author consortium pmid date trait efo analysis source outcome exposure covariates outcome_units exposure_units methylation_array tissue further_details n n_cohorts age sex ethnicity cpg chrpos chr pos gene type beta se p details study_id Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg24058132 chr14:88459866 14 88459866 GALC South shore -0.0062 0.00017 0 None 33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 2 at 6y with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg24058132 chr14:88459866 14 88459866 GALC South shore 0.016 0.001 0 None 33450751_Mulder-RH_age_model_2_at_6y_with_age_as_a_fixed_effect Xu CJ - 28056824 2017-01-05 Age 4 vs age 0 EFO_0000246 - Additional file 3 DNA methylation Age 4 vs age 0 Sex, cell counts and technical covariates Beta values - Illumina HumanMethylation450 Whole blood and cord blood - 269 2 - Both European cg24058132 chr14:88459866 14 88459866 GALC South shore - - 1.1100000000000001e-100 - 28056824_age_4_vs_age_0 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02748 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02748 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg24058132 chr14:88459866 14 88459866 GALC South shore 0.108304 0.008208 1.575389e-39 P02748 41361833_Josephine_Robertson_P02748_OSCA_model_1 Reynolds LM - 25404168 2014-11-18 Age EFO_0000246 Monocytes Additional file 1 DNA methylation Age Sex, ethnicity and technical covariates M values years Illumina HumanMethylation450 Monocytes - 1264 1 60 Both European,African,Admixed cg24058132 chr14:88459866 14 88459866 GALC South shore - - 6.299999999999999e-31 - 25404168_age_monocytes Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02750 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02750 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg24058132 chr14:88459866 14 88459866 GALC South shore 0.0811257 0.00822936 7.447719000000001e-23 P02750 41361833_Josephine_Robertson_P02750_OSCA_model_1 Yao C FHS, KORA F4, BLSA, InCHIANTI 33752734 2021-03-22 Gene expression of Affymetrix ID: 3575103 (gene symbol: GALC) None Meta-analysis Table S6 DNA methylation Gene expression of Affymetrix ID: 3575103 (gene symbol: GALC) Age, sex, cell composition (reference based), batch effects Beta Values None Illumina HumanMethylation450 Whole blood None 4170 1 Adults Both Unclear cg24058132 chr14:88459866 14 88459866 GALC South shore None None 2.5e-17 None 33752734_Yao-C_gene_expression_of_affymetrix_id__3575103__gene_symbol__galc__meta-analysis Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P08185 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P08185 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg24058132 chr14:88459866 14 88459866 GALC South shore -0.0527569 0.00824507 0.0000000001615673 P08185 41361833_Josephine_Robertson_P08185_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P00747 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P00747 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg24058132 chr14:88459866 14 88459866 GALC South shore -0.0581285 0.00942456 0.0000000007107828 P00747 41361833_Josephine_Robertson_P00747_OSCA_model_2 Dugue P-A Melbourne Collaborative Cohort Study 31789449 2019-11-04 Alcohol consumption EFO_0004329, EFO_0007878 Lifetime consumption discovery Supplementary Table 3 Alcohol consumption DNA methylation age, sex, smoking, body mass index country of birth, sample type, cell composition (reference based), batch effects g/day M Values Illumina HumanMethylation450 Whole blood None 5606 1 Adults Both Unclear cg24058132 chr14:88459866 14 88459866 GALC South shore None None 0.0000000012 None 31789449_Dugue-P-A_alcohol_consumption_lifetime_consumption_discovery Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01042 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01042 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg24058132 chr14:88459866 14 88459866 GALC South shore -0.049812 0.00824632 0.000000001573444 P01042 41361833_Josephine_Robertson_P01042_OSCA_model_1 Li S - 28811542 2017-08-15 Age EFO_0000246 - Table S1 DNA methylation Age Cell counts M values years Illumina HumanMethylation450 Whole blood - 1366 2 73 Missing European cg24058132 chr14:88459866 14 88459866 GALC South shore -0.0091 0.0015545 0.0000000024 - 28811542_age Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02671 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02671 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg24058132 chr14:88459866 14 88459866 GALC South shore 0.047886 0.0082471 0.000000006515116 P02671 41361833_Josephine_Robertson_P02671_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P00747 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P00747 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg24058132 chr14:88459866 14 88459866 GALC South shore -0.0539045 0.00943697 0.00000001137863 P00747 41361833_Josephine_Robertson_P00747_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01031 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01031 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg24058132 chr14:88459866 14 88459866 GALC South shore 0.0454052 0.00824806 0.00000003754492 P01031 41361833_Josephine_Robertson_P01031_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P29622 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P29622 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg24058132 chr14:88459866 14 88459866 GALC South shore -0.0424335 0.00824913 0.0000002724321 P29622 41361833_Josephine_Robertson_P29622_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P18428 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P18428 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg24058132 chr14:88459866 14 88459866 GALC South shore 0.0421362 0.00824924 0.0000003298723 P18428 41361833_Josephine_Robertson_P18428_OSCA_model_1 Dugue P-A Melbourne Collaborative Cohort Study 31789449 2019-11-04 Alcohol consumption EFO_0004329, EFO_0007878 Previous week consumption discovery Supplementary Table 3 Alcohol consumption DNA methylation age, sex, smoking, body mass index country of birth, sample type, cell composition (reference based), batch effects g/day M Values Illumina HumanMethylation450 Whole blood None 5606 1 Adults Both Unclear cg24058132 chr14:88459866 14 88459866 GALC South shore None None 0.0000006 None 31789449_Dugue-P-A_alcohol_consumption_previous_week_consumption_discovery Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P00747 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P00747 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg24058132 chr14:88459866 14 88459866 GALC South shore -0.0404649 0.00824981 0.0000009445004 P00747 41361833_Josephine_Robertson_P00747_OSCA_model_1 Singmann P - 26500701 2015-10-19 Sex EFO_0001271 KORA F4 Additional file 2 DNA methylation Sex Age, smoking, alcohol consumption, body mass index, triglycerides, total leucocytes, high-density lipoprotein, low-density lipoprotein, physical activity, diabetes, myocardial infarction, cell counts and technical covariates Beta values - Illumina HumanMethylation450 Whole blood - 1799 1 60 Both European cg24058132 chr14:88459866 14 88459866 GALC South shore - - 0.00000138 - 26500701_sex_kora_f4 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P08185 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P08185 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg24058132 chr14:88459866 14 88459866 GALC South shore -0.0443392 0.00922578 0.000001554979 P08185 41361833_Josephine_Robertson_P08185_OSCA_model_3 Reynolds LM - 25404168 2014-11-18 Age EFO_0000246 T cells Additional file 1 DNA methylation Age Sex, ethnicity and technical covariates M values Years Illumina HumanMethylation450 T cells - 227 1 - Missing None cg24058132 chr14:88459866 14 88459866 GALC South shore - - 0.0000021 - 25404168_age_t_cells Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01742 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01742 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg24058132 chr14:88459866 14 88459866 GALC South shore 0.0390247 0.00825028 0.000002264962 P01742 41361833_Josephine_Robertson_P01742_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P08185 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P08185 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg24058132 chr14:88459866 14 88459866 GALC South shore -0.0437862 0.00942252 0.000003397669 P08185 41361833_Josephine_Robertson_P08185_OSCA_model_2 Dugue P-A LOLIPOP, KORA 31789449 2019-11-04 Alcohol consumption EFO_0004329, EFO_0007878 Replication Supplementary Table 5 Alcohol consumption DNA methylation age, sex, smoking, body mass index country of birth, sample type, cell composition (reference based), batch effects g/day M Values Illumina HumanMethylation450 Whole blood None 5704 2 Adults Both Unclear cg24058132 chr14:88459866 14 88459866 GALC South shore None None 0.0000035 None 31789449_Dugue-P-A_alcohol_consumption_replication Robert F Hillary Generation Scotland 10.1101/2023.01.10.23284387 9/6/2023 Incident COPD None Basic model https://doi.org/10.5281/zenodo.8021411 DNA methylation Incident COPD Age, Sex, Cell composition (reference based) M values None Illumina HumanMethylationEPIC Whole blood None 17902 1 Adults (18-65y) Both European cg24058132 chr14:88459866 14 88459866 GALC South shore -0.037 0.00804 0.0000035 None Robert-F-Hillary_Incident_COPD_Basic_model Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02790 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02790 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg24058132 chr14:88459866 14 88459866 GALC South shore 0.0381982 0.00825055 0.000003692065 P02790 41361833_Josephine_Robertson_P02790_OSCA_model_1 Liu C CHARGE+ 27843151 2016-12-15 Alcohol consumption per day EFO_0007878, EFO_0004329 European ancestry Table S5 DNA methylation Alcohol consumption per day Age, sex, body mass index, cell counts and technical covariates Beta values g der day Illumina HumanMethylation450 Whole blood - 9643 10 64.2 Both European cg24058132 chr14:88459866 14 88459866 GALC South shore -0.00023162 5.07e-05 0.00000498 - 27843151_alcohol_consumption_per_day_european_ancestry Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02647 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02647 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg24058132 chr14:88459866 14 88459866 GALC South shore -0.0369557 0.00825093 0.000007556983 P02647 41361833_Josephine_Robertson_P02647_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01042 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P01042 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg24058132 chr14:88459866 14 88459866 GALC South shore -0.0418012 0.00942321 0.000009231883 P01042 41361833_Josephine_Robertson_P01042_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 O75636 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation O75636 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg24058132 chr14:88459866 14 88459866 GALC South shore -0.036448 0.00825109 0.00001006313 O75636 41361833_Josephine_Robertson_O75636_OSCA_model_1 Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 BMI EFO_0004340 sensitivity None DNA methylation BMI Age,Sex,Smoking,Cell composition (reference based),Batch effects Other kg/m2 Illumina HumanMethylationEPIC Whole blood None 17304 1 Adults Both European cg24058132 chr14:88459866 14 88459866 GALC South shore -0.223048 0.0508113 0.00001141651 None 39706196_Hannah-M.-Smith_bmi_sensitivity Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01042 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P01042 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg24058132 chr14:88459866 14 88459866 GALC South shore -0.0406271 0.00945841 0.00001755517 P01042 41361833_Josephine_Robertson_P01042_OSCA_model_3 Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 Glucose EFO_0004468 sensitivity None DNA methylation Glucose Age,Sex,Smoking,Cell composition (reference based),Batch effects Other mmol/L Illumina HumanMethylationEPIC Whole blood None 17908 1 Adults Both European cg24058132 chr14:88459866 14 88459866 GALC South shore -0.217406 0.0506507 0.00001778005 None 39706196_Hannah-M.-Smith_glucose_sensitivity Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04114 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P04114 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg24058132 chr14:88459866 14 88459866 GALC South shore -0.0353172 0.00825142 0.00001879698 P04114 41361833_Josephine_Robertson_P04114_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P43652 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P43652 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg24058132 chr14:88459866 14 88459866 GALC South shore -0.0349369 0.00825153 0.00002309744 P43652 41361833_Josephine_Robertson_P43652_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02647 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P02647 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg24058132 chr14:88459866 14 88459866 GALC South shore -0.0380787 0.00902093 0.00002445232 P02647 41361833_Josephine_Robertson_P02647_OSCA_model_3 Battram T GEO 23177740 2020-09-15 Age EFO_0000246 EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE40279 None DNA methylation Age Batch effects, cell composition (reference free) Beta Values Years Illumina HumanMethylation450 Whole blood None 656 1 Adults Both Unclear cg24058132 chr14:88459866 14 88459866 GALC South shore -0.0005 0.00012 0.000028 None 23177740_Battram-T_age_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse40279 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P27169 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P27169 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg24058132 chr14:88459866 14 88459866 GALC South shore -0.0344636 0.00825167 0.00002976555 P27169 41361833_Josephine_Robertson_P27169_OSCA_model_1 Darina Czamara BET, ITU, PREDO 38600394 Apr 10, 2024 sex EFO:0000001 meta-analysis of robust linear regression results per cohort None DNA methylation sex Smoking,Cell composition (reference based),Gestational age M values None Illumina HumanMethylationEPIC placenta None 746 3 Infants (< 4 years) Both European cg24058132 chr14:88459866 14 88459866 GALC South shore 0.0649872 0.0156217 0.00003181 None 38600394_Darina-Czamara_sex_meta-analysis_of_robust_linear_regression_results_per_cohort Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 Body fat EFO_0007800 sensitivity None DNA methylation Body fat Age,Sex,Smoking,Cell composition (reference based),Batch effects Other % Illumina HumanMethylationEPIC Whole blood None 17304 1 Adults Both European cg24058132 chr14:88459866 14 88459866 GALC South shore -0.212758 0.0511436 0.00003197666 None 39706196_Hannah-M.-Smith_body_fat_sensitivity Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02748 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P02748 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg24058132 chr14:88459866 14 88459866 GALC South shore 0.0382872 0.00928879 0.00003778832 P02748 41361833_Josephine_Robertson_P02748_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P43251 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P43251 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg24058132 chr14:88459866 14 88459866 GALC South shore -0.0339604 0.00825181 0.00003884291 P43251 41361833_Josephine_Robertson_P43251_OSCA_model_1 Sikdar S CHARGE 31536415 2019-09-19 Smoking EFO_0009115, EFO_0006527, EFO_0004318 random effects meta-analysis Table S2 DNA methylation Smoking Age, sex, cell composition (reference based), batch effects Beta Values None Illumina HumanMethylation450 Whole blood, CD4+ T cells, CD14+ monocytes None 15907 16 Adults Both European, African, Other cg24058132 chr14:88459866 14 88459866 GALC South shore -0.00342 0.00083 0.00004 None 31536415_Sikdar-S_smoking_random_effects_meta-analysis Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04004 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P04004 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg24058132 chr14:88459866 14 88459866 GALC South shore -0.0377343 0.00941978 0.00006209723 P04004 41361833_Josephine_Robertson_P04004_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01019 None OSCA model 3 10.5281/zenodo.16924748 DNA methylation P01019 Age,Sex,Cell composition (reference based),Body mass index, Smoking M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg24058132 chr14:88459866 14 88459866 GALC South shore -0.0378578 0.00945518 0.00006260734 P01019 41361833_Josephine_Robertson_P01019_OSCA_model_3 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01019 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P01019 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg24058132 chr14:88459866 14 88459866 GALC South shore -0.0369782 0.00943632 0.00008942821 P01019 41361833_Josephine_Robertson_P01019_OSCA_model_2 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P06396 None OSCA model 2 10.5281/zenodo.16924748 DNA methylation P06396 Age,Sex,Cell composition (reference based) M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg24058132 chr14:88459866 14 88459866 GALC South shore 0.0369585 0.00943604 0.00009015975 P06396 41361833_Josephine_Robertson_P06396_OSCA_model_2