author consortium pmid date trait efo analysis source outcome exposure covariates outcome_units exposure_units methylation_array tissue further_details n n_cohorts age sex ethnicity cpg chrpos chr pos gene type beta se p details study_id Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg27176129 chr20:43937155 20 43937155 MATN4;RBPJL South shore 0.0038 0.00025 0 None 33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 2 at 6y with age as a fixed effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg27176129 chr20:43937155 20 43937155 MATN4;RBPJL South shore -0.022 0.0012 0 None 33450751_Mulder-RH_age_model_2_at_6y_with_age_as_a_fixed_effect Mulder RH ALSPAC,Generation R 33450751 25/01/2021 sex PATO_0000047 Discovery http://epidelta.mrcieu.ac.uk/ DNA methylation sex gestational age,cohort,cell composition (reference based),batch effects Beta Values None Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg27176129 chr20:43937155 20 43937155 MATN4;RBPJL South shore -0.029 0.0029 0 None 33450751_Mulder-RH_sex_discovery Battram T GEO 30602389 2020-09-15 Tissue None EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE124366. Tissue types are buccal epithelial cells and peripheral blood mononuclear cells None DNA methylation Tissue Batch effects, cell composition (reference free) Beta Values None Illumina HumanMethylation450 Buccal cells and peripheral blood mononuclear cells None 215 1 Children Both European cg27176129 chr20:43937155 20 43937155 MATN4;RBPJL South shore 0.49296 0.00795 2.3e-129 None 30602389_Battram-T_tissue_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse124366__tissue_types_are_buccal_epithelial_cells_and_peripheral_blood_mononuclear_cells Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age EFO_0000246 Model 1 with age as a random effect http://epidelta.mrcieu.ac.uk/ DNA methylation age sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg27176129 chr20:43937155 20 43937155 MATN4;RBPJL South shore 0.003 None 6.1e-20 None 33450751_Mulder-RH_age_model_1_with_age_as_a_random_effect Yao C FHS, KORA F4, BLSA, InCHIANTI 33752734 2021-03-22 Gene expression of Affymetrix ID: 3886765 (gene symbol: PI3) None Meta-analysis Table S6 DNA methylation Gene expression of Affymetrix ID: 3886765 (gene symbol: PI3) Age, sex, cell composition (reference based), batch effects Beta Values None Illumina HumanMethylation450 Whole blood None 4170 1 Adults Both Unclear cg27176129 chr20:43937155 20 43937155 MATN4;RBPJL South shore None None 0.0000000000007 None 33752734_Yao-C_gene_expression_of_affymetrix_id__3886765__gene_symbol__pi3__meta-analysis Kashima K None 33564054 2021-02-09 gestational age EFO_0005112 None Supplementary Table 6 DNA methylation gestational age sex, batch effects, cell composition (reference based), cesarean section, maternal pre-pregnancy bmi, maternal smoking before pregnancy, chorioamnionitis, idiopathic premature rupture of the membrane, preeclampsia Beta Values weeks Illumina HumanMethylation450 Cord blood None 110 1 Infants Both East Asian cg27176129 chr20:43937155 20 43937155 MATN4;RBPJL South shore 0.0073 0.001 0.000000000093 None 33564054_Kashima-K_gestational_age Bozack PRISM 34569420 Oct 22, 2021 Infant sex PATO_0001894 Cord blood Supplementary table 8 DNA methylation Infant sex Cell composition (reference free), Batch effects, Ancestry (other) M values None Illumina HumanMethylation450 cord blood None 179 1 Infants Both European, African, Other cg27176129 chr20:43937155 20 43937155 MATN4;RBPJL South shore None None 0.000000054 None 34569420_Bozack_infant_sex_cord_blood Bohlin J - 27717397 2016-10-07 Gestational age EFO_0005112 Last menstrual period-estimated gestational age Table S2 DNA methylation Gestational age Offspring sex, maternal age, maternal smoking, study design, caesarean section and cell counts Beta values days Illumina HumanMethylation450 Cord blood - 1068 1 0 Both European cg27176129 chr20:43937155 20 43937155 MATN4;RBPJL South shore 0.00070871 0.00013839 0.000000361 - 27717397_gestational_age_last_menstrual_periodestimated_gestational_age Bohlin J - 27717397 2016-10-07 Gestational age EFO_0005112 Ultrasound-estimated gestational age Table S1 DNA methylation Gestational age Offspring sex, maternal age, maternal smoking, study design, caesarean section and cell counts Beta values days Illumina HumanMethylation450 Cord blood - 1068 1 0 Both European cg27176129 chr20:43937155 20 43937155 MATN4;RBPJL South shore 0.00067318 0.00015276 0.0000116 - 27717397_gestational_age_ultrasoundestimated_gestational_age Mulder RH ALSPAC,Generation R 33450751 25/01/2021 age*sex PATO_0000047,EFO_0000246 Discovery http://epidelta.mrcieu.ac.uk/ DNA methylation age*sex sex,gestational age,cohort,cell composition (reference based),batch effects Beta Values years Illumina HumanMethylation450 Whole blood None 2338 2 Children Both European cg27176129 chr20:43937155 20 43937155 MATN4;RBPJL South shore 0.0012 0.0003 0.000083 None 33450751_Mulder-RH_age_sex_discovery Tan Q Middleaged Danish Twins (MADT) 34427971 Aug 24, 2021 Age EFO_0000246 Discovery Table S1 DNA methylation Age Cell composition (reference based) M values years Illumina HumanMethylation450 Whole blood None 492 1 Geriatrics Males European cg27176129 chr20:43937155 20 43937155 MATN4;RBPJL South shore 0.0107 0.00266 0.000097 None 34427971_Tan-Q_age_discovery