author consortium pmid date trait efo analysis source outcome exposure covariates outcome_units exposure_units methylation_array tissue further_details n n_cohorts age sex ethnicity cpg chrpos chr pos gene type beta se p details study_id Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg26955290 chr17:7015607 17 7015607 ASGR2 Open sea 0.0029 0.00032 0 None 33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect Battram T GEO 30602389 2020-09-15 Tissue None EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells None DNA methylation Tissue Batch effects, cell composition (reference free) Beta Values None Illumina HumanMethylation450 Buccal cells and peripheral blood mononuclear cells None 215 1 Children Both European cg26955290 chr17:7015607 17 7015607 ASGR2 Open sea 0.20453 0.00992 1.1e-50 None 30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells Bonder MJ - 25282492 2014-10-04 Fetal vs adult liver UBERON_0002107, GO_0048513 - Additional file 2 DNA methylation Fetal vs adult liver Sex and technical covariates M values - Illumina HumanMethylation450 Liver - 195 2 - Missing None cg26955290 chr17:7015607 17 7015607 ASGR2 Open sea 1.63984 0.0938 3.27e-30 - 25282492_fetal_vs_adult_liver Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02748 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02748 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg26955290 chr17:7015607 17 7015607 ASGR2 Open sea -0.0716453 0.00823535 3.676215e-18 P02748 41361833_Josephine_Robertson_P02748_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02750 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02750 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg26955290 chr17:7015607 17 7015607 ASGR2 Open sea -0.0622215 0.00824057 0.00000000000004586501 P02750 41361833_Josephine_Robertson_P02750_OSCA_model_1 Yao C FHS, KORA F4, BLSA, InCHIANTI 33752734 2021-03-22 Gene expression of Affymetrix ID: 3743340 (gene symbol: ASGR2) None Meta-analysis Table S6 DNA methylation Gene expression of Affymetrix ID: 3743340 (gene symbol: ASGR2) Age, sex, cell composition (reference based), batch effects Beta Values None Illumina HumanMethylation450 Whole blood None 4170 1 Adults Both Unclear cg26955290 chr17:7015607 17 7015607 ASGR2 Open sea None None 0.000000000000048 None 33752734_Yao-C_gene_expression_of_affymetrix_id__3743340__gene_symbol__asgr2__meta-analysis Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P18428 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P18428 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg26955290 chr17:7015607 17 7015607 ASGR2 Open sea -0.0565549 0.00824336 0.000000000007128479 P18428 41361833_Josephine_Robertson_P18428_OSCA_model_1 Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 2 at 6y with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg26955290 chr17:7015607 17 7015607 ASGR2 Open sea -0.014 0.0021 0.000000000099 None 33450751_Mulder-RH_age_model_2_at_6y_with_age_as_a_fixed_effect Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P04114 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P04114 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg26955290 chr17:7015607 17 7015607 ASGR2 Open sea 0.0487725 0.00824675 0.000000003410034 P04114 41361833_Josephine_Robertson_P04114_OSCA_model_1 Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a random effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg26955290 chr17:7015607 17 7015607 ASGR2 Open sea 0.0026 None 0.0000018 None 33450751_Mulder-RH_age_model_1_with_age_as_a_random_effect Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 O75882 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation O75882 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg26955290 chr17:7015607 17 7015607 ASGR2 Open sea 0.0386105 0.00825041 0.000002896901 O75882 41361833_Josephine_Robertson_O75882_OSCA_model_1 Lu X Lifelines DEEP 32916427 2020-09-09 MEHP None None ST10 DNA methylation MEHP Age, Sex, body mass index, cell composition (reference based), batch effects Beta Values ng/24h Illumina HumanMethylation450 Whole blood The trait is a phthalate metabolite 622 1 Adults Both European cg26955290 chr17:7015607 17 7015607 ASGR2 Open sea 0.031 0.00669 0.0000037 None 32916427_Lu-X_mehp Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02790 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02790 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg26955290 chr17:7015607 17 7015607 ASGR2 Open sea -0.0374148 0.00825079 0.000005814258 P02790 41361833_Josephine_Robertson_P02790_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02671 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02671 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg26955290 chr17:7015607 17 7015607 ASGR2 Open sea -0.0363175 0.00825112 0.00001082549 P02671 41361833_Josephine_Robertson_P02671_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P01742 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P01742 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg26955290 chr17:7015607 17 7015607 ASGR2 Open sea -0.0361103 0.00825119 0.00001215048 P01742 41361833_Josephine_Robertson_P01742_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P29622 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P29622 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg26955290 chr17:7015607 17 7015607 ASGR2 Open sea 0.0355451 0.00825135 0.00001659641 P29622 41361833_Josephine_Robertson_P29622_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02649 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02649 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg26955290 chr17:7015607 17 7015607 ASGR2 Open sea 0.0349562 0.00825153 0.00002285818 P02649 41361833_Josephine_Robertson_P02649_OSCA_model_1 Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P27169 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P27169 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg26955290 chr17:7015607 17 7015607 ASGR2 Open sea 0.0341464 0.00825176 0.0000352185 P27169 41361833_Josephine_Robertson_P27169_OSCA_model_1 Inkster A Seven dataset from four North American cohorts. GSE73375, GSE75428, GSE98224, GSE74738, GSE100197, GSE108567, and GSE128827 34044884 03-08-2021 Sex PATO_0001894 Discovery Supplementary Table 1 DNA methylation Sex Ancestry (genomic PCs), Gestational age, Dataset M values None Illumina HumanMethylation450 Placenta None 585 4 Infants Both European, East Asian, African, Admixed cg26955290 chr17:7015607 17 7015607 ASGR2 Open sea 1.3 None 0.000066 None 34044884_Inkster-A_sex_discovery Gadd DA Generation Scotland 35945220 31/07/2022 IGF1 protein levels (SeqId = 8406-17) None SomaScan protein measurement https://doi.org/10.5281/zenodo.6801458 IGF1 protein levels (SeqId = 8406-17) DNA methylation Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking None M values Illumina HumanMethylationEPIC Whole blood Full UniProt name: Insulin-like growth factor I 774 1 Adults (18-65 years) Both European cg26955290 chr17:7015607 17 7015607 ASGR2 Open sea 0.35 0.088 0.000091 None Gadd-DA_igf1_protein_levels__seqid___8406-17__somascan_protein_measurement