author	consortium	pmid	date	trait	efo	analysis	source	outcome	exposure	covariates	outcome_units	exposure_units	methylation_array	tissue	further_details	n	n_cohorts	age	sex	ethnicity	cpg	chrpos	chr	pos	gene	type	beta	se	p	details	study_id
Hedman AK	-	28213390	2017-02-17	Serum total cholesterol	EFO_0004574	Discovery and replication	Table S2	DNA methylation	Serum total cholesterol	Age, sex, cell counts and technical covariates	Beta values	mg/dl	Illumina HumanMethylation450	Whole blood	Inverse variance weighted fixed-effect meta-analysis	4331	5	65	Both	None	cg00285394	chr8:126011954	8	126011954	SQLE	South shore	0.00019	2.57e-05	0.000000000000147	-	28213390_serum_total_cholesterol_discovery_and_replication
Hedman AK	-	28213390	2017-02-17	Serum total cholesterol	EFO_0004574	Discovery and replication adjusted for BMI	Table S6	DNA methylation	Serum total cholesterol	Age, sex, body mass index, cell counts and technical covariates	Beta values	mg/dl	Illumina HumanMethylation450	Whole blood	Inverse variance weighted fixed-effect meta-analysis	4331	5	65	Both	None	cg00285394	chr8:126011954	8	126011954	SQLE	South shore	0.0001885	2.58e-05	0.000000000000268	-	28213390_serum_total_cholesterol_discovery_and_replication_adjusted_for_bmi
Hedman AK	-	28213390	2017-02-17	Serum total cholesterol	EFO_0004574	Discovery and replication	Table S2	DNA methylation	Serum total cholesterol	Age, sex, cell counts and technical covariates	Beta values	mg/dl	Illumina HumanMethylation450	Whole blood	Inverse variance weighted fixed-effect meta-analysis	4331	5	65	Both	None	cg07839457	chr16:57023022	16	57023022	NLRC5	North shore	0.000251	3.53e-05	0.00000000000113	-	28213390_serum_total_cholesterol_discovery_and_replication
Hedman AK	-	28213390	2017-02-17	Serum total cholesterol	EFO_0004574	Discovery and replication adjusted for BMI	Table S6	DNA methylation	Serum total cholesterol	Age, sex, body mass index, cell counts and technical covariates	Beta values	mg/dl	Illumina HumanMethylation450	Whole blood	Inverse variance weighted fixed-effect meta-analysis	4331	5	65	Both	None	cg07839457	chr16:57023022	16	57023022	NLRC5	North shore	0.0002469	3.54e-05	0.00000000000309	-	28213390_serum_total_cholesterol_discovery_and_replication_adjusted_for_bmi
Hedman AK	-	28213390	2017-02-17	Serum total cholesterol	EFO_0004574	Discovery and replication	Table S2	DNA methylation	Serum total cholesterol	Age, sex, cell counts and technical covariates	Beta values	mg/dl	Illumina HumanMethylation450	Whole blood	Inverse variance weighted fixed-effect meta-analysis	4331	5	65	Both	None	cg09978077	chr22:42229983	22	42229983	SREBF2	Island	5.41e-05	7.8e-06	0.00000000000367	-	28213390_serum_total_cholesterol_discovery_and_replication
Hedman AK	-	28213390	2017-02-17	Serum total cholesterol	EFO_0004574	Discovery and replication adjusted for BMI	Table S6	DNA methylation	Serum total cholesterol	Age, sex, body mass index, cell counts and technical covariates	Beta values	mg/dl	Illumina HumanMethylation450	Whole blood	Inverse variance weighted fixed-effect meta-analysis	4331	5	65	Both	None	cg09978077	chr22:42229983	22	42229983	SREBF2	Island	5.34e-05	7.8e-06	0.00000000000825	-	28213390_serum_total_cholesterol_discovery_and_replication_adjusted_for_bmi
Hedman AK	-	28213390	2017-02-17	Serum total cholesterol	EFO_0004574	Discovery and replication	Table S2	DNA methylation	Serum total cholesterol	Age, sex, cell counts and technical covariates	Beta values	mg/dl	Illumina HumanMethylation450	Whole blood	Inverse variance weighted fixed-effect meta-analysis	4331	5	65	Both	None	cg23759710	chr2:42990957	2	42990957	OXER1	Open sea	-7.95e-05	1.17e-05	0.00000000000924	-	28213390_serum_total_cholesterol_discovery_and_replication
Hedman AK	-	28213390	2017-02-17	Serum total cholesterol	EFO_0004574	Discovery and replication adjusted for BMI	Table S6	DNA methylation	Serum total cholesterol	Age, sex, body mass index, cell counts and technical covariates	Beta values	mg/dl	Illumina HumanMethylation450	Whole blood	Inverse variance weighted fixed-effect meta-analysis	4331	5	65	Both	None	cg23759710	chr2:42990957	2	42990957	OXER1	Open sea	-7.92e-05	1.17e-05	0.0000000000116	-	28213390_serum_total_cholesterol_discovery_and_replication_adjusted_for_bmi
Hedman AK	-	28213390	2017-02-17	Serum total cholesterol	EFO_0004574	Discovery and replication adjusted for BMI	Table S6	DNA methylation	Serum total cholesterol	Age, sex, body mass index, cell counts and technical covariates	Beta values	mg/dl	Illumina HumanMethylation450	Whole blood	Inverse variance weighted fixed-effect meta-analysis	4331	5	65	Both	None	cg09737197	chr11:68607675	11	68607675	CPT1A	North shore	-9.15e-05	1.39e-05	0.0000000000386	-	28213390_serum_total_cholesterol_discovery_and_replication_adjusted_for_bmi
Hedman AK	-	28213390	2017-02-17	Serum total cholesterol	EFO_0004574	Discovery and replication	Table S2	DNA methylation	Serum total cholesterol	Age, sex, cell counts and technical covariates	Beta values	mg/dl	Illumina HumanMethylation450	Whole blood	Inverse variance weighted fixed-effect meta-analysis	4331	5	65	Both	None	cg09737197	chr11:68607675	11	68607675	CPT1A	North shore	-9.13e-05	1.38e-05	0.0000000000425	-	28213390_serum_total_cholesterol_discovery_and_replication
Hedman AK	-	28213390	2017-02-17	Serum total cholesterol	EFO_0004574	Discovery and replication	Table S2	DNA methylation	Serum total cholesterol	Age, sex, cell counts and technical covariates	Beta values	mg/dl	Illumina HumanMethylation450	Whole blood	Inverse variance weighted fixed-effect meta-analysis	4331	5	65	Both	None	cg21645268	chr8:11663584	8	11663584	FDFT1	North shelf	8.9e-05	1.35e-05	0.0000000000461	-	28213390_serum_total_cholesterol_discovery_and_replication
Hedman AK	-	28213390	2017-02-17	Serum total cholesterol	EFO_0004574	Discovery and replication	Table S2	DNA methylation	Serum total cholesterol	Age, sex, cell counts and technical covariates	Beta values	mg/dl	Illumina HumanMethylation450	Whole blood	Inverse variance weighted fixed-effect meta-analysis	4331	5	65	Both	None	cg17901584	chr1:55353706	1	55353706	DHCR24	South shore	0.000135	2.08e-05	0.0000000001	-	28213390_serum_total_cholesterol_discovery_and_replication
Hedman AK	-	28213390	2017-02-17	Serum total cholesterol	EFO_0004574	Discovery and replication adjusted for BMI	Table S6	DNA methylation	Serum total cholesterol	Age, sex, body mass index, cell counts and technical covariates	Beta values	mg/dl	Illumina HumanMethylation450	Whole blood	Inverse variance weighted fixed-effect meta-analysis	4331	5	65	Both	None	cg21645268	chr8:11663584	8	11663584	FDFT1	North shelf	8.69e-05	1.35e-05	0.000000000139	-	28213390_serum_total_cholesterol_discovery_and_replication_adjusted_for_bmi
Hedman AK	-	28213390	2017-02-17	Serum total cholesterol	EFO_0004574	Discovery	Table S2	DNA methylation	Serum total cholesterol	Age, sex, white cell counts, and technical covariates	Beta values	mg/dl	Illumina HumanMethylation450	Whole blood	Meta-analysis of 2 discovery cohorts	2306	2	68	Both	None	cg06780861	chr14:83683592	14	83683592	-	Open sea	0.000132	2.1e-05	0.000000000317	-	28213390_serum_total_cholesterol_discovery
Hedman AK	-	28213390	2017-02-17	Serum total cholesterol	EFO_0004574	Discovery adjusted for BMI	Table S6	DNA methylation	Serum total cholesterol	Age, sex, body mass index, cell counts and technical covariates	Beta values	mg/dl	Illumina HumanMethylation450	Whole blood	-	2306	2	68	Both	None	cg00285394	chr8:126011954	8	126011954	SQLE	South shore	0.0002146	3.45e-05	0.000000000483	-	28213390_serum_total_cholesterol_discovery_adjusted_for_bmi
Hedman AK	-	28213390	2017-02-17	Serum total cholesterol	EFO_0004574	Discovery	Table S2	DNA methylation	Serum total cholesterol	Age, sex, white cell counts, and technical covariates	Beta values	mg/dl	Illumina HumanMethylation450	Whole blood	Meta-analysis of 2 discovery cohorts	2306	2	68	Both	None	cg00285394	chr8:126011954	8	126011954	SQLE	South shore	0.000213	3.44e-05	0.000000000598	-	28213390_serum_total_cholesterol_discovery
Hedman AK	-	28213390	2017-02-17	Serum total cholesterol	EFO_0004574	Discovery adjusted for BMI	Table S6	DNA methylation	Serum total cholesterol	Age, sex, body mass index, cell counts and technical covariates	Beta values	mg/dl	Illumina HumanMethylation450	Whole blood	-	2306	2	68	Both	None	cg06780861	chr14:83683592	14	83683592	-	Open sea	0.0001292	2.1e-05	0.000000000767	-	28213390_serum_total_cholesterol_discovery_adjusted_for_bmi
Hedman AK	-	28213390	2017-02-17	Serum total cholesterol	EFO_0004574	Discovery	Table S2	DNA methylation	Serum total cholesterol	Age, sex, white cell counts, and technical covariates	Beta values	mg/dl	Illumina HumanMethylation450	Whole blood	Meta-analysis of 2 discovery cohorts	2306	2	68	Both	None	cg03188976	chr7:134443864	7	134443864	-	Open sea	0.0001325	2.17e-05	0.000000000994	-	28213390_serum_total_cholesterol_discovery
Hedman AK	-	28213390	2017-02-17	Serum total cholesterol	EFO_0004574	Discovery	Table S2	DNA methylation	Serum total cholesterol	Age, sex, white cell counts, and technical covariates	Beta values	mg/dl	Illumina HumanMethylation450	Whole blood	Meta-analysis of 2 discovery cohorts	2306	2	68	Both	None	cg21645268	chr8:11663584	8	11663584	FDFT1	North shelf	9.58e-05	1.57e-05	0.00000000104	-	28213390_serum_total_cholesterol_discovery
Hedman AK	-	28213390	2017-02-17	Serum total cholesterol	EFO_0004574	Discovery adjusted for BMI	Table S6	DNA methylation	Serum total cholesterol	Age, sex, body mass index, cell counts and technical covariates	Beta values	mg/dl	Illumina HumanMethylation450	Whole blood	-	2306	2	68	Both	None	cg03188976	chr7:134443864	7	134443864	-	Open sea	0.0001319	2.17e-05	0.00000000124	-	28213390_serum_total_cholesterol_discovery_adjusted_for_bmi
Hedman AK	-	28213390	2017-02-17	Serum total cholesterol	EFO_0004574	Discovery	Table S2	DNA methylation	Serum total cholesterol	Age, sex, white cell counts, and technical covariates	Beta values	mg/dl	Illumina HumanMethylation450	Whole blood	Meta-analysis of 2 discovery cohorts	2306	2	68	Both	None	cg09978077	chr22:42229983	22	42229983	SREBF2	Island	5.74e-05	9.5e-06	0.00000000179	-	28213390_serum_total_cholesterol_discovery
Hedman AK	-	28213390	2017-02-17	Serum total cholesterol	EFO_0004574	Discovery	Table S2	DNA methylation	Serum total cholesterol	Age, sex, white cell counts, and technical covariates	Beta values	mg/dl	Illumina HumanMethylation450	Whole blood	Meta-analysis of 2 discovery cohorts	2306	2	68	Both	None	cg18192491	chr6:114384871	6	114384871	HS3ST5	Open sea	0.0001456	2.43e-05	0.00000000194	-	28213390_serum_total_cholesterol_discovery
Hedman AK	-	28213390	2017-02-17	Serum total cholesterol	EFO_0004574	Discovery and replication adjusted for BMI	Table S6	DNA methylation	Serum total cholesterol	Age, sex, body mass index, cell counts and technical covariates	Beta values	mg/dl	Illumina HumanMethylation450	Whole blood	Inverse variance weighted fixed-effect meta-analysis	4331	5	65	Both	None	cg03188976	chr7:134443864	7	134443864	-	Open sea	0.0001005	1.68e-05	0.00000000231	-	28213390_serum_total_cholesterol_discovery_and_replication_adjusted_for_bmi
Hedman AK	-	28213390	2017-02-17	Serum total cholesterol	EFO_0004574	Discovery adjusted for BMI	Table S6	DNA methylation	Serum total cholesterol	Age, sex, body mass index, cell counts and technical covariates	Beta values	mg/dl	Illumina HumanMethylation450	Whole blood	-	2306	2	68	Both	None	cg09737197	chr11:68607675	11	68607675	CPT1A	North shore	-9.48e-05	1.59e-05	0.00000000236	-	28213390_serum_total_cholesterol_discovery_adjusted_for_bmi
Hedman AK	-	28213390	2017-02-17	Serum total cholesterol	EFO_0004574	Discovery	Table S2	DNA methylation	Serum total cholesterol	Age, sex, white cell counts, and technical covariates	Beta values	mg/dl	Illumina HumanMethylation450	Whole blood	Meta-analysis of 2 discovery cohorts	2306	2	68	Both	None	cg23759710	chr2:42990957	2	42990957	OXER1	Open sea	-8.15e-05	1.37e-05	0.00000000245	-	28213390_serum_total_cholesterol_discovery
Hedman AK	-	28213390	2017-02-17	Serum total cholesterol	EFO_0004574	Discovery	Table S2	DNA methylation	Serum total cholesterol	Age, sex, white cell counts, and technical covariates	Beta values	mg/dl	Illumina HumanMethylation450	Whole blood	Meta-analysis of 2 discovery cohorts	2306	2	68	Both	None	cg06621027	chr2:80179759	2	80179759	CTNNA2	Open sea	0.0001516	2.54e-05	0.00000000251	-	28213390_serum_total_cholesterol_discovery
Hedman AK	-	28213390	2017-02-17	Serum total cholesterol	EFO_0004574	Discovery adjusted for BMI	Table S6	DNA methylation	Serum total cholesterol	Age, sex, body mass index, cell counts and technical covariates	Beta values	mg/dl	Illumina HumanMethylation450	Whole blood	-	2306	2	68	Both	None	cg21645268	chr8:11663584	8	11663584	FDFT1	North shelf	9.36e-05	1.57e-05	0.00000000252	-	28213390_serum_total_cholesterol_discovery_adjusted_for_bmi
Hedman AK	-	28213390	2017-02-17	Serum total cholesterol	EFO_0004574	Discovery and replication	Table S2	DNA methylation	Serum total cholesterol	Age, sex, cell counts and technical covariates	Beta values	mg/dl	Illumina HumanMethylation450	Whole blood	Inverse variance weighted fixed-effect meta-analysis	4331	5	65	Both	None	cg06621027	chr2:80179759	2	80179759	CTNNA2	Open sea	0.000114	1.92e-05	0.00000000298	-	28213390_serum_total_cholesterol_discovery_and_replication
Hedman AK	-	28213390	2017-02-17	Serum total cholesterol	EFO_0004574	Discovery adjusted for BMI	Table S6	DNA methylation	Serum total cholesterol	Age, sex, body mass index, cell counts and technical covariates	Beta values	mg/dl	Illumina HumanMethylation450	Whole blood	-	2306	2	68	Both	None	cg09978077	chr22:42229983	22	42229983	SREBF2	Island	5.66e-05	9.5e-06	0.00000000303	-	28213390_serum_total_cholesterol_discovery_adjusted_for_bmi
Hedman AK	-	28213390	2017-02-17	Serum total cholesterol	EFO_0004574	Discovery adjusted for BMI	Table S6	DNA methylation	Serum total cholesterol	Age, sex, body mass index, cell counts and technical covariates	Beta values	mg/dl	Illumina HumanMethylation450	Whole blood	-	2306	2	68	Both	None	cg05337441	chr2:21266568	2	21266568	APOB	North shore	0.0002734	4.61e-05	0.0000000031	-	28213390_serum_total_cholesterol_discovery_adjusted_for_bmi
Hedman AK	-	28213390	2017-02-17	Serum total cholesterol	EFO_0004574	Discovery and replication	Table S2	DNA methylation	Serum total cholesterol	Age, sex, cell counts and technical covariates	Beta values	mg/dl	Illumina HumanMethylation450	Whole blood	Inverse variance weighted fixed-effect meta-analysis	4331	5	65	Both	None	cg03188976	chr7:134443864	7	134443864	-	Open sea	9.93e-05	1.68e-05	0.00000000318	-	28213390_serum_total_cholesterol_discovery_and_replication
Hedman AK	-	28213390	2017-02-17	Serum total cholesterol	EFO_0004574	Discovery	Table S2	DNA methylation	Serum total cholesterol	Age, sex, white cell counts, and technical covariates	Beta values	mg/dl	Illumina HumanMethylation450	Whole blood	Meta-analysis of 2 discovery cohorts	2306	2	68	Both	None	cg16466652	chr19:6271960	19	6271960	MLLT1	Island	-9.96e-05	1.68e-05	0.00000000333	-	28213390_serum_total_cholesterol_discovery
Hedman AK	-	28213390	2017-02-17	Serum total cholesterol	EFO_0004574	Discovery adjusted for BMI	Table S6	DNA methylation	Serum total cholesterol	Age, sex, body mass index, cell counts and technical covariates	Beta values	mg/dl	Illumina HumanMethylation450	Whole blood	-	2306	2	68	Both	None	cg23759710	chr2:42990957	2	42990957	OXER1	Open sea	-8.08e-05	1.37e-05	0.0000000036	-	28213390_serum_total_cholesterol_discovery_adjusted_for_bmi
Hedman AK	-	28213390	2017-02-17	Serum total cholesterol	EFO_0004574	Discovery	Table S2	DNA methylation	Serum total cholesterol	Age, sex, white cell counts, and technical covariates	Beta values	mg/dl	Illumina HumanMethylation450	Whole blood	Meta-analysis of 2 discovery cohorts	2306	2	68	Both	None	cg15878619	chr6:30687373	6	30687373	TUBB	North shore	6.72e-05	1.14e-05	0.00000000361	-	28213390_serum_total_cholesterol_discovery
Hedman AK	-	28213390	2017-02-17	Serum total cholesterol	EFO_0004574	Discovery and replication adjusted for BMI	Table S6	DNA methylation	Serum total cholesterol	Age, sex, body mass index, cell counts and technical covariates	Beta values	mg/dl	Illumina HumanMethylation450	Whole blood	Inverse variance weighted fixed-effect meta-analysis	4331	5	65	Both	None	cg06621027	chr2:80179759	2	80179759	CTNNA2	Open sea	0.0001133	1.93e-05	0.00000000418	-	28213390_serum_total_cholesterol_discovery_and_replication_adjusted_for_bmi
Hedman AK	-	28213390	2017-02-17	Serum total cholesterol	EFO_0004574	Discovery	Table S2	DNA methylation	Serum total cholesterol	Age, sex, white cell counts, and technical covariates	Beta values	mg/dl	Illumina HumanMethylation450	Whole blood	Meta-analysis of 2 discovery cohorts	2306	2	68	Both	None	cg09737197	chr11:68607675	11	68607675	CPT1A	North shore	-9.34e-05	1.59e-05	0.00000000419	-	28213390_serum_total_cholesterol_discovery
Hedman AK	-	28213390	2017-02-17	Serum total cholesterol	EFO_0004574	Discovery adjusted for BMI	Table S6	DNA methylation	Serum total cholesterol	Age, sex, body mass index, cell counts and technical covariates	Beta values	mg/dl	Illumina HumanMethylation450	Whole blood	-	2306	2	68	Both	None	cg18192491	chr6:114384871	6	114384871	HS3ST5	Open sea	0.0001424	2.42e-05	0.00000000426	-	28213390_serum_total_cholesterol_discovery_adjusted_for_bmi
Hedman AK	-	28213390	2017-02-17	Serum total cholesterol	EFO_0004574	Discovery	Table S2	DNA methylation	Serum total cholesterol	Age, sex, white cell counts, and technical covariates	Beta values	mg/dl	Illumina HumanMethylation450	Whole blood	Meta-analysis of 2 discovery cohorts	2306	2	68	Both	None	cg15705971	chr11:92110262	11	92110262	FAT3	Open sea	0.0001317	2.25e-05	0.00000000489	-	28213390_serum_total_cholesterol_discovery
Hedman AK	-	28213390	2017-02-17	Serum total cholesterol	EFO_0004574	Discovery	Table S2	DNA methylation	Serum total cholesterol	Age, sex, white cell counts, and technical covariates	Beta values	mg/dl	Illumina HumanMethylation450	Whole blood	Meta-analysis of 2 discovery cohorts	2306	2	68	Both	None	cg05337441	chr2:21266568	2	21266568	APOB	North shore	0.0002677	4.61e-05	0.00000000623	-	28213390_serum_total_cholesterol_discovery
Hedman AK	-	28213390	2017-02-17	Serum total cholesterol	EFO_0004574	Discovery adjusted for BMI	Table S6	DNA methylation	Serum total cholesterol	Age, sex, body mass index, cell counts and technical covariates	Beta values	mg/dl	Illumina HumanMethylation450	Whole blood	-	2306	2	68	Both	None	cg06621027	chr2:80179759	2	80179759	CTNNA2	Open sea	0.0001478	2.54e-05	0.00000000632	-	28213390_serum_total_cholesterol_discovery_adjusted_for_bmi
Hedman AK	-	28213390	2017-02-17	Serum total cholesterol	EFO_0004574	Discovery and replication	Table S2	DNA methylation	Serum total cholesterol	Age, sex, cell counts and technical covariates	Beta values	mg/dl	Illumina HumanMethylation450	Whole blood	Inverse variance weighted fixed-effect meta-analysis	4331	5	65	Both	None	cg00252813	chr12:6642229	12	6642229	GAPDH	North shore	6.92e-05	1.19e-05	0.0000000064	-	28213390_serum_total_cholesterol_discovery_and_replication
Hedman AK	-	28213390	2017-02-17	Serum total cholesterol	EFO_0004574	Discovery adjusted for BMI	Table S6	DNA methylation	Serum total cholesterol	Age, sex, body mass index, cell counts and technical covariates	Beta values	mg/dl	Illumina HumanMethylation450	Whole blood	-	2306	2	68	Both	None	cg16466652	chr19:6271960	19	6271960	MLLT1	Island	-9.77e-05	1.68e-05	0.00000000659	-	28213390_serum_total_cholesterol_discovery_adjusted_for_bmi
Hedman AK	-	28213390	2017-02-17	Serum total cholesterol	EFO_0004574	Discovery and replication	Table S2	DNA methylation	Serum total cholesterol	Age, sex, cell counts and technical covariates	Beta values	mg/dl	Illumina HumanMethylation450	Whole blood	Inverse variance weighted fixed-effect meta-analysis	4331	5	65	Both	None	cg13010621	chr6:92344723	6	92344723	-	Open sea	7.19e-05	1.24e-05	0.00000000713	-	28213390_serum_total_cholesterol_discovery_and_replication
Hedman AK	-	28213390	2017-02-17	Serum total cholesterol	EFO_0004574	Discovery	Table S2	DNA methylation	Serum total cholesterol	Age, sex, white cell counts, and technical covariates	Beta values	mg/dl	Illumina HumanMethylation450	Whole blood	Meta-analysis of 2 discovery cohorts	2306	2	68	Both	None	cg25738279	chr1:68027617	1	68027617	-	Open sea	9.01e-05	1.56e-05	0.0000000077	-	28213390_serum_total_cholesterol_discovery
Hedman AK	-	28213390	2017-02-17	Serum total cholesterol	EFO_0004574	Discovery	Table S2	DNA methylation	Serum total cholesterol	Age, sex, white cell counts, and technical covariates	Beta values	mg/dl	Illumina HumanMethylation450	Whole blood	Meta-analysis of 2 discovery cohorts	2306	2	68	Both	None	cg10001987	chr17:7381769	17	7381769	ZBTB4	North shore	-0.0002159	3.75e-05	0.00000000835	-	28213390_serum_total_cholesterol_discovery
Hedman AK	-	28213390	2017-02-17	Serum total cholesterol	EFO_0004574	Discovery adjusted for BMI	Table S6	DNA methylation	Serum total cholesterol	Age, sex, body mass index, cell counts and technical covariates	Beta values	mg/dl	Illumina HumanMethylation450	Whole blood	-	2306	2	68	Both	None	cg15878619	chr6:30687373	6	30687373	TUBB	North shore	6.53e-05	1.13e-05	0.00000000845	-	28213390_serum_total_cholesterol_discovery_adjusted_for_bmi
Hedman AK	-	28213390	2017-02-17	Serum total cholesterol	EFO_0004574	Discovery and replication	Table S2	DNA methylation	Serum total cholesterol	Age, sex, cell counts and technical covariates	Beta values	mg/dl	Illumina HumanMethylation450	Whole blood	Inverse variance weighted fixed-effect meta-analysis	4331	5	65	Both	None	cg01973483	chr12:123591123	12	123591123	PITPNM2	Open sea	-8.65e-05	1.51e-05	0.00000000984	-	28213390_serum_total_cholesterol_discovery_and_replication
Hedman AK	-	28213390	2017-02-17	Serum total cholesterol	EFO_0004574	Discovery adjusted for BMI	Table S6	DNA methylation	Serum total cholesterol	Age, sex, body mass index, cell counts and technical covariates	Beta values	mg/dl	Illumina HumanMethylation450	Whole blood	-	2306	2	68	Both	None	cg22023664	chr19:2619608	19	2619608	GNG7	North shelf	-9.28e-05	1.62e-05	0.00000001	-	28213390_serum_total_cholesterol_discovery_adjusted_for_bmi
Hedman AK	-	28213390	2017-02-17	Serum total cholesterol	EFO_0004574	Discovery adjusted for BMI	Table S6	DNA methylation	Serum total cholesterol	Age, sex, body mass index, cell counts and technical covariates	Beta values	mg/dl	Illumina HumanMethylation450	Whole blood	-	2306	2	68	Both	None	cg25738279	chr1:68027617	1	68027617	-	Open sea	8.94e-05	1.56e-05	0.0000000104	-	28213390_serum_total_cholesterol_discovery_adjusted_for_bmi
Hedman AK	-	28213390	2017-02-17	Serum total cholesterol	EFO_0004574	Discovery adjusted for BMI	Table S6	DNA methylation	Serum total cholesterol	Age, sex, body mass index, cell counts and technical covariates	Beta values	mg/dl	Illumina HumanMethylation450	Whole blood	-	2306	2	68	Both	None	cg15705971	chr11:92110262	11	92110262	FAT3	Open sea	0.0001288	2.25e-05	0.0000000109	-	28213390_serum_total_cholesterol_discovery_adjusted_for_bmi
Hedman AK	-	28213390	2017-02-17	Serum total cholesterol	EFO_0004574	Discovery and replication adjusted for BMI	Table S6	DNA methylation	Serum total cholesterol	Age, sex, body mass index, cell counts and technical covariates	Beta values	mg/dl	Illumina HumanMethylation450	Whole blood	Inverse variance weighted fixed-effect meta-analysis	4331	5	65	Both	None	cg13010621	chr6:92344723	6	92344723	-	Open sea	7.07e-05	1.24e-05	0.0000000119	-	28213390_serum_total_cholesterol_discovery_and_replication_adjusted_for_bmi
Hedman AK	-	28213390	2017-02-17	Serum total cholesterol	EFO_0004574	Discovery	Table S2	DNA methylation	Serum total cholesterol	Age, sex, white cell counts, and technical covariates	Beta values	mg/dl	Illumina HumanMethylation450	Whole blood	Meta-analysis of 2 discovery cohorts	2306	2	68	Both	None	cg05897122	chr4:53112707	4	53112707	-	Open sea	0.0001565	2.75e-05	0.0000000131	-	28213390_serum_total_cholesterol_discovery
Hedman AK	-	28213390	2017-02-17	Serum total cholesterol	EFO_0004574	Discovery	Table S2	DNA methylation	Serum total cholesterol	Age, sex, white cell counts, and technical covariates	Beta values	mg/dl	Illumina HumanMethylation450	Whole blood	Meta-analysis of 2 discovery cohorts	2306	2	68	Both	None	cg26874872	chr16:26156362	16	26156362	-	Open sea	0.0001556	2.74e-05	0.0000000131	-	28213390_serum_total_cholesterol_discovery
Hedman AK	-	28213390	2017-02-17	Serum total cholesterol	EFO_0004574	Discovery	Table S2	DNA methylation	Serum total cholesterol	Age, sex, white cell counts, and technical covariates	Beta values	mg/dl	Illumina HumanMethylation450	Whole blood	Meta-analysis of 2 discovery cohorts	2306	2	68	Both	None	cg22023664	chr19:2619608	19	2619608	GNG7	North shelf	-9.18e-05	1.62e-05	0.0000000135	-	28213390_serum_total_cholesterol_discovery
Hedman AK	-	28213390	2017-02-17	Serum total cholesterol	EFO_0004574	Discovery	Table S2	DNA methylation	Serum total cholesterol	Age, sex, white cell counts, and technical covariates	Beta values	mg/dl	Illumina HumanMethylation450	Whole blood	Meta-analysis of 2 discovery cohorts	2306	2	68	Both	None	cg22446998	chr5:155701819	5	155701819	-	Open sea	0.0001441	2.54e-05	0.0000000143	-	28213390_serum_total_cholesterol_discovery
Sayols-Baixeras S	-	28173150	2016-09-15	Serum total cholesterol	EFO_0004574	Discovery and replication adjusted for surrogate variables	Table S1	Serum total cholesterol	DNA methylation	Age, sex, smoking, cell counts and technical covariates	mg/dl	M values	Illumina HumanMethylation450	Whole blood	-	3187	2	65.7	Both	None	cg16000331	chr22:42230138	22	42230138	SREBF2	South shore	4.91	0.867	0.000000015	-	28173150_serum_total_cholesterol_discovery_and_replication_adjusted_for_surrogate_variables
Battram T	ARIES	None	2020-08-20	Serum total cholesterol	EFO_0004574	None	None	DNA methylation	Serum total cholesterol	Batch effects, cell composition (reference free), ancestry (genomic PCs)	Beta Values	mmol/l	Illumina HumanMethylation450	Whole blood	None	685	1	Adults	Females	European	cg24206531	chr10:81286397	10	81286397	-	Open sea	0.24	0.042	0.000000016	None	Battram-T_serum_total_cholesterol
Hedman AK	-	28213390	2017-02-17	Serum total cholesterol	EFO_0004574	Discovery	Table S2	DNA methylation	Serum total cholesterol	Age, sex, white cell counts, and technical covariates	Beta values	mg/dl	Illumina HumanMethylation450	Whole blood	Meta-analysis of 2 discovery cohorts	2306	2	68	Both	None	cg15380836	chr17:1553341	17	1553341	RILP	South shore	6.11e-05	1.08e-05	0.0000000165	-	28213390_serum_total_cholesterol_discovery
Hedman AK	-	28213390	2017-02-17	Serum total cholesterol	EFO_0004574	Discovery	Table S2	DNA methylation	Serum total cholesterol	Age, sex, white cell counts, and technical covariates	Beta values	mg/dl	Illumina HumanMethylation450	Whole blood	Meta-analysis of 2 discovery cohorts	2306	2	68	Both	None	cg00252813	chr12:6642229	12	6642229	GAPDH	North shore	8.25e-05	1.46e-05	0.0000000171	-	28213390_serum_total_cholesterol_discovery
Hedman AK	-	28213390	2017-02-17	Serum total cholesterol	EFO_0004574	Discovery	Table S2	DNA methylation	Serum total cholesterol	Age, sex, white cell counts, and technical covariates	Beta values	mg/dl	Illumina HumanMethylation450	Whole blood	Meta-analysis of 2 discovery cohorts	2306	2	68	Both	None	cg23475018	chr3:124277638	3	124277638	KALRN	Open sea	0.0001119	1.99e-05	0.0000000181	-	28213390_serum_total_cholesterol_discovery
Hedman AK	-	28213390	2017-02-17	Serum total cholesterol	EFO_0004574	Discovery	Table S2	DNA methylation	Serum total cholesterol	Age, sex, white cell counts, and technical covariates	Beta values	mg/dl	Illumina HumanMethylation450	Whole blood	Meta-analysis of 2 discovery cohorts	2306	2	68	Both	None	cg01575601	chr11:130398900	11	130398900	-	Open sea	0.0001317	2.34e-05	0.0000000188	-	28213390_serum_total_cholesterol_discovery
Hedman AK	-	28213390	2017-02-17	Serum total cholesterol	EFO_0004574	Discovery	Table S2	DNA methylation	Serum total cholesterol	Age, sex, white cell counts, and technical covariates	Beta values	mg/dl	Illumina HumanMethylation450	Whole blood	Meta-analysis of 2 discovery cohorts	2306	2	68	Both	None	cg13636014	chr9:84004731	9	84004731	-	Open sea	0.0001229	2.19e-05	0.0000000193	-	28213390_serum_total_cholesterol_discovery
Hedman AK	-	28213390	2017-02-17	Serum total cholesterol	EFO_0004574	Discovery and replication adjusted for BMI	Table S6	DNA methylation	Serum total cholesterol	Age, sex, body mass index, cell counts and technical covariates	Beta values	mg/dl	Illumina HumanMethylation450	Whole blood	Inverse variance weighted fixed-effect meta-analysis	4331	5	65	Both	None	cg25738279	chr1:68027617	1	68027617	-	Open sea	5.8e-05	1.03e-05	0.0000000196	-	28213390_serum_total_cholesterol_discovery_and_replication_adjusted_for_bmi
Hedman AK	-	28213390	2017-02-17	Serum total cholesterol	EFO_0004574	Discovery	Table S2	DNA methylation	Serum total cholesterol	Age, sex, white cell counts, and technical covariates	Beta values	mg/dl	Illumina HumanMethylation450	Whole blood	Meta-analysis of 2 discovery cohorts	2306	2	68	Both	None	cg22878054	chr11:99397252	11	99397252	CNTN5	Open sea	0.0001378	2.45e-05	0.0000000198	-	28213390_serum_total_cholesterol_discovery
Hedman AK	-	28213390	2017-02-17	Serum total cholesterol	EFO_0004574	Discovery adjusted for BMI	Table S6	DNA methylation	Serum total cholesterol	Age, sex, body mass index, cell counts and technical covariates	Beta values	mg/dl	Illumina HumanMethylation450	Whole blood	-	2306	2	68	Both	None	cg10001987	chr17:7381769	17	7381769	ZBTB4	North shore	-0.0002103	3.75e-05	0.0000000202	-	28213390_serum_total_cholesterol_discovery_adjusted_for_bmi
Hedman AK	-	28213390	2017-02-17	Serum total cholesterol	EFO_0004574	Discovery and replication adjusted for BMI	Table S6	DNA methylation	Serum total cholesterol	Age, sex, body mass index, cell counts and technical covariates	Beta values	mg/dl	Illumina HumanMethylation450	Whole blood	Inverse variance weighted fixed-effect meta-analysis	4331	5	65	Both	None	cg09802018	chr11:46357562	11	46357562	DGKZ	South shelf	-7.1e-05	1.27e-05	0.0000000212	-	28213390_serum_total_cholesterol_discovery_and_replication_adjusted_for_bmi
Hedman AK	-	28213390	2017-02-17	Serum total cholesterol	EFO_0004574	Discovery	Table S2	DNA methylation	Serum total cholesterol	Age, sex, white cell counts, and technical covariates	Beta values	mg/dl	Illumina HumanMethylation450	Whole blood	Meta-analysis of 2 discovery cohorts	2306	2	68	Both	None	cg21550580	chr3:65755382	3	65755382	MAGI1	Open sea	0.0001323	2.36e-05	0.0000000213	-	28213390_serum_total_cholesterol_discovery
Hedman AK	-	28213390	2017-02-17	Serum total cholesterol	EFO_0004574	Discovery and replication adjusted for BMI	Table S6	DNA methylation	Serum total cholesterol	Age, sex, body mass index, cell counts and technical covariates	Beta values	mg/dl	Illumina HumanMethylation450	Whole blood	Inverse variance weighted fixed-effect meta-analysis	4331	5	65	Both	None	cg21924447	chr2:138427803	2	138427803	THSD7B	Open sea	0.0001064	1.9e-05	0.0000000219	-	28213390_serum_total_cholesterol_discovery_and_replication_adjusted_for_bmi
Hedman AK	-	28213390	2017-02-17	Serum total cholesterol	EFO_0004574	Discovery adjusted for BMI	Table S6	DNA methylation	Serum total cholesterol	Age, sex, body mass index, cell counts and technical covariates	Beta values	mg/dl	Illumina HumanMethylation450	Whole blood	-	2306	2	68	Both	None	cg26874872	chr16:26156362	16	26156362	-	Open sea	0.0001531	2.74e-05	0.0000000231	-	28213390_serum_total_cholesterol_discovery_adjusted_for_bmi
Hedman AK	-	28213390	2017-02-17	Serum total cholesterol	EFO_0004574	Discovery adjusted for BMI	Table S6	DNA methylation	Serum total cholesterol	Age, sex, body mass index, cell counts and technical covariates	Beta values	mg/dl	Illumina HumanMethylation450	Whole blood	-	2306	2	68	Both	None	cg01575601	chr11:130398900	11	130398900	-	Open sea	0.0001309	2.35e-05	0.0000000238	-	28213390_serum_total_cholesterol_discovery_adjusted_for_bmi
Hedman AK	-	28213390	2017-02-17	Serum total cholesterol	EFO_0004574	Discovery and replication	Table S2	DNA methylation	Serum total cholesterol	Age, sex, cell counts and technical covariates	Beta values	mg/dl	Illumina HumanMethylation450	Whole blood	Inverse variance weighted fixed-effect meta-analysis	4331	5	65	Both	None	cg01955153	chr16:50769852	16	50769852	-	Open sea	5.92e-05	1.06e-05	0.000000024	-	28213390_serum_total_cholesterol_discovery_and_replication
Hedman AK	-	28213390	2017-02-17	Serum total cholesterol	EFO_0004574	Discovery adjusted for BMI	Table S6	DNA methylation	Serum total cholesterol	Age, sex, body mass index, cell counts and technical covariates	Beta values	mg/dl	Illumina HumanMethylation450	Whole blood	-	2306	2	68	Both	None	cg22446998	chr5:155701819	5	155701819	-	Open sea	0.0001413	2.54e-05	0.0000000278	-	28213390_serum_total_cholesterol_discovery_adjusted_for_bmi
Hedman AK	-	28213390	2017-02-17	Serum total cholesterol	EFO_0004574	Discovery	Table S2	DNA methylation	Serum total cholesterol	Age, sex, white cell counts, and technical covariates	Beta values	mg/dl	Illumina HumanMethylation450	Whole blood	Meta-analysis of 2 discovery cohorts	2306	2	68	Both	None	cg01955153	chr16:50769852	16	50769852	-	Open sea	7.13e-05	1.29e-05	0.0000000299	-	28213390_serum_total_cholesterol_discovery
Hedman AK	-	28213390	2017-02-17	Serum total cholesterol	EFO_0004574	Discovery adjusted for BMI	Table S6	DNA methylation	Serum total cholesterol	Age, sex, body mass index, cell counts and technical covariates	Beta values	mg/dl	Illumina HumanMethylation450	Whole blood	-	2306	2	68	Both	None	cg23475018	chr3:124277638	3	124277638	KALRN	Open sea	0.0001102	1.99e-05	0.0000000306	-	28213390_serum_total_cholesterol_discovery_adjusted_for_bmi
Hedman AK	-	28213390	2017-02-17	Serum total cholesterol	EFO_0004574	Discovery and replication adjusted for BMI	Table S6	DNA methylation	Serum total cholesterol	Age, sex, body mass index, cell counts and technical covariates	Beta values	mg/dl	Illumina HumanMethylation450	Whole blood	Inverse variance weighted fixed-effect meta-analysis	4331	5	65	Both	None	cg00252813	chr12:6642229	12	6642229	GAPDH	North shore	6.59e-05	1.19e-05	0.0000000325	-	28213390_serum_total_cholesterol_discovery_and_replication_adjusted_for_bmi
Hedman AK	-	28213390	2017-02-17	Serum total cholesterol	EFO_0004574	Discovery and replication	Table S2	DNA methylation	Serum total cholesterol	Age, sex, cell counts and technical covariates	Beta values	mg/dl	Illumina HumanMethylation450	Whole blood	Inverse variance weighted fixed-effect meta-analysis	4331	5	65	Both	None	cg09802018	chr11:46357562	11	46357562	DGKZ	South shelf	-6.99e-05	1.27e-05	0.0000000329	-	28213390_serum_total_cholesterol_discovery_and_replication
Hedman AK	-	28213390	2017-02-17	Serum total cholesterol	EFO_0004574	Discovery adjusted for BMI	Table S6	DNA methylation	Serum total cholesterol	Age, sex, body mass index, cell counts and technical covariates	Beta values	mg/dl	Illumina HumanMethylation450	Whole blood	-	2306	2	68	Both	None	cg05897122	chr4:53112707	4	53112707	-	Open sea	0.0001517	2.75e-05	0.0000000331	-	28213390_serum_total_cholesterol_discovery_adjusted_for_bmi
Hedman AK	-	28213390	2017-02-17	Serum total cholesterol	EFO_0004574	Discovery and replication	Table S2	DNA methylation	Serum total cholesterol	Age, sex, cell counts and technical covariates	Beta values	mg/dl	Illumina HumanMethylation450	Whole blood	Inverse variance weighted fixed-effect meta-analysis	4331	5	65	Both	None	cg21924447	chr2:138427803	2	138427803	THSD7B	Open sea	0.000105	1.89e-05	0.0000000352	-	28213390_serum_total_cholesterol_discovery_and_replication
Hedman AK	-	28213390	2017-02-17	Serum total cholesterol	EFO_0004574	Discovery	Table S2	DNA methylation	Serum total cholesterol	Age, sex, white cell counts, and technical covariates	Beta values	mg/dl	Illumina HumanMethylation450	Whole blood	Meta-analysis of 2 discovery cohorts	2306	2	68	Both	None	cg13010621	chr6:92344723	6	92344723	-	Open sea	8.66e-05	1.58e-05	0.000000039	-	28213390_serum_total_cholesterol_discovery
Hedman AK	-	28213390	2017-02-17	Serum total cholesterol	EFO_0004574	Discovery and replication	Table S2	DNA methylation	Serum total cholesterol	Age, sex, cell counts and technical covariates	Beta values	mg/dl	Illumina HumanMethylation450	Whole blood	Inverse variance weighted fixed-effect meta-analysis	4331	5	65	Both	None	cg09676013	chr6:33080500	6	33080500	HLA-DPB2	Open sea	0.000113	2.05e-05	0.0000000414	-	28213390_serum_total_cholesterol_discovery_and_replication
Hedman AK	-	28213390	2017-02-17	Serum total cholesterol	EFO_0004574	Discovery and replication	Table S2	DNA methylation	Serum total cholesterol	Age, sex, cell counts and technical covariates	Beta values	mg/dl	Illumina HumanMethylation450	Whole blood	Inverse variance weighted fixed-effect meta-analysis	4331	5	65	Both	None	cg25738279	chr1:68027617	1	68027617	-	Open sea	5.64e-05	1.03e-05	0.0000000429	-	28213390_serum_total_cholesterol_discovery_and_replication
Hedman AK	-	28213390	2017-02-17	Serum total cholesterol	EFO_0004574	Discovery	Table S2	DNA methylation	Serum total cholesterol	Age, sex, white cell counts, and technical covariates	Beta values	mg/dl	Illumina HumanMethylation450	Whole blood	Meta-analysis of 2 discovery cohorts	2306	2	68	Both	None	cg14406814	chr9:10232876	9	10232876	PTPRD	Open sea	0.0001186	2.17e-05	0.0000000441	-	28213390_serum_total_cholesterol_discovery
Hedman AK	-	28213390	2017-02-17	Serum total cholesterol	EFO_0004574	Discovery adjusted for BMI	Table S6	DNA methylation	Serum total cholesterol	Age, sex, body mass index, cell counts and technical covariates	Beta values	mg/dl	Illumina HumanMethylation450	Whole blood	-	2306	2	68	Both	None	cg15380836	chr17:1553341	17	1553341	RILP	South shore	5.92e-05	1.08e-05	0.0000000441	-	28213390_serum_total_cholesterol_discovery_adjusted_for_bmi
Hedman AK	-	28213390	2017-02-17	Serum total cholesterol	EFO_0004574	Discovery adjusted for BMI	Table S6	DNA methylation	Serum total cholesterol	Age, sex, body mass index, cell counts and technical covariates	Beta values	mg/dl	Illumina HumanMethylation450	Whole blood	-	2306	2	68	Both	None	cg13636014	chr9:84004731	9	84004731	-	Open sea	0.0001195	2.18e-05	0.0000000448	-	28213390_serum_total_cholesterol_discovery_adjusted_for_bmi
Hedman AK	-	28213390	2017-02-17	Serum total cholesterol	EFO_0004574	Discovery adjusted for BMI	Table S6	DNA methylation	Serum total cholesterol	Age, sex, body mass index, cell counts and technical covariates	Beta values	mg/dl	Illumina HumanMethylation450	Whole blood	-	2306	2	68	Both	None	cg00252813	chr12:6642229	12	6642229	GAPDH	North shore	7.97e-05	1.46e-05	0.000000045	-	28213390_serum_total_cholesterol_discovery_adjusted_for_bmi
Hedman AK	-	28213390	2017-02-17	Serum total cholesterol	EFO_0004574	Discovery and replication	Table S2	DNA methylation	Serum total cholesterol	Age, sex, cell counts and technical covariates	Beta values	mg/dl	Illumina HumanMethylation450	Whole blood	Inverse variance weighted fixed-effect meta-analysis	4331	5	65	Both	None	cg13636014	chr9:84004731	9	84004731	-	Open sea	9.03e-05	1.65e-05	0.0000000464	-	28213390_serum_total_cholesterol_discovery_and_replication
Hedman AK	-	28213390	2017-02-17	Serum total cholesterol	EFO_0004574	Discovery	Table S2	DNA methylation	Serum total cholesterol	Age, sex, white cell counts, and technical covariates	Beta values	mg/dl	Illumina HumanMethylation450	Whole blood	Meta-analysis of 2 discovery cohorts	2306	2	68	Both	None	cg17901584	chr1:55353706	1	55353706	DHCR24	South shore	0.0001493	2.73e-05	0.0000000473	-	28213390_serum_total_cholesterol_discovery
Hedman AK	-	28213390	2017-02-17	Serum total cholesterol	EFO_0004574	Discovery and replication	Table S2	DNA methylation	Serum total cholesterol	Age, sex, cell counts and technical covariates	Beta values	mg/dl	Illumina HumanMethylation450	Whole blood	Inverse variance weighted fixed-effect meta-analysis	4331	5	65	Both	None	cg22446998	chr5:155701819	5	155701819	-	Open sea	9.92e-05	1.82e-05	0.0000000473	-	28213390_serum_total_cholesterol_discovery_and_replication
Hedman AK	-	28213390	2017-02-17	Serum total cholesterol	EFO_0004574	Discovery adjusted for BMI	Table S6	DNA methylation	Serum total cholesterol	Age, sex, body mass index, cell counts and technical covariates	Beta values	mg/dl	Illumina HumanMethylation450	Whole blood	-	2306	2	68	Both	None	cg22878054	chr11:99397252	11	99397252	CNTN5	Open sea	0.0001337	2.45e-05	0.0000000503	-	28213390_serum_total_cholesterol_discovery_adjusted_for_bmi
Hedman AK	-	28213390	2017-02-17	Serum total cholesterol	EFO_0004574	Discovery adjusted for BMI	Table S6	DNA methylation	Serum total cholesterol	Age, sex, body mass index, cell counts and technical covariates	Beta values	mg/dl	Illumina HumanMethylation450	Whole blood	-	2306	2	68	Both	None	cg21550580	chr3:65755382	3	65755382	MAGI1	Open sea	0.0001281	2.36e-05	0.0000000571	-	28213390_serum_total_cholesterol_discovery_adjusted_for_bmi
Hedman AK	-	28213390	2017-02-17	Serum total cholesterol	EFO_0004574	Discovery adjusted for BMI	Table S6	DNA methylation	Serum total cholesterol	Age, sex, body mass index, cell counts and technical covariates	Beta values	mg/dl	Illumina HumanMethylation450	Whole blood	-	2306	2	68	Both	None	cg09802018	chr11:46357562	11	46357562	DGKZ	South shelf	-8.32e-05	1.53e-05	0.0000000579	-	28213390_serum_total_cholesterol_discovery_adjusted_for_bmi
Hedman AK	-	28213390	2017-02-17	Serum total cholesterol	EFO_0004574	Discovery and replication	Table S2	DNA methylation	Serum total cholesterol	Age, sex, cell counts and technical covariates	Beta values	mg/dl	Illumina HumanMethylation450	Whole blood	Inverse variance weighted fixed-effect meta-analysis	4331	5	65	Both	None	cg16466652	chr19:6271960	19	6271960	MLLT1	Island	-7.11e-05	1.31e-05	0.0000000625	-	28213390_serum_total_cholesterol_discovery_and_replication
Hedman AK	-	28213390	2017-02-17	Serum total cholesterol	EFO_0004574	Discovery	Table S2	DNA methylation	Serum total cholesterol	Age, sex, white cell counts, and technical covariates	Beta values	mg/dl	Illumina HumanMethylation450	Whole blood	Meta-analysis of 2 discovery cohorts	2306	2	68	Both	None	cg09802018	chr11:46357562	11	46357562	DGKZ	South shelf	-8.29e-05	1.53e-05	0.0000000651	-	28213390_serum_total_cholesterol_discovery
Hedman AK	-	28213390	2017-02-17	Serum total cholesterol	EFO_0004574	Discovery	Table S2	DNA methylation	Serum total cholesterol	Age, sex, white cell counts, and technical covariates	Beta values	mg/dl	Illumina HumanMethylation450	Whole blood	Meta-analysis of 2 discovery cohorts	2306	2	68	Both	None	cg07121693	chr10:44148437	10	44148437	-	South shelf	0.0001292	2.39e-05	0.0000000662	-	28213390_serum_total_cholesterol_discovery
Hedman AK	-	28213390	2017-02-17	Serum total cholesterol	EFO_0004574	Discovery	Table S2	DNA methylation	Serum total cholesterol	Age, sex, white cell counts, and technical covariates	Beta values	mg/dl	Illumina HumanMethylation450	Whole blood	Meta-analysis of 2 discovery cohorts	2306	2	68	Both	None	cg20448706	chr14:32941841	14	32941841	AKAP6	Open sea	0.0001338	2.48e-05	0.000000067	-	28213390_serum_total_cholesterol_discovery
Hedman AK	-	28213390	2017-02-17	Serum total cholesterol	EFO_0004574	Discovery and replication adjusted for BMI	Table S6	DNA methylation	Serum total cholesterol	Age, sex, body mass index, cell counts and technical covariates	Beta values	mg/dl	Illumina HumanMethylation450	Whole blood	Inverse variance weighted fixed-effect meta-analysis	4331	5	65	Both	None	cg22446998	chr5:155701819	5	155701819	-	Open sea	9.83e-05	1.82e-05	0.0000000698	-	28213390_serum_total_cholesterol_discovery_and_replication_adjusted_for_bmi
Hedman AK	-	28213390	2017-02-17	Serum total cholesterol	EFO_0004574	Discovery and replication	Table S2	DNA methylation	Serum total cholesterol	Age, sex, cell counts and technical covariates	Beta values	mg/dl	Illumina HumanMethylation450	Whole blood	Inverse variance weighted fixed-effect meta-analysis	4331	5	65	Both	None	cg10001987	chr17:7381769	17	7381769	ZBTB4	North shore	-0.000151	2.81e-05	0.0000000704	-	28213390_serum_total_cholesterol_discovery_and_replication
Hedman AK	-	28213390	2017-02-17	Serum total cholesterol	EFO_0004574	Discovery	Table S2	DNA methylation	Serum total cholesterol	Age, sex, white cell counts, and technical covariates	Beta values	mg/dl	Illumina HumanMethylation450	Whole blood	Meta-analysis of 2 discovery cohorts	2306	2	68	Both	None	cg01973483	chr12:123591123	12	123591123	PITPNM2	Open sea	-9.93e-05	1.84e-05	0.0000000718	-	28213390_serum_total_cholesterol_discovery
Hedman AK	-	28213390	2017-02-17	Serum total cholesterol	EFO_0004574	Discovery adjusted for BMI	Table S6	DNA methylation	Serum total cholesterol	Age, sex, body mass index, cell counts and technical covariates	Beta values	mg/dl	Illumina HumanMethylation450	Whole blood	-	2306	2	68	Both	None	cg03308494	chr12:58013267	12	58013267	SLC26A10	Island	9.88e-05	1.83e-05	0.0000000718	-	28213390_serum_total_cholesterol_discovery_adjusted_for_bmi
Hedman AK	-	28213390	2017-02-17	Serum total cholesterol	EFO_0004574	Discovery and replication adjusted for BMI	Table S6	DNA methylation	Serum total cholesterol	Age, sex, body mass index, cell counts and technical covariates	Beta values	mg/dl	Illumina HumanMethylation450	Whole blood	Inverse variance weighted fixed-effect meta-analysis	4331	5	65	Both	None	cg01955153	chr16:50769852	16	50769852	-	Open sea	5.69e-05	1.06e-05	0.0000000732	-	28213390_serum_total_cholesterol_discovery_and_replication_adjusted_for_bmi
Hedman AK	-	28213390	2017-02-17	Serum total cholesterol	EFO_0004574	Discovery and replication adjusted for BMI	Table S6	DNA methylation	Serum total cholesterol	Age, sex, body mass index, cell counts and technical covariates	Beta values	mg/dl	Illumina HumanMethylation450	Whole blood	Inverse variance weighted fixed-effect meta-analysis	4331	5	65	Both	None	cg13636014	chr9:84004731	9	84004731	-	Open sea	8.88e-05	1.65e-05	0.0000000752	-	28213390_serum_total_cholesterol_discovery_and_replication_adjusted_for_bmi
Hedman AK	-	28213390	2017-02-17	Serum total cholesterol	EFO_0004574	Discovery adjusted for BMI	Table S6	DNA methylation	Serum total cholesterol	Age, sex, body mass index, cell counts and technical covariates	Beta values	mg/dl	Illumina HumanMethylation450	Whole blood	-	2306	2	68	Both	None	cg14406814	chr9:10232876	9	10232876	PTPRD	Open sea	0.0001167	2.17e-05	0.0000000769	-	28213390_serum_total_cholesterol_discovery_adjusted_for_bmi
Hedman AK	-	28213390	2017-02-17	Serum total cholesterol	EFO_0004574	Discovery	Table S2	DNA methylation	Serum total cholesterol	Age, sex, white cell counts, and technical covariates	Beta values	mg/dl	Illumina HumanMethylation450	Whole blood	Meta-analysis of 2 discovery cohorts	2306	2	68	Both	None	cg06844864	chr12:57850192	12	57850192	INHBE	North shelf	6e-05	1.12e-05	0.0000000771	-	28213390_serum_total_cholesterol_discovery
Hedman AK	-	28213390	2017-02-17	Serum total cholesterol	EFO_0004574	Discovery	Table S2	DNA methylation	Serum total cholesterol	Age, sex, white cell counts, and technical covariates	Beta values	mg/dl	Illumina HumanMethylation450	Whole blood	Meta-analysis of 2 discovery cohorts	2306	2	68	Both	None	cg07839457	chr16:57023022	16	57023022	NLRC5	North shore	0.0002725	5.09e-05	0.0000000874	-	28213390_serum_total_cholesterol_discovery
Hedman AK	-	28213390	2017-02-17	Serum total cholesterol	EFO_0004574	Discovery	Table S2	DNA methylation	Serum total cholesterol	Age, sex, white cell counts, and technical covariates	Beta values	mg/dl	Illumina HumanMethylation450	Whole blood	Meta-analysis of 2 discovery cohorts	2306	2	68	Both	None	cg21635307	chr6:90319877	6	90319877	ANKRD6	Open sea	8.97e-05	1.68e-05	0.0000000887	-	28213390_serum_total_cholesterol_discovery
Hedman AK	-	28213390	2017-02-17	Serum total cholesterol	EFO_0004574	Discovery adjusted for BMI	Table S6	DNA methylation	Serum total cholesterol	Age, sex, body mass index, cell counts and technical covariates	Beta values	mg/dl	Illumina HumanMethylation450	Whole blood	-	2306	2	68	Both	None	cg10092517	chr14:104682880	14	104682880	-	Open sea	-0.0001554	2.91e-05	0.0000000903	-	28213390_serum_total_cholesterol_discovery_adjusted_for_bmi
Hedman AK	-	28213390	2017-02-17	Serum total cholesterol	EFO_0004574	Discovery	Table S2	DNA methylation	Serum total cholesterol	Age, sex, white cell counts, and technical covariates	Beta values	mg/dl	Illumina HumanMethylation450	Whole blood	Meta-analysis of 2 discovery cohorts	2306	2	68	Both	None	cg21924447	chr2:138427803	2	138427803	THSD7B	Open sea	0.0001419	2.65e-05	0.0000000906	-	28213390_serum_total_cholesterol_discovery
Hedman AK	-	28213390	2017-02-17	Serum total cholesterol	EFO_0004574	Discovery adjusted for BMI	Table S6	DNA methylation	Serum total cholesterol	Age, sex, body mass index, cell counts and technical covariates	Beta values	mg/dl	Illumina HumanMethylation450	Whole blood	-	2306	2	68	Both	None	cg01955153	chr16:50769852	16	50769852	-	Open sea	6.86e-05	1.28e-05	0.0000000909	-	28213390_serum_total_cholesterol_discovery_adjusted_for_bmi
Hedman AK	-	28213390	2017-02-17	Serum total cholesterol	EFO_0004574	Discovery adjusted for BMI	Table S6	DNA methylation	Serum total cholesterol	Age, sex, body mass index, cell counts and technical covariates	Beta values	mg/dl	Illumina HumanMethylation450	Whole blood	-	2306	2	68	Both	None	cg06181697	chr3:50294603	3	50294603	GNAI2	North shelf	0.0001216	2.28e-05	0.0000000952	-	28213390_serum_total_cholesterol_discovery_adjusted_for_bmi
Hedman AK	-	28213390	2017-02-17	Serum total cholesterol	EFO_0004574	Discovery adjusted for BMI	Table S6	DNA methylation	Serum total cholesterol	Age, sex, body mass index, cell counts and technical covariates	Beta values	mg/dl	Illumina HumanMethylation450	Whole blood	-	2306	2	68	Both	None	cg07839457	chr16:57023022	16	57023022	NLRC5	North shore	0.0002722	5.1e-05	0.0000000962	-	28213390_serum_total_cholesterol_discovery_adjusted_for_bmi
Hedman AK	-	28213390	2017-02-17	Serum total cholesterol	EFO_0004574	Discovery adjusted for BMI	Table S6	DNA methylation	Serum total cholesterol	Age, sex, body mass index, cell counts and technical covariates	Beta values	mg/dl	Illumina HumanMethylation450	Whole blood	-	2306	2	68	Both	None	cg24309555	chr2:21266956	2	21266956	APOB	Island	0.0002253	4.23e-05	0.0000000986	-	28213390_serum_total_cholesterol_discovery_adjusted_for_bmi
Hedman AK	-	28213390	2017-02-17	Serum total cholesterol	EFO_0004574	Discovery and replication	Table S2	DNA methylation	Serum total cholesterol	Age, sex, cell counts and technical covariates	Beta values	mg/dl	Illumina HumanMethylation450	Whole blood	Inverse variance weighted fixed-effect meta-analysis	4331	5	65	Both	None	cg22023664	chr19:2619608	19	2619608	GNG7	North shelf	-7.09e-05	1.33e-05	0.0000000989	-	28213390_serum_total_cholesterol_discovery_and_replication
Hedman AK	-	28213390	2017-02-17	Serum total cholesterol	EFO_0004574	Discovery	Table S2	DNA methylation	Serum total cholesterol	Age, sex, white cell counts, and technical covariates	Beta values	mg/dl	Illumina HumanMethylation450	Whole blood	Meta-analysis of 2 discovery cohorts	2306	2	68	Both	None	cg09676013	chr6:33080500	6	33080500	HLA-DPB2	Open sea	0.0001555	2.92e-05	0.000000099	-	28213390_serum_total_cholesterol_discovery
Hedman AK	-	28213390	2017-02-17	Serum total cholesterol	EFO_0004574	Discovery	Table S2	DNA methylation	Serum total cholesterol	Age, sex, white cell counts, and technical covariates	Beta values	mg/dl	Illumina HumanMethylation450	Whole blood	Meta-analysis of 2 discovery cohorts	2306	2	68	Both	None	cg17903590	chr1:28623081	1	28623081	-	Open sea	0.0001363	2.56e-05	0.0000001	-	28213390_serum_total_cholesterol_discovery
Hedman AK	-	28213390	2017-02-17	Serum total cholesterol	EFO_0004574	Discovery and replication adjusted for BMI	Table S6	DNA methylation	Serum total cholesterol	Age, sex, body mass index, cell counts and technical covariates	Beta values	mg/dl	Illumina HumanMethylation450	Whole blood	Inverse variance weighted fixed-effect meta-analysis	4331	5	65	Both	None	cg22023664	chr19:2619608	19	2619608	GNG7	North shelf	-7.09e-05	1.33e-05	0.000000101	-	28213390_serum_total_cholesterol_discovery_and_replication_adjusted_for_bmi
Hedman AK	-	28213390	2017-02-17	Serum total cholesterol	EFO_0004574	Discovery adjusted for BMI	Table S6	DNA methylation	Serum total cholesterol	Age, sex, body mass index, cell counts and technical covariates	Beta values	mg/dl	Illumina HumanMethylation450	Whole blood	-	2306	2	68	Both	None	cg21924447	chr2:138427803	2	138427803	THSD7B	Open sea	0.000141	2.65e-05	0.000000103	-	28213390_serum_total_cholesterol_discovery_adjusted_for_bmi
Hedman AK	-	28213390	2017-02-17	Serum total cholesterol	EFO_0004574	Discovery and replication adjusted for BMI	Table S6	DNA methylation	Serum total cholesterol	Age, sex, body mass index, cell counts and technical covariates	Beta values	mg/dl	Illumina HumanMethylation450	Whole blood	Inverse variance weighted fixed-effect meta-analysis	4331	5	65	Both	None	cg10001987	chr17:7381769	17	7381769	ZBTB4	North shore	-0.0001495	2.81e-05	0.000000106	-	28213390_serum_total_cholesterol_discovery_and_replication_adjusted_for_bmi
Hedman AK	-	28213390	2017-02-17	Serum total cholesterol	EFO_0004574	Discovery adjusted for BMI	Table S6	DNA methylation	Serum total cholesterol	Age, sex, body mass index, cell counts and technical covariates	Beta values	mg/dl	Illumina HumanMethylation450	Whole blood	-	2306	2	68	Both	None	cg13010621	chr6:92344723	6	92344723	-	Open sea	8.37e-05	1.57e-05	0.000000108	-	28213390_serum_total_cholesterol_discovery_adjusted_for_bmi
Hedman AK	-	28213390	2017-02-17	Serum total cholesterol	EFO_0004574	Discovery and replication adjusted for BMI	Table S6	DNA methylation	Serum total cholesterol	Age, sex, body mass index, cell counts and technical covariates	Beta values	mg/dl	Illumina HumanMethylation450	Whole blood	Inverse variance weighted fixed-effect meta-analysis	4331	5	65	Both	None	cg16466652	chr19:6271960	19	6271960	MLLT1	Island	-6.95e-05	1.32e-05	0.000000128	-	28213390_serum_total_cholesterol_discovery_and_replication_adjusted_for_bmi
Hedman AK	-	28213390	2017-02-17	Serum total cholesterol	EFO_0004574	Discovery and replication adjusted for BMI	Table S6	DNA methylation	Serum total cholesterol	Age, sex, body mass index, cell counts and technical covariates	Beta values	mg/dl	Illumina HumanMethylation450	Whole blood	Inverse variance weighted fixed-effect meta-analysis	4331	5	65	Both	None	cg05337441	chr2:21266568	2	21266568	APOB	North shore	0.0001539	2.95e-05	0.000000175	-	28213390_serum_total_cholesterol_discovery_and_replication_adjusted_for_bmi
Hedman AK	-	28213390	2017-02-17	Serum total cholesterol	EFO_0004574	Discovery and replication adjusted for BMI	Table S6	DNA methylation	Serum total cholesterol	Age, sex, body mass index, cell counts and technical covariates	Beta values	mg/dl	Illumina HumanMethylation450	Whole blood	Inverse variance weighted fixed-effect meta-analysis	4331	5	65	Both	None	cg15705971	chr11:92110262	11	92110262	FAT3	Open sea	8.86e-05	1.7e-05	0.000000181	-	28213390_serum_total_cholesterol_discovery_and_replication_adjusted_for_bmi
Hedman AK	-	28213390	2017-02-17	Serum total cholesterol	EFO_0004574	Discovery and replication	Table S2	DNA methylation	Serum total cholesterol	Age, sex, cell counts and technical covariates	Beta values	mg/dl	Illumina HumanMethylation450	Whole blood	Inverse variance weighted fixed-effect meta-analysis	4331	5	65	Both	None	cg15705971	chr11:92110262	11	92110262	FAT3	Open sea	8.74e-05	1.7e-05	0.000000253	-	28213390_serum_total_cholesterol_discovery_and_replication
Battram T	ARIES	None	2020-08-20	Serum total cholesterol	EFO_0004574	None	None	DNA methylation	Serum total cholesterol	Batch effects, cell composition (reference free), ancestry (genomic PCs)	Beta Values	mmol/l	Illumina HumanMethylation450	Whole blood	None	685	1	Adults	Females	European	cg19435859	chr17:2593076	17	2593076	KIAA0664	Island	-0.163	0.031	0.00000027	None	Battram-T_serum_total_cholesterol
Hedman AK	-	28213390	2017-02-17	Serum total cholesterol	EFO_0004574	Discovery and replication	Table S2	DNA methylation	Serum total cholesterol	Age, sex, cell counts and technical covariates	Beta values	mg/dl	Illumina HumanMethylation450	Whole blood	Inverse variance weighted fixed-effect meta-analysis	4331	5	65	Both	None	cg05897122	chr4:53112707	4	53112707	-	Open sea	9.76e-05	1.91e-05	0.000000336	-	28213390_serum_total_cholesterol_discovery_and_replication
Hedman AK	-	28213390	2017-02-17	Serum total cholesterol	EFO_0004574	Discovery and replication	Table S2	DNA methylation	Serum total cholesterol	Age, sex, cell counts and technical covariates	Beta values	mg/dl	Illumina HumanMethylation450	Whole blood	Inverse variance weighted fixed-effect meta-analysis	4331	5	65	Both	None	cg05337441	chr2:21266568	2	21266568	APOB	North shore	0.000149	2.94e-05	0.000000379	-	28213390_serum_total_cholesterol_discovery_and_replication
Hedman AK	-	28213390	2017-02-17	Serum total cholesterol	EFO_0004574	Discovery and replication adjusted for BMI	Table S6	DNA methylation	Serum total cholesterol	Age, sex, body mass index, cell counts and technical covariates	Beta values	mg/dl	Illumina HumanMethylation450	Whole blood	Inverse variance weighted fixed-effect meta-analysis	4331	5	65	Both	None	cg05897122	chr4:53112707	4	53112707	-	Open sea	9.65e-05	1.92e-05	0.000000494	-	28213390_serum_total_cholesterol_discovery_and_replication_adjusted_for_bmi
Hedman AK	-	28213390	2017-02-17	Serum total cholesterol	EFO_0004574	Discovery and replication	Table S2	DNA methylation	Serum total cholesterol	Age, sex, cell counts and technical covariates	Beta values	mg/dl	Illumina HumanMethylation450	Whole blood	Inverse variance weighted fixed-effect meta-analysis	4331	5	65	Both	None	cg06780861	chr14:83683592	14	83683592	-	Open sea	7.74e-05	1.56e-05	0.000000697	-	28213390_serum_total_cholesterol_discovery_and_replication
Battram T	ARIES	None	2020-08-20	Serum total cholesterol	EFO_0004574	None	None	DNA methylation	Serum total cholesterol	Batch effects, cell composition (reference free), ancestry (genomic PCs)	Beta Values	mmol/l	Illumina HumanMethylation450	Whole blood	None	685	1	Adults	Females	European	cg23523129	chr19:11457176	19	11457176	TMEM205;CCDC159	Island	0.158	0.032	0.00000082	None	Battram-T_serum_total_cholesterol
Battram T	ARIES	None	2020-08-20	Serum total cholesterol	EFO_0004574	None	None	DNA methylation	Serum total cholesterol	Batch effects, cell composition (reference free), ancestry (genomic PCs)	Beta Values	mmol/l	Illumina HumanMethylation450	Whole blood	None	685	1	Adults	Females	European	cg14337526	chr13:98086635	13	98086635	RAP2A	Island	0.159	0.032	0.00000083	None	Battram-T_serum_total_cholesterol
Hedman AK	-	28213390	2017-02-17	Serum total cholesterol	EFO_0004574	Discovery and replication adjusted for BMI	Table S6	DNA methylation	Serum total cholesterol	Age, sex, body mass index, cell counts and technical covariates	Beta values	mg/dl	Illumina HumanMethylation450	Whole blood	Inverse variance weighted fixed-effect meta-analysis	4331	5	65	Both	None	cg06780861	chr14:83683592	14	83683592	-	Open sea	7.65e-05	1.56e-05	0.00000098	-	28213390_serum_total_cholesterol_discovery_and_replication_adjusted_for_bmi
Sayols-Baixeras S	-	28173150	2016-09-15	Serum total cholesterol	EFO_0004574	Discovery adjusted for surrogate variables	Table S1	Serum total cholesterol	DNA methylation	Age, sex, smoking, cell counts and technical covariates	mg/dl	M values	Illumina HumanMethylation450	Whole blood	-	645	1	63.2	Both	None	cg06747543	chr19:18589894	19	18589894	ELL	Open sea	11.458	2.349	0.0000011	-	28173150_serum_total_cholesterol_discovery_adjusted_for_surrogate_variables
Sayols-Baixeras S	-	28173150	2016-09-15	Serum total cholesterol	EFO_0004574	Discovery adjusted for surrogate variables	Table S1	Serum total cholesterol	DNA methylation	Age, sex, smoking, cell counts and technical covariates	mg/dl	M values	Illumina HumanMethylation450	Whole blood	-	645	1	63.2	Both	None	cg05609864	chr16:24550579	16	24550579	RBBP6	North shore	9.885	2.071	0.0000018	-	28173150_serum_total_cholesterol_discovery_adjusted_for_surrogate_variables
Sayols-Baixeras S	-	28173150	2016-09-15	Serum total cholesterol	EFO_0004574	Discovery	Table S1	Serum total cholesterol	DNA methylation	Age, sex, smoking, cell counts and technical covariates	mg/dl	M values	Illumina HumanMethylation450	Whole blood	-	645	1	63.2	Both	None	cg00449821	chr1:155053823	1	155053823	EFNA3	Island	-6.092	1.28	0.0000019	-	28173150_serum_total_cholesterol_discovery
Sayols-Baixeras S	-	28173150	2016-09-15	Serum total cholesterol	EFO_0004574	Discovery adjusted for surrogate variables	Table S1	Serum total cholesterol	DNA methylation	Age, sex, smoking, cell counts and technical covariates	mg/dl	M values	Illumina HumanMethylation450	Whole blood	-	645	1	63.2	Both	None	cg00449821	chr1:155053823	1	155053823	EFNA3	Island	-6.609	1.388	0.0000019	-	28173150_serum_total_cholesterol_discovery_adjusted_for_surrogate_variables
Sayols-Baixeras S	-	28173150	2016-09-15	Serum total cholesterol	EFO_0004574	Discovery adjusted for surrogate variables	Table S1	Serum total cholesterol	DNA methylation	Age, sex, smoking, cell counts and technical covariates	mg/dl	M values	Illumina HumanMethylation450	Whole blood	-	645	1	63.2	Both	None	cg06224551	chr11:124670268	11	124670268	C11orf61	Island	6.551	1.377	0.0000019	-	28173150_serum_total_cholesterol_discovery_adjusted_for_surrogate_variables
Hedman AK	-	28213390	2017-02-17	Serum total cholesterol	EFO_0004574	Discovery and replication	Table S2	DNA methylation	Serum total cholesterol	Age, sex, cell counts and technical covariates	Beta values	mg/dl	Illumina HumanMethylation450	Whole blood	Inverse variance weighted fixed-effect meta-analysis	4331	5	65	Both	None	cg15380836	chr17:1553341	17	1553341	RILP	South shore	4.17e-05	8.8e-06	0.00000212	-	28213390_serum_total_cholesterol_discovery_and_replication
Sayols-Baixeras S	-	28173150	2016-09-15	Serum total cholesterol	EFO_0004574	Discovery adjusted for surrogate variables	Table S1	Serum total cholesterol	DNA methylation	Age, sex, smoking, cell counts and technical covariates	mg/dl	M values	Illumina HumanMethylation450	Whole blood	-	645	1	63.2	Both	None	cg26345203	chr14:23005866	14	23005866	-	Open sea	12.122	2.567	0.0000023	-	28173150_serum_total_cholesterol_discovery_adjusted_for_surrogate_variables
Hedman AK	-	28213390	2017-02-17	Serum total cholesterol	EFO_0004574	Replication	Table S2	DNA methylation	Serum total cholesterol	Age, sex, cell counts and technical covariates	Beta values	mg/dl	Illumina HumanMethylation450	Whole blood	-	2025	3	61	Both	None	cg07839457	chr16:57023022	16	57023022	NLRC5	North shore	0.0002313	4.9e-05	0.00000232	-	28213390_serum_total_cholesterol_replication
Sayols-Baixeras S	-	28173150	2016-09-15	Serum total cholesterol	EFO_0004574	Discovery adjusted for surrogate variables	Table S1	Serum total cholesterol	DNA methylation	Age, sex, smoking, cell counts and technical covariates	mg/dl	M values	Illumina HumanMethylation450	Whole blood	-	645	1	63.2	Both	None	cg22138573	chr13:60718665	13	60718665	DIAPH3	Open sea	-9.787	2.085	0.0000027	-	28173150_serum_total_cholesterol_discovery_adjusted_for_surrogate_variables
Sayols-Baixeras S	-	28173150	2016-09-15	Serum total cholesterol	EFO_0004574	Discovery adjusted for surrogate variables	Table S1	Serum total cholesterol	DNA methylation	Age, sex, smoking, cell counts and technical covariates	mg/dl	M values	Illumina HumanMethylation450	Whole blood	-	645	1	63.2	Both	None	cg13457700	chr10:5708797	10	5708797	ASB13	Island	8.99	1.922	0.0000029	-	28173150_serum_total_cholesterol_discovery_adjusted_for_surrogate_variables
Hedman AK	-	28213390	2017-02-17	Serum total cholesterol	EFO_0004574	Discovery and replication adjusted for BMI	Table S6	DNA methylation	Serum total cholesterol	Age, sex, body mass index, cell counts and technical covariates	Beta values	mg/dl	Illumina HumanMethylation450	Whole blood	Inverse variance weighted fixed-effect meta-analysis	4331	5	65	Both	None	cg15380836	chr17:1553341	17	1553341	RILP	South shore	4.1e-05	8.8e-06	0.00000329	-	28213390_serum_total_cholesterol_discovery_and_replication_adjusted_for_bmi
Sayols-Baixeras S	-	28173150	2016-09-15	Serum total cholesterol	EFO_0004574	Discovery adjusted for surrogate variables	Table S1	Serum total cholesterol	DNA methylation	Age, sex, smoking, cell counts and technical covariates	mg/dl	M values	Illumina HumanMethylation450	Whole blood	-	645	1	63.2	Both	None	cg24252746	chr15:45248932	15	45248932	C15orf43	Open sea	-7.707	1.664	0.0000036	-	28173150_serum_total_cholesterol_discovery_adjusted_for_surrogate_variables
Sayols-Baixeras S	-	28173150	2016-09-15	Serum total cholesterol	EFO_0004574	Discovery adjusted for surrogate variables	Table S1	Serum total cholesterol	DNA methylation	Age, sex, smoking, cell counts and technical covariates	mg/dl	M values	Illumina HumanMethylation450	Whole blood	-	645	1	63.2	Both	None	cg00624589	chr16:1094742	16	1094742	-	North shelf	-6.476	1.398	0.0000036	-	28173150_serum_total_cholesterol_discovery_adjusted_for_surrogate_variables
Hedman AK	-	28213390	2017-02-17	Serum total cholesterol	EFO_0004574	Discovery and replication	Table S2	DNA methylation	Serum total cholesterol	Age, sex, cell counts and technical covariates	Beta values	mg/dl	Illumina HumanMethylation450	Whole blood	Inverse variance weighted fixed-effect meta-analysis	4331	5	65	Both	None	cg15878619	chr6:30687373	6	30687373	TUBB	North shore	4.21e-05	9.1e-06	0.00000382	-	28213390_serum_total_cholesterol_discovery_and_replication
Sayols-Baixeras S	-	28173150	2016-09-15	Serum total cholesterol	EFO_0004574	Discovery adjusted for surrogate variables	Table S1	Serum total cholesterol	DNA methylation	Age, sex, smoking, cell counts and technical covariates	mg/dl	M values	Illumina HumanMethylation450	Whole blood	-	645	1	63.2	Both	None	cg04552480	chr16:12209538	16	12209538	SNX29	North shore	8.443	1.829	0.0000039	-	28173150_serum_total_cholesterol_discovery_adjusted_for_surrogate_variables
Sayols-Baixeras S	-	28173150	2016-09-15	Serum total cholesterol	EFO_0004574	Discovery adjusted for surrogate variables	Table S1	Serum total cholesterol	DNA methylation	Age, sex, smoking, cell counts and technical covariates	mg/dl	M values	Illumina HumanMethylation450	Whole blood	-	645	1	63.2	Both	None	cg20319775	chr20:10653482	20	10653482	JAG1	Island	9.379	2.031	0.0000039	-	28173150_serum_total_cholesterol_discovery_adjusted_for_surrogate_variables
Hedman AK	-	28213390	2017-02-17	Serum total cholesterol	EFO_0004574	Discovery and replication	Table S2	DNA methylation	Serum total cholesterol	Age, sex, cell counts and technical covariates	Beta values	mg/dl	Illumina HumanMethylation450	Whole blood	Inverse variance weighted fixed-effect meta-analysis	4331	5	65	Both	None	cg23475018	chr3:124277638	3	124277638	KALRN	Open sea	7.12e-05	1.54e-05	0.00000399	-	28213390_serum_total_cholesterol_discovery_and_replication
Hedman AK	-	28213390	2017-02-17	Serum total cholesterol	EFO_0004574	Discovery and replication	Table S2	DNA methylation	Serum total cholesterol	Age, sex, cell counts and technical covariates	Beta values	mg/dl	Illumina HumanMethylation450	Whole blood	Inverse variance weighted fixed-effect meta-analysis	4331	5	65	Both	None	cg21550580	chr3:65755382	3	65755382	MAGI1	Open sea	8.04e-05	1.75e-05	0.00000416	-	28213390_serum_total_cholesterol_discovery_and_replication
Hedman AK	-	28213390	2017-02-17	Serum total cholesterol	EFO_0004574	Discovery and replication	Table S2	DNA methylation	Serum total cholesterol	Age, sex, cell counts and technical covariates	Beta values	mg/dl	Illumina HumanMethylation450	Whole blood	Inverse variance weighted fixed-effect meta-analysis	4331	5	65	Both	None	cg26874872	chr16:26156362	16	26156362	-	Open sea	9.19e-05	2e-05	0.00000453	-	28213390_serum_total_cholesterol_discovery_and_replication
Sayols-Baixeras S	-	28173150	2016-09-15	Serum total cholesterol	EFO_0004574	Discovery adjusted for surrogate variables	Table S1	Serum total cholesterol	DNA methylation	Age, sex, smoking, cell counts and technical covariates	mg/dl	M values	Illumina HumanMethylation450	Whole blood	-	645	1	63.2	Both	None	cg10289790	chr14:105359915	14	105359915	KIAA0284	Island	-9.827	2.147	0.0000047	-	28173150_serum_total_cholesterol_discovery_adjusted_for_surrogate_variables
Battram T	ARIES	None	2020-08-20	Serum total cholesterol	EFO_0004574	None	None	DNA methylation	Serum total cholesterol	Batch effects, cell composition (reference free), ancestry (genomic PCs)	Beta Values	mmol/l	Illumina HumanMethylation450	Whole blood	None	685	1	Adults	Females	European	cg14004847	chr7:1930337	7	1930337	MAD1L1	Open sea	0.199	0.043	0.0000048	None	Battram-T_serum_total_cholesterol
Sayols-Baixeras S	-	28173150	2016-09-15	Serum total cholesterol	EFO_0004574	Discovery adjusted for surrogate variables	Table S1	Serum total cholesterol	DNA methylation	Age, sex, smoking, cell counts and technical covariates	mg/dl	M values	Illumina HumanMethylation450	Whole blood	-	645	1	63.2	Both	None	cg10361950	chr18:12039173	18	12039173	-	Island	7.932	1.743	0.0000053	-	28173150_serum_total_cholesterol_discovery_adjusted_for_surrogate_variables
Battram T	ARIES	None	2020-08-20	Serum total cholesterol	EFO_0004574	None	None	DNA methylation	Serum total cholesterol	Batch effects, cell composition (reference free), ancestry (genomic PCs)	Beta Values	mmol/l	Illumina HumanMethylation450	Whole blood	None	685	1	Adults	Females	European	cg22853943	chr2:4703822	2	4703822	-	Open sea	-0.176	0.038	0.0000054	None	Battram-T_serum_total_cholesterol
Sayols-Baixeras S	-	28173150	2016-09-15	Serum total cholesterol	EFO_0004574	Discovery	Table S1	Serum total cholesterol	DNA methylation	Age, sex, smoking, cell counts and technical covariates	mg/dl	M values	Illumina HumanMethylation450	Whole blood	-	645	1	63.2	Both	None	cg17878141	chr5:81521184	5	81521184	ATG10	Open sea	6.288	1.382	0.0000054	-	28173150_serum_total_cholesterol_discovery
Hedman AK	-	28213390	2017-02-17	Serum total cholesterol	EFO_0004574	Discovery and replication	Table S2	DNA methylation	Serum total cholesterol	Age, sex, cell counts and technical covariates	Beta values	mg/dl	Illumina HumanMethylation450	Whole blood	Inverse variance weighted fixed-effect meta-analysis	4331	5	65	Both	None	cg14406814	chr9:10232876	9	10232876	PTPRD	Open sea	7.47e-05	1.64e-05	0.00000548	-	28213390_serum_total_cholesterol_discovery_and_replication
Hedman AK	-	28213390	2017-02-17	Serum total cholesterol	EFO_0004574	Discovery and replication	Table S2	DNA methylation	Serum total cholesterol	Age, sex, cell counts and technical covariates	Beta values	mg/dl	Illumina HumanMethylation450	Whole blood	Inverse variance weighted fixed-effect meta-analysis	4331	5	65	Both	None	cg22878054	chr11:99397252	11	99397252	CNTN5	Open sea	8.2e-05	1.81e-05	0.00000551	-	28213390_serum_total_cholesterol_discovery_and_replication
Hedman AK	-	28213390	2017-02-17	Serum total cholesterol	EFO_0004574	Replication adjusted for BMI	Table S6	DNA methylation	Serum total cholesterol	Age, sex, body mass index, cell counts and technical covariates	Beta values	mg/dl	Illumina HumanMethylation450	Whole blood	-	2025	3	61	Both	None	cg07839457	chr16:57023022	16	57023022	NLRC5	North shore	0.0002234	4.92e-05	0.00000554	-	28213390_serum_total_cholesterol_replication_adjusted_for_bmi
Hedman AK	-	28213390	2017-02-17	Serum total cholesterol	EFO_0004574	Discovery and replication adjusted for BMI	Table S6	DNA methylation	Serum total cholesterol	Age, sex, body mass index, cell counts and technical covariates	Beta values	mg/dl	Illumina HumanMethylation450	Whole blood	Inverse variance weighted fixed-effect meta-analysis	4331	5	65	Both	None	cg24309555	chr2:21266956	2	21266956	APOB	Island	0.000134	2.95e-05	0.00000561	-	28213390_serum_total_cholesterol_discovery_and_replication_adjusted_for_bmi
Sayols-Baixeras S	-	28173150	2016-09-15	Serum total cholesterol	EFO_0004574	Discovery adjusted for surrogate variables	Table S1	Serum total cholesterol	DNA methylation	Age, sex, smoking, cell counts and technical covariates	mg/dl	M values	Illumina HumanMethylation450	Whole blood	-	645	1	63.2	Both	None	cg05876625	chr2:108723177	2	108723177	-	Open sea	8.115	1.788	0.0000057	-	28173150_serum_total_cholesterol_discovery_adjusted_for_surrogate_variables
Hedman AK	-	28213390	2017-02-17	Serum total cholesterol	EFO_0004574	Discovery and replication adjusted for BMI	Table S6	DNA methylation	Serum total cholesterol	Age, sex, body mass index, cell counts and technical covariates	Beta values	mg/dl	Illumina HumanMethylation450	Whole blood	Inverse variance weighted fixed-effect meta-analysis	4331	5	65	Both	None	cg21550580	chr3:65755382	3	65755382	MAGI1	Open sea	7.93e-05	1.75e-05	0.0000059	-	28213390_serum_total_cholesterol_discovery_and_replication_adjusted_for_bmi
Sayols-Baixeras S	-	28173150	2016-09-15	Serum total cholesterol	EFO_0004574	Discovery adjusted for surrogate variables	Table S1	Serum total cholesterol	DNA methylation	Age, sex, smoking, cell counts and technical covariates	mg/dl	M values	Illumina HumanMethylation450	Whole blood	-	645	1	63.2	Both	None	cg26226879	chr1:34642305	1	34642305	C1orf94	North shore	5.767	1.276	0.0000062	-	28173150_serum_total_cholesterol_discovery_adjusted_for_surrogate_variables
Hedman AK	-	28213390	2017-02-17	Serum total cholesterol	EFO_0004574	Discovery and replication adjusted for BMI	Table S6	DNA methylation	Serum total cholesterol	Age, sex, body mass index, cell counts and technical covariates	Beta values	mg/dl	Illumina HumanMethylation450	Whole blood	Inverse variance weighted fixed-effect meta-analysis	4331	5	65	Both	None	cg26874872	chr16:26156362	16	26156362	-	Open sea	9.06e-05	2.01e-05	0.00000643	-	28213390_serum_total_cholesterol_discovery_and_replication_adjusted_for_bmi
Sayols-Baixeras S	-	28173150	2016-09-15	Serum total cholesterol	EFO_0004574	Discovery adjusted for surrogate variables	Table S1	Serum total cholesterol	DNA methylation	Age, sex, smoking, cell counts and technical covariates	mg/dl	M values	Illumina HumanMethylation450	Whole blood	-	645	1	63.2	Both	None	cg06650596	chr5:1041028	5	1041028	-	South shelf	-7.28	1.617	0.0000068	-	28173150_serum_total_cholesterol_discovery_adjusted_for_surrogate_variables
Sayols-Baixeras S	-	28173150	2016-09-15	Serum total cholesterol	EFO_0004574	Discovery adjusted for surrogate variables	Table S1	Serum total cholesterol	DNA methylation	Age, sex, smoking, cell counts and technical covariates	mg/dl	M values	Illumina HumanMethylation450	Whole blood	-	645	1	63.2	Both	None	cg26343512	chr14:77413728	14	77413728	-	Open sea	8.059	1.794	0.0000071	-	28173150_serum_total_cholesterol_discovery_adjusted_for_surrogate_variables
Hedman AK	-	28213390	2017-02-17	Serum total cholesterol	EFO_0004574	Discovery and replication adjusted for BMI	Table S6	DNA methylation	Serum total cholesterol	Age, sex, body mass index, cell counts and technical covariates	Beta values	mg/dl	Illumina HumanMethylation450	Whole blood	Inverse variance weighted fixed-effect meta-analysis	4331	5	65	Both	None	cg14406814	chr9:10232876	9	10232876	PTPRD	Open sea	7.39e-05	1.65e-05	0.00000726	-	28213390_serum_total_cholesterol_discovery_and_replication_adjusted_for_bmi
Hedman AK	-	28213390	2017-02-17	Serum total cholesterol	EFO_0004574	Discovery and replication adjusted for BMI	Table S6	DNA methylation	Serum total cholesterol	Age, sex, body mass index, cell counts and technical covariates	Beta values	mg/dl	Illumina HumanMethylation450	Whole blood	Inverse variance weighted fixed-effect meta-analysis	4331	5	65	Both	None	cg22878054	chr11:99397252	11	99397252	CNTN5	Open sea	8.11e-05	1.81e-05	0.00000726	-	28213390_serum_total_cholesterol_discovery_and_replication_adjusted_for_bmi
Sayols-Baixeras S	-	28173150	2016-09-15	Serum total cholesterol	EFO_0004574	Discovery adjusted for surrogate variables	Table S1	Serum total cholesterol	DNA methylation	Age, sex, smoking, cell counts and technical covariates	mg/dl	M values	Illumina HumanMethylation450	Whole blood	-	645	1	63.2	Both	None	cg01771247	chr16:61846623	16	61846623	CDH8	Open sea	9.034	2.015	0.0000073	-	28173150_serum_total_cholesterol_discovery_adjusted_for_surrogate_variables
Hedman AK	-	28213390	2017-02-17	Serum total cholesterol	EFO_0004574	Discovery and replication adjusted for BMI	Table S6	DNA methylation	Serum total cholesterol	Age, sex, body mass index, cell counts and technical covariates	Beta values	mg/dl	Illumina HumanMethylation450	Whole blood	Inverse variance weighted fixed-effect meta-analysis	4331	5	65	Both	None	cg06181697	chr3:50294603	3	50294603	GNAI2	North shelf	7.64e-05	1.71e-05	0.00000746	-	28213390_serum_total_cholesterol_discovery_and_replication_adjusted_for_bmi
Sayols-Baixeras S	-	28173150	2016-09-15	Serum total cholesterol	EFO_0004574	Discovery	Table S1	Serum total cholesterol	DNA methylation	Age, sex, smoking, cell counts and technical covariates	mg/dl	M values	Illumina HumanMethylation450	Whole blood	-	645	1	63.2	Both	None	cg23245289	chr8:37698900	8	37698900	GPR124	Island	-7.135	1.599	0.0000081	-	28173150_serum_total_cholesterol_discovery
Hedman AK	-	28213390	2017-02-17	Serum total cholesterol	EFO_0004574	Discovery and replication adjusted for BMI	Table S6	DNA methylation	Serum total cholesterol	Age, sex, body mass index, cell counts and technical covariates	Beta values	mg/dl	Illumina HumanMethylation450	Whole blood	Inverse variance weighted fixed-effect meta-analysis	4331	5	65	Both	None	cg23475018	chr3:124277638	3	124277638	KALRN	Open sea	6.9e-05	1.55e-05	0.00000815	-	28213390_serum_total_cholesterol_discovery_and_replication_adjusted_for_bmi
Hedman AK	-	28213390	2017-02-17	Serum total cholesterol	EFO_0004574	Discovery and replication adjusted for BMI	Table S6	DNA methylation	Serum total cholesterol	Age, sex, body mass index, cell counts and technical covariates	Beta values	mg/dl	Illumina HumanMethylation450	Whole blood	Inverse variance weighted fixed-effect meta-analysis	4331	5	65	Both	None	cg15878619	chr6:30687373	6	30687373	TUBB	North shore	4.04e-05	9.1e-06	0.00000873	-	28213390_serum_total_cholesterol_discovery_and_replication_adjusted_for_bmi
Sayols-Baixeras S	-	28173150	2016-09-15	Serum total cholesterol	EFO_0004574	Discovery adjusted for surrogate variables	Table S1	Serum total cholesterol	DNA methylation	Age, sex, smoking, cell counts and technical covariates	mg/dl	M values	Illumina HumanMethylation450	Whole blood	-	645	1	63.2	Both	None	cg16000331	chr22:42230138	22	42230138	SREBF2	South shore	8.997	2.026	0.000009	-	28173150_serum_total_cholesterol_discovery_adjusted_for_surrogate_variables
Sayols-Baixeras S	-	28173150	2016-09-15	Serum total cholesterol	EFO_0004574	Discovery	Table S1	Serum total cholesterol	DNA methylation	Age, sex, smoking, cell counts and technical covariates	mg/dl	M values	Illumina HumanMethylation450	Whole blood	-	645	1	63.2	Both	None	cg24050047	chr7:33767686	7	33767686	-	Open sea	7.934	1.789	0.0000092	-	28173150_serum_total_cholesterol_discovery
Sayols-Baixeras S	-	28173150	2016-09-15	Serum total cholesterol	EFO_0004574	Discovery adjusted for surrogate variables	Table S1	Serum total cholesterol	DNA methylation	Age, sex, smoking, cell counts and technical covariates	mg/dl	M values	Illumina HumanMethylation450	Whole blood	-	645	1	63.2	Both	None	cg23206311	chr13:33002447	13	33002447	N4BP2L1	South shore	7.061	1.594	0.0000095	-	28173150_serum_total_cholesterol_discovery_adjusted_for_surrogate_variables
Sayols-Baixeras S	-	28173150	2016-09-15	Serum total cholesterol	EFO_0004574	Discovery adjusted for surrogate variables	Table S1	Serum total cholesterol	DNA methylation	Age, sex, smoking, cell counts and technical covariates	mg/dl	M values	Illumina HumanMethylation450	Whole blood	-	645	1	63.2	Both	None	cg24078828	chr3:149375789	3	149375789	WWTR1	Island	7.404	1.673	0.0000096	-	28173150_serum_total_cholesterol_discovery_adjusted_for_surrogate_variables
Battram T	ARIES	None	2020-08-20	Serum total cholesterol	EFO_0004574	None	None	DNA methylation	Serum total cholesterol	Batch effects, cell composition (reference free), ancestry (genomic PCs)	Beta Values	mmol/l	Illumina HumanMethylation450	Whole blood	None	685	1	Adults	Females	European	cg18286903	chr13:50367095	13	50367095	KPNA3	Island	0.148	0.033	0.00001	None	Battram-T_serum_total_cholesterol
Hedman AK	-	28213390	2017-02-17	Serum total cholesterol	EFO_0004574	Discovery and replication	Table S2	DNA methylation	Serum total cholesterol	Age, sex, cell counts and technical covariates	Beta values	mg/dl	Illumina HumanMethylation450	Whole blood	Inverse variance weighted fixed-effect meta-analysis	4331	5	65	Both	None	cg20448706	chr14:32941841	14	32941841	AKAP6	Open sea	7.89e-05	1.79e-05	0.0000106	-	28213390_serum_total_cholesterol_discovery_and_replication
Sayols-Baixeras S	-	28173150	2016-09-15	Serum total cholesterol	EFO_0004574	Discovery	Table S1	Serum total cholesterol	DNA methylation	Age, sex, smoking, cell counts and technical covariates	mg/dl	M values	Illumina HumanMethylation450	Whole blood	-	645	1	63.2	Both	None	cg26226879	chr1:34642305	1	34642305	C1orf94	North shore	5.464	1.245	0.000011	-	28173150_serum_total_cholesterol_discovery
Battram T	ARIES	None	2020-08-20	Serum total cholesterol	EFO_0004574	None	None	DNA methylation	Serum total cholesterol	Batch effects, cell composition (reference free), ancestry (genomic PCs)	Beta Values	mmol/l	Illumina HumanMethylation450	Whole blood	None	685	1	Adults	Females	European	cg16358080	chr11:377442	11	377442	B4GALNT4	North shore	-0.182	0.041	0.000011	None	Battram-T_serum_total_cholesterol
Hedman AK	-	28213390	2017-02-17	Serum total cholesterol	EFO_0004574	Discovery and replication	Table S2	DNA methylation	Serum total cholesterol	Age, sex, cell counts and technical covariates	Beta values	mg/dl	Illumina HumanMethylation450	Whole blood	Inverse variance weighted fixed-effect meta-analysis	4331	5	65	Both	None	cg07121693	chr10:44148437	10	44148437	-	South shelf	7.58e-05	1.73e-05	0.0000118	-	28213390_serum_total_cholesterol_discovery_and_replication
Sayols-Baixeras S	-	28173150	2016-09-15	Serum total cholesterol	EFO_0004574	Discovery	Table S1	Serum total cholesterol	DNA methylation	Age, sex, smoking, cell counts and technical covariates	mg/dl	M values	Illumina HumanMethylation450	Whole blood	-	645	1	63.2	Both	None	cg04552480	chr16:12209538	16	12209538	SNX29	North shore	6.85	1.567	0.000012	-	28173150_serum_total_cholesterol_discovery
Sayols-Baixeras S	-	28173150	2016-09-15	Serum total cholesterol	EFO_0004574	Discovery adjusted for surrogate variables	Table S1	Serum total cholesterol	DNA methylation	Age, sex, smoking, cell counts and technical covariates	mg/dl	M values	Illumina HumanMethylation450	Whole blood	-	645	1	63.2	Both	None	cg23245289	chr8:37698900	8	37698900	GPR124	Island	-7.026	1.609	0.000013	-	28173150_serum_total_cholesterol_discovery_adjusted_for_surrogate_variables
Battram T	ARIES	None	2020-08-20	Serum total cholesterol	EFO_0004574	None	None	DNA methylation	Serum total cholesterol	Batch effects, cell composition (reference free), ancestry (genomic PCs)	Beta Values	mmol/l	Illumina HumanMethylation450	Whole blood	None	685	1	Adults	Females	European	cg16178491	chr12:101603996	12	101603996	SLC5A8	South shore	-0.169	0.039	0.000014	None	Battram-T_serum_total_cholesterol
Battram T	ARIES	None	2020-08-20	Serum total cholesterol	EFO_0004574	None	None	DNA methylation	Serum total cholesterol	Batch effects, cell composition (reference free), ancestry (genomic PCs)	Beta Values	mmol/l	Illumina HumanMethylation450	Whole blood	None	685	1	Adults	Females	European	cg11151405	chr3:25634257	3	25634257	RARB	Open sea	-0.17	0.039	0.000015	None	Battram-T_serum_total_cholesterol
Battram T	ARIES	None	2020-08-20	Serum total cholesterol	EFO_0004574	None	None	DNA methylation	Serum total cholesterol	Batch effects, cell composition (reference free), ancestry (genomic PCs)	Beta Values	mmol/l	Illumina HumanMethylation450	Whole blood	None	685	1	Adults	Females	European	cg13325261	chr12:27486075	12	27486075	ARNTL2	Island	-0.127	0.029	0.000015	None	Battram-T_serum_total_cholesterol
Battram T	ARIES	None	2020-08-20	Serum total cholesterol	EFO_0004574	None	None	DNA methylation	Serum total cholesterol	Batch effects, cell composition (reference free), ancestry (genomic PCs)	Beta Values	mmol/l	Illumina HumanMethylation450	Whole blood	None	685	1	Adults	Females	European	cg15826485	chr14:21852455	14	21852455	SUPT16H	Island	0.101	0.023	0.000015	None	Battram-T_serum_total_cholesterol
Sayols-Baixeras S	-	28173150	2016-09-15	Serum total cholesterol	EFO_0004574	Discovery and replication	Table S1	Serum total cholesterol	DNA methylation	Age, sex, smoking, cell counts and technical covariates	mg/dl	M values	Illumina HumanMethylation450	Whole blood	-	3187	2	65.7	Both	None	cg16000331	chr22:42230138	22	42230138	SREBF2	South shore	3.183	0.736	0.000015	-	28173150_serum_total_cholesterol_discovery_and_replication
Battram T	ARIES	None	2020-08-20	Serum total cholesterol	EFO_0004574	None	None	DNA methylation	Serum total cholesterol	Batch effects, cell composition (reference free), ancestry (genomic PCs)	Beta Values	mmol/l	Illumina HumanMethylation450	Whole blood	None	685	1	Adults	Females	European	cg03998474	chr2:9696120	2	9696120	ADAM17	Island	0.104	0.024	0.000016	None	Battram-T_serum_total_cholesterol
Hedman AK	-	28213390	2017-02-17	Serum total cholesterol	EFO_0004574	Discovery and replication	Table S2	DNA methylation	Serum total cholesterol	Age, sex, cell counts and technical covariates	Beta values	mg/dl	Illumina HumanMethylation450	Whole blood	Inverse variance weighted fixed-effect meta-analysis	4331	5	65	Both	None	cg17903590	chr1:28623081	1	28623081	-	Open sea	8.55e-05	2e-05	0.0000185	-	28213390_serum_total_cholesterol_discovery_and_replication
Sayols-Baixeras S	-	28173150	2016-09-15	Serum total cholesterol	EFO_0004574	Discovery	Table S1	Serum total cholesterol	DNA methylation	Age, sex, smoking, cell counts and technical covariates	mg/dl	M values	Illumina HumanMethylation450	Whole blood	-	645	1	63.2	Both	None	cg05876625	chr2:108723177	2	108723177	-	Open sea	7.06	1.654	0.00002	-	28173150_serum_total_cholesterol_discovery
Battram T	ARIES	None	2020-08-20	Serum total cholesterol	EFO_0004574	None	None	DNA methylation	Serum total cholesterol	Batch effects, cell composition (reference free), ancestry (genomic PCs)	Beta Values	mmol/l	Illumina HumanMethylation450	Whole blood	None	685	1	Adults	Females	European	cg18057109	chr7:156409738	7	156409738	-	Island	0.161	0.037	0.00002	None	Battram-T_serum_total_cholesterol
Sayols-Baixeras S	-	28173150	2016-09-15	Serum total cholesterol	EFO_0004574	Discovery	Table S1	Serum total cholesterol	DNA methylation	Age, sex, smoking, cell counts and technical covariates	mg/dl	M values	Illumina HumanMethylation450	Whole blood	-	645	1	63.2	Both	None	cg00624589	chr16:1094742	16	1094742	-	North shelf	-5.955	1.397	0.00002	-	28173150_serum_total_cholesterol_discovery
Hedman AK	-	28213390	2017-02-17	Serum total cholesterol	EFO_0004574	Discovery and replication	Table S2	DNA methylation	Serum total cholesterol	Age, sex, cell counts and technical covariates	Beta values	mg/dl	Illumina HumanMethylation450	Whole blood	Inverse variance weighted fixed-effect meta-analysis	4331	5	65	Both	None	cg21635307	chr6:90319877	6	90319877	ANKRD6	Open sea	5.44e-05	1.28e-05	0.0000207	-	28213390_serum_total_cholesterol_discovery_and_replication
Sayols-Baixeras S	-	28173150	2016-09-15	Serum total cholesterol	EFO_0004574	Discovery adjusted for surrogate variables	Table S1	Serum total cholesterol	DNA methylation	Age, sex, smoking, cell counts and technical covariates	mg/dl	M values	Illumina HumanMethylation450	Whole blood	-	645	1	63.2	Both	None	cg17878141	chr5:81521184	5	81521184	ATG10	Open sea	6.783	1.613	0.000026	-	28173150_serum_total_cholesterol_discovery_adjusted_for_surrogate_variables
Battram T	ARIES	None	2020-08-20	Serum total cholesterol	EFO_0004574	None	None	DNA methylation	Serum total cholesterol	Batch effects, cell composition (reference free), ancestry (genomic PCs)	Beta Values	mmol/l	Illumina HumanMethylation450	Whole blood	None	685	1	Adults	Females	European	cg15440808	chr11:46638641	11	46638641	KIAA0652;HARBI1	Island	0.075	0.018	0.000026	None	Battram-T_serum_total_cholesterol
Battram T	ARIES	None	2020-08-20	Serum total cholesterol	EFO_0004574	None	None	DNA methylation	Serum total cholesterol	Batch effects, cell composition (reference free), ancestry (genomic PCs)	Beta Values	mmol/l	Illumina HumanMethylation450	Whole blood	None	685	1	Adults	Females	European	cg06112554	chr13:112255453	13	112255453	-	Open sea	-0.164	0.039	0.000029	None	Battram-T_serum_total_cholesterol
Battram T	ARIES	None	2020-08-20	Serum total cholesterol	EFO_0004574	None	None	DNA methylation	Serum total cholesterol	Batch effects, cell composition (reference free), ancestry (genomic PCs)	Beta Values	mmol/l	Illumina HumanMethylation450	Whole blood	None	685	1	Adults	Females	European	cg09954348	chr16:68540251	16	68540251	-	North shelf	0.145	0.034	0.000029	None	Battram-T_serum_total_cholesterol
Sayols-Baixeras S	-	28173150	2016-09-15	Serum total cholesterol	EFO_0004574	Replication adjusted for surrogate variables	Table S1	Serum total cholesterol	DNA methylation	Age, sex, smoking, cell counts and technical covariates	mg/dl	M values	Illumina HumanMethylation450	Whole blood	-	2542	1	66.3	Both	None	cg16000331	chr22:42230138	22	42230138	SREBF2	South shore	3.995	0.959	0.000031	-	28173150_serum_total_cholesterol_replication_adjusted_for_surrogate_variables
Hedman AK	-	28213390	2017-02-17	Serum total cholesterol	EFO_0004574	Replication	Table S2	DNA methylation	Serum total cholesterol	Age, sex, cell counts and technical covariates	Beta values	mg/dl	Illumina HumanMethylation450	Whole blood	-	2025	3	61	Both	None	cg00285394	chr8:126011954	8	126011954	SQLE	South shore	0.0001609	3.87e-05	0.0000316	-	28213390_serum_total_cholesterol_replication
Hedman AK	-	28213390	2017-02-17	Serum total cholesterol	EFO_0004574	Discovery and replication	Table S2	DNA methylation	Serum total cholesterol	Age, sex, cell counts and technical covariates	Beta values	mg/dl	Illumina HumanMethylation450	Whole blood	Inverse variance weighted fixed-effect meta-analysis	4331	5	65	Both	None	cg18192491	chr6:114384871	6	114384871	HS3ST5	Open sea	7.07e-05	1.7e-05	0.0000336	-	28213390_serum_total_cholesterol_discovery_and_replication
Battram T	ARIES	None	2020-08-20	Serum total cholesterol	EFO_0004574	None	None	DNA methylation	Serum total cholesterol	Batch effects, cell composition (reference free), ancestry (genomic PCs)	Beta Values	mmol/l	Illumina HumanMethylation450	Whole blood	None	685	1	Adults	Females	European	cg10092779	chr1:57294085	1	57294085	-	Open sea	0.14	0.034	0.000035	None	Battram-T_serum_total_cholesterol
Sayols-Baixeras S	-	28173150	2016-09-15	Serum total cholesterol	EFO_0004574	Discovery adjusted for surrogate variables	Table S1	Serum total cholesterol	DNA methylation	Age, sex, smoking, cell counts and technical covariates	mg/dl	M values	Illumina HumanMethylation450	Whole blood	-	645	1	63.2	Both	None	cg24050047	chr7:33767686	7	33767686	-	Open sea	7.856	1.898	0.000035	-	28173150_serum_total_cholesterol_discovery_adjusted_for_surrogate_variables
Sayols-Baixeras S	-	28173150	2016-09-15	Serum total cholesterol	EFO_0004574	Discovery and replication adjusted for surrogate variables	Table S1	Serum total cholesterol	DNA methylation	Age, sex, smoking, cell counts and technical covariates	mg/dl	M values	Illumina HumanMethylation450	Whole blood	-	3187	2	65.7	Both	None	cg06747543	chr19:18589894	19	18589894	ELL	Open sea	3.971	0.959	0.000035	-	28173150_serum_total_cholesterol_discovery_and_replication_adjusted_for_surrogate_variables
Battram T	ARIES	None	2020-08-20	Serum total cholesterol	EFO_0004574	None	None	DNA methylation	Serum total cholesterol	Batch effects, cell composition (reference free), ancestry (genomic PCs)	Beta Values	mmol/l	Illumina HumanMethylation450	Whole blood	None	685	1	Adults	Females	European	cg05880490	chr6:132890978	6	132890978	TAAR6	Open sea	-0.09	0.022	0.000037	None	Battram-T_serum_total_cholesterol
Battram T	ARIES	None	2020-08-20	Serum total cholesterol	EFO_0004574	None	None	DNA methylation	Serum total cholesterol	Batch effects, cell composition (reference free), ancestry (genomic PCs)	Beta Values	mmol/l	Illumina HumanMethylation450	Whole blood	None	685	1	Adults	Females	European	cg03818767	chr11:64338639	11	64338639	SLC22A11	South shelf	-0.144	0.035	0.000037	None	Battram-T_serum_total_cholesterol
Hedman AK	-	28213390	2017-02-17	Serum total cholesterol	EFO_0004574	Discovery and replication adjusted for BMI	Table S6	DNA methylation	Serum total cholesterol	Age, sex, body mass index, cell counts and technical covariates	Beta values	mg/dl	Illumina HumanMethylation450	Whole blood	Inverse variance weighted fixed-effect meta-analysis	4331	5	65	Both	None	cg03308494	chr12:58013267	12	58013267	SLC26A10	Island	5.69e-05	1.39e-05	0.0000411	-	28213390_serum_total_cholesterol_discovery_and_replication_adjusted_for_bmi
Battram T	ARIES	None	2020-08-20	Serum total cholesterol	EFO_0004574	None	None	DNA methylation	Serum total cholesterol	Batch effects, cell composition (reference free), ancestry (genomic PCs)	Beta Values	mmol/l	Illumina HumanMethylation450	Whole blood	None	685	1	Adults	Females	European	cg04231643	chr11:1803975	11	1803975	-	Open sea	0.143	0.035	0.000043	None	Battram-T_serum_total_cholesterol
Battram T	ARIES	None	2020-08-20	Serum total cholesterol	EFO_0004574	None	None	DNA methylation	Serum total cholesterol	Batch effects, cell composition (reference free), ancestry (genomic PCs)	Beta Values	mmol/l	Illumina HumanMethylation450	Whole blood	None	685	1	Adults	Females	European	cg06153498	chr4:8160591	4	8160591	ABLIM2	Island	0.145	0.035	0.000046	None	Battram-T_serum_total_cholesterol
Hedman AK	-	28213390	2017-02-17	Serum total cholesterol	EFO_0004574	Discovery and replication adjusted for BMI	Table S6	DNA methylation	Serum total cholesterol	Age, sex, body mass index, cell counts and technical covariates	Beta values	mg/dl	Illumina HumanMethylation450	Whole blood	Inverse variance weighted fixed-effect meta-analysis	4331	5	65	Both	None	cg18192491	chr6:114384871	6	114384871	HS3ST5	Open sea	6.94e-05	1.7e-05	0.0000465	-	28213390_serum_total_cholesterol_discovery_and_replication_adjusted_for_bmi
Battram T	ARIES	None	2020-08-20	Serum total cholesterol	EFO_0004574	None	None	DNA methylation	Serum total cholesterol	Batch effects, cell composition (reference free), ancestry (genomic PCs)	Beta Values	mmol/l	Illumina HumanMethylation450	Whole blood	None	685	1	Adults	Females	European	cg16692470	chr16:89184092	16	89184092	ACSF3	North shelf	-0.165	0.04	0.000049	None	Battram-T_serum_total_cholesterol
Sayols-Baixeras S	-	28173150	2016-09-15	Serum total cholesterol	EFO_0004574	Discovery	Table S1	Serum total cholesterol	DNA methylation	Age, sex, smoking, cell counts and technical covariates	mg/dl	M values	Illumina HumanMethylation450	Whole blood	-	645	1	63.2	Both	None	cg26345203	chr14:23005866	14	23005866	-	Open sea	8.898	2.207	0.000055	-	28173150_serum_total_cholesterol_discovery
Hedman AK	-	28213390	2017-02-17	Serum total cholesterol	EFO_0004574	Discovery and replication	Table S2	DNA methylation	Serum total cholesterol	Age, sex, cell counts and technical covariates	Beta values	mg/dl	Illumina HumanMethylation450	Whole blood	Inverse variance weighted fixed-effect meta-analysis	4331	5	65	Both	None	cg01575601	chr11:130398900	11	130398900	-	Open sea	7.17e-05	1.78e-05	0.0000555	-	28213390_serum_total_cholesterol_discovery_and_replication
Battram T	ARIES	None	2020-08-20	Serum total cholesterol	EFO_0004574	None	None	DNA methylation	Serum total cholesterol	Batch effects, cell composition (reference free), ancestry (genomic PCs)	Beta Values	mmol/l	Illumina HumanMethylation450	Whole blood	None	685	1	Adults	Females	European	cg18331909	chr7:4300845	7	4300845	SDK1	North shelf	-0.186	0.046	0.000058	None	Battram-T_serum_total_cholesterol
Battram T	ARIES	None	2020-08-20	Serum total cholesterol	EFO_0004574	None	None	DNA methylation	Serum total cholesterol	Batch effects, cell composition (reference free), ancestry (genomic PCs)	Beta Values	mmol/l	Illumina HumanMethylation450	Whole blood	None	685	1	Adults	Females	European	cg08944986	chr13:46718307	13	46718307	LCP1	Open sea	0.11	0.027	0.00006	None	Battram-T_serum_total_cholesterol
Hedman AK	-	28213390	2017-02-17	Serum total cholesterol	EFO_0004574	Replication adjusted for BMI	Table S6	DNA methylation	Serum total cholesterol	Age, sex, body mass index, cell counts and technical covariates	Beta values	mg/dl	Illumina HumanMethylation450	Whole blood	-	2025	3	61	Both	None	cg00285394	chr8:126011954	8	126011954	SQLE	South shore	0.0001554	3.88e-05	0.0000608	-	28213390_serum_total_cholesterol_replication_adjusted_for_bmi
Battram T	ARIES	None	2020-08-20	Serum total cholesterol	EFO_0004574	None	None	DNA methylation	Serum total cholesterol	Batch effects, cell composition (reference free), ancestry (genomic PCs)	Beta Values	mmol/l	Illumina HumanMethylation450	Whole blood	None	685	1	Adults	Females	European	cg24927800	chr2:220283214	2	220283214	DES	Island	-0.161	0.04	0.000064	None	Battram-T_serum_total_cholesterol
Battram T	ARIES	None	2020-08-20	Serum total cholesterol	EFO_0004574	None	None	DNA methylation	Serum total cholesterol	Batch effects, cell composition (reference free), ancestry (genomic PCs)	Beta Values	mmol/l	Illumina HumanMethylation450	Whole blood	None	685	1	Adults	Females	European	cg18663513	chr1:53793486	1	53793486	LRP8	Island	0.06	0.015	0.000066	None	Battram-T_serum_total_cholesterol
Battram T	ARIES	None	2020-08-20	Serum total cholesterol	EFO_0004574	None	None	DNA methylation	Serum total cholesterol	Batch effects, cell composition (reference free), ancestry (genomic PCs)	Beta Values	mmol/l	Illumina HumanMethylation450	Whole blood	None	685	1	Adults	Females	European	cg00795248	chr1:197888305	1	197888305	LHX9	South shore	-0.158	0.039	0.000067	None	Battram-T_serum_total_cholesterol
Battram T	ARIES	None	2020-08-20	Serum total cholesterol	EFO_0004574	None	None	DNA methylation	Serum total cholesterol	Batch effects, cell composition (reference free), ancestry (genomic PCs)	Beta Values	mmol/l	Illumina HumanMethylation450	Whole blood	None	685	1	Adults	Females	European	cg01676996	chr6:30619167	6	30619167	C6orf136	South shelf	-0.133	0.033	0.000067	None	Battram-T_serum_total_cholesterol
Battram T	ARIES	None	2020-08-20	Serum total cholesterol	EFO_0004574	None	None	DNA methylation	Serum total cholesterol	Batch effects, cell composition (reference free), ancestry (genomic PCs)	Beta Values	mmol/l	Illumina HumanMethylation450	Whole blood	None	685	1	Adults	Females	European	cg04657831	chr21:46707951	21	46707951	POFUT2;LOC642852	Island	-0.118	0.029	0.000067	None	Battram-T_serum_total_cholesterol
Battram T	ARIES	None	2020-08-20	Serum total cholesterol	EFO_0004574	None	None	DNA methylation	Serum total cholesterol	Batch effects, cell composition (reference free), ancestry (genomic PCs)	Beta Values	mmol/l	Illumina HumanMethylation450	Whole blood	None	685	1	Adults	Females	European	cg21091227	chr18:4454304	18	4454304	-	Island	-0.112	0.028	0.000068	None	Battram-T_serum_total_cholesterol
Battram T	ARIES	None	2020-08-20	Serum total cholesterol	EFO_0004574	None	None	DNA methylation	Serum total cholesterol	Batch effects, cell composition (reference free), ancestry (genomic PCs)	Beta Values	mmol/l	Illumina HumanMethylation450	Whole blood	None	685	1	Adults	Females	European	cg20566439	chr7:26955529	7	26955529	-	Open sea	0.117	0.029	0.000069	None	Battram-T_serum_total_cholesterol
Battram T	ARIES	None	2020-08-20	Serum total cholesterol	EFO_0004574	None	None	DNA methylation	Serum total cholesterol	Batch effects, cell composition (reference free), ancestry (genomic PCs)	Beta Values	mmol/l	Illumina HumanMethylation450	Whole blood	None	685	1	Adults	Females	European	cg15748490	chr1:240254960	1	240254960	FMN2	Island	-0.153	0.038	0.000072	None	Battram-T_serum_total_cholesterol
Battram T	ARIES	None	2020-08-20	Serum total cholesterol	EFO_0004574	None	None	DNA methylation	Serum total cholesterol	Batch effects, cell composition (reference free), ancestry (genomic PCs)	Beta Values	mmol/l	Illumina HumanMethylation450	Whole blood	None	685	1	Adults	Females	European	cg02277710	chr1:27931503	1	27931503	AHDC1	South shore	-0.168	0.042	0.000073	None	Battram-T_serum_total_cholesterol
Battram T	ARIES	None	2020-08-20	Serum total cholesterol	EFO_0004574	None	None	DNA methylation	Serum total cholesterol	Batch effects, cell composition (reference free), ancestry (genomic PCs)	Beta Values	mmol/l	Illumina HumanMethylation450	Whole blood	None	685	1	Adults	Females	European	cg17977250	chr3:158390778	3	158390778	LXN;GFM1	Open sea	0.097	0.024	0.000073	None	Battram-T_serum_total_cholesterol
Battram T	ARIES	None	2020-08-20	Serum total cholesterol	EFO_0004574	None	None	DNA methylation	Serum total cholesterol	Batch effects, cell composition (reference free), ancestry (genomic PCs)	Beta Values	mmol/l	Illumina HumanMethylation450	Whole blood	None	685	1	Adults	Females	European	cg24896109	chr7:91764007	7	91764007	CYP51A1	Island	-0.134	0.034	0.000073	None	Battram-T_serum_total_cholesterol
Sayols-Baixeras S	-	28173150	2016-09-15	Serum total cholesterol	EFO_0004574	Discovery and replication	Table S1	Serum total cholesterol	DNA methylation	Age, sex, smoking, cell counts and technical covariates	mg/dl	M values	Illumina HumanMethylation450	Whole blood	-	3187	2	65.7	Both	None	cg00449821	chr1:155053823	1	155053823	EFNA3	Island	-2.479	0.626	0.000075	-	28173150_serum_total_cholesterol_discovery_and_replication
Battram T	ARIES	None	2020-08-20	Serum total cholesterol	EFO_0004574	None	None	DNA methylation	Serum total cholesterol	Batch effects, cell composition (reference free), ancestry (genomic PCs)	Beta Values	mmol/l	Illumina HumanMethylation450	Whole blood	None	685	1	Adults	Females	European	cg06522206	chr12:117651299	12	117651299	NOS1	Open sea	-0.153	0.038	0.000077	None	Battram-T_serum_total_cholesterol
Battram T	ARIES	None	2020-08-20	Serum total cholesterol	EFO_0004574	None	None	DNA methylation	Serum total cholesterol	Batch effects, cell composition (reference free), ancestry (genomic PCs)	Beta Values	mmol/l	Illumina HumanMethylation450	Whole blood	None	685	1	Adults	Females	European	cg15129097	chr10:7376699	10	7376699	SFMBT2	Open sea	0.138	0.035	0.000079	None	Battram-T_serum_total_cholesterol
Battram T	ARIES	None	2020-08-20	Serum total cholesterol	EFO_0004574	None	None	DNA methylation	Serum total cholesterol	Batch effects, cell composition (reference free), ancestry (genomic PCs)	Beta Values	mmol/l	Illumina HumanMethylation450	Whole blood	None	685	1	Adults	Females	European	cg26740481	chr15:23931011	15	23931011	NDN	North shore	-0.144	0.036	0.000079	None	Battram-T_serum_total_cholesterol
Battram T	ARIES	None	2020-08-20	Serum total cholesterol	EFO_0004574	None	None	DNA methylation	Serum total cholesterol	Batch effects, cell composition (reference free), ancestry (genomic PCs)	Beta Values	mmol/l	Illumina HumanMethylation450	Whole blood	None	685	1	Adults	Females	European	cg06401027	chr12:8234690	12	8234690	NECAP1	Island	-0.109	0.027	0.00008	None	Battram-T_serum_total_cholesterol
Battram T	ARIES	None	2020-08-20	Serum total cholesterol	EFO_0004574	None	None	DNA methylation	Serum total cholesterol	Batch effects, cell composition (reference free), ancestry (genomic PCs)	Beta Values	mmol/l	Illumina HumanMethylation450	Whole blood	None	685	1	Adults	Females	European	cg00233335	chr10:75492561	10	75492561	-	Island	-0.15	0.038	0.000081	None	Battram-T_serum_total_cholesterol
Battram T	ARIES	None	2020-08-20	Serum total cholesterol	EFO_0004574	None	None	DNA methylation	Serum total cholesterol	Batch effects, cell composition (reference free), ancestry (genomic PCs)	Beta Values	mmol/l	Illumina HumanMethylation450	Whole blood	None	685	1	Adults	Females	European	cg05931265	chr11:122527736	11	122527736	UBASH3B	South shore	-0.094	0.024	0.000081	None	Battram-T_serum_total_cholesterol
Battram T	ARIES	None	2020-08-20	Serum total cholesterol	EFO_0004574	None	None	DNA methylation	Serum total cholesterol	Batch effects, cell composition (reference free), ancestry (genomic PCs)	Beta Values	mmol/l	Illumina HumanMethylation450	Whole blood	None	685	1	Adults	Females	European	cg12403889	chr1:11753338	1	11753338	C1orf187	South shore	-0.118	0.03	0.000085	None	Battram-T_serum_total_cholesterol
Hedman AK	-	28213390	2017-02-17	Serum total cholesterol	EFO_0004574	Discovery and replication adjusted for BMI	Table S6	DNA methylation	Serum total cholesterol	Age, sex, body mass index, cell counts and technical covariates	Beta values	mg/dl	Illumina HumanMethylation450	Whole blood	Inverse variance weighted fixed-effect meta-analysis	4331	5	65	Both	None	cg01575601	chr11:130398900	11	130398900	-	Open sea	7.02e-05	1.79e-05	0.0000858	-	28213390_serum_total_cholesterol_discovery_and_replication_adjusted_for_bmi
Battram T	ARIES	None	2020-08-20	Serum total cholesterol	EFO_0004574	None	None	DNA methylation	Serum total cholesterol	Batch effects, cell composition (reference free), ancestry (genomic PCs)	Beta Values	mmol/l	Illumina HumanMethylation450	Whole blood	None	685	1	Adults	Females	European	cg21276834	chr21:30365048	21	30365048	RNF160	Island	-0.111	0.028	0.000086	None	Battram-T_serum_total_cholesterol
Battram T	ARIES	None	2020-08-20	Serum total cholesterol	EFO_0004574	None	None	DNA methylation	Serum total cholesterol	Batch effects, cell composition (reference free), ancestry (genomic PCs)	Beta Values	mmol/l	Illumina HumanMethylation450	Whole blood	None	685	1	Adults	Females	European	cg11212172	chr10:53459438	10	53459438	PRKG1;CSTF2T	Island	0.133	0.034	0.000089	None	Battram-T_serum_total_cholesterol
Battram T	ARIES	None	2020-08-20	Serum total cholesterol	EFO_0004574	None	None	DNA methylation	Serum total cholesterol	Batch effects, cell composition (reference free), ancestry (genomic PCs)	Beta Values	mmol/l	Illumina HumanMethylation450	Whole blood	None	685	1	Adults	Females	European	cg03425194	chr15:25481443	15	25481443	-	Open sea	0.166	0.042	0.000091	None	Battram-T_serum_total_cholesterol
Battram T	ARIES	None	2020-08-20	Serum total cholesterol	EFO_0004574	None	None	DNA methylation	Serum total cholesterol	Batch effects, cell composition (reference free), ancestry (genomic PCs)	Beta Values	mmol/l	Illumina HumanMethylation450	Whole blood	None	685	1	Adults	Females	European	cg00512031	chr4:5021976	4	5021976	CYTL1	South shore	-0.162	0.041	0.000093	None	Battram-T_serum_total_cholesterol
Battram T	ARIES	None	2020-08-20	Serum total cholesterol	EFO_0004574	None	None	DNA methylation	Serum total cholesterol	Batch effects, cell composition (reference free), ancestry (genomic PCs)	Beta Values	mmol/l	Illumina HumanMethylation450	Whole blood	None	685	1	Adults	Females	European	cg00793186	chr5:139283100	5	139283100	NRG2	North shore	0.128	0.033	0.000094	None	Battram-T_serum_total_cholesterol
Battram T	ARIES	None	2020-08-20	Serum total cholesterol	EFO_0004574	None	None	DNA methylation	Serum total cholesterol	Batch effects, cell composition (reference free), ancestry (genomic PCs)	Beta Values	mmol/l	Illumina HumanMethylation450	Whole blood	None	685	1	Adults	Females	European	cg20839219	chr18:33710235	18	33710235	SLC39A6;ELP2	Island	-0.141	0.036	0.000098	None	Battram-T_serum_total_cholesterol
Battram T	ARIES	None	2020-08-20	Serum total cholesterol	EFO_0004574	None	None	DNA methylation	Serum total cholesterol	Batch effects, cell composition (reference free), ancestry (genomic PCs)	Beta Values	mmol/l	Illumina HumanMethylation450	Whole blood	None	685	1	Adults	Females	European	cg00340161	chr19:47207574	19	47207574	PRKD2	Island	0.164	0.042	0.000098	None	Battram-T_serum_total_cholesterol
Battram T	ARIES	None	2020-08-20	Serum total cholesterol	EFO_0004574	None	None	DNA methylation	Serum total cholesterol	Batch effects, cell composition (reference free), ancestry (genomic PCs)	Beta Values	mmol/l	Illumina HumanMethylation450	Whole blood	None	685	1	Adults	Females	European	cg24844387	chr6:20215399	6	20215399	-	South shelf	-0.094	0.024	0.000099	None	Battram-T_serum_total_cholesterol