author consortium pmid date trait efo analysis source outcome exposure covariates outcome_units exposure_units methylation_array tissue further_details n n_cohorts age sex ethnicity cpg chrpos chr pos gene type beta se p details study_id Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg27049766 chr19:58220516 19 58220516 ZNF154 Island 0.00059 0.000042 0 None 33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a random effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg27049766 chr19:58220516 19 58220516 ZNF154 Island 0.00082 None 2.9999999999999996e-243 None 33450751_Mulder-RH_age_model_1_with_age_as_a_random_effect Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 2 at 9y with age as a random effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg27049766 chr19:58220516 19 58220516 ZNF154 Island 0.002 None 2.6000000000000002e-37 None 33450751_Mulder-RH_age_model_2_at_9y_with_age_as_a_random_effect Wozniak MB - 23526956 2013-03-05 Clear cell renal carcinoma EFO_0000349, EFO_0000681 - Table S6 DNA methylation Clear cell renal carcinoma - M values - Illumina HumanMethylation450 Clear cell renal carcinoma tumour cells and adjacent healthy cells - 129 1 63 Both European cg27049766 chr19:58220516 19 58220516 ZNF154 Island - - 2.6900000000000002e-21 - 23526956_clear_cell_renal_carcinoma Nones K - 24500968 2014-05-09 Pancreatic ductal adenocarcinoma EFO_0002517 - Table S4 DNA methylation Pancreatic ductal adenocarcinoma - Beta values - Illumina HumanMethylation450 Pancreatic ductal adenocarcinoma and adjacent nontransformed pancreata - 196 1 - Missing None cg27049766 chr19:58220516 19 58220516 ZNF154 Island - - 1.56e-19 - 24500968_pancreatic_ductal_adenocarcinoma Marttila S - 25888029 2015-03-14 Ageing GO_0007568 - Additional file 1 DNA methylation Age group Sex and cell counts Beta values - Illumina HumanMethylation450 Peripheral blood mononuclear cells Variable dispersion beta regression model 143 1 58.5 Both European cg27049766 chr19:58220516 19 58220516 ZNF154 Island 1.19161282 0.1391 1.06e-17 - 25888029_ageing Singmann P - 26500701 2015-10-19 Sex EFO_0001271 KORA F4 Additional file 2 DNA methylation Sex Age, smoking, alcohol consumption, body mass index, triglycerides, total leucocytes, high-density lipoprotein, low-density lipoprotein, physical activity, diabetes, myocardial infarction, cell counts and technical covariates Beta values - Illumina HumanMethylation450 Whole blood - 1799 1 60 Both European cg27049766 chr19:58220516 19 58220516 ZNF154 Island - - 7.51e-16 - 26500701_sex_kora_f4 Yao C FHS, KORA F4, BLSA, InCHIANTI 33752734 2021-03-22 Gene expression of Affymetrix ID: 3872560 (gene symbol: ZNF256) None Meta-analysis Table S6 DNA methylation Gene expression of Affymetrix ID: 3872560 (gene symbol: ZNF256) Age, sex, cell composition (reference based), batch effects Beta Values None Illumina HumanMethylation450 Whole blood None 4170 1 Adults Both Unclear cg27049766 chr19:58220516 19 58220516 ZNF154 Island None None 0.0000000000000043 None 33752734_Yao-C_gene_expression_of_affymetrix_id__3872560__gene_symbol__znf256__meta-analysis Battram T GEO 23177740 2020-09-15 Age EFO_0000246 EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE40279 None DNA methylation Age Batch effects, cell composition (reference free) Beta Values Years Illumina HumanMethylation450 Whole blood None 656 1 Adults Both Unclear cg27049766 chr19:58220516 19 58220516 ZNF154 Island 0.00096 0.00015 0.00000000071 None 23177740_Battram-T_age_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse40279 Yao C FHS, KORA F4, BLSA, InCHIANTI 33752734 2021-03-22 Gene expression of Affymetrix ID: 3872398 (gene symbol: ZNF671) None Meta-analysis Table S6 DNA methylation Gene expression of Affymetrix ID: 3872398 (gene symbol: ZNF671) Age, sex, cell composition (reference based), batch effects Beta Values None Illumina HumanMethylation450 Whole blood None 4170 1 Adults Both Unclear cg27049766 chr19:58220516 19 58220516 ZNF154 Island None None 0.0000000012 None 33752734_Yao-C_gene_expression_of_affymetrix_id__3872398__gene_symbol__znf671__meta-analysis Dugue P-A Melbourne Collaborative Cohort Study 31789449 2019-11-04 Alcohol consumption EFO_0004329, EFO_0007878 Lifetime consumption discovery Supplementary Table 3 Alcohol consumption DNA methylation age, sex, smoking, body mass index country of birth, sample type, cell composition (reference based), batch effects g/day M Values Illumina HumanMethylation450 Whole blood None 5606 1 Adults Both Unclear cg27049766 chr19:58220516 19 58220516 ZNF154 Island None None 0.0000041 None 31789449_Dugue-P-A_alcohol_consumption_lifetime_consumption_discovery Dugue P-A Melbourne Collaborative Cohort Study 31789449 2019-11-04 Alcohol consumption EFO_0004329, EFO_0007878 Previous week consumption discovery Supplementary Table 3 Alcohol consumption DNA methylation age, sex, smoking, body mass index country of birth, sample type, cell composition (reference based), batch effects g/day M Values Illumina HumanMethylation450 Whole blood None 5606 1 Adults Both Unclear cg27049766 chr19:58220516 19 58220516 ZNF154 Island None None 0.00003 None 31789449_Dugue-P-A_alcohol_consumption_previous_week_consumption_discovery Liu C CHARGE+ 27843151 2016-12-15 Alcohol consumption per day EFO_0007878, EFO_0004329 European ancestry Table S5 DNA methylation Alcohol consumption per day Age, sex, body mass index, cell counts and technical covariates Beta values g der day Illumina HumanMethylation450 Whole blood - 9643 10 64.2 Both European cg27049766 chr19:58220516 19 58220516 ZNF154 Island -0.00011151 2.73e-05 0.0000451 - 27843151_alcohol_consumption_per_day_european_ancestry Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P02775 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P02775 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg27049766 chr19:58220516 19 58220516 ZNF154 Island -0.033393 0.00825197 0.00005221717 P02775 41361833_Josephine_Robertson_P02775_OSCA_model_1 Hannah M. Smith Generation Scotland 39706196 Jan 2, 2025 Total cholesterol EFO_0004574 discovery None DNA methylation Total cholesterol Age,Sex,Smoking,Cell composition (reference based) Other mmol/L Illumina HumanMethylationEPIC Whole blood None 18270 1 Adults Both European cg27049766 chr19:58220516 19 58220516 ZNF154 Island 0.0570618 0.014588 0.00009203962 None 39706196_Hannah-M.-Smith_total_cholesterol_discovery Josephine Robertson Generation Scotland 41361833 Dec 8, 2025 P08571 None OSCA model 1 10.5281/zenodo.16924748 DNA methylation P08571 Age,Sex M values None Illumina HumanMethylationEPIC whole blood None 14671 1 Adults (18-65 years) Both European cg27049766 chr19:58220516 19 58220516 ZNF154 Island -0.0321989 0.00825229 0.00009589948 P08571 41361833_Josephine_Robertson_P08571_OSCA_model_1