF protein levels (SeqId = 5822-22)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	GDNF protein levels (SeqId = 5822-22)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Glial cell line-derived neurotrophic factor	774	1	Adults (18-65 years)	Both	European	cg22930808	chr3:122281881	3	122281881	PARP9;DTX3L	North shore	-0.51	0.124	0.000036	None	Gadd-DA_gdnf_protein_levels__seqid___5822-22__somascan_protein_measurement
Robert F Hillary	Generation Scotland	10.1101/2023.01.10.23284387	9/6/2023	Incident Chronic Kidney Disease	None	Basic model	https://doi.org/10.5281/zenodo.8021411	DNA methylation	Incident Chronic Kidney Disease	Age, Sex, Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	None	18000	1	Adults (18-65y)	Both	European	cg22930808	chr3:122281881	3	122281881	PARP9;DTX3L	North shore	-0.011	0.00275	0.000038	None	Robert-F-Hillary_Incident_Chronic_Kidney_Disease_Basic_model
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0G2JRQ6	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	A0A0G2JRQ6	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg22930808	chr3:122281881	3	122281881	PARP9;DTX3L	North shore	-0.0359264	0.00872684	0.00003863211	A0A0G2JRQ6	41361833_Josephine_Robertson_A0A0G2JRQ6_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P19827	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P19827	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg22930808	chr3:122281881	3	122281881	PARP9;DTX3L	North shore	0.0360586	0.00875906	0.00003863989	P19827	41361833_Josephine_Robertson_P19827_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P51884	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P51884	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg22930808	chr3:122281881	3	122281881	PARP9;DTX3L	North shore	0.0338759	0.00825183	0.00004060503	P51884	41361833_Josephine_Robertson_P51884_OSCA_model_1
Gadd DA	Generation Scotland	35945220	31/07/2022	TNFRSF1B protein levels (SeqId = 8368-102)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	TNFRSF1B protein levels (SeqId = 8368-102)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Tumor necrosis factor receptor superfamily member 1B	774	1	Adults (18-65 years)	Both	European	cg22930808	chr3:122281881	3	122281881	PARP9;DTX3L	North shore	-0.51	0.124	0.000041	None	Gadd-DA_tnfrsf1b_protein_levels__seqid___8368-102__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	FAP protein levels (SeqId = 5029-3)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	FAP protein levels (SeqId = 5029-3)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Prolyl endopeptidase FAP	774	1	Adults (18-65 years)	Both	European	cg22930808	chr3:122281881	3	122281881	PARP9;DTX3L	North shore	0.51	0.124	0.000042	None	Gadd-DA_fap_protein_levels__seqid___5029-3__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	MRC2 protein levels (SeqId = 3041-55)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	MRC2 protein levels (SeqId = 3041-55)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: C-type mannose receptor 2	774	1	Adults (18-65 years)	Both	European	cg22930808	chr3:122281881	3	122281881	PARP9;DTX3L	North shore	0.505	0.124	0.000045	None	Gadd-DA_mrc2_protein_levels__seqid___3041-55__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04114	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P04114	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg22930808	chr3:122281881	3	122281881	PARP9;DTX3L	North shore	0.0349144	0.00855637	0.0000451728	P04114	41361833_Josephine_Robertson_P04114_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0G2JRQ6	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	A0A0G2JRQ6	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg22930808	chr3:122281881	3	122281881	PARP9;DTX3L	North shore	-0.0355274	0.00872456	0.00004683314	A0A0G2JRQ6	41361833_Josephine_Robertson_A0A0G2JRQ6_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O95445	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	O95445	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg22930808	chr3:122281881	3	122281881	PARP9;DTX3L	North shore	0.0388794	0.00958945	0.00005052412	O95445	41361833_Josephine_Robertson_O95445_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06727	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P06727	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg22930808	chr3:122281881	3	122281881	PARP9;DTX3L	North shore	0.0353554	0.00872909	0.00005141694	P06727	41361833_Josephine_Robertson_P06727_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0G2JRQ6	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	A0A0G2JRQ6	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg22930808	chr3:122281881	3	122281881	PARP9;DTX3L	North shore	-0.0387157	0.00962356	0.00005774801	A0A0G2JRQ6	41361833_Josephine_Robertson_A0A0G2JRQ6_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00450	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P00450	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg22930808	chr3:122281881	3	122281881	PARP9;DTX3L	North shore	-0.0350753	0.0087269	0.0000586841	P00450	41361833_Josephine_Robertson_P00450_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P43251	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P43251	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg22930808	chr3:122281881	3	122281881	PARP9;DTX3L	North shore	0.0350219	0.00874647	0.00006255512	P43251	41361833_Josephine_Robertson_P43251_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P20851	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P20851	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg22930808	chr3:122281881	3	122281881	PARP9;DTX3L	North shore	-0.0330258	0.00825207	0.00006308577	P20851	41361833_Josephine_Robertson_P20851_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0C4DH35	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	A0A0C4DH35	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg22930808	chr3:122281881	3	122281881	PARP9;DTX3L	North shore	-0.0346916	0.0086919	0.00006604263	A0A0C4DH35	41361833_Josephine_Robertson_A0A0C4DH35_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0J9YX35	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	A0A0J9YX35	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg22930808	chr3:122281881	3	122281881	PARP9;DTX3L	North shore	-0.0383903	0.00962219	0.00006645938	A0A0J9YX35	41361833_Josephine_Robertson_A0A0J9YX35_OSCA_model_4
Gadd DA	Generation Scotland	35945220	31/07/2022	GZMA protein levels (SeqId = 3440-7)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	GZMA protein levels (SeqId = 3440-7)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Granzyme A	774	1	Adults (18-65 years)	Both	European	cg22930808	chr3:122281881	3	122281881	PARP9;DTX3L	North shore	-0.49	0.124	0.000067	None	Gadd-DA_gzma_protein_levels__seqid___3440-7__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	EPHB2 protein levels (SeqId = 8225-86)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	EPHB2 protein levels (SeqId = 8225-86)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Ephrin type-B receptor 2	774	1	Adults (18-65 years)	Both	European	cg22930808	chr3:122281881	3	122281881	PARP9;DTX3L	North shore	-0.49	0.124	0.000067	None	Gadd-DA_ephb2_protein_levels__seqid___8225-86__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P19827	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P19827	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg22930808	chr3:122281881	3	122281881	PARP9;DTX3L	North shore	0.0328587	0.00825211	0.00006871018	P19827	41361833_Josephine_Robertson_P19827_OSCA_model_1
Gadd DA	Generation Scotland	35945220	31/07/2022	TXNDC5 protein levels (SeqId = 11212-7)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	TXNDC5 protein levels (SeqId = 11212-7)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Thioredoxin domain-containing protein 5	774	1	Adults (18-65 years)	Both	European	cg22930808	chr3:122281881	3	122281881	PARP9;DTX3L	North shore	-0.491	0.124	0.000073	None	Gadd-DA_txndc5_protein_levels__seqid___11212-7__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	PTP4A1 protein levels (SeqId = 17812-2)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	PTP4A1 protein levels (SeqId = 17812-2)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Protein tyrosine phosphatase type IVA 1	774	1	Adults (18-65 years)	Both	European	cg22930808	chr3:122281881	3	122281881	PARP9;DTX3L	North shore	-0.49	0.12	0.000078	None	Gadd-DA_ptp4a1_protein_levels__seqid___17812-2__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	Q9Y5Y7	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	Q9Y5Y7	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg22930808	chr3:122281881	3	122281881	PARP9;DTX3L	North shore	0.0344788	0.00873646	0.00007965872	Q9Y5Y7	41361833_Josephine_Robertson_Q9Y5Y7_OSCA_model_2
Gadd DA	Generation Scotland	35945220	31/07/2022	CD163 protein levels (SeqId = 5028-59)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	CD163 protein levels (SeqId = 5028-59)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Scavenger receptor cysteine-rich type 1 protein M130	774	1	Adults (18-65 years)	Both	European	cg22930808	chr3:122281881	3	122281881	PARP9;DTX3L	North shore	-0.49	0.124	0.00008	None	Gadd-DA_cd163_protein_levels__seqid___5028-59__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02747	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02747	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg22930808	chr3:122281881	3	122281881	PARP9;DTX3L	North shore	-0.032519	0.0082522	0.00008164113	P02747	41361833_Josephine_Robertson_P02747_OSCA_model_1
Gadd DA	Generation Scotland	35945220	31/07/2022	ZNF41 protein levels (SeqId = 10003-15)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	ZNF41 protein levels (SeqId = 10003-15)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Zinc finger protein 41	774	1	Adults (18-65 years)	Both	European	cg22930808	chr3:122281881	3	122281881	PARP9;DTX3L	North shore	-0.49	0.124	0.000086	None	Gadd-DA_znf41_protein_levels__seqid___10003-15__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	DSCAM protein levels (SeqId = 9175-48)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	DSCAM protein levels (SeqId = 9175-48)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Down syndrome cell adhesion molecule	774	1	Adults (18-65 years)	Both	European	cg22930808	chr3:122281881	3	122281881	PARP9;DTX3L	North shore	-0.49	0.124	0.000088	None	Gadd-DA_dscam_protein_levels__seqid___9175-48__somascan_protein_measurement