author	consortium	pmid	date	trait	efo	analysis	source	outcome	exposure	covariates	outcome_units	exposure_units	methylation_array	tissue	further_details	n	n_cohorts	age	sex	ethnicity	cpg	chrpos	chr	pos	gene	type	beta	se	p	details	study_id
Sayols-Baixeras S	-	28173150	2016-09-15	Serum triglycerides	EFO_0004530, CHEBI_17855	Discovery and replication	Table S1	Serum triglycerides	DNA methylation	Age, sex, smoking, cell counts and technical covariates	mg/dl	M values	Illumina HumanMethylation450	Whole blood	Triglycerides levels were log-transformed	3187	2	65.7	Both	None	cg27243685	chr21:43642366	21	43642366	ABCG1	South shelf	0.047	0.004	0	-	28173150_serum_triglycerides_discovery_and_replication
Sayols-Baixeras S	-	28173150	2016-09-15	Serum triglycerides	EFO_0004530, CHEBI_17855	Discovery and replication adjusted for surrogate variables	Table S1	Serum triglycerides	DNA methylation	Age, sex, smoking, cell counts and technical covariates	mg/dl	M values	Illumina HumanMethylation450	Whole blood	Triglycerides levels were log-transformed	3187	2	65.7	Both	None	cg27243685	chr21:43642366	21	43642366	ABCG1	South shelf	0.064	0.004	0	-	28173150_serum_triglycerides_discovery_and_replication_adjusted_for_surrogate_variables
Sayols-Baixeras S	-	28173150	2016-09-15	Serum high-density lipoprotein cholesterol	EFO_0004612, CHEBI_47775	Discovery and replication	Table S1	Serum high-density lipoprotein cholesterol	DNA methylation	Age, sex, smoking, cell counts and technical covariates	mg/dl	M values	Illumina HumanMethylation450	Whole blood	-	3187	2	65.7	Both	None	cg27243685	chr21:43642366	21	43642366	ABCG1	South shelf	-2.564	0.254	0	-	28173150_serum_highdensity_lipoprotein_cholesterol_discovery_and_replication
Sayols-Baixeras S	-	28173150	2016-09-15	Serum high-density lipoprotein cholesterol	EFO_0004612, CHEBI_47775	Discovery and replication adjusted for surrogate variables	Table S1	Serum high-density lipoprotein cholesterol	DNA methylation	Age, sex, smoking, cell counts and technical covariates	mg/dl	M values	Illumina HumanMethylation450	Whole blood	-	3187	2	65.7	Both	None	cg27243685	chr21:43642366	21	43642366	ABCG1	South shelf	-3.798	0.319	0	-	28173150_serum_highdensity_lipoprotein_cholesterol_discovery_and_replication_adjusted_for_surrogate_variables
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	HDL cholesterol	EFO_0004612	discovery	None	DNA methylation	HDL cholesterol	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	mmol/L	Illumina HumanMethylationEPIC	Whole blood	None	18225	1	Adults	Both	European	cg27243685	chr21:43642366	21	43642366	ABCG1	South shelf	-0.986969	0.0355909	8.090314e-166	None	39706196_Hannah-M.-Smith_hdl_cholesterol_discovery
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	HDL cholesterol	EFO_0004612	sensitivity	None	DNA methylation	HDL cholesterol	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	mmol/L	Illumina HumanMethylationEPIC	Whole blood	None	18225	1	Adults	Both	European	cg27243685	chr21:43642366	21	43642366	ABCG1	South shelf	-1.04047	0.0410526	2.654775e-139	None	39706196_Hannah-M.-Smith_hdl_cholesterol_sensitivity
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	BMI	EFO_0004340	discovery	None	DNA methylation	BMI	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	kg/m2	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg27243685	chr21:43642366	21	43642366	ABCG1	South shelf	0.929276	0.0368781	1.25042e-137	None	39706196_Hannah-M.-Smith_bmi_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04004	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P04004	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg27243685	chr21:43642366	21	43642366	ABCG1	South shelf	0.196583	0.00878341	4.0006719999999997e-109	P04004	41361833_Josephine_Robertson_P04004_OSCA_model_2
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	Body fat	EFO_0007800	discovery	None	DNA methylation	Body fat	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	%	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg27243685	chr21:43642366	21	43642366	ABCG1	South shelf	0.821391	0.0371131	4.731335e-107	None	39706196_Hannah-M.-Smith_body_fat_discovery
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	BMI	EFO_0004340	sensitivity	None	DNA methylation	BMI	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	kg/m2	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg27243685	chr21:43642366	21	43642366	ABCG1	South shelf	0.921382	0.042437	3.789001e-103	None	39706196_Hannah-M.-Smith_bmi_sensitivity
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01024	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P01024	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg27243685	chr21:43642366	21	43642366	ABCG1	South shelf	0.183969	0.00882318	3.600382e-95	P01024	41361833_Josephine_Robertson_P01024_OSCA_model_2
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	Waist-hip ratio	EFO_0004343	discovery	None	DNA methylation	Waist-hip ratio	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	None	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg27243685	chr21:43642366	21	43642366	ABCG1	South shelf	0.760284	0.0370717	2.266651e-92	None	39706196_Hannah-M.-Smith_waist-hip_ratio_discovery
Robert F. Hillary	Generation Scotland	doi.org/10.1101/2023.11.02.23298000	Nov 3, 2023	C-reactive protein (CRP) levels	None	Basic model	None	C-reactive protein (CRP) levels	DNA methylation	Age, Sex, Cell composition (reference based), Batch effects	mg/L	Beta values	Illumina HumanMethylationEPIC	Whole blood	None	17936	1	Adults	Both	European	cg27243685	chr21:43642366	21	43642366	ABCG1	South shelf	5.4	0.273	1.1e-84	Basic_Model	Robert-F.-Hillary_c-reactive_protein__crp__levels_basic_model
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	Body fat	EFO_0007800	sensitivity	None	DNA methylation	Body fat	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	%	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg27243685	chr21:43642366	21	43642366	ABCG1	South shelf	0.81949	0.0428396	9.841692e-81	None	39706196_Hannah-M.-Smith_body_fat_sensitivity
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04004	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P04004	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg27243685	chr21:43642366	21	43642366	ABCG1	South shelf	0.17819	0.00988458	7.14066e-72	P04004	41361833_Josephine_Robertson_P04004_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04004	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04004	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg27243685	chr21:43642366	21	43642366	ABCG1	South shelf	0.146564	0.00816741	3.028462e-71	P04004	41361833_Josephine_Robertson_P04004_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01024	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01024	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg27243685	chr21:43642366	21	43642366	ABCG1	South shelf	0.142789	0.00817197	1.114117e-67	P01024	41361833_Josephine_Robertson_P01024_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02647	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P02647	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg27243685	chr21:43642366	21	43642366	ABCG1	South shelf	-0.154066	0.00883418	1.972744e-67	P02647	41361833_Josephine_Robertson_P02647_OSCA_model_2
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	Waist-hip ratio	EFO_0004343	sensitivity	None	DNA methylation	Waist-hip ratio	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	None	Illumina HumanMethylationEPIC	Whole blood	None	17304	1	Adults	Both	European	cg27243685	chr21:43642366	21	43642366	ABCG1	South shelf	0.727742	0.0427768	2.217486e-64	None	39706196_Hannah-M.-Smith_waist-hip_ratio_sensitivity
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04004	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P04004	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg27243685	chr21:43642366	21	43642366	ABCG1	South shelf	0.143514	0.00868582	8.907814e-61	P04004	41361833_Josephine_Robertson_P04004_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02647	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02647	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg27243685	chr21:43642366	21	43642366	ABCG1	South shelf	-0.12137	0.00819553	2.891825e-49	P02647	41361833_Josephine_Robertson_P02647_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P18428	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P18428	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg27243685	chr21:43642366	21	43642366	ABCG1	South shelf	0.123183	0.00880742	3.632011e-44	P18428	41361833_Josephine_Robertson_P18428_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	Q13790	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	Q13790	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg27243685	chr21:43642366	21	43642366	ABCG1	South shelf	-0.124295	0.00889748	4.574078999999999e-44	Q13790	41361833_Josephine_Robertson_Q13790_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P08603	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P08603	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg27243685	chr21:43642366	21	43642366	ABCG1	South shelf	0.121581	0.00888493	2.304743e-42	P08603	41361833_Josephine_Robertson_P08603_OSCA_model_2
Robert F Hillary	Generation Scotland	10.1101/2023.01.10.23284387	9/6/2023	Incident Type 2 Diabetes	None	Basic model	https://doi.org/10.5281/zenodo.8021411	DNA methylation	Incident Type 2 Diabetes	Age, Sex, Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	None	17749	1	Adults (18-65y)	Both	European	cg27243685	chr21:43642366	21	43642366	ABCG1	South shelf	0.1	0.00772	4.6e-41	None	Robert-F-Hillary_Incident_Type_2_Diabetes_Basic_model
Sayols-Baixeras S	-	28173150	2016-09-15	Serum triglycerides	EFO_0004530, CHEBI_17855	Replication adjusted for surrogate variables	Table S1	Serum triglycerides	DNA methylation	Age, sex, smoking, cell counts and technical covariates	mg/dl	M values	Illumina HumanMethylation450	Whole blood	Triglycerides levels were log-transformed	2542	1	66.3	Both	None	cg27243685	chr21:43642366	21	43642366	ABCG1	South shelf	0.065	0.005	2.6e-38	-	28173150_serum_triglycerides_replication_adjusted_for_surrogate_variables
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01008	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P01008	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg27243685	chr21:43642366	21	43642366	ABCG1	South shelf	-0.115166	0.00890288	4.5628489999999994e-38	P01008	41361833_Josephine_Robertson_P01008_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	Q13790	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	Q13790	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg27243685	chr21:43642366	21	43642366	ABCG1	South shelf	-0.105062	0.00821088	2.750145e-37	Q13790	41361833_Josephine_Robertson_Q13790_OSCA_model_1
Robert F Hillary	Generation Scotland	10.1101/2023.01.10.23284387	9/6/2023	Prevalent Type 2 Diabetes (Self-report)	None	Basic model	https://doi.org/10.5281/zenodo.8021411	DNA methylation	Prevalent Type 2 Diabetes (Self-report)	Age, Sex, Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	None	18005	1	Adults (18-65y)	Both	European	cg27243685	chr21:43642366	21	43642366	ABCG1	South shelf	0.22	0.0172	3.5e-37	None	Robert-F-Hillary_Prevalent_Type_2_Diabetes_(Self-report)_Basic_model
Yao C	FHS, KORA F4, BLSA, InCHIANTI	33752734	2021-03-22	Gene expression of Affymetrix ID: 3922444 (gene symbol: ABCG1)	None	Meta-analysis	Table S6	DNA methylation	Gene expression of Affymetrix ID: 3922444 (gene symbol: ABCG1)	Age, sex, cell composition (reference based), batch effects	Beta Values	None	Illumina HumanMethylation450	Whole blood	None	4170	1	Adults	Both	Unclear	cg27243685	chr21:43642366	21	43642366	ABCG1	South shelf	None	None	1.3e-36	None	33752734_Yao-C_gene_expression_of_affymetrix_id__3922444__gene_symbol__abcg1__meta-analysis
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P43652	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P43652	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg27243685	chr21:43642366	21	43642366	ABCG1	South shelf	0.103247	0.00821245	4.619046e-36	P43652	41361833_Josephine_Robertson_P43652_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01024	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P01024	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg27243685	chr21:43642366	21	43642366	ABCG1	South shelf	0.118179	0.00940502	5.012107e-36	P01024	41361833_Josephine_Robertson_P01024_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01024	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P01024	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg27243685	chr21:43642366	21	43642366	ABCG1	South shelf	0.0994351	0.00825035	2.712135e-33	P01024	41361833_Josephine_Robertson_P01024_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	Q15848	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	Q15848	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg27243685	chr21:43642366	21	43642366	ABCG1	South shelf	-0.103134	0.00891704	8.343626e-31	Q15848	41361833_Josephine_Robertson_Q15848_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P43652	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P43652	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg27243685	chr21:43642366	21	43642366	ABCG1	South shelf	0.103044	0.00891374	8.921322e-31	P43652	41361833_Josephine_Robertson_P43652_OSCA_model_2
Wahl S	-	28002404	2017-01-05	Body mass index	EFO_0004340	Discovery and replication	Table S3	Body mass index	DNA methylation	Age, sex, smoking, physical activity index, alcohol consumption, cell counts and technical covariates	kg/m2	Beta values	Illumina HumanMethylation450	Whole blood	Weighted Z-test meta-analysis	10238	13	54.5	Both	European,South Asian	cg27243685	chr21:43642366	21	43642366	ABCG1	South shelf	-	-	1.3000000000000001e-30	-	28002404_body_mass_index_discovery_and_replication
Sayols-Baixeras S	-	28173150	2016-09-15	Serum high-density lipoprotein cholesterol	EFO_0004612, CHEBI_47775	Replication adjusted for surrogate variables	Table S1	Serum high-density lipoprotein cholesterol	DNA methylation	Age, sex, smoking, cell counts and technical covariates	mg/dl	M values	Illumina HumanMethylation450	Whole blood	-	2542	1	66.3	Both	None	cg27243685	chr21:43642366	21	43642366	ABCG1	South shelf	-4.54	0.397	2.8000000000000002e-30	-	28173150_serum_highdensity_lipoprotein_cholesterol_replication_adjusted_for_surrogate_variables
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	Glucose	EFO_0004468	sensitivity	None	DNA methylation	Glucose	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	mmol/L	Illumina HumanMethylationEPIC	Whole blood	None	17908	1	Adults	Both	European	cg27243685	chr21:43642366	21	43642366	ABCG1	South shelf	0.484989	0.0425123	4.83348e-30	None	39706196_Hannah-M.-Smith_glucose_sensitivity
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P08603	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P08603	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg27243685	chr21:43642366	21	43642366	ABCG1	South shelf	0.0933636	0.00822051	9.072757e-30	P08603	41361833_Josephine_Robertson_P08603_OSCA_model_1
Sayols-Baixeras S	-	28173150	2016-09-15	Serum triglycerides	EFO_0004530, CHEBI_17855	Replication	Table S1	Serum triglycerides	DNA methylation	Age, sex, smoking, cell counts and technical covariates	mg/dl	M values	Illumina HumanMethylation450	Whole blood	Triglycerides levels were log-transformed	2542	1	66.3	Both	None	cg27243685	chr21:43642366	21	43642366	ABCG1	South shelf	0.047	0.004	6.7e-28	-	28173150_serum_triglycerides_replication
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02647	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P02647	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg27243685	chr21:43642366	21	43642366	ABCG1	South shelf	-0.0940486	0.0086624	2.344705e-27	P02647	41361833_Josephine_Robertson_P02647_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00740	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P00740	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg27243685	chr21:43642366	21	43642366	ABCG1	South shelf	0.0957085	0.00890648	7.795134e-27	P00740	41361833_Josephine_Robertson_P00740_OSCA_model_2
Hedman AK	-	28213390	2017-02-17	Serum triglycerides	EFO_0004530, CHEBI_17855	Discovery	Table S5	DNA methylation	Serum triglycerides	Age, sex, cell counts and technical covariates	Beta values	mg/dl	Illumina HumanMethylation450	Whole blood	-	2306	2	68	Both	None	cg27243685	chr21:43642366	21	43642366	ABCG1	South shelf	0.0122234	0.0011635	8.12e-26	-	28213390_serum_triglycerides_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01008	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01008	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg27243685	chr21:43642366	21	43642366	ABCG1	South shelf	-0.0865281	0.0082256	8.6904e-26	P01008	41361833_Josephine_Robertson_P01008_OSCA_model_1
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	Glucose	EFO_0004468	discovery	None	DNA methylation	Glucose	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	mmol/L	Illumina HumanMethylationEPIC	Whole blood	None	17908	1	Adults	Both	European	cg27243685	chr21:43642366	21	43642366	ABCG1	South shelf	0.382307	0.0367445	2.792712e-25	None	39706196_Hannah-M.-Smith_glucose_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06396	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P06396	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg27243685	chr21:43642366	21	43642366	ABCG1	South shelf	-0.0926907	0.00891458	3.109961e-25	P06396	41361833_Josephine_Robertson_P06396_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01742	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P01742	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg27243685	chr21:43642366	21	43642366	ABCG1	South shelf	0.0916573	0.00887642	6.547387e-25	P01742	41361833_Josephine_Robertson_P01742_OSCA_model_2
Hedman AK	-	28213390	2017-02-17	Serum triglycerides	EFO_0004530, CHEBI_17855	Discovery and replication	Table S5	DNA methylation	Serum triglycerides	Age, sex, cell counts and technical covariates	Beta values	mg/dl	Illumina HumanMethylation450	Whole blood	Inverse variance weighted fixed-effect meta-analysis	4261	5	65	Both	None	cg27243685	chr21:43642366	21	43642366	ABCG1	South shelf	0.0081344	0.0007955	1.52e-24	-	28213390_serum_triglycerides_discovery_and_replication
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01023	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P01023	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg27243685	chr21:43642366	21	43642366	ABCG1	South shelf	-0.0904292	0.00889177	3.2484149999999998e-24	P01023	41361833_Josephine_Robertson_P01023_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	Q15848	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	Q15848	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg27243685	chr21:43642366	21	43642366	ABCG1	South shelf	-0.105469	0.0103706	3.250776e-24	Q15848	41361833_Josephine_Robertson_Q15848_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06727	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P06727	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg27243685	chr21:43642366	21	43642366	ABCG1	South shelf	-0.0902339	0.0089213	5.7141039999999995e-24	P06727	41361833_Josephine_Robertson_P06727_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	Q15848	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	Q15848	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg27243685	chr21:43642366	21	43642366	ABCG1	South shelf	-0.0828963	0.00822815	8.540789e-24	Q15848	41361833_Josephine_Robertson_Q15848_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	Q08380	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	Q08380	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg27243685	chr21:43642366	21	43642366	ABCG1	South shelf	0.0892602	0.00893062	1.9080260000000002e-23	Q08380	41361833_Josephine_Robertson_Q08380_OSCA_model_2
Wahl S	-	28002404	2017-01-05	Body mass index	EFO_0004340	European ancestry discovery	Table S3	Body mass index	DNA methylation	Age, sex, smoking, physical activity index, alcohol consumption, cell counts and technical covariates	kg/m2	Beta values	Illumina HumanMethylation450	Whole blood	-	2707	3	57.9	Both	European	cg27243685	chr21:43642366	21	43642366	ABCG1	South shelf	44.78	4.58	1.4000000000000002e-22	-	28002404_body_mass_index_european_ancestry_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P20742	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P20742	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg27243685	chr21:43642366	21	43642366	ABCG1	South shelf	-0.0864941	0.00890897	3.23118e-22	P20742	41361833_Josephine_Robertson_P20742_OSCA_model_2
Sayols-Baixeras S	-	28173150	2016-09-15	Serum high-density lipoprotein cholesterol	EFO_0004612, CHEBI_47775	Replication	Table S1	Serum high-density lipoprotein cholesterol	DNA methylation	Age, sex, smoking, cell counts and technical covariates	mg/dl	M values	Illumina HumanMethylation450	Whole blood	-	2542	1	66.3	Both	None	cg27243685	chr21:43642366	21	43642366	ABCG1	South shelf	-3.218	0.334	5.1e-22	-	28173150_serum_highdensity_lipoprotein_cholesterol_replication
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P18428	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P18428	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg27243685	chr21:43642366	21	43642366	ABCG1	South shelf	0.0847632	0.00884599	1.100717e-21	P18428	41361833_Josephine_Robertson_P18428_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P55056	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P55056	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg27243685	chr21:43642366	21	43642366	ABCG1	South shelf	0.0784317	0.00823114	1.8381699999999998e-21	P55056	41361833_Josephine_Robertson_P55056_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O14791	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	O14791	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg27243685	chr21:43642366	21	43642366	ABCG1	South shelf	0.0849386	0.0089298	2.159586e-21	O14791	41361833_Josephine_Robertson_O14791_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P05546	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P05546	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg27243685	chr21:43642366	21	43642366	ABCG1	South shelf	0.0844733	0.00890939	2.887338e-21	P05546	41361833_Josephine_Robertson_P05546_OSCA_model_2
Demerath EW	-	25935004	2015-08-01	Body mass index	EFO_0004340	Meta-analysis	Table 2	DNA methylation	Body mass index	Age, sex, smoking, study centre, alcohol consumption, education, household income, physical activity, cell counts and technical covariates	Beta values	kg/m2	Illumina HumanMethylation450	Leukocytes, whole blood and CD4+ T cells	Regression coefficient per 1 SD of body mass index	5464	4	59.6	Both	European,African	cg27243685	chr21:43642366	21	43642366	ABCG1	South shelf	-	-	4.230000000000001e-21	-	25935004_body_mass_index_metaanalysis
Wahl S	-	28002404	2017-01-05	Body mass index	EFO_0004340	All ancestry discovery	Table S3	Body mass index	DNA mehtylation	Age, sex, smoking, physical activity index, alcohol consumption, cell counts and technical covariates	kg/m2	Beta values	Illumina HumanMethylation450	Whole blood	-	5387	4	54.5	Both	European,South Asian	cg27243685	chr21:43642366	21	43642366	ABCG1	South shelf	31	3.1	8.2e-21	-	28002404_body_mass_index_all_ancestry_discovery
Hedman AK	-	28213390	2017-02-17	Serum high-density lipoprotein cholesterol	EFO_0004612, CHEBI_47775	Discovery and replication	Table S4	DNA methylation	Serum high-density lipoprotein cholesterol	Age, sex, cell counts and technical covariates	Beta values	mg/dl	Illumina HumanMethylation450	Whole blood	Inverse variance weighted fixed-effect meta-analysis	3889	4	63	Both	None	cg27243685	chr21:43642366	21	43642366	ABCG1	South shelf	-0.0002449	2.64e-05	2.01e-20	-	28213390_serum_highdensity_lipoprotein_cholesterol_discovery_and_replication
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P14151	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P14151	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg27243685	chr21:43642366	21	43642366	ABCG1	South shelf	-0.0815442	0.00892441	7.234841999999999e-20	P14151	41361833_Josephine_Robertson_P14151_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	Q15848	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	Q15848	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg27243685	chr21:43642366	21	43642366	ABCG1	South shelf	-0.0827291	0.00906024	7.658321e-20	Q15848	41361833_Josephine_Robertson_Q15848_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01019	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P01019	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg27243685	chr21:43642366	21	43642366	ABCG1	South shelf	0.09421	0.0103578	1.060306e-19	P01019	41361833_Josephine_Robertson_P01019_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	Q08380	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	Q08380	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg27243685	chr21:43642366	21	43642366	ABCG1	South shelf	0.0747286	0.00823349	1.265419e-19	Q08380	41361833_Josephine_Robertson_Q08380_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O14791	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	O14791	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg27243685	chr21:43642366	21	43642366	ABCG1	South shelf	0.0942733	0.0103911	1.308433e-19	O14791	41361833_Josephine_Robertson_O14791_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01023	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01023	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg27243685	chr21:43642366	21	43642366	ABCG1	South shelf	-0.074155	0.00823384	2.3933379999999996e-19	P01023	41361833_Josephine_Robertson_P01023_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02647	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P02647	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg27243685	chr21:43642366	21	43642366	ABCG1	South shelf	-0.0889553	0.00987992	2.448541e-19	P02647	41361833_Josephine_Robertson_P02647_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00747	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P00747	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg27243685	chr21:43642366	21	43642366	ABCG1	South shelf	0.0931539	0.0103575	2.6750919999999997e-19	P00747	41361833_Josephine_Robertson_P00747_OSCA_model_4
Robert F Hillary	Generation Scotland	10.1101/2023.01.10.23284387	9/6/2023	Incident Type 2 Diabetes	None	Fully-adjusted model	https://doi.org/10.5281/zenodo.8021411	DNA methylation	Incident Type 2 Diabetes	Age, Sex, Smoking, Cell composition (reference based), Ancestry (genomic PCs), Body mass index, Socio-economic position, Education, Alcohol consumption	M values	None	Illumina HumanMethylationEPIC	Whole blood	None	13971	1	Adults (18-65y)	Both	European	cg27243685	chr21:43642366	21	43642366	ABCG1	South shelf	0.075	0.00837	2.9e-19	None	Robert-F-Hillary_Incident_Type_2_Diabetes_Fully-adjusted_model
Robert F Hillary	Generation Scotland	10.1101/2023.01.10.23284387	9/6/2023	Prevalent Ischemic Heart Disease (Self-report)	None	Basic model	https://doi.org/10.5281/zenodo.8021411	DNA methylation	Prevalent Ischemic Heart Disease (Self-report)	Age, Sex, Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	None	18059	1	Adults (18-65y)	Both	European	cg27243685	chr21:43642366	21	43642366	ABCG1	South shelf	0.16	0.0185	4.6e-19	None	Robert-F-Hillary_Prevalent_Ischemic_Heart_Disease_(Self-report)_Basic_model
Hedman AK	-	28213390	2017-02-17	Serum high-density lipoprotein cholesterol	EFO_0004612, CHEBI_47775	Discovery	Table S4	DNA methylation	Serum high-density lipoprotein cholesterol	Age, sex, cell counts and technical covariates	Beta values	mg/dl	Illumina HumanMethylation450	Whole blood	-	2306	2	68	Both	None	cg27243685	chr21:43642366	21	43642366	ABCG1	South shelf	-0.0002816	3.18e-05	9.34e-19	-	28213390_serum_highdensity_lipoprotein_cholesterol_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P55056	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P55056	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg27243685	chr21:43642366	21	43642366	ABCG1	South shelf	0.0919022	0.0104107	1.188619e-18	P55056	41361833_Josephine_Robertson_P55056_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01042	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P01042	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg27243685	chr21:43642366	21	43642366	ABCG1	South shelf	0.0916249	0.0103918	1.306106e-18	P01042	41361833_Josephine_Robertson_P01042_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O14791	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	O14791	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg27243685	chr21:43642366	21	43642366	ABCG1	South shelf	0.072552	0.00823481	1.385017e-18	O14791	41361833_Josephine_Robertson_O14791_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O75882	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	O75882	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg27243685	chr21:43642366	21	43642366	ABCG1	South shelf	0.0722809	0.00823497	1.8566710000000002e-18	O75882	41361833_Josephine_Robertson_O75882_OSCA_model_1
Gomez-Alonso MDC	KORA F4	33413638	2021-01-07	XS-VLDL-TG_pct	None	Meta-analysis	Table S2	DNA methylation	XS-VLDL-TG_pct	Age, sex, smoking, body mass index, CRP, HbA1c, alcohol consumption, lipid-lowering drugs, hypertension, history of myocardial infarction, level of physical activity, cell composition (reference based)	Beta Values	%	Illumina HumanMethylation450	Whole blood	Triglycerides to total lipids ratio in very small VLDL	5414	4	Adults	Both	European	cg27243685	chr21:43642366	21	43642366	ABCG1	South shelf	1.89	0.217	2.8e-18	None	33413638_Gomez-Alonso-MDC_xs-vldl-tg_pct_meta-analysis
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P14151	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P14151	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg27243685	chr21:43642366	21	43642366	ABCG1	South shelf	-0.0717482	0.00823529	3.292802e-18	P14151	41361833_Josephine_Robertson_P14151_OSCA_model_1
Gomez-Alonso MDC	KORA F4	33413638	2021-01-07	M-VLDL-TG	None	Meta-analysis	Table S2	DNA methylation	M-VLDL-TG	Age, sex, smoking, body mass index, CRP, HbA1c, alcohol consumption, lipid-lowering drugs, hypertension, history of myocardial infarction, level of physical activity, cell composition (reference based)	Beta Values	mmol/L	Illumina HumanMethylation450	Whole blood	Triglycerides in medium VLDL	5414	4	Adults	Both	European	cg27243685	chr21:43642366	21	43642366	ABCG1	South shelf	5.1	0.59	4e-18	None	33413638_Gomez-Alonso-MDC_m-vldl-tg_meta-analysis
Gomez-Alonso MDC	KORA F4	33413638	2021-01-07	S-VLDL-CE_pct	None	Meta-analysis	Table S2	DNA methylation	S-VLDL-CE_pct	Age, sex, smoking, body mass index, CRP, HbA1c, alcohol consumption, lipid-lowering drugs, hypertension, history of myocardial infarction, level of physical activity, cell composition (reference based)	Beta Values	%	Illumina HumanMethylation450	Whole blood	Cholesterol esters to total lipids ratio in small VLDL	5414	4	Adults	Both	European	cg27243685	chr21:43642366	21	43642366	ABCG1	South shelf	-1.55	0.179	4.4e-18	None	33413638_Gomez-Alonso-MDC_s-vldl-ce_pct_meta-analysis
Gomez-Alonso MDC	KORA F4	33413638	2021-01-07	S-VLDL-C_pct	None	Meta-analysis	Table S2	DNA methylation	S-VLDL-C_pct	Age, sex, smoking, body mass index, CRP, HbA1c, alcohol consumption, lipid-lowering drugs, hypertension, history of myocardial infarction, level of physical activity, cell composition (reference based)	Beta Values	%	Illumina HumanMethylation450	Whole blood	Total cholesterol to total lipids ratio in small VLDL	5414	4	Adults	Both	European	cg27243685	chr21:43642366	21	43642366	ABCG1	South shelf	-1.09	0.126	4.8e-18	None	33413638_Gomez-Alonso-MDC_s-vldl-c_pct_meta-analysis
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg27243685	chr21:43642366	21	43642366	ABCG1	South shelf	-0.0713626	0.00823552	4.972117e-18	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_1
Hedman AK	-	28213390	2017-02-17	Serum triglycerides	EFO_0004530, CHEBI_17855	Discovery adjusted for BMI	Table S9	DNA methylation	Serum triglycerides	Age, sex, body mass index, cell counts and technical covariates	Beta values	mg/dl	Illumina HumanMethylation450	Whole blood	-	2306	2	68	Both	None	cg27243685	chr21:43642366	21	43642366	ABCG1	South shelf	0.010416	0.0012039	5.08e-18	-	28213390_serum_triglycerides_discovery_adjusted_for_bmi
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P55056	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P55056	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg27243685	chr21:43642366	21	43642366	ABCG1	South shelf	0.0771617	0.00893529	6.436446e-18	P55056	41361833_Josephine_Robertson_P55056_OSCA_model_2
Gomez-Alonso MDC	KORA F4	33413638	2021-01-07	VLDL-TG	None	Meta-analysis	Table S2	DNA methylation	VLDL-TG	Age, sex, smoking, body mass index, CRP, HbA1c, alcohol consumption, lipid-lowering drugs, hypertension, history of myocardial infarction, level of physical activity, cell composition (reference based)	Beta Values	mmol/L	Illumina HumanMethylation450	Whole blood	Triglycerides in VLDL	5414	4	Adults	Both	European	cg27243685	chr21:43642366	21	43642366	ABCG1	South shelf	4.4	0.51	7.3e-18	None	33413638_Gomez-Alonso-MDC_vldl-tg_meta-analysis
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P20742	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P20742	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg27243685	chr21:43642366	21	43642366	ABCG1	South shelf	-0.070989	0.00823574	7.396122e-18	P20742	41361833_Josephine_Robertson_P20742_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P36955	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P36955	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg27243685	chr21:43642366	21	43642366	ABCG1	South shelf	0.0768838	0.00894152	8.883892e-18	P36955	41361833_Josephine_Robertson_P36955_OSCA_model_2
Hedman AK	-	28213390	2017-02-17	Serum triglycerides	EFO_0004530, CHEBI_17855	Discovery and replication adjusted for BMI	Table S9	DNA methylation	Serum triglycerides	Age, sex, body mass index, cell counts and technical covariates	Beta values	mg/dl	Illumina HumanMethylation450	Whole blood	Inverse variance weighted fixed-effect meta-analysis	4261	5	65	Both	None	cg27243685	chr21:43642366	21	43642366	ABCG1	South shelf	0.0071	8e-04	1.63e-17	-	28213390_serum_triglycerides_discovery_and_replication_adjusted_for_bmi
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P18428	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P18428	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg27243685	chr21:43642366	21	43642366	ABCG1	South shelf	0.0856706	0.0100751	2.0208430000000002e-17	P18428	41361833_Josephine_Robertson_P18428_OSCA_model_4
Gomez-Alonso MDC	KORA F4	33413638	2021-01-07	S-VLDL-TG	None	Meta-analysis	Table S2	DNA methylation	S-VLDL-TG	Age, sex, smoking, body mass index, CRP, HbA1c, alcohol consumption, lipid-lowering drugs, hypertension, history of myocardial infarction, level of physical activity, cell composition (reference based)	Beta Values	mmol/L	Illumina HumanMethylation450	Whole blood	Triglycerides in small VLDL	5414	4	Adults	Both	European	cg27243685	chr21:43642366	21	43642366	ABCG1	South shelf	3.7	0.44	4.8e-17	None	33413638_Gomez-Alonso-MDC_s-vldl-tg_meta-analysis
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	Q13790	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	Q13790	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg27243685	chr21:43642366	21	43642366	ABCG1	South shelf	-0.0732952	0.00882932	1.118617e-16	Q13790	41361833_Josephine_Robertson_Q13790_OSCA_model_3
Robert F Hillary	Generation Scotland	10.1101/2023.01.10.23284387	9/6/2023	Prevalent Type 2 Diabetes (Self-report)	None	Fully-adjusted model	https://doi.org/10.5281/zenodo.8021411	DNA methylation	Prevalent Type 2 Diabetes (Self-report)	Age, Sex, Cell composition (reference based), Ancestry (genomic PCs), Body mass index, Socio-economic position, Education, Alcohol consumption	M values	None	Illumina HumanMethylationEPIC	Whole blood	None	14350	1	Adults (18-65y)	Both	European	cg27243685	chr21:43642366	21	43642366	ABCG1	South shelf	0.15	0.0184	1.7e-16	None	Robert-F-Hillary_Prevalent_Type_2_Diabetes_(Self-report)_Fully-adjusted_model
Braun KVE	-	28194238	2016-06-16	High-density lipoprotein cholesterol	EFO_0004612, CHEBI_47775	Discovery and replication	Table S1	DNA methylation	High-density lipoprotein cholesterol	Age, sex, smoking, cell counts and technical covariates	Beta values	mmol/l	Illumina HumanMethylation450	Whole blood	-	1485	2	64	Both	None	cg27243685	chr21:43642366	21	43642366	ABCG1	South shelf	-0.0105	0.0013	2.79e-16	-	28194238_highdensity_lipoprotein_cholesterol_discovery_and_replication
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06727	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P06727	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg27243685	chr21:43642366	21	43642366	ABCG1	South shelf	-0.0841293	0.0102977	3.341817e-16	P06727	41361833_Josephine_Robertson_P06727_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P43652	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P43652	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg27243685	chr21:43642366	21	43642366	ABCG1	South shelf	0.0822542	0.0101704	6.560266e-16	P43652	41361833_Josephine_Robertson_P43652_OSCA_model_4
Robert F. Hillary	Generation Scotland	doi.org/10.1101/2023.11.02.23298000	Nov 3, 2023	C-reactive protein (CRP) levels	None	Fully-adjusted model	None	C-reactive protein (CRP) levels	DNA methylation	Age, Sex, Smoking, Cell composition (reference based), Batch effects, Ancestry (genomic PCs), Body mass index, Socio-economic position, Education, Alcohol consumption	mg/L	Beta values	Illumina HumanMethylationEPIC	Whole blood	None	14040	1	Adults	Both	European	cg27243685	chr21:43642366	21	43642366	ABCG1	South shelf	2.3	0.289	7.1e-16	Fully_Adjusted_Model	Robert-F.-Hillary_c-reactive_protein__crp__levels_fully-adjusted_model
Gomez-Alonso MDC	KORA F4	33413638	2021-01-07	M-VLDL-P	None	Meta-analysis	Table S2	DNA methylation	M-VLDL-P	Age, sex, smoking, body mass index, CRP, HbA1c, alcohol consumption, lipid-lowering drugs, hypertension, history of myocardial infarction, level of physical activity, cell composition (reference based)	Beta Values	mol/L	Illumina HumanMethylation450	Whole blood	Concentration of medium VLDL particles	5414	4	Adults	Both	European	cg27243685	chr21:43642366	21	43642366	ABCG1	South shelf	4.1	0.52	0.000000000000001	None	33413638_Gomez-Alonso-MDC_m-vldl-p_meta-analysis
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02750	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02750	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg27243685	chr21:43642366	21	43642366	ABCG1	South shelf	-0.065651	0.00823876	0.000000000000001723005	P02750	41361833_Josephine_Robertson_P02750_OSCA_model_1
Mendelson MM	-	28095459	2017-01-17	Body mass index	EFO_0004340	Meta-analysis	Table S1	DNA methylation	Body mass index	Age, sex, cell counts and technical covariates	Beta values	kg/m2	Illumina HumanMethylation450	Whole blood	Weighted Z-test meta-analysis	3743	4	69.2	Both	European	cg27243685	chr21:43642366	21	43642366	ABCG1	South shelf	-	-	0.00000000000000229	-	28095459_body_mass_index_metaanalysis
Gomez-Alonso MDC	KORA F4	33413638	2021-01-07	Serum-TG	EFO_0004530	Meta-analysis	Table S2	DNA methylation	Serum-TG	Age, sex, smoking, body mass index, CRP, HbA1c, alcohol consumption, lipid-lowering drugs, hypertension, history of myocardial infarction, level of physical activity, cell composition (reference based)	Beta Values	mmol/L	Illumina HumanMethylation450	Whole blood	Serum total triglycerides	5414	4	Adults	Both	European	cg27243685	chr21:43642366	21	43642366	ABCG1	South shelf	3.1	0.39	0.0000000000000023	None	33413638_Gomez-Alonso-MDC_serum-tg_meta-analysis
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P18428	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P18428	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg27243685	chr21:43642366	21	43642366	ABCG1	South shelf	0.0652566	0.00823897	0.000000000000002535063	P18428	41361833_Josephine_Robertson_P18428_OSCA_model_1
Gomez-Alonso MDC	KORA F4	33413638	2021-01-07	M-VLDL-L	None	Meta-analysis	Table S2	DNA methylation	M-VLDL-L	Age, sex, smoking, body mass index, CRP, HbA1c, alcohol consumption, lipid-lowering drugs, hypertension, history of myocardial infarction, level of physical activity, cell composition (reference based)	Beta Values	mmol/L	Illumina HumanMethylation450	Whole blood	Total lipids in medium VLDL	5414	4	Adults	Both	European	cg27243685	chr21:43642366	21	43642366	ABCG1	South shelf	4	0.51	0.000000000000004	None	33413638_Gomez-Alonso-MDC_m-vldl-l_meta-analysis
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	C9JB55	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	C9JB55	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg27243685	chr21:43642366	21	43642366	ABCG1	South shelf	0.081948	0.0104446	0.000000000000004592381	C9JB55	41361833_Josephine_Robertson_C9JB55_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00742	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P00742	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg27243685	chr21:43642366	21	43642366	ABCG1	South shelf	0.0694356	0.00893877	0.000000000000008505699	P00742	41361833_Josephine_Robertson_P00742_OSCA_model_2
Braun KVE	-	28194238	2016-06-16	Triglycerides	EFO_0004530, CHEBI_17855	Discovery and replication	Table S1	DNA methylation	Triglycerides	Age, sex, smoking, cell counts and technical covariates	Beta values	mmol/l	Illumina HumanMethylation450	Whole blood	-	1485	2	64	Both	None	cg27243685	chr21:43642366	21	43642366	ABCG1	South shelf	0.0085	0.0011	0.0000000000000099	-	28194238_triglycerides_discovery_and_replication
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P35858	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P35858	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg27243685	chr21:43642366	21	43642366	ABCG1	South shelf	0.0800922	0.0103773	0.0000000000000125798	P35858	41361833_Josephine_Robertson_P35858_OSCA_model_4
Mendelson MM	-	28095459	2017-01-17	Body mass index	EFO_0004340	Framingham Heart Study Batch 2	Table S1	DNA methylation	Body mass index	Age, sex and technical covariates	-	kg/m2	Illumina HumanMethylation450	Whole blood	DNA methylation was inverse normally rank transformed	1935	1	67	Both	European	cg27243685	chr21:43642366	21	43642366	ABCG1	South shelf	0.0321	0.00411	0.0000000000000137	-	28095459_body_mass_index_framingham_heart_study_batch_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P36955	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P36955	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg27243685	chr21:43642366	21	43642366	ABCG1	South shelf	0.0633717	0.00823998	0.00000000000001555373	P36955	41361833_Josephine_Robertson_P36955_OSCA_model_1
Gomez-Alonso MDC	KORA F4	33413638	2021-01-07	L-VLDL-P	None	Meta-analysis	Table S2	DNA methylation	L-VLDL-P	Age, sex, smoking, body mass index, CRP, HbA1c, alcohol consumption, lipid-lowering drugs, hypertension, history of myocardial infarction, level of physical activity, cell composition (reference based)	Beta Values	mol/L	Illumina HumanMethylation450	Whole blood	Concentration of large VLDL particles	5414	4	Adults	Both	European	cg27243685	chr21:43642366	21	43642366	ABCG1	South shelf	9	1.17	0.000000000000017	None	33413638_Gomez-Alonso-MDC_l-vldl-p_meta-analysis
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06396	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P06396	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg27243685	chr21:43642366	21	43642366	ABCG1	South shelf	-0.0693285	0.00903058	0.00000000000001729963	P06396	41361833_Josephine_Robertson_P06396_OSCA_model_3
Demerath EW	-	25935004	2015-08-01	Body mass index	EFO_0004340	Replication	Table 2	DNA methylation	Body mass index	Age, sex, smoking, study centre and technical covariates	Beta values	kg/m2	Illumina HumanMethylation450	Whole blood and CD4+ T cells	Regression coefficient per 1 SD of body mass index	3368	3	61.7	Both	European	cg27243685	chr21:43642366	21	43642366	ABCG1	South shelf	-	-	0.0000000000000185	-	25935004_body_mass_index_replication
Gomez-Alonso MDC	KORA F4	33413638	2021-01-07	L-VLDL-L	None	Meta-analysis	Table S2	DNA methylation	L-VLDL-L	Age, sex, smoking, body mass index, CRP, HbA1c, alcohol consumption, lipid-lowering drugs, hypertension, history of myocardial infarction, level of physical activity, cell composition (reference based)	Beta Values	mmol/L	Illumina HumanMethylation450	Whole blood	Total lipids in large VLDL	5414	4	Adults	Both	European	cg27243685	chr21:43642366	21	43642366	ABCG1	South shelf	8.9	1.16	0.000000000000021	None	33413638_Gomez-Alonso-MDC_l-vldl-l_meta-analysis
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	C9JB55	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	C9JB55	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg27243685	chr21:43642366	21	43642366	ABCG1	South shelf	0.0690779	0.00912339	0.00000000000003908415	C9JB55	41361833_Josephine_Robertson_C9JB55_OSCA_model_3
Liu J	Rotterdam Study III-1, Rotterdam Study II-3 and Rotterdam Study III-2, Netherlands Twin Register, UK adult Twin registry	31197173	2013-06-19	fasting insulin	EFO_0004466	Base	Supplementary Data 1	DNA methylation	fasting insulin	Age, sex, smoking, cell composition (reference based), batch effects	Beta Values	log pmol/L	Illumina HumanMethylation450	whole blood	None	4808	4	Adults	Both	European	cg27243685	chr21:43642366	21	43642366	ABCG1	South shelf	3.32	0.44	0.00000000000004	4738	31197173_Liu-J_fasting_insulin_base
Gomez-Alonso MDC	KORA F4	33413638	2021-01-07	M-VLDL-PL	None	Meta-analysis	Table S2	DNA methylation	M-VLDL-PL	Age, sex, smoking, body mass index, CRP, HbA1c, alcohol consumption, lipid-lowering drugs, hypertension, history of myocardial infarction, level of physical activity, cell composition (reference based)	Beta Values	mmol/L	Illumina HumanMethylation450	Whole blood	Phospholipids in medium VLDL	5414	4	Adults	Both	European	cg27243685	chr21:43642366	21	43642366	ABCG1	South shelf	3.7	0.49	0.000000000000043	None	33413638_Gomez-Alonso-MDC_m-vldl-pl_meta-analysis
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O14791	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	O14791	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg27243685	chr21:43642366	21	43642366	ABCG1	South shelf	0.0686852	0.00908822	0.00000000000004348022	O14791	41361833_Josephine_Robertson_O14791_OSCA_model_3
Gomez-Alonso MDC	KORA F4	33413638	2021-01-07	M-VLDL-FC	None	Meta-analysis	Table S2	DNA methylation	M-VLDL-FC	Age, sex, smoking, body mass index, CRP, HbA1c, alcohol consumption, lipid-lowering drugs, hypertension, history of myocardial infarction, level of physical activity, cell composition (reference based)	Beta Values	mmol/L	Illumina HumanMethylation450	Whole blood	Free cholesterol in medium VLDL	5414	4	Adults	Both	European	cg27243685	chr21:43642366	21	43642366	ABCG1	South shelf	4.3	0.57	0.000000000000045	None	33413638_Gomez-Alonso-MDC_m-vldl-fc_meta-analysis
Gomez-Alonso MDC	KORA F4	33413638	2021-01-07	S-HDL-TG	None	Meta-analysis	Table S2	DNA methylation	S-HDL-TG	Age, sex, smoking, body mass index, CRP, HbA1c, alcohol consumption, lipid-lowering drugs, hypertension, history of myocardial infarction, level of physical activity, cell composition (reference based)	Beta Values	mmol/L	Illumina HumanMethylation450	Whole blood	Triglycerides in small HDL	5414	4	Adults	Both	European	cg27243685	chr21:43642366	21	43642366	ABCG1	South shelf	2	0.27	0.00000000000005	None	33413638_Gomez-Alonso-MDC_s-hdl-tg_meta-analysis
Gomez-Alonso MDC	KORA F4	33413638	2021-01-07	L-VLDL-TG	None	Meta-analysis	Table S2	DNA methylation	L-VLDL-TG	Age, sex, smoking, body mass index, CRP, HbA1c, alcohol consumption, lipid-lowering drugs, hypertension, history of myocardial infarction, level of physical activity, cell composition (reference based)	Beta Values	mmol/L	Illumina HumanMethylation450	Whole blood	Triglycerides in large VLDL	5414	4	Adults	Both	European	cg27243685	chr21:43642366	21	43642366	ABCG1	South shelf	10.3	1.38	0.000000000000078	None	33413638_Gomez-Alonso-MDC_l-vldl-tg_meta-analysis
Jiantao Ma	FHS	30796027	Feb 22, 2019	hepatic fat	EFO_0010821	Discovery	Table 1	DNA methylation	hepatic fat	Age, Sex, Cell composition (reference based), Batch effects	Beta values	None	Illumina HumanMethylation450	whole blood	None	1496	1	Adults	Both	European	cg27243685	chr21:43642366	21	43642366	ABCG1	South shelf	None	None	0.00000000000012	None	30796027_Jiantao-Ma_hepatic_fat_discovery
Gomez-Alonso MDC	KORA F4	33413638	2021-01-07	IDL.TG_pct	None	Meta-analysis	Table S2	DNA methylation	IDL.TG_pct	Age, sex, smoking, body mass index, CRP, HbA1c, alcohol consumption, lipid-lowering drugs, hypertension, history of myocardial infarction, level of physical activity, cell composition (reference based)	Beta Values	%	Illumina HumanMethylation450	Whole blood	Triglycerides to total lipids ratio in IDL	5414	4	Adults	Both	European	cg27243685	chr21:43642366	21	43642366	ABCG1	South shelf	1.72	0.23	0.00000000000014	None	33413638_Gomez-Alonso-MDC_idl_tg_pct_meta-analysis
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06396	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P06396	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg27243685	chr21:43642366	21	43642366	ABCG1	South shelf	-0.0610045	0.00824119	0.0000000000001410255	P06396	41361833_Josephine_Robertson_P06396_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P05546	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P05546	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg27243685	chr21:43642366	21	43642366	ABCG1	South shelf	0.0609031	0.00824124	0.0000000000001547124	P05546	41361833_Josephine_Robertson_P05546_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00742	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P00742	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg27243685	chr21:43642366	21	43642366	ABCG1	South shelf	0.0603515	0.00824152	0.0000000000002553725	P00742	41361833_Josephine_Robertson_P00742_OSCA_model_1
Pfeiffer L	-	25583993	2015-01-12	Triglycerides	EFO_0004530, CHEBI_17855	Discovery	Table 2	Triglycerides	DNA methylation	Age, sex, smoking, body mass index, alcohol consumption, physical activity, hypertension, history of MI, hemoglobin A1c, C-reactive protein, lipid-lowering drugs intake and cell counts	mg/dl	Beta values	Illumina HumanMethylation450	Whole blood	-	1776	1	61	Both	European	cg27243685	chr21:43642366	21	43642366	ABCG1	South shelf	0.064	0.009	0.000000000000324	-	25583993_triglycerides_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01042	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01042	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg27243685	chr21:43642366	21	43642366	ABCG1	South shelf	0.0599484	0.00824172	0.0000000000003672756	P01042	41361833_Josephine_Robertson_P01042_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P25311	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P25311	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg27243685	chr21:43642366	21	43642366	ABCG1	South shelf	-0.0596836	0.00824185	0.0000000000004657071	P25311	41361833_Josephine_Robertson_P25311_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06396	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P06396	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg27243685	chr21:43642366	21	43642366	ABCG1	South shelf	-0.0744537	0.010293	0.0000000000004943633	P06396	41361833_Josephine_Robertson_P06396_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00740	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P00740	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg27243685	chr21:43642366	21	43642366	ABCG1	South shelf	0.0649095	0.00899767	0.000000000000569773	P00740	41361833_Josephine_Robertson_P00740_OSCA_model_3
Gomez-Alonso MDC	KORA F4	33413638	2021-01-07	XS-VLDL-TG	None	Meta-analysis	Table S2	DNA methylation	XS-VLDL-TG	Age, sex, smoking, body mass index, CRP, HbA1c, alcohol consumption, lipid-lowering drugs, hypertension, history of myocardial infarction, level of physical activity, cell composition (reference based)	Beta Values	mmol/L	Illumina HumanMethylation450	Whole blood	Triglycerides in very small VLDL	5414	4	Adults	Both	European	cg27243685	chr21:43642366	21	43642366	ABCG1	South shelf	2.3	0.32	0.00000000000063	None	33413638_Gomez-Alonso-MDC_xs-vldl-tg_meta-analysis
Ma J	FHS, RS, CARDIA, MESA	30936141	2020-05-22	Hepatic Fat	EFO_0006506, EFO_0008421	Meta-analysis model 1	Table 1	DNA methylation	Hepatic Fat	Age, sex	Beta Values	Hounsfield units	Illumina HumanMethylation450	Whole blood	Model 1 = adjusted for sex + age	3400	4	Adults	Both	European	cg27243685	chr21:43642366	21	43642366	ABCG1	South shelf	None	None	0.00000000000068	None	30936141_Ma-J_hepatic_fat_meta-analysis_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00740	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P00740	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg27243685	chr21:43642366	21	43642366	ABCG1	South shelf	0.059245	0.00824207	0.0000000000006885846	P00740	41361833_Josephine_Robertson_P00740_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02787	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P02787	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg27243685	chr21:43642366	21	43642366	ABCG1	South shelf	0.0739707	0.0103494	0.0000000000009263646	P02787	41361833_Josephine_Robertson_P02787_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	Q13790	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	Q13790	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg27243685	chr21:43642366	21	43642366	ABCG1	South shelf	-0.072035	0.0101018	0.000000000001043839	Q13790	41361833_Josephine_Robertson_Q13790_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02787	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P02787	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg27243685	chr21:43642366	21	43642366	ABCG1	South shelf	0.0641957	0.00907373	0.000000000001563331	P02787	41361833_Josephine_Robertson_P02787_OSCA_model_3
Hedman AK	-	28213390	2017-02-17	Serum high-density lipoprotein cholesterol	EFO_0004612, CHEBI_47775	Discovery and replication adjusted for BMI	Table S8	DNA methylation	Serum high-density lipoprotein cholesterol	Age, sex, body mass index, cell counts and technical covariates	Beta values	mg/dl	Illumina HumanMethylation450	Whole blood	Inverse variance weighted fixed-effect meta-analysis	3889	4	65	Both	None	cg27243685	chr21:43642366	21	43642366	ABCG1	South shelf	-0.0001971	2.79e-05	0.00000000000168	-	28213390_serum_highdensity_lipoprotein_cholesterol_discovery_and_replication_adjusted_for_bmi
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O75882	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	O75882	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg27243685	chr21:43642366	21	43642366	ABCG1	South shelf	0.0629568	0.00891282	0.000000000001695229	O75882	41361833_Josephine_Robertson_O75882_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06727	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P06727	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg27243685	chr21:43642366	21	43642366	ABCG1	South shelf	-0.0582027	0.00824257	0.000000000001724524	P06727	41361833_Josephine_Robertson_P06727_OSCA_model_1
Ma J	FHS, RS, CARDIA, MESA	30936141	2020-05-22	Hepatic Fat	EFO_0006506, EFO_0008421	Meta-analysis model 2	Table 1	DNA methylation	Hepatic Fat	Age, sex	Beta Values	Hounsfield units	Illumina HumanMethylation450	Whole blood	Model 2 = model 1 + smoking + physical activity + alcohol consumption	3400	4	Adults	Both	European	cg27243685	chr21:43642366	21	43642366	ABCG1	South shelf	None	None	0.0000000000021	None	30936141_Ma-J_hepatic_fat_meta-analysis_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06727	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P06727	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg27243685	chr21:43642366	21	43642366	ABCG1	South shelf	-0.0634637	0.00902625	0.000000000002141025	P06727	41361833_Josephine_Robertson_P06727_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P10643	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P10643	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg27243685	chr21:43642366	21	43642366	ABCG1	South shelf	-0.0577513	0.00824279	0.000000000002554006	P10643	41361833_Josephine_Robertson_P10643_OSCA_model_1
Gomez-Alonso MDC	KORA F4	33413638	2021-01-07	S-HDL-TG_pct	None	Meta-analysis	Table S2	DNA methylation	S-HDL-TG_pct	Age, sex, smoking, body mass index, CRP, HbA1c, alcohol consumption, lipid-lowering drugs, hypertension, history of myocardial infarction, level of physical activity, cell composition (reference based)	Beta Values	%	Illumina HumanMethylation450	Whole blood	Triglycerides to total lipids ratio in small HDL	5414	4	Adults	Both	European	cg27243685	chr21:43642366	21	43642366	ABCG1	South shelf	1.9	0.28	0.0000000000037	None	33413638_Gomez-Alonso-MDC_s-hdl-tg_pct_meta-analysis
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	C9JB55	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	C9JB55	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg27243685	chr21:43642366	21	43642366	ABCG1	South shelf	0.0620634	0.00894513	0.000000000004136803	C9JB55	41361833_Josephine_Robertson_C9JB55_OSCA_model_2
Gomez-Alonso MDC	KORA F4	33413638	2021-01-07	S-VLDL-P	None	Meta-analysis	Table S2	DNA methylation	S-VLDL-P	Age, sex, smoking, body mass index, CRP, HbA1c, alcohol consumption, lipid-lowering drugs, hypertension, history of myocardial infarction, level of physical activity, cell composition (reference based)	Beta Values	mol/L	Illumina HumanMethylation450	Whole blood	Concentration of small VLDL particles	5414	4	Adults	Both	European	cg27243685	chr21:43642366	21	43642366	ABCG1	South shelf	2.3	0.33	0.0000000000042	None	33413638_Gomez-Alonso-MDC_s-vldl-p_meta-analysis
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	Total cholesterol	EFO_0004574	sensitivity	None	DNA methylation	Total cholesterol	Age,Sex,Smoking,Cell composition (reference based),Batch effects	Other	mmol/L	Illumina HumanMethylationEPIC	Whole blood	None	18270	1	Adults	Both	European	cg27243685	chr21:43642366	21	43642366	ABCG1	South shelf	-0.289497	0.0418671	0.000000000004844915	None	39706196_Hannah-M.-Smith_total_cholesterol_sensitivity
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01008	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P01008	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg27243685	chr21:43642366	21	43642366	ABCG1	South shelf	-0.0607767	0.00879307	0.00000000000497998	P01008	41361833_Josephine_Robertson_P01008_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02743	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P02743	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg27243685	chr21:43642366	21	43642366	ABCG1	South shelf	0.06168	0.00893831	0.000000000005389268	P02743	41361833_Josephine_Robertson_P02743_OSCA_model_2
Wahl S	-	28002404	2017-01-05	Body mass index	EFO_0004340	All ancestry replication	Table S3	Body mass index	DNA methylation	Age, sex, smoking, physical activity index, alcohol consumption, cell counts and technical covariates	kg/m2	Beta values	Illumina HumanMethylation450	Whole blood	-	4851	9	54.5	Both	European,South Asian	cg27243685	chr21:43642366	21	43642366	ABCG1	South shelf	17.4	2.5	0.0000000000067	-	28002404_body_mass_index_all_ancestry_replication
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P55056	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P55056	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg27243685	chr21:43642366	21	43642366	ABCG1	South shelf	0.062493	0.00909854	0.000000000006750847	P55056	41361833_Josephine_Robertson_P55056_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O95445	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	O95445	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg27243685	chr21:43642366	21	43642366	ABCG1	South shelf	-0.0608013	0.00894715	0.00000000001120226	O95445	41361833_Josephine_Robertson_O95445_OSCA_model_2
Demerath EW	-	25935004	2015-08-01	Waist circumference	EFO_0004342	Discovery	Table S5	DNA methylation	Waist circumference	Age, sex, smoking, study centre, alcohol consumption, education, household income, physical activity, cell counts and technical covariates	Beta values	cm	Illumina HumanMethylation450	Leukocytes	Regression coefficient per 1 SD of waist circumference	2097	1	56.2	Both	African	cg27243685	chr21:43642366	21	43642366	ABCG1	South shelf	0.0069	0.001	0.0000000000139	-	25935004_waist_circumference_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04114	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04114	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg27243685	chr21:43642366	21	43642366	ABCG1	South shelf	0.0555357	0.00824383	0.00000000001681315	P04114	41361833_Josephine_Robertson_P04114_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P51884	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P51884	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg27243685	chr21:43642366	21	43642366	ABCG1	South shelf	-0.0597621	0.00890943	0.00000000002049171	P51884	41361833_Josephine_Robertson_P51884_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02671	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02671	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg27243685	chr21:43642366	21	43642366	ABCG1	South shelf	-0.0550492	0.00824405	0.00000000002518762	P02671	41361833_Josephine_Robertson_P02671_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01742	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P01742	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg27243685	chr21:43642366	21	43642366	ABCG1	South shelf	0.0595615	0.00893137	0.00000000002671294	P01742	41361833_Josephine_Robertson_P01742_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P27169	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P27169	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg27243685	chr21:43642366	21	43642366	ABCG1	South shelf	-0.0594556	0.00892693	0.00000000002830959	P27169	41361833_Josephine_Robertson_P27169_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P14151	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P14151	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg27243685	chr21:43642366	21	43642366	ABCG1	South shelf	-0.060129	0.00905542	0.00000000003244639	P14151	41361833_Josephine_Robertson_P14151_OSCA_model_3
Hedman AK	-	28213390	2017-02-17	Serum high-density lipoprotein cholesterol	EFO_0004612, CHEBI_47775	Discovery adjusted for BMI	Table S7	DNA methylation	Serum high-density lipoprotein cholesterol	Age, sex, body mass index, cell counts and technical covariates	Beta values	mg/dl	Illumina HumanMethylation450	Whole blood	-	2306	2	68	Both	None	cg27243685	chr21:43642366	21	43642366	ABCG1	South shelf	-0.0002228	3.37e-05	0.0000000000372	-	28213390_serum_highdensity_lipoprotein_cholesterol_discovery_adjusted_for_bmi
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	Q08380	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	Q08380	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg27243685	chr21:43642366	21	43642366	ABCG1	South shelf	0.0594894	0.00902991	0.00000000004608617	Q08380	41361833_Josephine_Robertson_Q08380_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00747	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P00747	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg27243685	chr21:43642366	21	43642366	ABCG1	South shelf	0.0596893	0.00908949	0.00000000005312195	P00747	41361833_Josephine_Robertson_P00747_OSCA_model_3
Gomez-Alonso MDC	KORA F4	33413638	2021-01-07	S-VLDL-L	None	Meta-analysis	Table S2	DNA methylation	S-VLDL-L	Age, sex, smoking, body mass index, CRP, HbA1c, alcohol consumption, lipid-lowering drugs, hypertension, history of myocardial infarction, level of physical activity, cell composition (reference based)	Beta Values	mmol/L	Illumina HumanMethylation450	Whole blood	Total lipids in small VLDL	5414	4	Adults	Both	European	cg27243685	chr21:43642366	21	43642366	ABCG1	South shelf	2.1	0.33	0.000000000063	None	33413638_Gomez-Alonso-MDC_s-vldl-l_meta-analysis
Gomez-Alonso MDC	KORA F4	33413638	2021-01-07	S-VLDL-PL	None	Meta-analysis	Table S2	DNA methylation	S-VLDL-PL	Age, sex, smoking, body mass index, CRP, HbA1c, alcohol consumption, lipid-lowering drugs, hypertension, history of myocardial infarction, level of physical activity, cell composition (reference based)	Beta Values	mmol/L	Illumina HumanMethylation450	Whole blood	Phospholipids in small VLDL	5414	4	Adults	Both	European	cg27243685	chr21:43642366	21	43642366	ABCG1	South shelf	2	0.31	0.00000000009	None	33413638_Gomez-Alonso-MDC_s-vldl-pl_meta-analysis
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00740	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P00740	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg27243685	chr21:43642366	21	43642366	ABCG1	South shelf	0.0667953	0.0103028	0.00000000009267588	P00740	41361833_Josephine_Robertson_P00740_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O75882	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	O75882	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg27243685	chr21:43642366	21	43642366	ABCG1	South shelf	0.0671036	0.0103787	0.0000000001041432	O75882	41361833_Josephine_Robertson_O75882_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P43652	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P43652	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg27243685	chr21:43642366	21	43642366	ABCG1	South shelf	0.0573094	0.00889156	0.0000000001189188	P43652	41361833_Josephine_Robertson_P43652_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P14151	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P14151	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg27243685	chr21:43642366	21	43642366	ABCG1	South shelf	-0.0661119	0.0103009	0.0000000001422667	P14151	41361833_Josephine_Robertson_P14151_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01042	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P01042	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg27243685	chr21:43642366	21	43642366	ABCG1	South shelf	0.0582987	0.00910641	0.0000000001580834	P01042	41361833_Josephine_Robertson_P01042_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P05546	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P05546	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg27243685	chr21:43642366	21	43642366	ABCG1	South shelf	0.0573918	0.0090071	0.0000000001923521	P05546	41361833_Josephine_Robertson_P05546_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02748	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P02748	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg27243685	chr21:43642366	21	43642366	ABCG1	South shelf	-0.0643501	0.0101527	0.000000000239246	P02748	41361833_Josephine_Robertson_P02748_OSCA_model_4
Sayols-Baixeras S	-	28173150	2016-09-15	Serum triglycerides	EFO_0004530, CHEBI_17855	Discovery adjusted for surrogate variables	Table S1	Serum triglycerides	DNA methylation	Age, sex, smoking, cell counts and technical covariates	mg/dl	M values	Illumina HumanMethylation450	Whole blood	Triglycerides levels were log-transformed	645	1	63.2	Both	None	cg27243685	chr21:43642366	21	43642366	ABCG1	South shelf	0.061	0.01	0.00000000025	-	28173150_serum_triglycerides_discovery_adjusted_for_surrogate_variables
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01008	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P01008	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg27243685	chr21:43642366	21	43642366	ABCG1	South shelf	-0.0635173	0.0100711	0.0000000002929163	P01008	41361833_Josephine_Robertson_P01008_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01042	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P01042	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg27243685	chr21:43642366	21	43642366	ABCG1	South shelf	0.0561998	0.00892448	0.0000000003115904	P01042	41361833_Josephine_Robertson_P01042_OSCA_model_2
Gomez-Alonso MDC	KORA F4	33413638	2021-01-07	S-LDL-TG_pct	None	Meta-analysis	Table S2	DNA methylation	S-LDL-TG_pct	Age, sex, smoking, body mass index, CRP, HbA1c, alcohol consumption, lipid-lowering drugs, hypertension, history of myocardial infarction, level of physical activity, cell composition (reference based)	Beta Values	%	Illumina HumanMethylation450	Whole blood	Triglycerides to total lipids ratio in small LDL	5414	4	Adults	Both	European	cg27243685	chr21:43642366	21	43642366	ABCG1	South shelf	1.58	0.25	0.00000000038	None	33413638_Gomez-Alonso-MDC_s-ldl-tg_pct_meta-analysis
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01023	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P01023	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg27243685	chr21:43642366	21	43642366	ABCG1	South shelf	-0.0623631	0.00996743	0.000000000404176	P01023	41361833_Josephine_Robertson_P01023_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P10643	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P10643	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg27243685	chr21:43642366	21	43642366	ABCG1	South shelf	-0.0558422	0.0089316	0.0000000004159055	P10643	41361833_Josephine_Robertson_P10643_OSCA_model_2
Petersen A-K	KORA F4	24014485	2013-09-06	M35718_dihomo-linolenate_20:3n3_or_n6	EFO_0004727, EFO_0004725	snps as covariates model	Table S4	M35718_dihomo-linolenate_20:3n3_or_n6	DNA methylation	Age, sex, body mass index, cell composition (reference based), genotype	None	Beta Values	Illumina HumanMethylation450	Whole blood	used three nearby snps as covariates	1760	1	Adults	Both	European	cg27243685	chr21:43642366	21	43642366	ABCG1	South shelf	-0.93	0.189	0.00000000047	None	24014485_Petersen-A-K_m35718_dihomo-linolenate_20_3n3_or_n6_snps_as_covariates_model
Petersen A-K	KORA F4	24014485	2013-09-06	M35718_dihomo-linolenate_20:3n3_or_n6	EFO_0004727, EFO_0004725	no snps model	Table S2	M35718_dihomo-linolenate_20:3n3_or_n6	DNA methylation	Age, sex, body mass index, cell composition (reference based)	None	Beta Values	Illumina HumanMethylation450	Whole blood	None	1760	1	Adults	Both	European	cg27243685	chr21:43642366	21	43642366	ABCG1	South shelf	-0.93	0.187	0.00000000048	None	24014485_Petersen-A-K_m35718_dihomo-linolenate_20_3n3_or_n6_no_snps_model
Robert F Hillary	Generation Scotland	10.1101/2023.01.10.23284387	9/6/2023	Prevalent Ischemic Heart Disease (Self-report)	None	Fully-adjusted model	https://doi.org/10.5281/zenodo.8021411	DNA methylation	Prevalent Ischemic Heart Disease (Self-report)	Age, Sex, Cell composition (reference based), Ancestry (genomic PCs), Body mass index, Socio-economic position, Education, Alcohol consumption	M values	None	Illumina HumanMethylationEPIC	Whole blood	None	14391	1	Adults (18-65y)	Both	European	cg27243685	chr21:43642366	21	43642366	ABCG1	South shelf	0.12	0.0199	0.00000000059	None	Robert-F-Hillary_Prevalent_Ischemic_Heart_Disease_(Self-report)_Fully-adjusted_model
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P05546	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P05546	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg27243685	chr21:43642366	21	43642366	ABCG1	South shelf	0.0635457	0.0103122	0.0000000007363176	P05546	41361833_Josephine_Robertson_P05546_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01019	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P01019	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg27243685	chr21:43642366	21	43642366	ABCG1	South shelf	0.0557411	0.00910363	0.0000000009420165	P01019	41361833_Josephine_Robertson_P01019_OSCA_model_3
Wahl S	-	28002404	2017-01-05	Body mass index	EFO_0004340	European ancestry replication	Table S3	Body mass index	DNA methylation	Age, sex, smoking, physical activity index, alcohol consumption, cell counts and technical covariates	kg/m2	Beta values	Illumina HumanMethylation450	Whole blood	-	4195	8	54.6	Both	European	cg27243685	chr21:43642366	21	43642366	ABCG1	South shelf	11.92	1.96	0.0000000011	-	28002404_body_mass_index_european_ancestry_replication
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	B1AHL2	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	B1AHL2	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg27243685	chr21:43642366	21	43642366	ABCG1	South shelf	-0.0535853	0.00893384	0.000000002044383	B1AHL2	41361833_Josephine_Robertson_B1AHL2_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	Q08380	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	Q08380	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg27243685	chr21:43642366	21	43642366	ABCG1	South shelf	0.0620372	0.0103465	0.00000000207052	Q08380	41361833_Josephine_Robertson_Q08380_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00742	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P00742	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg27243685	chr21:43642366	21	43642366	ABCG1	South shelf	0.0545479	0.0091009	0.000000002099608	P00742	41361833_Josephine_Robertson_P00742_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00450	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P00450	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg27243685	chr21:43642366	21	43642366	ABCG1	South shelf	0.0541329	0.00912012	0.00000000299466	P00450	41361833_Josephine_Robertson_P00450_OSCA_model_3
Gadd DA	Generation Scotland	35945220	31/07/2022	HMGCS1 protein levels (SeqId = 13496-19)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	HMGCS1 protein levels (SeqId = 13496-19)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Hydroxymethylglutaryl-CoA synthase, cytoplasmic	774	1	Adults (18-65 years)	Both	European	cg27243685	chr21:43642366	21	43642366	ABCG1	South shelf	1.1	0.185	0.000000003	None	Gadd-DA_hmgcs1_protein_levels__seqid___13496-19__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00450	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P00450	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg27243685	chr21:43642366	21	43642366	ABCG1	South shelf	0.0521638	0.00893967	0.000000005489268	P00450	41361833_Josephine_Robertson_P00450_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01834	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P01834	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg27243685	chr21:43642366	21	43642366	ABCG1	South shelf	-0.0518946	0.00890279	0.000000005692414	P01834	41361833_Josephine_Robertson_P01834_OSCA_model_2
Ochoa-Rosales C	ESTHER, KORA-F4 , LOLIPOP, SHIP-Trend	32033992	2020-04-01	Statin use	GO_0036273	Discovery	Table 1	Statin use	DNA methylation	sex, age, smoking, body mass index, systolic blood pressure, antihypertensive medication, coronary heart disease, type 2 diabetes, cell composition (reference based)	None	Beta Values	Illumina HumanMethylation450	Whole blood	Some cohorts used the Illumina HumanMethylationEPIC, but results were restricted to sites measured by the HM450	6820	4	Adults	Both	European	cg27243685	chr21:43642366	21	43642366	ABCG1	South shelf	0.0044	0.0008	0.000000006	None	32033992_Ochoa-Rosales-C_statin_use_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P69905	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P69905	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg27243685	chr21:43642366	21	43642366	ABCG1	South shelf	-0.0519806	0.00894914	0.000000006436175	P69905	41361833_Josephine_Robertson_P69905_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P25311	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P25311	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg27243685	chr21:43642366	21	43642366	ABCG1	South shelf	-0.0510811	0.00894406	0.00000001143797	P25311	41361833_Josephine_Robertson_P25311_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00742	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P00742	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg27243685	chr21:43642366	21	43642366	ABCG1	South shelf	0.0594718	0.010426	0.00000001191486	P00742	41361833_Josephine_Robertson_P00742_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P20742	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P20742	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg27243685	chr21:43642366	21	43642366	ABCG1	South shelf	-0.0570569	0.0100759	0.00000001518124	P20742	41361833_Josephine_Robertson_P20742_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P51884	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P51884	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg27243685	chr21:43642366	21	43642366	ABCG1	South shelf	-0.0586313	0.0103786	0.00000001641325	P51884	41361833_Josephine_Robertson_P51884_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	C9JB55	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	C9JB55	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg27243685	chr21:43642366	21	43642366	ABCG1	South shelf	0.046584	0.00824761	0.00000001651626	C9JB55	41361833_Josephine_Robertson_C9JB55_OSCA_model_1
Wahl S	-	28002404	2017-01-05	Body mass index	EFO_0004340	South Asian ancestry discovery	Table S3	Body mass index	DNA methylation	Age, sex, smoking, physical activity index, alcohol consumption, cell counts and technical covariates	kg/m2	Beta values	Illumina HumanMethylation450	Whole blood	-	2680	1	51.0	Both	South Asian	cg27243685	chr21:43642366	21	43642366	ABCG1	South shelf	22.39	3.49	0.000000017	-	28002404_body_mass_index_south_asian_ancestry_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O75636	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	O75636	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg27243685	chr21:43642366	21	43642366	ABCG1	South shelf	0.0460785	0.0082478	0.00000002354584	O75636	41361833_Josephine_Robertson_O75636_OSCA_model_1
Gomez-Alonso MDC	KORA F4	33413638	2021-01-07	S-VLDL-FC	None	Meta-analysis	Table S2	DNA methylation	S-VLDL-FC	Age, sex, smoking, body mass index, CRP, HbA1c, alcohol consumption, lipid-lowering drugs, hypertension, history of myocardial infarction, level of physical activity, cell composition (reference based)	Beta Values	mmol/L	Illumina HumanMethylation450	Whole blood	Free cholesterol in small VLDL	5414	4	Adults	Both	European	cg27243685	chr21:43642366	21	43642366	ABCG1	South shelf	1.9	0.34	0.000000024	None	33413638_Gomez-Alonso-MDC_s-vldl-fc_meta-analysis
Demerath EW	-	25935004	2015-08-01	Body mass index	EFO_0004340	Discovery	Table S4	DNA methylation	Body mass index	Age, sex, smoking, study centre, alcohol consumption, education, household income, physical activity, cell counts and technical covariates	Beta values	kg/m2	Illumina HumanMethylation450	Leukocytes	Regression coefficient per 1 SD of body mass index	2096	1	56.2	Both	African	cg27243685	chr21:43642366	21	43642366	ABCG1	South shelf	0.0057	0.001	0.0000000361	-	25935004_body_mass_index_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00747	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P00747	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg27243685	chr21:43642366	21	43642366	ABCG1	South shelf	0.048993	0.00893425	0.00000004233504	P00747	41361833_Josephine_Robertson_P00747_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	Q96PD5	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	Q96PD5	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg27243685	chr21:43642366	21	43642366	ABCG1	South shelf	-0.0490596	0.00895119	0.00000004304232	Q96PD5	41361833_Josephine_Robertson_Q96PD5_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01742	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P01742	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg27243685	chr21:43642366	21	43642366	ABCG1	South shelf	0.0451556	0.00824815	0.00000004456196	P01742	41361833_Josephine_Robertson_P01742_OSCA_model_1
Sayols-Baixeras S	-	28173150	2016-09-15	Serum triglycerides	EFO_0004530, CHEBI_17855	Discovery	Table S1	Serum triglycerides	DNA methylation	Age, sex, smoking, cell counts and technical covariates	mg/dl	M values	Illumina HumanMethylation450	Whole blood	Triglycerides levels were log-transformed	645	1	63.2	Both	None	cg27243685	chr21:43642366	21	43642366	ABCG1	South shelf	0.044	0.008	0.000000065	-	28173150_serum_triglycerides_discovery
Gomez-Alonso MDC	KORA F4	33413638	2021-01-07	M-HDL-TG	None	Meta-analysis	Table S2	DNA methylation	M-HDL-TG	Age, sex, smoking, body mass index, CRP, HbA1c, alcohol consumption, lipid-lowering drugs, hypertension, history of myocardial infarction, level of physical activity, cell composition (reference based)	Beta Values	mmol/L	Illumina HumanMethylation450	Whole blood	Triglycerides in medium HDL	5414	4	Adults	Both	European	cg27243685	chr21:43642366	21	43642366	ABCG1	South shelf	1.7	0.31	0.000000068	None	33413638_Gomez-Alonso-MDC_m-hdl-tg_meta-analysis
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0G2JMB2	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	A0A0G2JMB2	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg27243685	chr21:43642366	21	43642366	ABCG1	South shelf	0.0444924	0.0082484	0.00000006994953	A0A0G2JMB2	41361833_Josephine_Robertson_A0A0G2JMB2_OSCA_model_1
Robert F Hillary	Generation Scotland	10.1101/2023.01.10.23284387	9/6/2023	Prevalent Stroke (Self-report)	None	Basic model	https://doi.org/10.5281/zenodo.8021411	DNA methylation	Prevalent Stroke (Self-report)	Age, Sex, Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	None	18056	1	Adults (18-65y)	Both	European	cg27243685	chr21:43642366	21	43642366	ABCG1	South shelf	0.068	0.01277	0.000000097	None	Robert-F-Hillary_Prevalent_Stroke_(Self-report)_Basic_model
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00450	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P00450	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg27243685	chr21:43642366	21	43642366	ABCG1	South shelf	0.0551857	0.0104257	0.0000001218889	P00450	41361833_Josephine_Robertson_P00450_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02751	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02751	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg27243685	chr21:43642366	21	43642366	ABCG1	South shelf	0.0436065	0.00824872	0.0000001264944	P02751	41361833_Josephine_Robertson_P02751_OSCA_model_1
Hannah M. Smith	Generation Scotland	39706196	Jan 2, 2025	Total cholesterol	EFO_0004574	discovery	None	DNA methylation	Total cholesterol	Age,Sex,Smoking,Cell composition (reference based)	Other	mmol/L	Illumina HumanMethylationEPIC	Whole blood	None	18270	1	Adults	Both	European	cg27243685	chr21:43642366	21	43642366	ABCG1	South shelf	-0.190909	0.036183	0.0000001333827	None	39706196_Hannah-M.-Smith_total_cholesterol_discovery
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02743	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02743	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg27243685	chr21:43642366	21	43642366	ABCG1	South shelf	0.043315	0.00824882	0.0000001533439	P02743	41361833_Josephine_Robertson_P02743_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P80108	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P80108	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg27243685	chr21:43642366	21	43642366	ABCG1	South shelf	0.043166	0.00824888	0.0000001691188	P80108	41361833_Josephine_Robertson_P80108_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O95445	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	O95445	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg27243685	chr21:43642366	21	43642366	ABCG1	South shelf	-0.0430731	0.00824891	0.0000001797407	O95445	41361833_Josephine_Robertson_O95445_OSCA_model_1
Gomez-Alonso MDC	KORA F4	33413638	2021-01-07	L-LDL-FC_pct	None	Meta-analysis	Table S2	DNA methylation	L-LDL-FC_pct	Age, sex, smoking, body mass index, CRP, HbA1c, alcohol consumption, lipid-lowering drugs, hypertension, history of myocardial infarction, level of physical activity, cell composition (reference based)	Beta Values	%	Illumina HumanMethylation450	Whole blood	Free cholesterol to total lipids ratio in large LDL	5414	4	Adults	Both	European	cg27243685	chr21:43642366	21	43642366	ABCG1	South shelf	-0.35	0.067	0.00000018	None	33413638_Gomez-Alonso-MDC_l-ldl-fc_pct_meta-analysis
Gomez-Alonso MDC	KORA F4	33413638	2021-01-07	S-LDL-TG	None	Meta-analysis	Table S2	DNA methylation	S-LDL-TG	Age, sex, smoking, body mass index, CRP, HbA1c, alcohol consumption, lipid-lowering drugs, hypertension, history of myocardial infarction, level of physical activity, cell composition (reference based)	Beta Values	mmol/L	Illumina HumanMethylation450	Whole blood	Triglycerides in small LDL	5414	4	Adults	Both	European	cg27243685	chr21:43642366	21	43642366	ABCG1	South shelf	1.8	0.35	0.0000002	None	33413638_Gomez-Alonso-MDC_s-ldl-tg_meta-analysis
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O75882	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	O75882	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg27243685	chr21:43642366	21	43642366	ABCG1	South shelf	0.0470322	0.00906621	0.0000002158166	O75882	41361833_Josephine_Robertson_O75882_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P51884	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P51884	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg27243685	chr21:43642366	21	43642366	ABCG1	South shelf	-0.0470809	0.00907731	0.000000216953	P51884	41361833_Josephine_Robertson_P51884_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02760	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P02760	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg27243685	chr21:43642366	21	43642366	ABCG1	South shelf	-0.0459349	0.00894851	0.0000002884218	P02760	41361833_Josephine_Robertson_P02760_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	Q96PD5	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	Q96PD5	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg27243685	chr21:43642366	21	43642366	ABCG1	South shelf	-0.0533109	0.0104505	0.0000003415438	Q96PD5	41361833_Josephine_Robertson_Q96PD5_OSCA_model_4
Liu J	Rotterdam Study III-1, Rotterdam Study II-3 and Rotterdam Study III-2, Netherlands Twin Register, UK adult Twin registry	31197173	2013-06-19	fasting insulin	EFO_0004466	Base plus BMI	Supplementary Data 1	DNA methylation	fasting insulin	Age, sex, smoking, cell composition (reference based), batch effects, body mass index	Beta Values	log pmol/L	Illumina HumanMethylation450	whole blood	None	4808	4	Adults	Both	European	cg27243685	chr21:43642366	21	43642366	ABCG1	South shelf	2.04	0.4	0.00000036	4738	31197173_Liu-J_fasting_insulin_base_plus_bmi
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	B1AHL2	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	B1AHL2	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg27243685	chr21:43642366	21	43642366	ABCG1	South shelf	-0.0418685	0.00824933	0.0000003914632	B1AHL2	41361833_Josephine_Robertson_B1AHL2_OSCA_model_1
Xu K	-	27826092	2018-01-01	Body mass index	EFO_0004340	-	Table 2	DNA methylation	Body mass index	Age, sex, ethnicity, cell counts and technical covariates	Beta values	kg/m2	Illumina HumanMehtylation450	Whole blood	-	510	1	29	Both	European,African,Other	cg27243685	chr21:43642366	21	43642366	ABCG1	South shelf	9e-04	0.00017	0.000000405	-	27826092_body_mass_index
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P80108	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P80108	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg27243685	chr21:43642366	21	43642366	ABCG1	South shelf	0.0449049	0.00895549	0.000000538683	P80108	41361833_Josephine_Robertson_P80108_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0G2JMB2	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	A0A0G2JMB2	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg27243685	chr21:43642366	21	43642366	ABCG1	South shelf	0.0442981	0.00895347	0.0000007597165	A0A0G2JMB2	41361833_Josephine_Robertson_A0A0G2JMB2_OSCA_model_2
Wahl S	-	28002404	2017-01-05	Body mass index	EFO_0004340	South Asian ancestry replication	Table S3	Body mass index	DNA methylation	Age, sex, smoking, physical activity index, alcohol consumption, cell counts and technical covariates	kg/m2	Beta values	Illumina HumanMethylation450	Whole blood	-	656	1	53.8	Both	South Asian	cg27243685	chr21:43642366	21	43642366	ABCG1	South shelf	59.9	12.02	0.00000085	-	28002404_body_mass_index_south_asian_ancestry_replication
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04196	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P04196	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg27243685	chr21:43642366	21	43642366	ABCG1	South shelf	-0.0439788	0.00894228	0.0000008834555	P04196	41361833_Josephine_Robertson_P04196_OSCA_model_2
Gadd DA	Generation Scotland	35945220	31/07/2022	GPD1 protein levels (SeqId = 13697-51)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	GPD1 protein levels (SeqId = 13697-51)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Glycerol-3-phosphate dehydrogenase [NAD(+)], cytoplasmic	774	1	Adults (18-65 years)	Both	European	cg27243685	chr21:43642366	21	43642366	ABCG1	South shelf	0.91	0.185	0.0000009	None	Gadd-DA_gpd1_protein_levels__seqid___13697-51__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02649	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P02649	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg27243685	chr21:43642366	21	43642366	ABCG1	South shelf	-0.0513066	0.0104664	0.000000958731	P02649	41361833_Josephine_Robertson_P02649_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P36955	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P36955	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg27243685	chr21:43642366	21	43642366	ABCG1	South shelf	0.0500296	0.010215	0.0000009802715	P36955	41361833_Josephine_Robertson_P36955_OSCA_model_4
Ma J	CARDSYA, FHS, MESA, RS	30936141	2019-02-21	Nonalcoholic fatty liver disease	EFO_0003095, EFO_1001248	discovery and replication	Table 1	Nonalcoholic fatty liver disease	DNA methylation	Age, sex, cell composition (reference based)	None	Beta Values	Illumina HumanMethylation450	Whole Blood, Monocytes	None	4525	4	Adults	Both	European	cg27243685	chr21:43642366	21	43642366	ABCG1	South shelf	None	None	0.0000012	None	30936141_Ma-J_nonalcoholic_fatty_liver_disease_discovery_and_replication
Ma J	FHS, RS, CARDIA, MESA	30936141	2020-05-22	Hepatic Fat	EFO_0006506, EFO_0008421	Meta-analysis model 3	Table 1	DNA methylation	Hepatic Fat	Age, sex	Beta Values	Hounsfield units	Illumina HumanMethylation450	Whole blood	Model 3 = model 2 + BMI	3400	4	Adults	Both	European	cg27243685	chr21:43642366	21	43642366	ABCG1	South shelf	None	None	0.0000012	None	30936141_Ma-J_hepatic_fat_meta-analysis_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02790	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P02790	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg27243685	chr21:43642366	21	43642366	ABCG1	South shelf	0.0495413	0.0103223	0.000001606983	P02790	41361833_Josephine_Robertson_P02790_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02790	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P02790	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg27243685	chr21:43642366	21	43642366	ABCG1	South shelf	0.0420059	0.00890105	0.000002389456	P02790	41361833_Josephine_Robertson_P02790_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02649	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P02649	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg27243685	chr21:43642366	21	43642366	ABCG1	South shelf	-0.0429664	0.00913228	0.000002563149	P02649	41361833_Josephine_Robertson_P02649_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P08185	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P08185	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg27243685	chr21:43642366	21	43642366	ABCG1	South shelf	0.0475566	0.01011	0.000002575467	P08185	41361833_Josephine_Robertson_P08185_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00747	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P00747	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg27243685	chr21:43642366	21	43642366	ABCG1	South shelf	0.0387967	0.00825036	0.000002594324	P00747	41361833_Josephine_Robertson_P00747_OSCA_model_1
Mulder RH	ALSPAC,Generation R	33450751	25/01/2021	age	EFO_0000246	Model 1 with age as a fixed effect	http://epidelta.mrcieu.ac.uk/	DNA methylation	age	sex,gestational age,cohort,cell composition (reference based),batch effects	Beta Values	years	Illumina HumanMethylation450	Whole blood	None	2338	2	Children	Both	European	cg27243685	chr21:43642366	21	43642366	ABCG1	South shelf	-0.00083	0.00018	0.0000027	None	33450751_Mulder-RH_age_model_1_with_age_as_a_fixed_effect
Gadd DA	Generation Scotland	35945220	31/07/2022	PSAT1 protein levels (SeqId = 18342-2)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	PSAT1 protein levels (SeqId = 18342-2)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Phosphoserine aminotransferase	774	1	Adults (18-65 years)	Both	European	cg27243685	chr21:43642366	21	43642366	ABCG1	South shelf	0.87	0.185	0.0000027	None	Gadd-DA_psat1_protein_levels__seqid___18342-2__somascan_protein_measurement
Mamtani M	-	26798409	2016-01-20	Hypertriglyceridemic waist	EFO_0004342, EFO_0004530	-	Table S2	Liability function of hypertriglyceridemic waist	DNA methylation	Age, sex, use of statin, use of anti-hypertensive, use of diabetic medications, cell counts and technical covariates	Beta values	-	Illumina HumanMethylation450	Peripheral blood	-	850	1	46.8	Both	None	cg27243685	chr21:43642366	21	43642366	ABCG1	South shelf	-0.28441292	0.06107	0.00000321	-	26798409_hypertriglyceridemic_waist
Battram T	ARIES	None	2020-08-20	Triglycerides in medium HDL	EFO_0004530	None	None	DNA methylation	Triglycerides in medium HDL	Batch effects, cell composition (reference free), ancestry (genomic PCs)	Beta Values	mmol/l	Illumina HumanMethylation450	Whole blood	None	683	1	Adults	Females	European	cg27243685	chr21:43642366	21	43642366	ABCG1	South shelf	10	2.1	0.0000035	None	Battram-T_triglycerides_in_medium_hdl
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P08603	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P08603	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg27243685	chr21:43642366	21	43642366	ABCG1	South shelf	0.0388384	0.00837923	0.000003598779	P08603	41361833_Josephine_Robertson_P08603_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02760	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02760	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg27243685	chr21:43642366	21	43642366	ABCG1	South shelf	-0.0381838	0.00825055	0.000003723227	P02760	41361833_Josephine_Robertson_P02760_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P20851	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P20851	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg27243685	chr21:43642366	21	43642366	ABCG1	South shelf	0.0413192	0.00894932	0.000003925997	P20851	41361833_Josephine_Robertson_P20851_OSCA_model_2
Robert F Hillary	Generation Scotland	10.1101/2023.01.10.23284387	9/6/2023	Incident Ischemic Heart Disease	None	Basic model	https://doi.org/10.5281/zenodo.8021411	DNA methylation	Incident Ischemic Heart Disease	Age, Sex, Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	Whole blood	None	17483	1	Adults (18-65y)	Both	European	cg27243685	chr21:43642366	21	43642366	ABCG1	South shelf	0.034	0.0074	0.000004	None	Robert-F-Hillary_Incident_Ischemic_Heart_Disease_Basic_model
Gadd DA	Generation Scotland	35945220	31/07/2022	CPM protein levels (SeqId = 9416-77)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	CPM protein levels (SeqId = 9416-77)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Carboxypeptidase M	774	1	Adults (18-65 years)	Both	European	cg27243685	chr21:43642366	21	43642366	ABCG1	South shelf	0.85	0.185	0.0000041	None	Gadd-DA_cpm_protein_levels__seqid___9416-77__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	Q96PD5	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	Q96PD5	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg27243685	chr21:43642366	21	43642366	ABCG1	South shelf	-0.0417764	0.00912683	0.00000474844	Q96PD5	41361833_Josephine_Robertson_Q96PD5_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01019	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P01019	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg27243685	chr21:43642366	21	43642366	ABCG1	South shelf	0.0409243	0.00894128	0.000004755564	P01019	41361833_Josephine_Robertson_P01019_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04114	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P04114	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg27243685	chr21:43642366	21	43642366	ABCG1	South shelf	0.0404893	0.00884873	0.000004784888	P04114	41361833_Josephine_Robertson_P04114_OSCA_model_2
Battram T	ARIES	None	2020-08-20	Triglycerides in small HDL	EFO_0004530	None	None	DNA methylation	Triglycerides in small HDL	Batch effects, cell composition (reference free), ancestry (genomic PCs)	Beta Values	mmol/l	Illumina HumanMethylation450	Whole blood	None	682	1	Adults	Females	European	cg27243685	chr21:43642366	21	43642366	ABCG1	South shelf	10.1	2.2	0.0000052	None	Battram-T_triglycerides_in_small_hdl
Sayols-Baixeras S	-	28173150	2016-09-15	Serum high-density lipoprotein cholesterol	EFO_0004612, CHEBI_47775	Discovery	Table S1	Serum high-density lipoprotein cholesterol	DNA methylation	Age, sex, smoking, cell counts and technical covariates	mg/dl	M values	Illumina HumanMethylation450	Whole blood	-	645	1	63.2	Both	None	cg27243685	chr21:43642366	21	43642366	ABCG1	South shelf	-2.438	0.537	0.0000057	-	28173150_serum_highdensity_lipoprotein_cholesterol_discovery
Gadd DA	Generation Scotland	35945220	31/07/2022	SDCBP protein levels (SeqId = 17806-6)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	SDCBP protein levels (SeqId = 17806-6)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Syntenin-1	774	1	Adults (18-65 years)	Both	European	cg27243685	chr21:43642366	21	43642366	ABCG1	South shelf	0.841	0.185	0.0000057	None	Gadd-DA_sdcbp_protein_levels__seqid___17806-6__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02649	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P02649	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg27243685	chr21:43642366	21	43642366	ABCG1	South shelf	-0.0404682	0.00894977	0.000006182343	P02649	41361833_Josephine_Robertson_P02649_OSCA_model_2
Ochoa-Rosales C	Rotterdam Study	32033992	2020-04-01	Statin use	GO_0036273	Replication	Table 1	Statin use	DNA methylation	sex, age, smoking, body mass index, systolic blood pressure, antihypertensive medication, coronary heart disease, type 2 diabetes, cell composition (reference based)	None	Beta Values	Illumina HumanMethylation450	Whole blood	None	1450	1	Adults	Both	European	cg27243685	chr21:43642366	21	43642366	ABCG1	South shelf	0.0069	0.0015	0.0000064	None	32033992_Ochoa-Rosales-C_statin_use_replication
Battram T	ARIES	None	2020-08-20	Total cholesterol to total lipids ratio in very small VLDL	EFO_0004574	None	None	DNA methylation	Total cholesterol to total lipids ratio in very small VLDL	Batch effects, cell composition (reference free), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylation450	Whole blood	None	678	1	Adults	Females	European	cg27243685	chr21:43642366	21	43642366	ABCG1	South shelf	-0.036	0.0079	0.0000069	None	Battram-T_total_cholesterol_to_total_lipids_ratio_in_very_small_vldl
Battram T	ARIES	None	2020-08-20	Total lipids in small HDL	EFO_0004529	None	None	DNA methylation	Total lipids in small HDL	Batch effects, cell composition (reference free), ancestry (genomic PCs)	Beta Values	mmol/l	Illumina HumanMethylation450	Whole blood	None	685	1	Adults	Females	European	cg27243685	chr21:43642366	21	43642366	ABCG1	South shelf	1.12	0.25	0.0000079	None	Battram-T_total_lipids_in_small_hdl
Gomez-Alonso MDC	KORA F4	33413638	2021-01-07	TGtoPG	None	Meta-analysis	Table S2	DNA methylation	TGtoPG	Age, sex, smoking, body mass index, CRP, HbA1c, alcohol consumption, lipid-lowering drugs, hypertension, history of myocardial infarction, level of physical activity, cell composition (reference based)	Beta Values	None	Illumina HumanMethylation450	Whole blood	Ratio of triglycerides to phosphoglycerides	5414	4	Adults	Both	European	cg27243685	chr21:43642366	21	43642366	ABCG1	South shelf	2.53	0.57	0.000009	None	33413638_Gomez-Alonso-MDC_tgtopg_meta-analysis
Gadd DA	Generation Scotland	35945220	31/07/2022	ADH4 protein levels (SeqId = 8325-37)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	ADH4 protein levels (SeqId = 8325-37)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Alcohol dehydrogenase 4	774	1	Adults (18-65 years)	Both	European	cg27243685	chr21:43642366	21	43642366	ABCG1	South shelf	0.82	0.185	0.000009	None	Gadd-DA_adh4_protein_levels__seqid___8325-37__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	RET protein levels (SeqId = 3220-40)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	RET protein levels (SeqId = 3220-40)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Proto-oncogene tyrosine-protein kinase receptor Ret	774	1	Adults (18-65 years)	Both	European	cg27243685	chr21:43642366	21	43642366	ABCG1	South shelf	0.82	0.185	0.0000091	None	Gadd-DA_ret_protein_levels__seqid___3220-40__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00734	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P00734	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg27243685	chr21:43642366	21	43642366	ABCG1	South shelf	-0.0395787	0.00892776	0.000009351043	P00734	41361833_Josephine_Robertson_P00734_OSCA_model_2
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P35858	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P35858	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg27243685	chr21:43642366	21	43642366	ABCG1	South shelf	0.0402892	0.00910901	0.000009803667	P35858	41361833_Josephine_Robertson_P35858_OSCA_model_3
Jiantao Ma	RS, MESA, CARDIA	30796027	Feb 22, 2019	hepatic fat	EFO_0010821	Replication	Table 1	DNA methylation	hepatic fat	Age, Sex, Cell composition (reference based), Batch effects	Beta values	None	Illumina HumanMethylation450	whole blood	None	1904	3	Adults	Both	European	cg27243685	chr21:43642366	21	43642366	ABCG1	South shelf	None	None	0.000011	None	30796027_Jiantao-Ma_hepatic_fat_replication
Gomez-Alonso MDC	KORA F4	33413638	2021-01-07	MUFA	EFO_0006823	Meta-analysis	Table S2	DNA methylation	MUFA	Age, sex, smoking, body mass index, CRP, HbA1c, alcohol consumption, lipid-lowering drugs, hypertension, history of myocardial infarction, level of physical activity, cell composition (reference based)	Beta Values	mmol/L	Illumina HumanMethylation450	Whole blood	Monounsaturated fatty acids 16:1, 18:1	5414	4	Adults	Both	European	cg27243685	chr21:43642366	21	43642366	ABCG1	South shelf	1.14	0.26	0.000011	None	33413638_Gomez-Alonso-MDC_mufa_meta-analysis
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04275	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P04275	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg27243685	chr21:43642366	21	43642366	ABCG1	South shelf	-0.0362137	0.00825116	0.00001147065	P04275	41361833_Josephine_Robertson_P04275_OSCA_model_1
Battram T	ARIES	None	2020-08-20	Triglycerides to total lipids ratio in medium HDL	EFO_0004530	None	None	DNA methylation	Triglycerides to total lipids ratio in medium HDL	Batch effects, cell composition (reference free), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylation450	Whole blood	None	683	1	Adults	Females	European	cg27243685	chr21:43642366	21	43642366	ABCG1	South shelf	0.103	0.023	0.000012	None	Battram-T_triglycerides_to_total_lipids_ratio_in_medium_hdl
Gadd DA	Generation Scotland	35945220	31/07/2022	FAH protein levels (SeqId = 11424-4)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	FAH protein levels (SeqId = 11424-4)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Fumarylacetoacetase	774	1	Adults (18-65 years)	Both	European	cg27243685	chr21:43642366	21	43642366	ABCG1	South shelf	0.81	0.185	0.000012	None	Gadd-DA_fah_protein_levels__seqid___11424-4__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P69905	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P69905	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg27243685	chr21:43642366	21	43642366	ABCG1	South shelf	-0.0398004	0.00911796	0.00001279592	P69905	41361833_Josephine_Robertson_P69905_OSCA_model_3
Gadd DA	Generation Scotland	35945220	31/07/2022	ASL protein levels (SeqId = 11241-8)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	ASL protein levels (SeqId = 11241-8)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Argininosuccinate lyase	774	1	Adults (18-65 years)	Both	European	cg27243685	chr21:43642366	21	43642366	ABCG1	South shelf	0.8	0.185	0.000013	None	Gadd-DA_asl_protein_levels__seqid___11241-8__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	ACY1 protein levels (SeqId = 3343-1)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	ACY1 protein levels (SeqId = 3343-1)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Aminoacylase-1	774	1	Adults (18-65 years)	Both	European	cg27243685	chr21:43642366	21	43642366	ABCG1	South shelf	0.81	0.185	0.000013	None	Gadd-DA_acy1_protein_levels__seqid___3343-1__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	INSL5 protein levels (SeqId = 10462-14)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	INSL5 protein levels (SeqId = 10462-14)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Insulin-like peptide INSL5	774	1	Adults (18-65 years)	Both	European	cg27243685	chr21:43642366	21	43642366	ABCG1	South shelf	0.8	0.185	0.000015	None	Gadd-DA_insl5_protein_levels__seqid___10462-14__somascan_protein_measurement
Battram T	ARIES	None	2020-08-20	Triglycerides in IDL	EFO_0004530	None	None	DNA methylation	Triglycerides in IDL	Batch effects, cell composition (reference free), ancestry (genomic PCs)	Beta Values	mmol/l	Illumina HumanMethylation450	Whole blood	None	683	1	Adults	Females	European	cg27243685	chr21:43642366	21	43642366	ABCG1	South shelf	3.9	0.9	0.000016	None	Battram-T_triglycerides_in_idl
Battram T	ARIES	None	2020-08-20	Triglycerides in very small VLDL	EFO_0004530	None	None	DNA methylation	Triglycerides in very small VLDL	Batch effects, cell composition (reference free), ancestry (genomic PCs)	Beta Values	mmol/l	Illumina HumanMethylation450	Whole blood	None	680	1	Adults	Females	European	cg27243685	chr21:43642366	21	43642366	ABCG1	South shelf	3.7	0.85	0.000017	None	Battram-T_triglycerides_in_very_small_vldl
Gadd DA	Generation Scotland	35945220	31/07/2022	FBP1 protein levels (SeqId = 7206-20)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	FBP1 protein levels (SeqId = 7206-20)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Fructose-1,6-bisphosphatase 1	774	1	Adults (18-65 years)	Both	European	cg27243685	chr21:43642366	21	43642366	ABCG1	South shelf	0.79	0.185	0.000017	None	Gadd-DA_fbp1_protein_levels__seqid___7206-20__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P69905	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P69905	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg27243685	chr21:43642366	21	43642366	ABCG1	South shelf	-0.0353173	0.00825142	0.00001879496	P69905	41361833_Josephine_Robertson_P69905_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P27169	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P27169	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg27243685	chr21:43642366	21	43642366	ABCG1	South shelf	-0.0388125	0.0090699	0.00001887017	P27169	41361833_Josephine_Robertson_P27169_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P43251	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P43251	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg27243685	chr21:43642366	21	43642366	ABCG1	South shelf	0.0352079	0.00825145	0.00001994711	P43251	41361833_Josephine_Robertson_P43251_OSCA_model_1
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04196	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P04196	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg27243685	chr21:43642366	21	43642366	ABCG1	South shelf	-0.03892	0.00912241	0.00001998808	P04196	41361833_Josephine_Robertson_P04196_OSCA_model_3
Gadd DA	Generation Scotland	35945220	31/07/2022	FKBP6 protein levels (SeqId = 12529-32)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	FKBP6 protein levels (SeqId = 12529-32)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Inactive peptidyl-prolyl cis-trans isomerase FKBP6	774	1	Adults (18-65 years)	Both	European	cg27243685	chr21:43642366	21	43642366	ABCG1	South shelf	0.79	0.185	0.00002	None	Gadd-DA_fkbp6_protein_levels__seqid___12529-32__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P08603	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P08603	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg27243685	chr21:43642366	21	43642366	ABCG1	South shelf	0.0407776	0.00956909	0.00002044291	P08603	41361833_Josephine_Robertson_P08603_OSCA_model_4
Sayols-Baixeras S	-	28173150	2016-09-15	Serum high-density lipoprotein cholesterol	EFO_0004612, CHEBI_47775	Discovery adjusted for surrogate variables	Table S1	Serum high-density lipoprotein cholesterol	DNA methylation	Age, sex, smoking, cell counts and technical covariates	mg/dl	M values	Illumina HumanMethylation450	Whole blood	-	645	1	63.2	Both	None	cg27243685	chr21:43642366	21	43642366	ABCG1	South shelf	-1.665	0.391	0.000021	-	28173150_serum_highdensity_lipoprotein_cholesterol_discovery_adjusted_for_surrogate_variables
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	A0A0G2JMB2	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	A0A0G2JMB2	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg27243685	chr21:43642366	21	43642366	ABCG1	South shelf	0.0386223	0.00909191	0.00002170398	A0A0G2JMB2	41361833_Josephine_Robertson_A0A0G2JMB2_OSCA_model_3
Gadd DA	Generation Scotland	35945220	31/07/2022	RBP5 protein levels (SeqId = 19241-31)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	RBP5 protein levels (SeqId = 19241-31)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Retinol-binding protein 5	774	1	Adults (18-65 years)	Both	European	cg27243685	chr21:43642366	21	43642366	ABCG1	South shelf	0.78	0.185	0.000022	None	Gadd-DA_rbp5_protein_levels__seqid___19241-31__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P01834	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P01834	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg27243685	chr21:43642366	21	43642366	ABCG1	South shelf	-0.0434794	0.010274	0.00002330376	P01834	41361833_Josephine_Robertson_P01834_OSCA_model_4
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02787	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P02787	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg27243685	chr21:43642366	21	43642366	ABCG1	South shelf	0.0377938	0.00895546	0.00002455563	P02787	41361833_Josephine_Robertson_P02787_OSCA_model_2
Pfeiffer L	-	25583993	2015-01-12	Triglycerides	EFO_0004530, CHEBI_17855	Replication	Table 2	Triglycerides	DNA methylation	Age, sex, smoking, body mass index, alcohol consumption, physical activity, hypertension, history of MI, hemoglobin A1c, C-reactive protein, lipid-lowering drugs intake and cell counts	mg/dl	Beta values	Illumina HumanMethylation450	Whole blood	-	971	2	62	Both	European	cg27243685	chr21:43642366	21	43642366	ABCG1	South shelf	-	-	0.0000249	-	25583993_triglycerides_replication
Battram T	GEO	27886173	2020-09-15	Crohn's disease	EFO_0000384	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE87640	None	DNA methylation	Crohn's disease	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Whole blood	None	161	1	Adults	Both	European	cg27243685	chr21:43642366	21	43642366	ABCG1	South shelf	-0.0132	0.00303	0.000025	None	27886173_Battram-T_crohn_s_disease_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse87640
Gomez-Alonso MDC	KORA F4	33413638	2021-01-07	XS-VLDL-C_pct	None	Meta-analysis	Table S2	DNA methylation	XS-VLDL-C_pct	Age, sex, smoking, body mass index, CRP, HbA1c, alcohol consumption, lipid-lowering drugs, hypertension, history of myocardial infarction, level of physical activity, cell composition (reference based)	Beta Values	%	Illumina HumanMethylation450	Whole blood	Total cholesterol to total lipids ratio in very small VLDL	5414	4	Adults	Both	European	cg27243685	chr21:43642366	21	43642366	ABCG1	South shelf	-0.57	0.14	0.000026	None	33413638_Gomez-Alonso-MDC_xs-vldl-c_pct_meta-analysis
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P04196	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	P04196	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg27243685	chr21:43642366	21	43642366	ABCG1	South shelf	-0.0438435	0.0104342	0.00002662744	P04196	41361833_Josephine_Robertson_P04196_OSCA_model_4
Gadd DA	Generation Scotland	35945220	31/07/2022	DEFB1 protein levels (SeqId = 6629-3)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	DEFB1 protein levels (SeqId = 6629-3)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Beta-defensin 1	774	1	Adults (18-65 years)	Both	European	cg27243685	chr21:43642366	21	43642366	ABCG1	South shelf	0.774	0.185	0.00003	None	Gadd-DA_defb1_protein_levels__seqid___6629-3__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	GEM protein levels (SeqId = 12817-1)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	GEM protein levels (SeqId = 12817-1)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: GTP-binding protein GEM	774	1	Adults (18-65 years)	Both	European	cg27243685	chr21:43642366	21	43642366	ABCG1	South shelf	0.77	0.19	0.000032	None	Gadd-DA_gem_protein_levels__seqid___12817-1__somascan_protein_measurement
Battram T	ARIES	None	2020-08-20	Cholesterol esters to total lipids ratio in medium HDL	EFO_0008589	None	None	DNA methylation	Cholesterol esters to total lipids ratio in medium HDL	Batch effects, cell composition (reference free), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylation450	Whole blood	None	683	1	Adults	Females	European	cg27243685	chr21:43642366	21	43642366	ABCG1	South shelf	-0.063	0.015	0.000033	None	Battram-T_cholesterol_esters_to_total_lipids_ratio_in_medium_hdl
Gadd DA	Generation Scotland	35945220	31/07/2022	SORD protein levels (SeqId = 15447-45)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	SORD protein levels (SeqId = 15447-45)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Sorbitol dehydrogenase	774	1	Adults (18-65 years)	Both	European	cg27243685	chr21:43642366	21	43642366	ABCG1	South shelf	0.77	0.185	0.000035	None	Gadd-DA_sord_protein_levels__seqid___15447-45__somascan_protein_measurement
Battram T	ARIES	None	2020-08-20	Total body mass	EFO_0004338	None	None	DNA methylation	Total body mass	Batch effects, cell composition (reference free), ancestry (genomic PCs)	Beta Values	g	Illumina HumanMethylation450	Whole blood	DXA scan measurement	704	1	Adults	Females	European	cg27243685	chr21:43642366	21	43642366	ABCG1	South shelf	0.0000088	0.0000021	0.000036	None	Battram-T_total_body_mass
Gadd DA	Generation Scotland	35945220	31/07/2022	PTPRU protein levels (SeqId = 8337-65)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	PTPRU protein levels (SeqId = 8337-65)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Receptor-type tyrosine-protein phosphatase U	774	1	Adults (18-65 years)	Both	European	cg27243685	chr21:43642366	21	43642366	ABCG1	South shelf	0.76	0.185	0.000037	None	Gadd-DA_ptpru_protein_levels__seqid___8337-65__somascan_protein_measurement
Battram T	ARIES	None	2020-08-20	Total tissue mass	None	None	None	DNA methylation	Total tissue mass	Batch effects, cell composition (reference free), ancestry (genomic PCs)	Beta Values	g	Illumina HumanMethylation450	Whole blood	DXA scan measurement	704	1	Adults	Females	European	cg27243685	chr21:43642366	21	43642366	ABCG1	South shelf	0.0000089	0.0000022	0.000037	None	Battram-T_total_tissue_mass
Battram T	ARIES	None	2020-08-20	VLDL cholesterol	EFO_0008317	fasting	None	DNA methylation	VLDL cholesterol	Batch effects, cell composition (reference free), ancestry (genomic PCs)	Beta Values	mmol/l	Illumina HumanMethylation450	Whole blood	None	678	1	Adults	Females	European	cg27243685	chr21:43642366	21	43642366	ABCG1	South shelf	0.66	0.16	0.000037	None	Battram-T_vldl_cholesterol_fasting
Hedman AK	-	28213390	2017-02-17	Serum triglycerides	EFO_0004530, CHEBI_17855	Replication	Table S5	DNA methylation	Serum triglycerides	Age, sex, cell counts and technical covariates	Beta values	mg/dl	Illumina HumanMethylation450	Whole blood	-	1955	3	61	Both	None	cg27243685	chr21:43642366	21	43642366	ABCG1	South shelf	0.0045077	0.0010929	0.0000372	-	28213390_serum_triglycerides_replication
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02751	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P02751	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg27243685	chr21:43642366	21	43642366	ABCG1	South shelf	0.0368603	0.00893926	0.00003753485	P02751	41361833_Josephine_Robertson_P02751_OSCA_model_2
Battram T	ARIES	None	2020-08-20	Trunk total mass	EFO_0004338	None	None	DNA methylation	Trunk total mass	Batch effects, cell composition (reference free), ancestry (genomic PCs)	Beta Values	g	Illumina HumanMethylation450	Whole blood	DXA scan measurement	699	1	Adults	Females	European	cg27243685	chr21:43642366	21	43642366	ABCG1	South shelf	0.000016	0.0000038	0.000038	None	Battram-T_trunk_total_mass
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	Q96PD5	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	Q96PD5	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg27243685	chr21:43642366	21	43642366	ABCG1	South shelf	-0.0339821	0.0082518	0.00003840331	Q96PD5	41361833_Josephine_Robertson_Q96PD5_OSCA_model_1
Battram T	ARIES	None	2020-08-20	Triglycerides	EFO_0004530	fasting	None	DNA methylation	Triglycerides	Batch effects, cell composition (reference free), ancestry (genomic PCs)	Beta Values	mmol/l	Illumina HumanMethylation450	Whole blood	None	678	1	Adults	Females	European	cg27243685	chr21:43642366	21	43642366	ABCG1	South shelf	0.3	0.073	0.000039	None	Battram-T_triglycerides_fasting
Joubert BR	PACE	27040690	2016-04-07	Maternal smoking in pregnancy	EFO_0006527, EFO_0005671, EFO_0004318, EFO_0002950	Any maternal smoking in pregnancy effect on newborns	Table S3	DNA methylation	Maternal smoking in pregnancy	Maternal age, maternal education, parity and technical covariates	Beta values	-	Illumina HumanMethylation450	Cord blood	-	6685	13	0	Missing	European,East Asian,African,Admixed,Other	cg27243685	chr21:43642366	21	43642366	ABCG1	South shelf	0.003	0.001	0.0000399	-	27040690_maternal_smoking_in_pregnancy_any_maternal_smoking_in_pregnancy_effect_on_newborns
Battram T	ARIES	None	2020-08-20	Trunk tissue mass	None	None	None	DNA methylation	Trunk tissue mass	Batch effects, cell composition (reference free), ancestry (genomic PCs)	Beta Values	g	Illumina HumanMethylation450	Whole blood	DXA scan measurement	699	1	Adults	Females	European	cg27243685	chr21:43642366	21	43642366	ABCG1	South shelf	0.000016	0.0000038	0.000041	None	Battram-T_trunk_tissue_mass
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P02787	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P02787	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg27243685	chr21:43642366	21	43642366	ABCG1	South shelf	0.0337654	0.00825186	0.00004302327	P02787	41361833_Josephine_Robertson_P02787_OSCA_model_1
Battram T	ARIES	None	2020-08-20	Total cholesterol to total lipids ratio in medium HDL	EFO_0004574	None	None	DNA methylation	Total cholesterol to total lipids ratio in medium HDL	Batch effects, cell composition (reference free), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylation450	Whole blood	None	682	1	Adults	Females	European	cg27243685	chr21:43642366	21	43642366	ABCG1	South shelf	-0.062	0.0151	0.000044	None	Battram-T_total_cholesterol_to_total_lipids_ratio_in_medium_hdl
Battram T	ARIES	None	2020-08-20	Phospholipids in small VLDL	EFO_0004639	None	None	DNA methylation	Phospholipids in small VLDL	Batch effects, cell composition (reference free), ancestry (genomic PCs)	Beta Values	mmol/l	Illumina HumanMethylation450	Whole blood	None	683	1	Adults	Females	European	cg27243685	chr21:43642366	21	43642366	ABCG1	South shelf	2.8	0.69	0.000048	None	Battram-T_phospholipids_in_small_vldl
Gadd DA	Generation Scotland	35945220	31/07/2022	IL18R1 protein levels (SeqId = 14079-14)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	IL18R1 protein levels (SeqId = 14079-14)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Interleukin-18 receptor 1	774	1	Adults (18-65 years)	Both	European	cg27243685	chr21:43642366	21	43642366	ABCG1	South shelf	0.75	0.185	0.000048	None	Gadd-DA_il18r1_protein_levels__seqid___14079-14__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	ALDOB protein levels (SeqId = 18185-118)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	ALDOB protein levels (SeqId = 18185-118)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Fructose-bisphosphate aldolase B	774	1	Adults (18-65 years)	Both	European	cg27243685	chr21:43642366	21	43642366	ABCG1	South shelf	0.75	0.185	0.000049	None	Gadd-DA_aldob_protein_levels__seqid___18185-118__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	NEU1 protein levels (SeqId = 15426-5)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	NEU1 protein levels (SeqId = 15426-5)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Sialidase-1	774	1	Adults (18-65 years)	Both	European	cg27243685	chr21:43642366	21	43642366	ABCG1	South shelf	0.75	0.185	0.000051	None	Gadd-DA_neu1_protein_levels__seqid___15426-5__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	ALDOC protein levels (SeqId = 9876-20)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	ALDOC protein levels (SeqId = 9876-20)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Fructose-bisphosphate aldolase C	774	1	Adults (18-65 years)	Both	European	cg27243685	chr21:43642366	21	43642366	ABCG1	South shelf	0.749	0.185	0.000051	None	Gadd-DA_aldoc_protein_levels__seqid___9876-20__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	AKR7A3 protein levels (SeqId = 18173-11)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	AKR7A3 protein levels (SeqId = 18173-11)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Aflatoxin B1 aldehyde reductase member 3	774	1	Adults (18-65 years)	Both	European	cg27243685	chr21:43642366	21	43642366	ABCG1	South shelf	0.75	0.185	0.000052	None	Gadd-DA_akr7a3_protein_levels__seqid___18173-11__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P20742	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P20742	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg27243685	chr21:43642366	21	43642366	ABCG1	South shelf	-0.0357332	0.00883106	0.00005229971	P20742	41361833_Josephine_Robertson_P20742_OSCA_model_3
Gadd DA	Generation Scotland	35945220	31/07/2022	HTRA1 protein levels (SeqId = 15594-47)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	HTRA1 protein levels (SeqId = 15594-47)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Serine protease HTRA1	774	1	Adults (18-65 years)	Both	European	cg27243685	chr21:43642366	21	43642366	ABCG1	South shelf	0.75	0.19	0.000054	None	Gadd-DA_htra1_protein_levels__seqid___15594-47__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	SELE protein levels (SeqId = 3470-1)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	SELE protein levels (SeqId = 3470-1)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: E-selectin	774	1	Adults (18-65 years)	Both	European	cg27243685	chr21:43642366	21	43642366	ABCG1	South shelf	0.75	0.185	0.000055	None	Gadd-DA_sele_protein_levels__seqid___3470-1__somascan_protein_measurement
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P00734	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	P00734	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg27243685	chr21:43642366	21	43642366	ABCG1	South shelf	-0.0366944	0.00910685	0.00005622006	P00734	41361833_Josephine_Robertson_P00734_OSCA_model_3
Battram T	ARIES	None	2020-08-20	Cholesterol esters to total lipids ratio in very small VLDL	EFO_0008589	None	None	DNA methylation	Cholesterol esters to total lipids ratio in very small VLDL	Batch effects, cell composition (reference free), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylation450	Whole blood	None	680	1	Adults	Females	European	cg27243685	chr21:43642366	21	43642366	ABCG1	South shelf	-0.036	0.009	0.000059	None	Battram-T_cholesterol_esters_to_total_lipids_ratio_in_very_small_vldl
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P20851	None	OSCA model 1	10.5281/zenodo.16924748	DNA methylation	P20851	Age,Sex	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg27243685	chr21:43642366	21	43642366	ABCG1	South shelf	0.0331486	0.00825203	0.00005923328	P20851	41361833_Josephine_Robertson_P20851_OSCA_model_1
Gadd DA	Generation Scotland	35945220	31/07/2022	UGDH protein levels (SeqId = 17755-5)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	UGDH protein levels (SeqId = 17755-5)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: UDP-glucose 6-dehydrogenase	774	1	Adults (18-65 years)	Both	European	cg27243685	chr21:43642366	21	43642366	ABCG1	South shelf	0.744	0.185	0.00006	None	Gadd-DA_ugdh_protein_levels__seqid___17755-5__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	INHBA protein levels (SeqId = 19622-7)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	INHBA protein levels (SeqId = 19622-7)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Inhibin beta A chain	774	1	Adults (18-65 years)	Both	European	cg27243685	chr21:43642366	21	43642366	ABCG1	South shelf	0.74	0.185	0.000063	None	Gadd-DA_inhba_protein_levels__seqid___19622-7__somascan_protein_measurement
Battram T	ARIES	None	2020-08-20	Concentration of small VLDL particles	EFO_0008317	None	None	DNA methylation	Concentration of small VLDL particles	Batch effects, cell composition (reference free), ancestry (genomic PCs)	Beta Values	mol/l	Illumina HumanMethylation450	Whole blood	None	681	1	Adults	Females	European	cg27243685	chr21:43642366	21	43642366	ABCG1	South shelf	13000000	None	0.000071	None	Battram-T_concentration_of_small_vldl_particles
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O95445	None	OSCA model 3	10.5281/zenodo.16924748	DNA methylation	O95445	Age,Sex,Cell composition (reference based),Body mass index, Smoking	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg27243685	chr21:43642366	21	43642366	ABCG1	South shelf	-0.0360272	0.00907062	0.00007165694	O95445	41361833_Josephine_Robertson_O95445_OSCA_model_3
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	P06312	None	OSCA model 2	10.5281/zenodo.16924748	DNA methylation	P06312	Age,Sex,Cell composition (reference based)	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg27243685	chr21:43642366	21	43642366	ABCG1	South shelf	-0.035293	0.00892672	0.00007733388	P06312	41361833_Josephine_Robertson_P06312_OSCA_model_2
Gadd DA	Generation Scotland	35945220	31/07/2022	DSG2 protein levels (SeqId = 9484-75)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	DSG2 protein levels (SeqId = 9484-75)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Desmoglein-2	774	1	Adults (18-65 years)	Both	European	cg27243685	chr21:43642366	21	43642366	ABCG1	South shelf	-0.73	0.185	0.000078	None	Gadd-DA_dsg2_protein_levels__seqid___9484-75__somascan_protein_measurement
Battram T	ARIES	None	2020-08-20	Total cholesterol to total lipids ratio in large HDL	EFO_0004574	None	None	DNA methylation	Total cholesterol to total lipids ratio in large HDL	Batch effects, cell composition (reference free), ancestry (genomic PCs)	Beta Values	None	Illumina HumanMethylation450	Whole blood	None	678	1	Adults	Females	European	cg27243685	chr21:43642366	21	43642366	ABCG1	South shelf	-0.034	0.0085	0.000082	None	Battram-T_total_cholesterol_to_total_lipids_ratio_in_large_hdl
Josephine Robertson	Generation Scotland	41361833	Dec 8, 2025	O95445	None	OSCA model 4	10.5281/zenodo.16924748	DNA methylation	O95445	Age,Sex,Cell composition (reference based),Body mass index, Smoking,20 DNAm PCs	M values	None	Illumina HumanMethylationEPIC	whole blood	None	14671	1	Adults (18-65 years)	Both	European	cg27243685	chr21:43642366	21	43642366	ABCG1	South shelf	-0.0408954	0.010385	0.0000825729	O95445	41361833_Josephine_Robertson_O95445_OSCA_model_4
Battram T	ARIES	None	2020-08-20	Total lipids in small VLDL	EFO_0004529	None	None	DNA methylation	Total lipids in small VLDL	Batch effects, cell composition (reference free), ancestry (genomic PCs)	Beta Values	mmol/l	Illumina HumanMethylation450	Whole blood	None	681	1	Adults	Females	European	cg27243685	chr21:43642366	21	43642366	ABCG1	South shelf	0.59	0.149	0.000087	None	Battram-T_total_lipids_in_small_vldl
Battram T	GEO	27886173	2020-09-15	Inflammatory bowel disease	EFO_0003767	EWAS Catalog re-analysis of GEO data. GEO accession ID is GSE87640	None	DNA methylation	Inflammatory bowel disease	Batch effects, cell composition (reference free)	Beta Values	None	Illumina HumanMethylation450	Whole blood	None	240	1	Adults	Both	European	cg27243685	chr21:43642366	21	43642366	ABCG1	South shelf	0.0108	0.00271	0.000089	None	27886173_Battram-T_inflammatory_bowel_disease_ewas_catalog_re-analysis_of_geo_data__geo_accession_id_is_gse87640
Gadd DA	Generation Scotland	35945220	31/07/2022	SDCBP2 protein levels (SeqId = 19261-12)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	SDCBP2 protein levels (SeqId = 19261-12)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Syntenin-2	774	1	Adults (18-65 years)	Both	European	cg27243685	chr21:43642366	21	43642366	ABCG1	South shelf	0.73	0.19	0.00009	None	Gadd-DA_sdcbp2_protein_levels__seqid___19261-12__somascan_protein_measurement
Battram T	ARIES	None	2020-08-20	Free cholesterol in small VLDL	EFO_0008591	None	None	DNA methylation	Free cholesterol in small VLDL	Batch effects, cell composition (reference free), ancestry (genomic PCs)	Beta Values	mmol/l	Illumina HumanMethylation450	Whole blood	None	683	1	Adults	Females	European	cg27243685	chr21:43642366	21	43642366	ABCG1	South shelf	4	1.02	0.000091	None	Battram-T_free_cholesterol_in_small_vldl
Gadd DA	Generation Scotland	35945220	31/07/2022	NFASC protein levels (SeqId = 7179-69)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	NFASC protein levels (SeqId = 7179-69)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Neurofascin	774	1	Adults (18-65 years)	Both	European	cg27243685	chr21:43642366	21	43642366	ABCG1	South shelf	0.72	0.185	0.000092	None	Gadd-DA_nfasc_protein_levels__seqid___7179-69__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	HRSP12 protein levels (SeqId = 14636-25)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	HRSP12 protein levels (SeqId = 14636-25)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: 2-iminobutanoate/2-iminopropanoate deaminase	774	1	Adults (18-65 years)	Both	European	cg27243685	chr21:43642366	21	43642366	ABCG1	South shelf	0.72	0.185	0.000093	None	Gadd-DA_hrsp12_protein_levels__seqid___14636-25__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	OTC protein levels (SeqId = 15431-31)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	OTC protein levels (SeqId = 15431-31)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Ornithine carbamoyltransferase, mitochondrial	774	1	Adults (18-65 years)	Both	European	cg27243685	chr21:43642366	21	43642366	ABCG1	South shelf	0.72	0.185	0.000097	None	Gadd-DA_otc_protein_levels__seqid___15431-31__somascan_protein_measurement
Gadd DA	Generation Scotland	35945220	31/07/2022	ALDH1A1 protein levels (SeqId = 11265-8)	None	SomaScan protein measurement	https://doi.org/10.5281/zenodo.6801458	ALDH1A1 protein levels (SeqId = 11265-8)	DNA methylation	Age, sex, pQTLs, batch effects, ancestry (genomic PCs), depression, cell composition (reference based), body mass index, smoking	None	M values	Illumina HumanMethylationEPIC	Whole blood	Full UniProt name: Retinal dehydrogenase 1	774	1	Adults (18-65 years)	Both	European	cg27243685	chr21:43642366	21	43642366	ABCG1	South shelf	0.72	0.185	0.000099	None	Gadd-DA_aldh1a1_protein_levels__seqid___11265-8__somascan_protein_measurement