author	consortium	pmid	date	trait	efo	analysis	source	outcome	exposure	covariates	outcome_units	exposure_units	methylation_array	tissue	further_details	n	n_cohorts	age	sex	ethnicity	cpg	chrpos	chr	pos	gene	type	beta	se	p	details	study_id
Freeman JR	-	27602958	2016-10-25	Smoking pack-years	EFO_0006526, EFO_0005671, EFO_0004318	Discovery and replication	Additional file 1	DNA methylation	Smoking pack-years	Age, sex, ethnicity, cell type, EGFR mutation status and KRAS mutation status	M values	Pack-years	Illumina HumanMethylation450	Lung adenocarcinoma and lung squamous cell	-	511	1	66.8	Both	European,African,Other	cg16579555	chr17:29298352	17	29298352	RNF135	Island	-1.40548871	0.1531	4.23e-20	-	27602958_smoking_packyears_discovery_and_replication
Freeman JR	-	27602958	2016-10-25	Smoking pack-years	EFO_0006526, EFO_0005671, EFO_0004318	Discovery and replication	Additional file 1	DNA methylation	Smoking pack-years	Age, sex, ethnicity, cell type, EGFR mutation status and KRAS mutation status	M values	Pack-years	Illumina HumanMethylation450	Lung adenocarcinoma and lung squamous cell	-	511	1	66.8	Both	European,African,Other	cg16654732	chr5:170846517	5	170846517	FGF18	Island	-1.34235338	0.1473	8.07e-20	-	27602958_smoking_packyears_discovery_and_replication
Freeman JR	-	27602958	2016-10-25	Smoking pack-years	EFO_0006526, EFO_0005671, EFO_0004318	Discovery and replication	Additional file 1	DNA methylation	Smoking pack-years	Age, sex, ethnicity, cell type, EGFR mutation status and KRAS mutation status	M values	Pack-years	Illumina HumanMethylation450	Lung adenocarcinoma and lung squamous cell	-	511	1	66.8	Both	European,African,Other	cg00032419	chr17:27895566	17	27895566	TP53I13	Island	-1.22751597	0.136	1.83e-19	-	27602958_smoking_packyears_discovery_and_replication
Freeman JR	-	27602958	2016-10-25	Smoking pack-years	EFO_0006526, EFO_0005671, EFO_0004318	Discovery and replication	Additional file 1	DNA methylation	Smoking pack-years	Age, sex, ethnicity, cell type, EGFR mutation status and KRAS mutation status	M values	Pack-years	Illumina HumanMethylation450	Lung adenocarcinoma and lung squamous cell	-	511	1	66.8	Both	European,African,Other	cg01014490	chr1:714177	1	714177	-	Island	-1.18795733	0.1361	2.58e-18	-	27602958_smoking_packyears_discovery_and_replication
Freeman JR	-	27602958	2016-10-25	Smoking pack-years	EFO_0006526, EFO_0005671, EFO_0004318	Lung squamous cell	Additional file 3	DNA methylation	Smoking pack-years	Age, sex, ethnicity, cell type, EGFR mutation status and KRAS mutation status	M values	Pack-years	Illumina HumanMethylation450	Lung squamous cell	-	511	1	66.8	Both	European,African,Other	cg16579555	chr17:29298352	17	29298352	RNF135	Island	-2.4541397	0.2997	2.66e-16	-	27602958_smoking_packyears_lung_squamous_cell
Freeman JR	-	27602958	2016-10-25	Smoking pack-years	EFO_0006526, EFO_0005671, EFO_0004318	Discovery and replication	Additional file 1	DNA methylation	Smoking pack-years	Age, sex, ethnicity, cell type, EGFR mutation status and KRAS mutation status	M values	Pack-years	Illumina HumanMethylation450	Lung adenocarcinoma and lung squamous cell	-	511	1	66.8	Both	European,African,Other	cg24843246	chr19:7621952	19	7621952	PNPLA6	Island	1.12321937	0.1381	4.16e-16	-	27602958_smoking_packyears_discovery_and_replication
Freeman JR	-	27602958	2016-10-25	Smoking pack-years	EFO_0006526, EFO_0005671, EFO_0004318	Lung squamous cell	Additional file 3	DNA methylation	Smoking pack-years	Age, sex, ethnicity, cell type, EGFR mutation status and KRAS mutation status	M values	Pack-years	Illumina HumanMethylation450	Lung squamous cell	-	511	1	66.8	Both	European,African,Other	cg16654732	chr5:170846517	5	170846517	FGF18	Island	-2.1409475	0.2648	6.14e-16	-	27602958_smoking_packyears_lung_squamous_cell
Freeman JR	-	27602958	2016-10-25	Smoking pack-years	EFO_0006526, EFO_0005671, EFO_0004318	Lung squamous cell	Additional file 3	DNA methylation	Smoking pack-years	Age, sex, ethnicity, cell type, EGFR mutation status and KRAS mutation status	M values	Pack-years	Illumina HumanMethylation450	Lung squamous cell	-	511	1	66.8	Both	European,African,Other	cg00032419	chr17:27895566	17	27895566	TP53I13	Island	-2.0022302	0.2497	0.00000000000000106	-	27602958_smoking_packyears_lung_squamous_cell
Freeman JR	-	27602958	2016-10-25	Smoking pack-years	EFO_0006526, EFO_0005671, EFO_0004318	Discovery and replication	Additional file 1	DNA methylation	Smoking pack-years	Age, sex, ethnicity, cell type, EGFR mutation status and KRAS mutation status	M values	Pack-years	Illumina HumanMethylation450	Lung adenocarcinoma and lung squamous cell	-	511	1	66.8	Both	European,African,Other	cg00265578	chr17:27895564	17	27895564	TP53I13	Island	-0.90328596	0.1134	0.00000000000000161	-	27602958_smoking_packyears_discovery_and_replication
Freeman JR	-	27602958	2016-10-25	Smoking pack-years	EFO_0006526, EFO_0005671, EFO_0004318	Discovery and replication	Additional file 1	DNA methylation	Smoking pack-years	Age, sex, ethnicity, cell type, EGFR mutation status and KRAS mutation status	M values	Pack-years	Illumina HumanMethylation450	Lung adenocarcinoma and lung squamous cell	-	511	1	66.8	Both	European,African,Other	cg08135278	chr1:226070709	1	226070709	TMEM63A	Island	-0.96824738	0.1226	0.0000000000000029	-	27602958_smoking_packyears_discovery_and_replication
Freeman JR	-	27602958	2016-10-25	Smoking pack-years	EFO_0006526, EFO_0005671, EFO_0004318	Discovery and replication	Additional file 1	DNA methylation	Smoking pack-years	Age, sex, ethnicity, cell type, EGFR mutation status and KRAS mutation status	M values	Pack-years	Illumina HumanMethylation450	Lung adenocarcinoma and lung squamous cell	-	511	1	66.8	Both	European,African,Other	cg13204512	chr17:29298184	17	29298184	RNF135	Island	-1.04923321	0.134	0.00000000000000481	-	27602958_smoking_packyears_discovery_and_replication
Freeman JR	-	27602958	2016-10-25	Smoking pack-years	EFO_0006526, EFO_0005671, EFO_0004318	Lung squamous cell	Additional file 3	DNA methylation	Smoking pack-years	Age, sex, ethnicity, cell type, EGFR mutation status and KRAS mutation status	M values	Pack-years	Illumina HumanMethylation450	Lung squamous cell	-	511	1	66.8	Both	European,African,Other	cg11122493	chr17:74706551	17	74706551	MXRA7	Island	-1.9884011	0.261	0.0000000000000255	-	27602958_smoking_packyears_lung_squamous_cell
Freeman JR	-	27602958	2016-10-25	Smoking pack-years	EFO_0006526, EFO_0005671, EFO_0004318	Discovery and replication	Additional file 1	DNA methylation	Smoking pack-years	Age, sex, ethnicity, cell type, EGFR mutation status and KRAS mutation status	M values	Pack-years	Illumina HumanMethylation450	Lung adenocarcinoma and lung squamous cell	-	511	1	66.8	Both	European,African,Other	cg20480233	chr14:23451154	14	23451154	JUB	Island	-1.18803438	0.1561	0.0000000000000271	-	27602958_smoking_packyears_discovery_and_replication
Freeman JR	-	27602958	2016-10-25	Smoking pack-years	EFO_0006526, EFO_0005671, EFO_0004318	Discovery and replication	Additional file 1	DNA methylation	Smoking pack-years	Age, sex, ethnicity, cell type, EGFR mutation status and KRAS mutation status	M values	Pack-years	Illumina HumanMethylation450	Lung adenocarcinoma and lung squamous cell	-	511	1	66.8	Both	European,African,Other	cg24599345	chr2:85645863	2	85645863	-	Island	-0.69035587	0.0909	0.0000000000000299	-	27602958_smoking_packyears_discovery_and_replication
Freeman JR	-	27602958	2016-10-25	Smoking pack-years	EFO_0006526, EFO_0005671, EFO_0004318	Discovery and replication	Additional file 1	DNA methylation	Smoking pack-years	Age, sex, ethnicity, cell type, EGFR mutation status and KRAS mutation status	M values	Pack-years	Illumina HumanMethylation450	Lung adenocarcinoma and lung squamous cell	-	511	1	66.8	Both	European,African,Other	cg26369667	chr11:101981789	11	101981789	YAP1	Island	-0.87548096	0.1154	0.0000000000000322	-	27602958_smoking_packyears_discovery_and_replication
Freeman JR	-	27602958	2016-10-25	Smoking pack-years	EFO_0006526, EFO_0005671, EFO_0004318	Discovery and replication	Additional file 1	DNA methylation	Smoking pack-years	Age, sex, ethnicity, cell type, EGFR mutation status and KRAS mutation status	M values	Pack-years	Illumina HumanMethylation450	Lung adenocarcinoma and lung squamous cell	-	511	1	66.8	Both	European,African,Other	cg05624510	chr15:41245527	15	41245527	CHAC1	Island	-0.80774406	0.1068	0.0000000000000394	-	27602958_smoking_packyears_discovery_and_replication
Freeman JR	-	27602958	2016-10-25	Smoking pack-years	EFO_0006526, EFO_0005671, EFO_0004318	Discovery and replication	Additional file 1	DNA methylation	Smoking pack-years	Age, sex, ethnicity, cell type, EGFR mutation status and KRAS mutation status	M values	Pack-years	Illumina HumanMethylation450	Lung adenocarcinoma and lung squamous cell	-	511	1	66.8	Both	European,African,Other	cg19508701	chr8:9008170	8	9008170	PPP1R3B	Island	-0.83663706	0.1117	0.0000000000000698	-	27602958_smoking_packyears_discovery_and_replication
Freeman JR	-	27602958	2016-10-25	Smoking pack-years	EFO_0006526, EFO_0005671, EFO_0004318	Lung squamous cell	Additional file 3	DNA methylation	Smoking pack-years	Age, sex, ethnicity, cell type, EGFR mutation status and KRAS mutation status	M values	Pack-years	Illumina HumanMethylation450	Lung squamous cell	-	511	1	66.8	Both	European,African,Other	cg13204512	chr17:29298184	17	29298184	RNF135	Island	-1.9256804	0.2632	0.000000000000256	-	27602958_smoking_packyears_lung_squamous_cell
Freeman JR	-	27602958	2016-10-25	Smoking pack-years	EFO_0006526, EFO_0005671, EFO_0004318	Discovery and replication	Additional file 1	DNA methylation	Smoking pack-years	Age, sex, ethnicity, cell type, EGFR mutation status and KRAS mutation status	M values	Pack-years	Illumina HumanMethylation450	Lung adenocarcinoma and lung squamous cell	-	511	1	66.8	Both	European,African,Other	cg21273098	chr6:109762418	6	109762418	SMPD2;PPIL6	Island	-0.29226382	0.0401	0.000000000000311	-	27602958_smoking_packyears_discovery_and_replication
Freeman JR	-	27602958	2016-10-25	Smoking pack-years	EFO_0006526, EFO_0005671, EFO_0004318	Lung squamous cell	Additional file 3	DNA methylation	Smoking pack-years	Age, sex, ethnicity, cell type, EGFR mutation status and KRAS mutation status	M values	Pack-years	Illumina HumanMethylation450	Lung squamous cell	-	511	1	66.8	Both	European,African,Other	cg00265578	chr17:27895564	17	27895564	TP53I13	Island	-1.4277477	0.1963	0.000000000000346	-	27602958_smoking_packyears_lung_squamous_cell
Freeman JR	-	27602958	2016-10-25	Smoking pack-years	EFO_0006526, EFO_0005671, EFO_0004318	Lung squamous cell	Additional file 3	DNA methylation	Smoking pack-years	Age, sex, ethnicity, cell type, EGFR mutation status and KRAS mutation status	M values	Pack-years	Illumina HumanMethylation450	Lung squamous cell	-	511	1	66.8	Both	European,African,Other	cg01014490	chr1:714177	1	714177	-	Island	-1.7035448	0.2376	0.000000000000758	-	27602958_smoking_packyears_lung_squamous_cell
Freeman JR	-	27602958	2016-10-25	Smoking pack-years	EFO_0006526, EFO_0005671, EFO_0004318	Discovery and replication	Additional file 1	DNA methylation	Smoking pack-years	Age, sex, ethnicity, cell type, EGFR mutation status and KRAS mutation status	M values	Pack-years	Illumina HumanMethylation450	Lung adenocarcinoma and lung squamous cell	-	511	1	66.8	Both	European,African,Other	cg11345323	chr1:1981825	1	1981825	PRKCZ	Island	-0.75927442	0.1059	0.000000000000764	-	27602958_smoking_packyears_discovery_and_replication
Freeman JR	-	27602958	2016-10-25	Smoking pack-years	EFO_0006526, EFO_0005671, EFO_0004318	Discovery and replication	Additional file 1	DNA methylation	Smoking pack-years	Age, sex, ethnicity, cell type, EGFR mutation status and KRAS mutation status	M values	Pack-years	Illumina HumanMethylation450	Lung adenocarcinoma and lung squamous cell	-	511	1	66.8	Both	European,African,Other	cg11122493	chr17:74706551	17	74706551	MXRA7	Island	-1.09009968	0.1523	0.000000000000823	-	27602958_smoking_packyears_discovery_and_replication
Freeman JR	-	27602958	2016-10-25	Smoking pack-years	EFO_0006526, EFO_0005671, EFO_0004318	Discovery and replication	Additional file 1	DNA methylation	Smoking pack-years	Age, sex, ethnicity, cell type, EGFR mutation status and KRAS mutation status	M values	Pack-years	Illumina HumanMethylation450	Lung adenocarcinoma and lung squamous cell	-	511	1	66.8	Both	European,African,Other	cg18699112	chr17:81009351	17	81009351	B3GNTL1	Island	-0.60999057	0.0855	0.000000000000992	-	27602958_smoking_packyears_discovery_and_replication
Freeman JR	-	27602958	2016-10-25	Smoking pack-years	EFO_0006526, EFO_0005671, EFO_0004318	Lung squamous cell	Additional file 3	DNA methylation	Smoking pack-years	Age, sex, ethnicity, cell type, EGFR mutation status and KRAS mutation status	M values	Pack-years	Illumina HumanMethylation450	Lung squamous cell	-	511	1	66.8	Both	European,African,Other	cg08135278	chr1:226070709	1	226070709	TMEM63A	Island	-1.5739699	0.2212	0.00000000000111	-	27602958_smoking_packyears_lung_squamous_cell
Freeman JR	-	27602958	2016-10-25	Smoking pack-years	EFO_0006526, EFO_0005671, EFO_0004318	Discovery and replication	Additional file 1	DNA methylation	Smoking pack-years	Age, sex, ethnicity, cell type, EGFR mutation status and KRAS mutation status	M values	Pack-years	Illumina HumanMethylation450	Lung adenocarcinoma and lung squamous cell	-	511	1	66.8	Both	European,African,Other	cg06818515	chr16:2944443	16	2944443	FLYWCH2	Island	0.60777985	0.0857	0.0000000000013	-	27602958_smoking_packyears_discovery_and_replication
Freeman JR	-	27602958	2016-10-25	Smoking pack-years	EFO_0006526, EFO_0005671, EFO_0004318	Discovery and replication	Additional file 1	DNA methylation	Smoking pack-years	Age, sex, ethnicity, cell type, EGFR mutation status and KRAS mutation status	M values	Pack-years	Illumina HumanMethylation450	Lung adenocarcinoma and lung squamous cell	-	511	1	66.8	Both	European,African,Other	cg09939831	chr14:55596647	14	55596647	LGALS3	Island	-0.88556868	0.1252	0.00000000000152	-	27602958_smoking_packyears_discovery_and_replication
Freeman JR	-	27602958	2016-10-25	Smoking pack-years	EFO_0006526, EFO_0005671, EFO_0004318	Discovery and replication	Additional file 1	DNA methylation	Smoking pack-years	Age, sex, ethnicity, cell type, EGFR mutation status and KRAS mutation status	M values	Pack-years	Illumina HumanMethylation450	Lung adenocarcinoma and lung squamous cell	-	511	1	66.8	Both	European,African,Other	cg25144930	chr11:2398505	11	2398505	CD81	Island	-0.83473303	0.118	0.00000000000153	-	27602958_smoking_packyears_discovery_and_replication
Freeman JR	-	27602958	2016-10-25	Smoking pack-years	EFO_0006526, EFO_0005671, EFO_0004318	Discovery	Additional file 1	DNA methylation	Smoking pack-years	Age, sex, ethnicity, cell type, EGFR mutation status and KRAS mutation status	M values	Pack-years	Illumina HumanMethylation450	Lung adenocarcinoma and lung squamous cell	-	326	1	67	Both	European,African,Other	cg01014490	chr1:714177	1	714177	-	Island	-1.2615349	0.1794	0.00000000000205	-	27602958_smoking_packyears_discovery
Freeman JR	-	27602958	2016-10-25	Smoking pack-years	EFO_0006526, EFO_0005671, EFO_0004318	Discovery and replication	Additional file 1	DNA methylation	Smoking pack-years	Age, sex, ethnicity, cell type, EGFR mutation status and KRAS mutation status	M values	Pack-years	Illumina HumanMethylation450	Lung adenocarcinoma and lung squamous cell	-	511	1	66.8	Both	European,African,Other	cg07766672	chr8:143808440	8	143808440	C8orf55	Island	-0.72189995	0.1036	0.00000000000328	-	27602958_smoking_packyears_discovery_and_replication
Freeman JR	-	27602958	2016-10-25	Smoking pack-years	EFO_0006526, EFO_0005671, EFO_0004318	Discovery and replication	Additional file 1	DNA methylation	Smoking pack-years	Age, sex, ethnicity, cell type, EGFR mutation status and KRAS mutation status	M values	Pack-years	Illumina HumanMethylation450	Lung adenocarcinoma and lung squamous cell	-	511	1	66.8	Both	European,African,Other	cg16200496	chr19:13107141	19	13107141	NFIX	Island	-0.72126022	0.1036	0.0000000000034	-	27602958_smoking_packyears_discovery_and_replication
Freeman JR	-	27602958	2016-10-25	Smoking pack-years	EFO_0006526, EFO_0005671, EFO_0004318	Lung squamous cell	Additional file 3	DNA methylation	Smoking pack-years	Age, sex, ethnicity, cell type, EGFR mutation status and KRAS mutation status	M values	Pack-years	Illumina HumanMethylation450	Lung squamous cell	-	511	1	66.8	Both	European,African,Other	cg26369667	chr11:101981789	11	101981789	YAP1	Island	-1.4352979	0.2068	0.0000000000039	-	27602958_smoking_packyears_lung_squamous_cell
Freeman JR	-	27602958	2016-10-25	Smoking pack-years	EFO_0006526, EFO_0005671, EFO_0004318	Lung squamous cell	Additional file 3	DNA methylation	Smoking pack-years	Age, sex, ethnicity, cell type, EGFR mutation status and KRAS mutation status	M values	Pack-years	Illumina HumanMethylation450	Lung squamous cell	-	511	1	66.8	Both	European,African,Other	cg19508701	chr8:9008170	8	9008170	PPP1R3B	Island	-1.3217764	0.1906	0.0000000000041	-	27602958_smoking_packyears_lung_squamous_cell
Freeman JR	-	27602958	2016-10-25	Smoking pack-years	EFO_0006526, EFO_0005671, EFO_0004318	Discovery and replication	Additional file 1	DNA methylation	Smoking pack-years	Age, sex, ethnicity, cell type, EGFR mutation status and KRAS mutation status	M values	Pack-years	Illumina HumanMethylation450	Lung adenocarcinoma and lung squamous cell	-	511	1	66.8	Both	European,African,Other	cg19634213	chr10:89621792	10	89621792	PTEN;KILLIN	Island	-0.89985917	0.1298	0.00000000000413	-	27602958_smoking_packyears_discovery_and_replication
Freeman JR	-	27602958	2016-10-25	Smoking pack-years	EFO_0006526, EFO_0005671, EFO_0004318	Discovery and replication	Additional file 1	DNA methylation	Smoking pack-years	Age, sex, ethnicity, cell type, EGFR mutation status and KRAS mutation status	M values	Pack-years	Illumina HumanMethylation450	Lung adenocarcinoma and lung squamous cell	-	511	1	66.8	Both	European,African,Other	cg07243103	chr16:699355	16	699355	WDR90	Island	-0.3776608	0.0546	0.00000000000478	-	27602958_smoking_packyears_discovery_and_replication
Freeman JR	-	27602958	2016-10-25	Smoking pack-years	EFO_0006526, EFO_0005671, EFO_0004318	Discovery and replication	Additional file 1	DNA methylation	Smoking pack-years	Age, sex, ethnicity, cell type, EGFR mutation status and KRAS mutation status	M values	Pack-years	Illumina HumanMethylation450	Lung adenocarcinoma and lung squamous cell	-	511	1	66.8	Both	European,African,Other	cg26569144	chr5:170846504	5	170846504	FGF18	Island	-0.8461958	0.1225	0.00000000000488	-	27602958_smoking_packyears_discovery_and_replication
Freeman JR	-	27602958	2016-10-25	Smoking pack-years	EFO_0006526, EFO_0005671, EFO_0004318	Discovery and replication	Additional file 1	DNA methylation	Smoking pack-years	Age, sex, ethnicity, cell type, EGFR mutation status and KRAS mutation status	M values	Pack-years	Illumina HumanMethylation450	Lung adenocarcinoma and lung squamous cell	-	511	1	66.8	Both	European,African,Other	cg18617333	chr8:143808383	8	143808383	C8orf55	Island	-0.71259613	0.1032	0.00000000000503	-	27602958_smoking_packyears_discovery_and_replication
Freeman JR	-	27602958	2016-10-25	Smoking pack-years	EFO_0006526, EFO_0005671, EFO_0004318	Discovery	Additional file 1	DNA methylation	Smoking pack-years	Age, sex, ethnicity, cell type, EGFR mutation status and KRAS mutation status	M values	Pack-years	Illumina HumanMethylation450	Lung adenocarcinoma and lung squamous cell	-	326	1	67	Both	European,African,Other	cg16654732	chr5:170846517	5	170846517	FGF18	Island	-1.3157231	0.1921	0.00000000000739	-	27602958_smoking_packyears_discovery
Freeman JR	-	27602958	2016-10-25	Smoking pack-years	EFO_0006526, EFO_0005671, EFO_0004318	Discovery and replication	Additional file 1	DNA methylation	Smoking pack-years	Age, sex, ethnicity, cell type, EGFR mutation status and KRAS mutation status	M values	Pack-years	Illumina HumanMethylation450	Lung adenocarcinoma and lung squamous cell	-	511	1	66.8	Both	European,African,Other	cg05933803	chr17:27895641	17	27895641	TP53I13	Island	-0.17405611	0.0254	0.00000000000747	-	27602958_smoking_packyears_discovery_and_replication
Freeman JR	-	27602958	2016-10-25	Smoking pack-years	EFO_0006526, EFO_0005671, EFO_0004318	Discovery and replication	Additional file 1	DNA methylation	Smoking pack-years	Age, sex, ethnicity, cell type, EGFR mutation status and KRAS mutation status	M values	Pack-years	Illumina HumanMethylation450	Lung adenocarcinoma and lung squamous cell	-	511	1	66.8	Both	European,African,Other	cg03586437	chr1:226070052	1	226070052	TMEM63A	Island	-0.68999255	0.1008	0.00000000000767	-	27602958_smoking_packyears_discovery_and_replication
Freeman JR	-	27602958	2016-10-25	Smoking pack-years	EFO_0006526, EFO_0005671, EFO_0004318	Discovery and replication	Additional file 1	DNA methylation	Smoking pack-years	Age, sex, ethnicity, cell type, EGFR mutation status and KRAS mutation status	M values	Pack-years	Illumina HumanMethylation450	Lung adenocarcinoma and lung squamous cell	-	511	1	66.8	Both	European,African,Other	cg18496502	chr19:42880157	19	42880157	MEGF8	Island	0.86976769	0.1271	0.00000000000769	-	27602958_smoking_packyears_discovery_and_replication
Freeman JR	-	27602958	2016-10-25	Smoking pack-years	EFO_0006526, EFO_0005671, EFO_0004318	Discovery	Additional file 1	DNA methylation	Smoking pack-years	Age, sex, ethnicity, cell type, EGFR mutation status and KRAS mutation status	M values	Pack-years	Illumina HumanMethylation450	Lung adenocarcinoma and lung squamous cell	-	326	1	67	Both	European,African,Other	cg16579555	chr17:29298352	17	29298352	RNF135	Island	-1.3633508	0.1992	0.00000000000771	-	27602958_smoking_packyears_discovery
Freeman JR	-	27602958	2016-10-25	Smoking pack-years	EFO_0006526, EFO_0005671, EFO_0004318	Lung squamous cell	Additional file 3	DNA methylation	Smoking pack-years	Age, sex, ethnicity, cell type, EGFR mutation status and KRAS mutation status	M values	Pack-years	Illumina HumanMethylation450	Lung squamous cell	-	511	1	66.8	Both	European,African,Other	cg01725199	chr9:101569990	9	101569990	GALNT12	Island	-0.8855553	0.1295	0.00000000000789	-	27602958_smoking_packyears_lung_squamous_cell
Freeman JR	-	27602958	2016-10-25	Smoking pack-years	EFO_0006526, EFO_0005671, EFO_0004318	Discovery	Additional file 1	DNA methylation	Smoking pack-years	Age, sex, ethnicity, cell type, EGFR mutation status and KRAS mutation status	M values	Pack-years	Illumina HumanMethylation450	Lung adenocarcinoma and lung squamous cell	-	326	1	67	Both	European,African,Other	cg00032419	chr17:27895566	17	27895566	TP53I13	Island	-1.2477155	0.1825	0.00000000000803	-	27602958_smoking_packyears_discovery
Freeman JR	-	27602958	2016-10-25	Smoking pack-years	EFO_0006526, EFO_0005671, EFO_0004318	Discovery and replication	Additional file 1	DNA methylation	Smoking pack-years	Age, sex, ethnicity, cell type, EGFR mutation status and KRAS mutation status	M values	Pack-years	Illumina HumanMethylation450	Lung adenocarcinoma and lung squamous cell	-	511	1	66.8	Both	European,African,Other	cg19168961	chr15:41245649	15	41245649	CHAC1	Island	-0.49071929	0.0718	0.00000000000841	-	27602958_smoking_packyears_discovery_and_replication
Freeman JR	-	27602958	2016-10-25	Smoking pack-years	EFO_0006526, EFO_0005671, EFO_0004318	Discovery and replication	Additional file 1	DNA methylation	Smoking pack-years	Age, sex, ethnicity, cell type, EGFR mutation status and KRAS mutation status	M values	Pack-years	Illumina HumanMethylation450	Lung adenocarcinoma and lung squamous cell	-	511	1	66.8	Both	European,African,Other	cg20849378	chr7:1516084	7	1516084	INTS1	Island	0.83941766	0.1231	0.00000000000904	-	27602958_smoking_packyears_discovery_and_replication
Freeman JR	-	27602958	2016-10-25	Smoking pack-years	EFO_0006526, EFO_0005671, EFO_0004318	Lung squamous cell	Additional file 3	DNA methylation	Smoking pack-years	Age, sex, ethnicity, cell type, EGFR mutation status and KRAS mutation status	M values	Pack-years	Illumina HumanMethylation450	Lung squamous cell	-	511	1	66.8	Both	European,African,Other	cg18699112	chr17:81009351	17	81009351	B3GNTL1	Island	-1.1796811	0.1733	0.00000000000983	-	27602958_smoking_packyears_lung_squamous_cell
Freeman JR	-	27602958	2016-10-25	Smoking pack-years	EFO_0006526, EFO_0005671, EFO_0004318	Discovery and replication	Additional file 1	DNA methylation	Smoking pack-years	Age, sex, ethnicity, cell type, EGFR mutation status and KRAS mutation status	M values	Pack-years	Illumina HumanMethylation450	Lung adenocarcinoma and lung squamous cell	-	511	1	66.8	Both	European,African,Other	cg22409276	chr15:40763763	15	40763763	CHST14	Island	-0.8112444	0.1193	0.0000000000104	-	27602958_smoking_packyears_discovery_and_replication
Freeman JR	-	27602958	2016-10-25	Smoking pack-years	EFO_0006526, EFO_0005671, EFO_0004318	Discovery and replication	Additional file 1	DNA methylation	Smoking pack-years	Age, sex, ethnicity, cell type, EGFR mutation status and KRAS mutation status	M values	Pack-years	Illumina HumanMethylation450	Lung adenocarcinoma and lung squamous cell	-	511	1	66.8	Both	European,African,Other	cg21701395	chr8:95961492	8	95961492	TP53INP1	Island	-0.78434439	0.1153	0.0000000000105	-	27602958_smoking_packyears_discovery_and_replication
Freeman JR	-	27602958	2016-10-25	Smoking pack-years	EFO_0006526, EFO_0005671, EFO_0004318	Lung squamous cell	Additional file 3	DNA methylation	Smoking pack-years	Age, sex, ethnicity, cell type, EGFR mutation status and KRAS mutation status	M values	Pack-years	Illumina HumanMethylation450	Lung squamous cell	-	511	1	66.8	Both	European,African,Other	cg11345323	chr1:1981825	1	1981825	PRKCZ	Island	-1.3493311	0.1993	0.000000000013	-	27602958_smoking_packyears_lung_squamous_cell
Freeman JR	-	27602958	2016-10-25	Smoking pack-years	EFO_0006526, EFO_0005671, EFO_0004318	Lung squamous cell	Additional file 3	DNA methylation	Smoking pack-years	Age, sex, ethnicity, cell type, EGFR mutation status and KRAS mutation status	M values	Pack-years	Illumina HumanMethylation450	Lung squamous cell	-	511	1	66.8	Both	European,African,Other	cg03586437	chr1:226070052	1	226070052	TMEM63A	Island	-1.37949	0.2038	0.0000000000131	-	27602958_smoking_packyears_lung_squamous_cell
Freeman JR	-	27602958	2016-10-25	Smoking pack-years	EFO_0006526, EFO_0005671, EFO_0004318	Lung squamous cell	Additional file 3	DNA methylation	Smoking pack-years	Age, sex, ethnicity, cell type, EGFR mutation status and KRAS mutation status	M values	Pack-years	Illumina HumanMethylation450	Lung squamous cell	-	511	1	66.8	Both	European,African,Other	cg05624510	chr15:41245527	15	41245527	CHAC1	Island	-1.243213	0.1838	0.0000000000134	-	27602958_smoking_packyears_lung_squamous_cell
Freeman JR	-	27602958	2016-10-25	Smoking pack-years	EFO_0006526, EFO_0005671, EFO_0004318	Discovery and replication	Additional file 1	DNA methylation	Smoking pack-years	Age, sex, ethnicity, cell type, EGFR mutation status and KRAS mutation status	M values	Pack-years	Illumina HumanMethylation450	Lung adenocarcinoma and lung squamous cell	-	511	1	66.8	Both	European,African,Other	cg01725199	chr9:101569990	9	101569990	GALNT12	Island	-0.51807168	0.0777	0.0000000000258	-	27602958_smoking_packyears_discovery_and_replication
Freeman JR	-	27602958	2016-10-25	Smoking pack-years	EFO_0006526, EFO_0005671, EFO_0004318	Discovery and replication	Additional file 1	DNA methylation	Smoking pack-years	Age, sex, ethnicity, cell type, EGFR mutation status and KRAS mutation status	M values	Pack-years	Illumina HumanMethylation450	Lung adenocarcinoma and lung squamous cell	-	511	1	66.8	Both	European,African,Other	cg02456708	chr17:27895477	17	27895477	ABHD15;TP53I13	Island	-0.56544459	0.0849	0.0000000000269	-	27602958_smoking_packyears_discovery_and_replication
Freeman JR	-	27602958	2016-10-25	Smoking pack-years	EFO_0006526, EFO_0005671, EFO_0004318	Lung squamous cell	Additional file 3	DNA methylation	Smoking pack-years	Age, sex, ethnicity, cell type, EGFR mutation status and KRAS mutation status	M values	Pack-years	Illumina HumanMethylation450	Lung squamous cell	-	511	1	66.8	Both	European,African,Other	cg20215367	chr8:143808432	8	143808432	C8orf55	Island	-1.0707262	0.161	0.0000000000295	-	27602958_smoking_packyears_lung_squamous_cell
Freeman JR	-	27602958	2016-10-25	Smoking pack-years	EFO_0006526, EFO_0005671, EFO_0004318	Discovery and replication	Additional file 1	DNA methylation	Smoking pack-years	Age, sex, ethnicity, cell type, EGFR mutation status and KRAS mutation status	M values	Pack-years	Illumina HumanMethylation450	Lung adenocarcinoma and lung squamous cell	-	511	1	66.8	Both	European,African,Other	cg24948990	chr8:143820828	8	143820828	-	Island	-0.79672327	0.1201	0.0000000000323	-	27602958_smoking_packyears_discovery_and_replication
Freeman JR	-	27602958	2016-10-25	Smoking pack-years	EFO_0006526, EFO_0005671, EFO_0004318	Discovery and replication	Additional file 1	DNA methylation	Smoking pack-years	Age, sex, ethnicity, cell type, EGFR mutation status and KRAS mutation status	M values	Pack-years	Illumina HumanMethylation450	Lung adenocarcinoma and lung squamous cell	-	511	1	66.8	Both	European,African,Other	cg05288071	chr19:7712539	19	7712539	STXBP2	South shore	0.85478003	0.1292	0.0000000000369	-	27602958_smoking_packyears_discovery_and_replication
Freeman JR	-	27602958	2016-10-25	Smoking pack-years	EFO_0006526, EFO_0005671, EFO_0004318	Discovery and replication	Additional file 1	DNA methylation	Smoking pack-years	Age, sex, ethnicity, cell type, EGFR mutation status and KRAS mutation status	M values	Pack-years	Illumina HumanMethylation450	Lung adenocarcinoma and lung squamous cell	-	511	1	66.8	Both	European,African,Other	cg06370133	chr2:113914844	2	113914844	-	Island	-0.63086287	0.0955	0.0000000000403	-	27602958_smoking_packyears_discovery_and_replication
Freeman JR	-	27602958	2016-10-25	Smoking pack-years	EFO_0006526, EFO_0005671, EFO_0004318	Discovery and replication	Additional file 1	DNA methylation	Smoking pack-years	Age, sex, ethnicity, cell type, EGFR mutation status and KRAS mutation status	M values	Pack-years	Illumina HumanMethylation450	Lung adenocarcinoma and lung squamous cell	-	511	1	66.8	Both	European,African,Other	cg09378497	chr16:1525169	16	1525169	CLCN7	Island	-0.63278204	0.0962	0.0000000000477	-	27602958_smoking_packyears_discovery_and_replication
Freeman JR	-	27602958	2016-10-25	Smoking pack-years	EFO_0006526, EFO_0005671, EFO_0004318	Discovery and replication	Additional file 1	DNA methylation	Smoking pack-years	Age, sex, ethnicity, cell type, EGFR mutation status and KRAS mutation status	M values	Pack-years	Illumina HumanMethylation450	Lung adenocarcinoma and lung squamous cell	-	511	1	66.8	Both	European,African,Other	cg03779431	chr21:27543124	21	27543124	APP	Island	-0.37834685	0.0575	0.0000000000481	-	27602958_smoking_packyears_discovery_and_replication
Freeman JR	-	27602958	2016-10-25	Smoking pack-years	EFO_0006526, EFO_0005671, EFO_0004318	Discovery and replication	Additional file 1	DNA methylation	Smoking pack-years	Age, sex, ethnicity, cell type, EGFR mutation status and KRAS mutation status	M values	Pack-years	Illumina HumanMethylation450	Lung adenocarcinoma and lung squamous cell	-	511	1	66.8	Both	European,African,Other	cg13570982	chr14:55596240	14	55596240	LGALS3	Island	-1.00382152	0.1527	0.000000000049	-	27602958_smoking_packyears_discovery_and_replication
Freeman JR	-	27602958	2016-10-25	Smoking pack-years	EFO_0006526, EFO_0005671, EFO_0004318	Lung squamous cell	Additional file 3	DNA methylation	Smoking pack-years	Age, sex, ethnicity, cell type, EGFR mutation status and KRAS mutation status	M values	Pack-years	Illumina HumanMethylation450	Lung squamous cell	-	511	1	66.8	Both	European,African,Other	cg16726667	chr16:68002228	16	68002228	SLC12A4	Island	-1.4555379	0.2218	0.0000000000532	-	27602958_smoking_packyears_lung_squamous_cell
Freeman JR	-	27602958	2016-10-25	Smoking pack-years	EFO_0006526, EFO_0005671, EFO_0004318	Lung squamous cell	Additional file 3	DNA methylation	Smoking pack-years	Age, sex, ethnicity, cell type, EGFR mutation status and KRAS mutation status	M values	Pack-years	Illumina HumanMethylation450	Lung squamous cell	-	511	1	66.8	Both	European,African,Other	cg02456708	chr17:27895477	17	27895477	ABHD15;TP53I13	Island	-0.8989247	0.1372	0.0000000000569	-	27602958_smoking_packyears_lung_squamous_cell
Freeman JR	-	27602958	2016-10-25	Smoking pack-years	EFO_0006526, EFO_0005671, EFO_0004318	Discovery and replication	Additional file 1	DNA methylation	Smoking pack-years	Age, sex, ethnicity, cell type, EGFR mutation status and KRAS mutation status	M values	Pack-years	Illumina HumanMethylation450	Lung adenocarcinoma and lung squamous cell	-	511	1	66.8	Both	European,African,Other	cg06788803	chr1:45805948	1	45805948	MUTYH;TOE1	Island	-0.30325075	0.0464	0.0000000000662	-	27602958_smoking_packyears_discovery_and_replication
Freeman JR	-	27602958	2016-10-25	Smoking pack-years	EFO_0006526, EFO_0005671, EFO_0004318	Discovery and replication	Additional file 1	DNA methylation	Smoking pack-years	Age, sex, ethnicity, cell type, EGFR mutation status and KRAS mutation status	M values	Pack-years	Illumina HumanMethylation450	Lung adenocarcinoma and lung squamous cell	-	511	1	66.8	Both	European,African,Other	cg20215367	chr8:143808432	8	143808432	C8orf55	Island	-0.60279724	0.0927	0.0000000000777	-	27602958_smoking_packyears_discovery_and_replication
Freeman JR	-	27602958	2016-10-25	Smoking pack-years	EFO_0006526, EFO_0005671, EFO_0004318	Lung squamous cell	Additional file 3	DNA methylation	Smoking pack-years	Age, sex, ethnicity, cell type, EGFR mutation status and KRAS mutation status	M values	Pack-years	Illumina HumanMethylation450	Lung squamous cell	-	511	1	66.8	Both	European,African,Other	cg05933803	chr17:27895641	17	27895641	TP53I13	Island	-0.2949198	0.0454	0.0000000000787	-	27602958_smoking_packyears_lung_squamous_cell
Freeman JR	-	27602958	2016-10-25	Smoking pack-years	EFO_0006526, EFO_0005671, EFO_0004318	Discovery and replication	Additional file 1	DNA methylation	Smoking pack-years	Age, sex, ethnicity, cell type, EGFR mutation status and KRAS mutation status	M values	Pack-years	Illumina HumanMethylation450	Lung adenocarcinoma and lung squamous cell	-	511	1	66.8	Both	European,African,Other	cg22865720	chr1:1981816	1	1981816	PRKCZ	Island	-0.61485768	0.0951	0.000000000101	-	27602958_smoking_packyears_discovery_and_replication
Freeman JR	-	27602958	2016-10-25	Smoking pack-years	EFO_0006526, EFO_0005671, EFO_0004318	Discovery	Additional file 1	DNA methylation	Smoking pack-years	Age, sex, ethnicity, cell type, EGFR mutation status and KRAS mutation status	M values	Pack-years	Illumina HumanMethylation450	Lung adenocarcinoma and lung squamous cell	-	326	1	67	Both	European,African,Other	cg24843246	chr19:7621952	19	7621952	PNPLA6	Island	1.253473	0.194	0.000000000104	-	27602958_smoking_packyears_discovery
Freeman JR	-	27602958	2016-10-25	Smoking pack-years	EFO_0006526, EFO_0005671, EFO_0004318	Lung squamous cell	Additional file 3	DNA methylation	Smoking pack-years	Age, sex, ethnicity, cell type, EGFR mutation status and KRAS mutation status	M values	Pack-years	Illumina HumanMethylation450	Lung squamous cell	-	511	1	66.8	Both	European,African,Other	cg07766672	chr8:143808440	8	143808440	C8orf55	Island	-1.1905856	0.1847	0.000000000116	-	27602958_smoking_packyears_lung_squamous_cell
Freeman JR	-	27602958	2016-10-25	Smoking pack-years	EFO_0006526, EFO_0005671, EFO_0004318	Discovery and replication	Additional file 1	DNA methylation	Smoking pack-years	Age, sex, ethnicity, cell type, EGFR mutation status and KRAS mutation status	M values	Pack-years	Illumina HumanMethylation450	Lung adenocarcinoma and lung squamous cell	-	511	1	66.8	Both	European,African,Other	cg25924823	chr8:145113480	8	145113480	OPLAH	Island	0.59453119	0.0924	0.000000000122	-	27602958_smoking_packyears_discovery_and_replication
Freeman JR	-	27602958	2016-10-25	Smoking pack-years	EFO_0006526, EFO_0005671, EFO_0004318	Lung squamous cell	Additional file 3	DNA methylation	Smoking pack-years	Age, sex, ethnicity, cell type, EGFR mutation status and KRAS mutation status	M values	Pack-years	Illumina HumanMethylation450	Lung squamous cell	-	511	1	66.8	Both	European,African,Other	cg25924823	chr8:145113480	8	145113480	OPLAH	Island	1.326561	0.2066	0.000000000136	-	27602958_smoking_packyears_lung_squamous_cell
Freeman JR	-	27602958	2016-10-25	Smoking pack-years	EFO_0006526, EFO_0005671, EFO_0004318	Discovery and replication	Additional file 1	DNA methylation	Smoking pack-years	Age, sex, ethnicity, cell type, EGFR mutation status and KRAS mutation status	M values	Pack-years	Illumina HumanMethylation450	Lung adenocarcinoma and lung squamous cell	-	511	1	66.8	Both	European,African,Other	cg23087239	chr3:134080574	3	134080574	AMOTL2	Island	0.71411125	0.1113	0.000000000139	-	27602958_smoking_packyears_discovery_and_replication
Freeman JR	-	27602958	2016-10-25	Smoking pack-years	EFO_0006526, EFO_0005671, EFO_0004318	Discovery and replication	Additional file 1	DNA methylation	Smoking pack-years	Age, sex, ethnicity, cell type, EGFR mutation status and KRAS mutation status	M values	Pack-years	Illumina HumanMethylation450	Lung adenocarcinoma and lung squamous cell	-	511	1	66.8	Both	European,African,Other	cg03705926	chr19:6740952	19	6740952	TRIP10	Island	-0.69589047	0.1087	0.000000000151	-	27602958_smoking_packyears_discovery_and_replication
Freeman JR	-	27602958	2016-10-25	Smoking pack-years	EFO_0006526, EFO_0005671, EFO_0004318	Discovery and replication	Additional file 1	DNA methylation	Smoking pack-years	Age, sex, ethnicity, cell type, EGFR mutation status and KRAS mutation status	M values	Pack-years	Illumina HumanMethylation450	Lung adenocarcinoma and lung squamous cell	-	511	1	66.8	Both	European,African,Other	cg23790326	chr15:41245406	15	41245406	CHAC1	Island	-0.6156771	0.0962	0.000000000156	-	27602958_smoking_packyears_discovery_and_replication
Freeman JR	-	27602958	2016-10-25	Smoking pack-years	EFO_0006526, EFO_0005671, EFO_0004318	Discovery and replication	Additional file 1	DNA methylation	Smoking pack-years	Age, sex, ethnicity, cell type, EGFR mutation status and KRAS mutation status	M values	Pack-years	Illumina HumanMethylation450	Lung adenocarcinoma and lung squamous cell	-	511	1	66.8	Both	European,African,Other	cg24198953	chr19:18451444	19	18451444	PGPEP1	Island	-0.84073724	0.1314	0.000000000156	-	27602958_smoking_packyears_discovery_and_replication
Freeman JR	-	27602958	2016-10-25	Smoking pack-years	EFO_0006526, EFO_0005671, EFO_0004318	Lung squamous cell	Additional file 3	DNA methylation	Smoking pack-years	Age, sex, ethnicity, cell type, EGFR mutation status and KRAS mutation status	M values	Pack-years	Illumina HumanMethylation450	Lung squamous cell	-	511	1	66.8	Both	European,African,Other	cg26569144	chr5:170846504	5	170846504	FGF18	Island	-1.3737048	0.2151	0.000000000169	-	27602958_smoking_packyears_lung_squamous_cell
Freeman JR	-	27602958	2016-10-25	Smoking pack-years	EFO_0006526, EFO_0005671, EFO_0004318	Lung squamous cell	Additional file 3	DNA methylation	Smoking pack-years	Age, sex, ethnicity, cell type, EGFR mutation status and KRAS mutation status	M values	Pack-years	Illumina HumanMethylation450	Lung squamous cell	-	511	1	66.8	Both	European,African,Other	cg24948990	chr8:143820828	8	143820828	-	Island	-1.4324765	0.2244	0.000000000174	-	27602958_smoking_packyears_lung_squamous_cell
Freeman JR	-	27602958	2016-10-25	Smoking pack-years	EFO_0006526, EFO_0005671, EFO_0004318	Discovery and replication	Additional file 1	DNA methylation	Smoking pack-years	Age, sex, ethnicity, cell type, EGFR mutation status and KRAS mutation status	M values	Pack-years	Illumina HumanMethylation450	Lung adenocarcinoma and lung squamous cell	-	511	1	66.8	Both	European,African,Other	cg22296620	chr15:45315419	15	45315419	SORD	Island	0.31755522	0.0498	0.000000000183	-	27602958_smoking_packyears_discovery_and_replication
Freeman JR	-	27602958	2016-10-25	Smoking pack-years	EFO_0006526, EFO_0005671, EFO_0004318	Discovery and replication	Additional file 1	DNA methylation	Smoking pack-years	Age, sex, ethnicity, cell type, EGFR mutation status and KRAS mutation status	M values	Pack-years	Illumina HumanMethylation450	Lung adenocarcinoma and lung squamous cell	-	511	1	66.8	Both	European,African,Other	cg16726667	chr16:68002228	16	68002228	SLC12A4	Island	-0.72995248	0.1148	0.000000000201	-	27602958_smoking_packyears_discovery_and_replication
Freeman JR	-	27602958	2016-10-25	Smoking pack-years	EFO_0006526, EFO_0005671, EFO_0004318	Discovery and replication	Additional file 1	DNA methylation	Smoking pack-years	Age, sex, ethnicity, cell type, EGFR mutation status and KRAS mutation status	M values	Pack-years	Illumina HumanMethylation450	Lung adenocarcinoma and lung squamous cell	-	511	1	66.8	Both	European,African,Other	cg09876101	chr16:699357	16	699357	WDR90	Island	-0.31263913	0.0492	0.000000000202	-	27602958_smoking_packyears_discovery_and_replication
Freeman JR	-	27602958	2016-10-25	Smoking pack-years	EFO_0006526, EFO_0005671, EFO_0004318	Lung squamous cell	Additional file 3	DNA methylation	Smoking pack-years	Age, sex, ethnicity, cell type, EGFR mutation status and KRAS mutation status	M values	Pack-years	Illumina HumanMethylation450	Lung squamous cell	-	511	1	66.8	Both	European,African,Other	cg23326811	chr10:11865525	10	11865525	C10orf47	Island	-1.1760754	0.1858	0.000000000247	-	27602958_smoking_packyears_lung_squamous_cell
Freeman JR	-	27602958	2016-10-25	Smoking pack-years	EFO_0006526, EFO_0005671, EFO_0004318	Discovery and replication	Additional file 1	DNA methylation	Smoking pack-years	Age, sex, ethnicity, cell type, EGFR mutation status and KRAS mutation status	M values	Pack-years	Illumina HumanMethylation450	Lung adenocarcinoma and lung squamous cell	-	511	1	66.8	Both	European,African,Other	cg20737072	chr19:5785252	19	5785252	PRR22;DUS3L	North shore	0.58164012	0.092	0.000000000261	-	27602958_smoking_packyears_discovery_and_replication
Freeman JR	-	27602958	2016-10-25	Smoking pack-years	EFO_0006526, EFO_0005671, EFO_0004318	Discovery and replication	Additional file 1	DNA methylation	Smoking pack-years	Age, sex, ethnicity, cell type, EGFR mutation status and KRAS mutation status	M values	Pack-years	Illumina HumanMethylation450	Lung adenocarcinoma and lung squamous cell	-	511	1	66.8	Both	European,African,Other	cg13620366	chr9:138839624	9	138839624	UBAC1	Open sea	0.68067218	0.1079	0.000000000281	-	27602958_smoking_packyears_discovery_and_replication
Freeman JR	-	27602958	2016-10-25	Smoking pack-years	EFO_0006526, EFO_0005671, EFO_0004318	Discovery and replication	Additional file 1	DNA methylation	Smoking pack-years	Age, sex, ethnicity, cell type, EGFR mutation status and KRAS mutation status	M values	Pack-years	Illumina HumanMethylation450	Lung adenocarcinoma and lung squamous cell	-	511	1	66.8	Both	European,African,Other	cg22005634	chr20:62152128	20	62152128	PPDPF	Island	-0.47786295	0.0758	0.000000000296	-	27602958_smoking_packyears_discovery_and_replication
Freeman JR	-	27602958	2016-10-25	Smoking pack-years	EFO_0006526, EFO_0005671, EFO_0004318	Discovery and replication	Additional file 1	DNA methylation	Smoking pack-years	Age, sex, ethnicity, cell type, EGFR mutation status and KRAS mutation status	M values	Pack-years	Illumina HumanMethylation450	Lung adenocarcinoma and lung squamous cell	-	511	1	66.8	Both	European,African,Other	cg19916637	chr8:95961757	8	95961757	TP53INP1	Island	-0.65180825	0.1035	0.000000000304	-	27602958_smoking_packyears_discovery_and_replication
Freeman JR	-	27602958	2016-10-25	Smoking pack-years	EFO_0006526, EFO_0005671, EFO_0004318	Lung squamous cell	Additional file 3	DNA methylation	Smoking pack-years	Age, sex, ethnicity, cell type, EGFR mutation status and KRAS mutation status	M values	Pack-years	Illumina HumanMethylation450	Lung squamous cell	-	511	1	66.8	Both	European,African,Other	cg24843246	chr19:7621952	19	7621952	PNPLA6	Island	1.6675987	0.2649	0.000000000306	-	27602958_smoking_packyears_lung_squamous_cell
Freeman JR	-	27602958	2016-10-25	Smoking pack-years	EFO_0006526, EFO_0005671, EFO_0004318	Discovery and replication	Additional file 1	DNA methylation	Smoking pack-years	Age, sex, ethnicity, cell type, EGFR mutation status and KRAS mutation status	M values	Pack-years	Illumina HumanMethylation450	Lung adenocarcinoma and lung squamous cell	-	511	1	66.8	Both	European,African,Other	cg23326811	chr10:11865525	10	11865525	C10orf47	Island	-0.65737913	0.1046	0.000000000325	-	27602958_smoking_packyears_discovery_and_replication
Freeman JR	-	27602958	2016-10-25	Smoking pack-years	EFO_0006526, EFO_0005671, EFO_0004318	Lung squamous cell	Additional file 3	DNA methylation	Smoking pack-years	Age, sex, ethnicity, cell type, EGFR mutation status and KRAS mutation status	M values	Pack-years	Illumina HumanMethylation450	Lung squamous cell	-	511	1	66.8	Both	European,African,Other	cg21701395	chr8:95961492	8	95961492	TP53INP1	Island	-1.0492844	0.168	0.000000000417	-	27602958_smoking_packyears_lung_squamous_cell
Freeman JR	-	27602958	2016-10-25	Smoking pack-years	EFO_0006526, EFO_0005671, EFO_0004318	Discovery and replication	Additional file 1	DNA methylation	Smoking pack-years	Age, sex, ethnicity, cell type, EGFR mutation status and KRAS mutation status	M values	Pack-years	Illumina HumanMethylation450	Lung adenocarcinoma and lung squamous cell	-	511	1	66.8	Both	European,African,Other	cg06839820	chr22:43485161	22	43485161	TTLL1	Island	-0.55561659	0.0892	0.000000000473	-	27602958_smoking_packyears_discovery_and_replication
Freeman JR	-	27602958	2016-10-25	Smoking pack-years	EFO_0006526, EFO_0005671, EFO_0004318	Lung squamous cell	Additional file 3	DNA methylation	Smoking pack-years	Age, sex, ethnicity, cell type, EGFR mutation status and KRAS mutation status	M values	Pack-years	Illumina HumanMethylation450	Lung squamous cell	-	511	1	66.8	Both	European,African,Other	cg19168961	chr15:41245649	15	41245649	CHAC1	Island	-0.8669026	0.1396	0.000000000532	-	27602958_smoking_packyears_lung_squamous_cell
Freeman JR	-	27602958	2016-10-25	Smoking pack-years	EFO_0006526, EFO_0005671, EFO_0004318	Discovery and replication	Additional file 1	DNA methylation	Smoking pack-years	Age, sex, ethnicity, cell type, EGFR mutation status and KRAS mutation status	M values	Pack-years	Illumina HumanMethylation450	Lung adenocarcinoma and lung squamous cell	-	511	1	66.8	Both	European,African,Other	cg13341720	chr19:6740888	19	6740888	TRIP10	Island	-0.53225296	0.0858	0.000000000552	-	27602958_smoking_packyears_discovery_and_replication
Freeman JR	-	27602958	2016-10-25	Smoking pack-years	EFO_0006526, EFO_0005671, EFO_0004318	Lung squamous cell	Additional file 3	DNA methylation	Smoking pack-years	Age, sex, ethnicity, cell type, EGFR mutation status and KRAS mutation status	M values	Pack-years	Illumina HumanMethylation450	Lung squamous cell	-	511	1	66.8	Both	European,African,Other	cg22409276	chr15:40763763	15	40763763	CHST14	Island	-1.4036394	0.2263	0.000000000559	-	27602958_smoking_packyears_lung_squamous_cell
Freeman JR	-	27602958	2016-10-25	Smoking pack-years	EFO_0006526, EFO_0005671, EFO_0004318	Lung squamous cell	Additional file 3	DNA methylation	Smoking pack-years	Age, sex, ethnicity, cell type, EGFR mutation status and KRAS mutation status	M values	Pack-years	Illumina HumanMethylation450	Lung squamous cell	-	511	1	66.8	Both	European,African,Other	cg22296620	chr15:45315419	15	45315419	SORD	Island	0.4858306	0.0785	0.000000000615	-	27602958_smoking_packyears_lung_squamous_cell
Freeman JR	-	27602958	2016-10-25	Smoking pack-years	EFO_0006526, EFO_0005671, EFO_0004318	Lung squamous cell	Additional file 3	DNA methylation	Smoking pack-years	Age, sex, ethnicity, cell type, EGFR mutation status and KRAS mutation status	M values	Pack-years	Illumina HumanMethylation450	Lung squamous cell	-	511	1	66.8	Both	European,African,Other	cg16200496	chr19:13107141	19	13107141	NFIX	Island	-1.2037897	0.1949	0.000000000657	-	27602958_smoking_packyears_lung_squamous_cell
Freeman JR	-	27602958	2016-10-25	Smoking pack-years	EFO_0006526, EFO_0005671, EFO_0004318	Discovery and replication	Additional file 1	DNA methylation	Smoking pack-years	Age, sex, ethnicity, cell type, EGFR mutation status and KRAS mutation status	M values	Pack-years	Illumina HumanMethylation450	Lung adenocarcinoma and lung squamous cell	-	511	1	66.8	Both	European,African,Other	cg25975165	chr1:2444426	1	2444426	PANK4	North shore	0.72539428	0.1178	0.000000000731	-	27602958_smoking_packyears_discovery_and_replication
Freeman JR	-	27602958	2016-10-25	Smoking pack-years	EFO_0006526, EFO_0005671, EFO_0004318	Discovery and replication	Additional file 1	DNA methylation	Smoking pack-years	Age, sex, ethnicity, cell type, EGFR mutation status and KRAS mutation status	M values	Pack-years	Illumina HumanMethylation450	Lung adenocarcinoma and lung squamous cell	-	511	1	66.8	Both	European,African,Other	cg09025960	chr1:226070808	1	226070808	TMEM63A	Island	-0.63143962	0.1031	0.000000000895	-	27602958_smoking_packyears_discovery_and_replication
Freeman JR	-	27602958	2016-10-25	Smoking pack-years	EFO_0006526, EFO_0005671, EFO_0004318	Lung squamous cell	Additional file 3	DNA methylation	Smoking pack-years	Age, sex, ethnicity, cell type, EGFR mutation status and KRAS mutation status	M values	Pack-years	Illumina HumanMethylation450	Lung squamous cell	-	511	1	66.8	Both	European,African,Other	cg18496502	chr19:42880157	19	42880157	MEGF8	Island	1.7894614	0.2924	0.00000000094	-	27602958_smoking_packyears_lung_squamous_cell
Freeman JR	-	27602958	2016-10-25	Smoking pack-years	EFO_0006526, EFO_0005671, EFO_0004318	Lung squamous cell	Additional file 3	DNA methylation	Smoking pack-years	Age, sex, ethnicity, cell type, EGFR mutation status and KRAS mutation status	M values	Pack-years	Illumina HumanMethylation450	Lung squamous cell	-	511	1	66.8	Both	European,African,Other	cg09939831	chr14:55596647	14	55596647	LGALS3	Island	-1.3707346	0.224	0.000000000946	-	27602958_smoking_packyears_lung_squamous_cell
Freeman JR	-	27602958	2016-10-25	Smoking pack-years	EFO_0006526, EFO_0005671, EFO_0004318	Lung squamous cell	Additional file 3	DNA methylation	Smoking pack-years	Age, sex, ethnicity, cell type, EGFR mutation status and KRAS mutation status	M values	Pack-years	Illumina HumanMethylation450	Lung squamous cell	-	511	1	66.8	Both	European,African,Other	cg09378497	chr16:1525169	16	1525169	CLCN7	Island	-0.8741179	0.143	0.000000000974	-	27602958_smoking_packyears_lung_squamous_cell
Freeman JR	-	27602958	2016-10-25	Smoking pack-years	EFO_0006526, EFO_0005671, EFO_0004318	Replication	Additional file 1	DNA methylation	Smoking pack-years	Age, sex, ethnicity, cell type, EGFR mutation status and KRAS mutation status	M values	Pack-years	Illumina HumanMethylation450	Lung adenocarcinoma and lung squamous cell	-	185	1	66.4	Both	European,African,Other	cg16579555	chr17:29298352	17	29298352	RNF135	Island	-1.5127885	0.2475	0.000000000977	-	27602958_smoking_packyears_replication
Freeman JR	-	27602958	2016-10-25	Smoking pack-years	EFO_0006526, EFO_0005671, EFO_0004318	Lung squamous cell	Additional file 3	DNA methylation	Smoking pack-years	Age, sex, ethnicity, cell type, EGFR mutation status and KRAS mutation status	M values	Pack-years	Illumina HumanMethylation450	Lung squamous cell	-	511	1	66.8	Both	European,African,Other	cg13570982	chr14:55596240	14	55596240	LGALS3	Island	-1.5529784	0.2541	0.000000000984	-	27602958_smoking_packyears_lung_squamous_cell
Freeman JR	-	27602958	2016-10-25	Smoking pack-years	EFO_0006526, EFO_0005671, EFO_0004318	Discovery and replication	Additional file 1	DNA methylation	Smoking pack-years	Age, sex, ethnicity, cell type, EGFR mutation status and KRAS mutation status	M values	Pack-years	Illumina HumanMethylation450	Lung adenocarcinoma and lung squamous cell	-	511	1	66.8	Both	European,African,Other	cg22515201	chr22:38577827	22	38577827	PLA2G6	Island	-0.85930094	0.1408	0.00000000104	-	27602958_smoking_packyears_discovery_and_replication
Freeman JR	-	27602958	2016-10-25	Smoking pack-years	EFO_0006526, EFO_0005671, EFO_0004318	Discovery and replication	Additional file 1	DNA methylation	Smoking pack-years	Age, sex, ethnicity, cell type, EGFR mutation status and KRAS mutation status	M values	Pack-years	Illumina HumanMethylation450	Lung adenocarcinoma and lung squamous cell	-	511	1	66.8	Both	European,African,Other	cg13426839	chr19:539489	19	539489	CDC34	Island	0.73188992	0.1202	0.00000000113	-	27602958_smoking_packyears_discovery_and_replication
Freeman JR	-	27602958	2016-10-25	Smoking pack-years	EFO_0006526, EFO_0005671, EFO_0004318	Lung squamous cell	Additional file 3	DNA methylation	Smoking pack-years	Age, sex, ethnicity, cell type, EGFR mutation status and KRAS mutation status	M values	Pack-years	Illumina HumanMethylation450	Lung squamous cell	-	511	1	66.8	Both	European,African,Other	cg18617333	chr8:143808383	8	143808383	C8orf55	Island	-1.1074711	0.1825	0.00000000129	-	27602958_smoking_packyears_lung_squamous_cell
Freeman JR	-	27602958	2016-10-25	Smoking pack-years	EFO_0006526, EFO_0005671, EFO_0004318	Lung squamous cell	Additional file 3	DNA methylation	Smoking pack-years	Age, sex, ethnicity, cell type, EGFR mutation status and KRAS mutation status	M values	Pack-years	Illumina HumanMethylation450	Lung squamous cell	-	511	1	66.8	Both	European,African,Other	cg24599345	chr2:85645863	2	85645863	-	Island	-0.9201804	0.152	0.0000000014	-	27602958_smoking_packyears_lung_squamous_cell
Freeman JR	-	27602958	2016-10-25	Smoking pack-years	EFO_0006526, EFO_0005671, EFO_0004318	Discovery and replication	Additional file 1	DNA methylation	Smoking pack-years	Age, sex, ethnicity, cell type, EGFR mutation status and KRAS mutation status	M values	Pack-years	Illumina HumanMethylation450	Lung adenocarcinoma and lung squamous cell	-	511	1	66.8	Both	European,African,Other	cg04029055	chr17:37213281	17	37213281	-	Open sea	-0.56480005	0.0933	0.00000000144	-	27602958_smoking_packyears_discovery_and_replication
Freeman JR	-	27602958	2016-10-25	Smoking pack-years	EFO_0006526, EFO_0005671, EFO_0004318	Discovery	Additional file 1	DNA methylation	Smoking pack-years	Age, sex, ethnicity, cell type, EGFR mutation status and KRAS mutation status	M values	Pack-years	Illumina HumanMethylation450	Lung adenocarcinoma and lung squamous cell	-	326	1	67	Both	European,African,Other	cg24599345	chr2:85645863	2	85645863	-	Island	-0.8179452	0.1353	0.00000000151	-	27602958_smoking_packyears_discovery
Freeman JR	-	27602958	2016-10-25	Smoking pack-years	EFO_0006526, EFO_0005671, EFO_0004318	Lung squamous cell	Additional file 3	DNA methylation	Smoking pack-years	Age, sex, ethnicity, cell type, EGFR mutation status and KRAS mutation status	M values	Pack-years	Illumina HumanMethylation450	Lung squamous cell	-	511	1	66.8	Both	European,African,Other	cg22005634	chr20:62152128	20	62152128	PPDPF	Island	-0.8746524	0.1449	0.00000000156	-	27602958_smoking_packyears_lung_squamous_cell
Freeman JR	-	27602958	2016-10-25	Smoking pack-years	EFO_0006526, EFO_0005671, EFO_0004318	Discovery and replication	Additional file 1	DNA methylation	Smoking pack-years	Age, sex, ethnicity, cell type, EGFR mutation status and KRAS mutation status	M values	Pack-years	Illumina HumanMethylation450	Lung adenocarcinoma and lung squamous cell	-	511	1	66.8	Both	European,African,Other	cg26185554	chr17:1391406	17	1391406	MYO1C	Island	-0.62501894	0.1039	0.0000000018	-	27602958_smoking_packyears_discovery_and_replication
Freeman JR	-	27602958	2016-10-25	Smoking pack-years	EFO_0006526, EFO_0005671, EFO_0004318	Lung squamous cell	Additional file 3	DNA methylation	Smoking pack-years	Age, sex, ethnicity, cell type, EGFR mutation status and KRAS mutation status	M values	Pack-years	Illumina HumanMethylation450	Lung squamous cell	-	511	1	66.8	Both	European,African,Other	cg22865720	chr1:1981816	1	1981816	PRKCZ	Island	-1.0492846	0.1746	0.00000000187	-	27602958_smoking_packyears_lung_squamous_cell
Freeman JR	-	27602958	2016-10-25	Smoking pack-years	EFO_0006526, EFO_0005671, EFO_0004318	Lung squamous cell	Additional file 3	DNA methylation	Smoking pack-years	Age, sex, ethnicity, cell type, EGFR mutation status and KRAS mutation status	M values	Pack-years	Illumina HumanMethylation450	Lung squamous cell	-	511	1	66.8	Both	European,African,Other	cg14716208	chr3:52089752	3	52089752	DUSP7	Island	-1.3148817	0.2199	0.00000000224	-	27602958_smoking_packyears_lung_squamous_cell
Freeman JR	-	27602958	2016-10-25	Smoking pack-years	EFO_0006526, EFO_0005671, EFO_0004318	Discovery	Additional file 1	DNA methylation	Smoking pack-years	Age, sex, ethnicity, cell type, EGFR mutation status and KRAS mutation status	M values	Pack-years	Illumina HumanMethylation450	Lung adenocarcinoma and lung squamous cell	-	326	1	67	Both	European,African,Other	cg20480233	chr14:23451154	14	23451154	JUB	Island	-1.3377383	0.2241	0.00000000238	-	27602958_smoking_packyears_discovery
Freeman JR	-	27602958	2016-10-25	Smoking pack-years	EFO_0006526, EFO_0005671, EFO_0004318	Lung squamous cell	Additional file 3	DNA methylation	Smoking pack-years	Age, sex, ethnicity, cell type, EGFR mutation status and KRAS mutation status	M values	Pack-years	Illumina HumanMethylation450	Lung squamous cell	-	511	1	66.8	Both	European,African,Other	cg07469408	chr14:75894384	14	75894384	JDP2	Island	-0.8775874	0.1471	0.00000000245	-	27602958_smoking_packyears_lung_squamous_cell
Freeman JR	-	27602958	2016-10-25	Smoking pack-years	EFO_0006526, EFO_0005671, EFO_0004318	Discovery and replication	Additional file 1	DNA methylation	Smoking pack-years	Age, sex, ethnicity, cell type, EGFR mutation status and KRAS mutation status	M values	Pack-years	Illumina HumanMethylation450	Lung adenocarcinoma and lung squamous cell	-	511	1	66.8	Both	European,African,Other	cg15469014	chr19:11032172	19	11032172	CARM1	Island	0.5110231	0.0857	0.00000000245	-	27602958_smoking_packyears_discovery_and_replication
Freeman JR	-	27602958	2016-10-25	Smoking pack-years	EFO_0006526, EFO_0005671, EFO_0004318	Discovery	Additional file 1	DNA methylation	Smoking pack-years	Age, sex, ethnicity, cell type, EGFR mutation status and KRAS mutation status	M values	Pack-years	Illumina HumanMethylation450	Lung adenocarcinoma and lung squamous cell	-	326	1	67	Both	European,African,Other	cg11122493	chr17:74706551	17	74706551	MXRA7	Island	-1.2507964	0.2097	0.00000000246	-	27602958_smoking_packyears_discovery
Freeman JR	-	27602958	2016-10-25	Smoking pack-years	EFO_0006526, EFO_0005671, EFO_0004318	Discovery and replication	Additional file 1	DNA methylation	Smoking pack-years	Age, sex, ethnicity, cell type, EGFR mutation status and KRAS mutation status	M values	Pack-years	Illumina HumanMethylation450	Lung adenocarcinoma and lung squamous cell	-	511	1	66.8	Both	European,African,Other	cg07556403	chr20:62152146	20	62152146	PPDPF	Island	-0.51134187	0.0857	0.00000000246	-	27602958_smoking_packyears_discovery_and_replication
Freeman JR	-	27602958	2016-10-25	Smoking pack-years	EFO_0006526, EFO_0005671, EFO_0004318	Lung squamous cell	Additional file 3	DNA methylation	Smoking pack-years	Age, sex, ethnicity, cell type, EGFR mutation status and KRAS mutation status	M values	Pack-years	Illumina HumanMethylation450	Lung squamous cell	-	511	1	66.8	Both	European,African,Other	cg26185554	chr17:1391406	17	1391406	MYO1C	Island	-0.891775	0.1498	0.00000000263	-	27602958_smoking_packyears_lung_squamous_cell
Freeman JR	-	27602958	2016-10-25	Smoking pack-years	EFO_0006526, EFO_0005671, EFO_0004318	Lung squamous cell	Additional file 3	DNA methylation	Smoking pack-years	Age, sex, ethnicity, cell type, EGFR mutation status and KRAS mutation status	M values	Pack-years	Illumina HumanMethylation450	Lung squamous cell	-	511	1	66.8	Both	European,African,Other	cg06370133	chr2:113914844	2	113914844	-	Island	-1.1235178	0.1888	0.00000000264	-	27602958_smoking_packyears_lung_squamous_cell
Freeman JR	-	27602958	2016-10-25	Smoking pack-years	EFO_0006526, EFO_0005671, EFO_0004318	Discovery	Additional file 1	DNA methylation	Smoking pack-years	Age, sex, ethnicity, cell type, EGFR mutation status and KRAS mutation status	M values	Pack-years	Illumina HumanMethylation450	Lung adenocarcinoma and lung squamous cell	-	326	1	67	Both	European,African,Other	cg00265578	chr17:27895564	17	27895564	TP53I13	Island	-0.8827826	0.1485	0.00000000274	-	27602958_smoking_packyears_discovery
Freeman JR	-	27602958	2016-10-25	Smoking pack-years	EFO_0006526, EFO_0005671, EFO_0004318	Replication	Additional file 1	DNA methylation	Smoking pack-years	Age, sex, ethnicity, cell type, EGFR mutation status and KRAS mutation status	M values	Pack-years	Illumina HumanMethylation450	Lung adenocarcinoma and lung squamous cell	-	185	1	66.4	Both	European,African,Other	cg16654732	chr5:170846517	5	170846517	FGF18	Island	-1.4256012	0.2398	0.00000000276	-	27602958_smoking_packyears_replication
Freeman JR	-	27602958	2016-10-25	Smoking pack-years	EFO_0006526, EFO_0005671, EFO_0004318	Discovery and replication	Additional file 1	DNA methylation	Smoking pack-years	Age, sex, ethnicity, cell type, EGFR mutation status and KRAS mutation status	M values	Pack-years	Illumina HumanMethylation450	Lung adenocarcinoma and lung squamous cell	-	511	1	66.8	Both	European,African,Other	cg00106446	chr1:247242130	1	247242130	ZNF670	Island	0.15463298	0.0261	0.00000000299	-	27602958_smoking_packyears_discovery_and_replication
Freeman JR	-	27602958	2016-10-25	Smoking pack-years	EFO_0006526, EFO_0005671, EFO_0004318	Discovery and replication	Additional file 1	DNA methylation	Smoking pack-years	Age, sex, ethnicity, cell type, EGFR mutation status and KRAS mutation status	M values	Pack-years	Illumina HumanMethylation450	Lung adenocarcinoma and lung squamous cell	-	511	1	66.8	Both	European,African,Other	cg13264059	chr10:129705415	10	129705415	PTPRE	Island	-0.534618	0.0903	0.00000000322	-	27602958_smoking_packyears_discovery_and_replication
Freeman JR	-	27602958	2016-10-25	Smoking pack-years	EFO_0006526, EFO_0005671, EFO_0004318	Lung squamous cell	Additional file 3	DNA methylation	Smoking pack-years	Age, sex, ethnicity, cell type, EGFR mutation status and KRAS mutation status	M values	Pack-years	Illumina HumanMethylation450	Lung squamous cell	-	511	1	66.8	Both	European,African,Other	cg20849378	chr7:1516084	7	1516084	INTS1	Island	1.5824337	0.268	0.00000000352	-	27602958_smoking_packyears_lung_squamous_cell
Freeman JR	-	27602958	2016-10-25	Smoking pack-years	EFO_0006526, EFO_0005671, EFO_0004318	Discovery and replication	Additional file 1	DNA methylation	Smoking pack-years	Age, sex, ethnicity, cell type, EGFR mutation status and KRAS mutation status	M values	Pack-years	Illumina HumanMethylation450	Lung adenocarcinoma and lung squamous cell	-	511	1	66.8	Both	European,African,Other	cg25771041	chr3:149376042	3	149376042	WWTR1	Island	-0.38697291	0.0656	0.00000000363	-	27602958_smoking_packyears_discovery_and_replication
Freeman JR	-	27602958	2016-10-25	Smoking pack-years	EFO_0006526, EFO_0005671, EFO_0004318	Lung squamous cell	Additional file 3	DNA methylation	Smoking pack-years	Age, sex, ethnicity, cell type, EGFR mutation status and KRAS mutation status	M values	Pack-years	Illumina HumanMethylation450	Lung squamous cell	-	511	1	66.8	Both	European,African,Other	cg25975165	chr1:2444426	1	2444426	PANK4	North shore	1.5961493	0.2724	0.00000000464	-	27602958_smoking_packyears_lung_squamous_cell
Freeman JR	-	27602958	2016-10-25	Smoking pack-years	EFO_0006526, EFO_0005671, EFO_0004318	Discovery and replication	Additional file 1	DNA methylation	Smoking pack-years	Age, sex, ethnicity, cell type, EGFR mutation status and KRAS mutation status	M values	Pack-years	Illumina HumanMethylation450	Lung adenocarcinoma and lung squamous cell	-	511	1	66.8	Both	European,African,Other	cg23423230	chr21:43327978	21	43327978	C2CD2	Island	0.4719543	0.0806	0.00000000468	-	27602958_smoking_packyears_discovery_and_replication
Freeman JR	-	27602958	2016-10-25	Smoking pack-years	EFO_0006526, EFO_0005671, EFO_0004318	Discovery and replication	Additional file 1	DNA methylation	Smoking pack-years	Age, sex, ethnicity, cell type, EGFR mutation status and KRAS mutation status	M values	Pack-years	Illumina HumanMethylation450	Lung adenocarcinoma and lung squamous cell	-	511	1	66.8	Both	European,African,Other	cg14826215	chr7:139762483	7	139762483	PARP12	Island	-0.56005526	0.0959	0.00000000513	-	27602958_smoking_packyears_discovery_and_replication
Freeman JR	-	27602958	2016-10-25	Smoking pack-years	EFO_0006526, EFO_0005671, EFO_0004318	Discovery and replication	Additional file 1	DNA methylation	Smoking pack-years	Age, sex, ethnicity, cell type, EGFR mutation status and KRAS mutation status	M values	Pack-years	Illumina HumanMethylation450	Lung adenocarcinoma and lung squamous cell	-	511	1	66.8	Both	European,African,Other	cg17323383	chr3:182896670	3	182896670	MCF2L2	North shore	-0.80454275	0.1378	0.00000000521	-	27602958_smoking_packyears_discovery_and_replication
Freeman JR	-	27602958	2016-10-25	Smoking pack-years	EFO_0006526, EFO_0005671, EFO_0004318	Discovery and replication	Additional file 1	DNA methylation	Smoking pack-years	Age, sex, ethnicity, cell type, EGFR mutation status and KRAS mutation status	M values	Pack-years	Illumina HumanMethylation450	Lung adenocarcinoma and lung squamous cell	-	511	1	66.8	Both	European,African,Other	cg04880618	chr17:74706567	17	74706567	MXRA7	Island	-0.91912298	0.1579	0.00000000587	-	27602958_smoking_packyears_discovery_and_replication
Freeman JR	-	27602958	2016-10-25	Smoking pack-years	EFO_0006526, EFO_0005671, EFO_0004318	Discovery and replication	Additional file 1	DNA methylation	Smoking pack-years	Age, sex, ethnicity, cell type, EGFR mutation status and KRAS mutation status	M values	Pack-years	Illumina HumanMethylation450	Lung adenocarcinoma and lung squamous cell	-	511	1	66.8	Both	European,African,Other	cg07469408	chr14:75894384	14	75894384	JDP2	Island	-0.4154833	0.0717	0.00000000679	-	27602958_smoking_packyears_discovery_and_replication
Freeman JR	-	27602958	2016-10-25	Smoking pack-years	EFO_0006526, EFO_0005671, EFO_0004318	Discovery and replication	Additional file 1	DNA methylation	Smoking pack-years	Age, sex, ethnicity, cell type, EGFR mutation status and KRAS mutation status	M values	Pack-years	Illumina HumanMethylation450	Lung adenocarcinoma and lung squamous cell	-	511	1	66.8	Both	European,African,Other	cg02250553	chr10:134511404	10	134511404	INPP5A	Open sea	0.46570863	0.0805	0.00000000718	-	27602958_smoking_packyears_discovery_and_replication
Freeman JR	-	27602958	2016-10-25	Smoking pack-years	EFO_0006526, EFO_0005671, EFO_0004318	Discovery	Additional file 1	DNA methylation	Smoking pack-years	Age, sex, ethnicity, cell type, EGFR mutation status and KRAS mutation status	M values	Pack-years	Illumina HumanMethylation450	Lung adenocarcinoma and lung squamous cell	-	326	1	67	Both	European,African,Other	cg26369667	chr11:101981789	11	101981789	YAP1	Island	-0.8896947	0.1538	0.00000000731	-	27602958_smoking_packyears_discovery
Freeman JR	-	27602958	2016-10-25	Smoking pack-years	EFO_0006526, EFO_0005671, EFO_0004318	Lung squamous cell	Additional file 3	DNA methylation	Smoking pack-years	Age, sex, ethnicity, cell type, EGFR mutation status and KRAS mutation status	M values	Pack-years	Illumina HumanMethylation450	Lung squamous cell	-	511	1	66.8	Both	European,African,Other	cg00106446	chr1:247242130	1	247242130	ZNF670	Island	0.2774783	0.048	0.00000000756	-	27602958_smoking_packyears_lung_squamous_cell
Freeman JR	-	27602958	2016-10-25	Smoking pack-years	EFO_0006526, EFO_0005671, EFO_0004318	Lung squamous cell	Additional file 3	DNA methylation	Smoking pack-years	Age, sex, ethnicity, cell type, EGFR mutation status and KRAS mutation status	M values	Pack-years	Illumina HumanMethylation450	Lung squamous cell	-	511	1	66.8	Both	European,African,Other	cg07556403	chr20:62152146	20	62152146	PPDPF	Island	-0.9389645	0.1626	0.00000000765	-	27602958_smoking_packyears_lung_squamous_cell
Freeman JR	-	27602958	2016-10-25	Smoking pack-years	EFO_0006526, EFO_0005671, EFO_0004318	Discovery and replication	Additional file 1	DNA methylation	Smoking pack-years	Age, sex, ethnicity, cell type, EGFR mutation status and KRAS mutation status	M values	Pack-years	Illumina HumanMethylation450	Lung adenocarcinoma and lung squamous cell	-	511	1	66.8	Both	European,African,Other	cg02516388	chr17:48503634	17	48503634	ACSF2	Island	-0.25158932	0.0436	0.00000000779	-	27602958_smoking_packyears_discovery_and_replication
Freeman JR	-	27602958	2016-10-25	Smoking pack-years	EFO_0006526, EFO_0005671, EFO_0004318	Lung squamous cell	Additional file 3	DNA methylation	Smoking pack-years	Age, sex, ethnicity, cell type, EGFR mutation status and KRAS mutation status	M values	Pack-years	Illumina HumanMethylation450	Lung squamous cell	-	511	1	66.8	Both	European,African,Other	cg02250553	chr10:134511404	10	134511404	INPP5A	Open sea	0.9153437	0.1587	0.00000000811	-	27602958_smoking_packyears_lung_squamous_cell
Freeman JR	-	27602958	2016-10-25	Smoking pack-years	EFO_0006526, EFO_0005671, EFO_0004318	Discovery and replication	Additional file 1	DNA methylation	Smoking pack-years	Age, sex, ethnicity, cell type, EGFR mutation status and KRAS mutation status	M values	Pack-years	Illumina HumanMethylation450	Lung adenocarcinoma and lung squamous cell	-	511	1	66.8	Both	European,African,Other	cg11004501	chr13:77461056	13	77461056	KCTD12	Island	-0.47028743	0.082	0.00000000981	-	27602958_smoking_packyears_discovery_and_replication
Freeman JR	-	27602958	2016-10-25	Smoking pack-years	EFO_0006526, EFO_0005671, EFO_0004318	Discovery and replication	Additional file 1	DNA methylation	Smoking pack-years	Age, sex, ethnicity, cell type, EGFR mutation status and KRAS mutation status	M values	Pack-years	Illumina HumanMethylation450	Lung adenocarcinoma and lung squamous cell	-	511	1	66.8	Both	European,African,Other	cg13128305	chr8:95961759	8	95961759	TP53INP1	Island	-0.51342601	0.0896	0.0000000101	-	27602958_smoking_packyears_discovery_and_replication
Freeman JR	-	27602958	2016-10-25	Smoking pack-years	EFO_0006526, EFO_0005671, EFO_0004318	Discovery	Additional file 1	DNA methylation	Smoking pack-years	Age, sex, ethnicity, cell type, EGFR mutation status and KRAS mutation status	M values	Pack-years	Illumina HumanMethylation450	Lung adenocarcinoma and lung squamous cell	-	326	1	67	Both	European,African,Other	cg08135278	chr1:226070709	1	226070709	TMEM63A	Island	-0.8109431	0.1419	0.0000000111	-	27602958_smoking_packyears_discovery
Freeman JR	-	27602958	2016-10-25	Smoking pack-years	EFO_0006526, EFO_0005671, EFO_0004318	Discovery and replication	Additional file 1	DNA methylation	Smoking pack-years	Age, sex, ethnicity, cell type, EGFR mutation status and KRAS mutation status	M values	Pack-years	Illumina HumanMethylation450	Lung adenocarcinoma and lung squamous cell	-	511	1	66.8	Both	European,African,Other	cg14716208	chr3:52089752	3	52089752	DUSP7	Island	-0.81538082	0.1429	0.0000000115	-	27602958_smoking_packyears_discovery_and_replication
Freeman JR	-	27602958	2016-10-25	Smoking pack-years	EFO_0006526, EFO_0005671, EFO_0004318	Lung squamous cell	Additional file 3	DNA methylation	Smoking pack-years	Age, sex, ethnicity, cell type, EGFR mutation status and KRAS mutation status	M values	Pack-years	Illumina HumanMethylation450	Lung squamous cell	-	511	1	66.8	Both	European,African,Other	cg20480233	chr14:23451154	14	23451154	JUB	Island	-1.5970418	0.2798	0.0000000115	-	27602958_smoking_packyears_lung_squamous_cell
Freeman JR	-	27602958	2016-10-25	Smoking pack-years	EFO_0006526, EFO_0005671, EFO_0004318	Discovery and replication	Additional file 1	DNA methylation	Smoking pack-years	Age, sex, ethnicity, cell type, EGFR mutation status and KRAS mutation status	M values	Pack-years	Illumina HumanMethylation450	Lung adenocarcinoma and lung squamous cell	-	511	1	66.8	Both	European,African,Other	cg02112681	chr7:1120141	7	1120141	C7orf50	Island	0.62070826	0.1089	0.0000000119	-	27602958_smoking_packyears_discovery_and_replication
Freeman JR	-	27602958	2016-10-25	Smoking pack-years	EFO_0006526, EFO_0005671, EFO_0004318	Lung squamous cell	Additional file 3	DNA methylation	Smoking pack-years	Age, sex, ethnicity, cell type, EGFR mutation status and KRAS mutation status	M values	Pack-years	Illumina HumanMethylation450	Lung squamous cell	-	511	1	66.8	Both	European,African,Other	cg13128305	chr8:95961759	8	95961759	TP53INP1	Island	-0.9122143	0.1602	0.0000000123	-	27602958_smoking_packyears_lung_squamous_cell
Freeman JR	-	27602958	2016-10-25	Smoking pack-years	EFO_0006526, EFO_0005671, EFO_0004318	Discovery	Additional file 1	DNA methylation	Smoking pack-years	Age, sex, ethnicity, cell type, EGFR mutation status and KRAS mutation status	M values	Pack-years	Illumina HumanMethylation450	Lung adenocarcinoma and lung squamous cell	-	326	1	67	Both	European,African,Other	cg20849378	chr7:1516084	7	1516084	INTS1	Island	0.9487442	0.1666	0.0000000124	-	27602958_smoking_packyears_discovery
Freeman JR	-	27602958	2016-10-25	Smoking pack-years	EFO_0006526, EFO_0005671, EFO_0004318	Discovery and replication	Additional file 1	DNA methylation	Smoking pack-years	Age, sex, ethnicity, cell type, EGFR mutation status and KRAS mutation status	M values	Pack-years	Illumina HumanMethylation450	Lung adenocarcinoma and lung squamous cell	-	511	1	66.8	Both	European,African,Other	cg08806263	chr16:699293	16	699293	WDR90	Island	-0.24415347	0.0429	0.000000013	-	27602958_smoking_packyears_discovery_and_replication
Freeman JR	-	27602958	2016-10-25	Smoking pack-years	EFO_0006526, EFO_0005671, EFO_0004318	Lung squamous cell	Additional file 3	DNA methylation	Smoking pack-years	Age, sex, ethnicity, cell type, EGFR mutation status and KRAS mutation status	M values	Pack-years	Illumina HumanMethylation450	Lung squamous cell	-	511	1	66.8	Both	European,African,Other	cg25144930	chr11:2398505	11	2398505	CD81	Island	-1.0437789	0.1837	0.0000000132	-	27602958_smoking_packyears_lung_squamous_cell
Freeman JR	-	27602958	2016-10-25	Smoking pack-years	EFO_0006526, EFO_0005671, EFO_0004318	Discovery and replication	Additional file 1	DNA methylation	Smoking pack-years	Age, sex, ethnicity, cell type, EGFR mutation status and KRAS mutation status	M values	Pack-years	Illumina HumanMethylation450	Lung adenocarcinoma and lung squamous cell	-	511	1	66.8	Both	European,African,Other	cg21919790	chr17:72926781	17	72926781	OTOP2	Open sea	-0.52882812	0.0933	0.0000000143	-	27602958_smoking_packyears_discovery_and_replication
Freeman JR	-	27602958	2016-10-25	Smoking pack-years	EFO_0006526, EFO_0005671, EFO_0004318	Lung squamous cell	Additional file 3	DNA methylation	Smoking pack-years	Age, sex, ethnicity, cell type, EGFR mutation status and KRAS mutation status	M values	Pack-years	Illumina HumanMethylation450	Lung squamous cell	-	511	1	66.8	Both	European,African,Other	cg15469014	chr19:11032172	19	11032172	CARM1	Island	1.08375	0.1913	0.0000000146	-	27602958_smoking_packyears_lung_squamous_cell
Freeman JR	-	27602958	2016-10-25	Smoking pack-years	EFO_0006526, EFO_0005671, EFO_0004318	Discovery and replication	Additional file 1	DNA methylation	Smoking pack-years	Age, sex, ethnicity, cell type, EGFR mutation status and KRAS mutation status	M values	Pack-years	Illumina HumanMethylation450	Lung adenocarcinoma and lung squamous cell	-	511	1	66.8	Both	European,African,Other	cg16142707	chr3:156544075	3	156544075	LEKR1	Island	-0.76182544	0.1345	0.0000000148	-	27602958_smoking_packyears_discovery_and_replication
Freeman JR	-	27602958	2016-10-25	Smoking pack-years	EFO_0006526, EFO_0005671, EFO_0004318	Discovery and replication	Additional file 1	DNA methylation	Smoking pack-years	Age, sex, ethnicity, cell type, EGFR mutation status and KRAS mutation status	M values	Pack-years	Illumina HumanMethylation450	Lung adenocarcinoma and lung squamous cell	-	511	1	66.8	Both	European,African,Other	cg09923107	chr20:30193892	20	30193892	ID1	Island	-0.71773021	0.1267	0.0000000149	-	27602958_smoking_packyears_discovery_and_replication
Freeman JR	-	27602958	2016-10-25	Smoking pack-years	EFO_0006526, EFO_0005671, EFO_0004318	Discovery	Additional file 1	DNA methylation	Smoking pack-years	Age, sex, ethnicity, cell type, EGFR mutation status and KRAS mutation status	M values	Pack-years	Illumina HumanMethylation450	Lung adenocarcinoma and lung squamous cell	-	326	1	67	Both	European,African,Other	cg13570982	chr14:55596240	14	55596240	LGALS3	Island	-1.1766062	0.2083	0.0000000161	-	27602958_smoking_packyears_discovery
Freeman JR	-	27602958	2016-10-25	Smoking pack-years	EFO_0006526, EFO_0005671, EFO_0004318	Discovery	Additional file 1	DNA methylation	Smoking pack-years	Age, sex, ethnicity, cell type, EGFR mutation status and KRAS mutation status	M values	Pack-years	Illumina HumanMethylation450	Lung adenocarcinoma and lung squamous cell	-	326	1	67	Both	European,African,Other	cg09939831	chr14:55596647	14	55596647	LGALS3	Island	-0.933492	0.1653	0.0000000165	-	27602958_smoking_packyears_discovery
Freeman JR	-	27602958	2016-10-25	Smoking pack-years	EFO_0006526, EFO_0005671, EFO_0004318	Discovery	Additional file 1	DNA methylation	Smoking pack-years	Age, sex, ethnicity, cell type, EGFR mutation status and KRAS mutation status	M values	Pack-years	Illumina HumanMethylation450	Lung adenocarcinoma and lung squamous cell	-	326	1	67	Both	European,African,Other	cg13204512	chr17:29298184	17	29298184	RNF135	Island	-0.9116255	0.1618	0.0000000176	-	27602958_smoking_packyears_discovery
Freeman JR	-	27602958	2016-10-25	Smoking pack-years	EFO_0006526, EFO_0005671, EFO_0004318	Discovery and replication	Additional file 1	DNA methylation	Smoking pack-years	Age, sex, ethnicity, cell type, EGFR mutation status and KRAS mutation status	M values	Pack-years	Illumina HumanMethylation450	Lung adenocarcinoma and lung squamous cell	-	511	1	66.8	Both	European,African,Other	cg08874430	chr8:11659970	8	11659970	FDFT1	Island	-0.37867246	0.0674	0.0000000194	-	27602958_smoking_packyears_discovery_and_replication
Freeman JR	-	27602958	2016-10-25	Smoking pack-years	EFO_0006526, EFO_0005671, EFO_0004318	Lung squamous cell	Additional file 3	DNA methylation	Smoking pack-years	Age, sex, ethnicity, cell type, EGFR mutation status and KRAS mutation status	M values	Pack-years	Illumina HumanMethylation450	Lung squamous cell	-	511	1	66.8	Both	European,African,Other	cg02516388	chr17:48503634	17	48503634	ACSF2	Island	-0.4878394	0.0869	0.0000000196	-	27602958_smoking_packyears_lung_squamous_cell
Freeman JR	-	27602958	2016-10-25	Smoking pack-years	EFO_0006526, EFO_0005671, EFO_0004318	Lung adenocarcinoma	Additional file 2	DNA methylation	Smoking pack-years	Age, sex, ethnicity, cell type, EGFR mutation status and KRAS mutation status	M values	Pack-years	Illumina HumanMethylation450	Lung adenocarcinoma	-	511	1	66.8	Both	European,African,Other	cg24843246	chr19:7621952	19	7621952	PNPLA6	Island	0.84399431	0.1505	0.0000000204	-	27602958_smoking_packyears_lung_adenocarcinoma
Freeman JR	-	27602958	2016-10-25	Smoking pack-years	EFO_0006526, EFO_0005671, EFO_0004318	Discovery and replication	Additional file 1	DNA methylation	Smoking pack-years	Age, sex, ethnicity, cell type, EGFR mutation status and KRAS mutation status	M values	Pack-years	Illumina HumanMethylation450	Lung adenocarcinoma and lung squamous cell	-	511	1	66.8	Both	European,African,Other	cg08118159	chr19:41055208	19	41055208	SPTBN4	Island	-0.36362714	0.065	0.0000000217	-	27602958_smoking_packyears_discovery_and_replication
Freeman JR	-	27602958	2016-10-25	Smoking pack-years	EFO_0006526, EFO_0005671, EFO_0004318	Lung squamous cell	Additional file 3	DNA methylation	Smoking pack-years	Age, sex, ethnicity, cell type, EGFR mutation status and KRAS mutation status	M values	Pack-years	Illumina HumanMethylation450	Lung squamous cell	-	511	1	66.8	Both	European,African,Other	cg11516830	chr17:75242950	17	75242950	-	Island	0.7508916	0.1342	0.0000000219	-	27602958_smoking_packyears_lung_squamous_cell
Freeman JR	-	27602958	2016-10-25	Smoking pack-years	EFO_0006526, EFO_0005671, EFO_0004318	Discovery	Additional file 1	DNA methylation	Smoking pack-years	Age, sex, ethnicity, cell type, EGFR mutation status and KRAS mutation status	M values	Pack-years	Illumina HumanMethylation450	Lung adenocarcinoma and lung squamous cell	-	326	1	67	Both	European,African,Other	cg21273098	chr6:109762418	6	109762418	SMPD2;PPIL6	Island	-0.321047	0.0577	0.0000000257	-	27602958_smoking_packyears_discovery
Freeman JR	-	27602958	2016-10-25	Smoking pack-years	EFO_0006526, EFO_0005671, EFO_0004318	Discovery and replication	Additional file 1	DNA methylation	Smoking pack-years	Age, sex, ethnicity, cell type, EGFR mutation status and KRAS mutation status	M values	Pack-years	Illumina HumanMethylation450	Lung adenocarcinoma and lung squamous cell	-	511	1	66.8	Both	European,African,Other	cg19390357	chr16:12211186	16	12211186	SNX29	Island	0.61022453	0.1096	0.0000000257	-	27602958_smoking_packyears_discovery_and_replication
Freeman JR	-	27602958	2016-10-25	Smoking pack-years	EFO_0006526, EFO_0005671, EFO_0004318	Lung squamous cell	Additional file 3	DNA methylation	Smoking pack-years	Age, sex, ethnicity, cell type, EGFR mutation status and KRAS mutation status	M values	Pack-years	Illumina HumanMethylation450	Lung squamous cell	-	511	1	66.8	Both	European,African,Other	cg23087239	chr3:134080574	3	134080574	AMOTL2	Island	1.1624412	0.2091	0.0000000273	-	27602958_smoking_packyears_lung_squamous_cell
Freeman JR	-	27602958	2016-10-25	Smoking pack-years	EFO_0006526, EFO_0005671, EFO_0004318	Discovery	Additional file 1	DNA methylation	Smoking pack-years	Age, sex, ethnicity, cell type, EGFR mutation status and KRAS mutation status	M values	Pack-years	Illumina HumanMethylation450	Lung adenocarcinoma and lung squamous cell	-	326	1	67	Both	European,African,Other	cg19634213	chr10:89621792	10	89621792	PTEN;KILLIN	Island	-0.9844345	0.1774	0.0000000286	-	27602958_smoking_packyears_discovery
Freeman JR	-	27602958	2016-10-25	Smoking pack-years	EFO_0006526, EFO_0005671, EFO_0004318	Lung squamous cell	Additional file 3	DNA methylation	Smoking pack-years	Age, sex, ethnicity, cell type, EGFR mutation status and KRAS mutation status	M values	Pack-years	Illumina HumanMethylation450	Lung squamous cell	-	511	1	66.8	Both	European,African,Other	cg25771041	chr3:149376042	3	149376042	WWTR1	Island	-0.6822823	0.1233	0.0000000317	-	27602958_smoking_packyears_lung_squamous_cell
Freeman JR	-	27602958	2016-10-25	Smoking pack-years	EFO_0006526, EFO_0005671, EFO_0004318	Discovery	Additional file 1	DNA methylation	Smoking pack-years	Age, sex, ethnicity, cell type, EGFR mutation status and KRAS mutation status	M values	Pack-years	Illumina HumanMethylation450	Lung adenocarcinoma and lung squamous cell	-	326	1	67	Both	European,African,Other	cg19508701	chr8:9008170	8	9008170	PPP1R3B	Island	-0.766428	0.1386	0.0000000318	-	27602958_smoking_packyears_discovery
Freeman JR	-	27602958	2016-10-25	Smoking pack-years	EFO_0006526, EFO_0005671, EFO_0004318	Lung squamous cell	Additional file 3	DNA methylation	Smoking pack-years	Age, sex, ethnicity, cell type, EGFR mutation status and KRAS mutation status	M values	Pack-years	Illumina HumanMethylation450	Lung squamous cell	-	511	1	66.8	Both	European,African,Other	cg23790326	chr15:41245406	15	41245406	CHAC1	Island	-0.8556949	0.1547	0.0000000321	-	27602958_smoking_packyears_lung_squamous_cell
Freeman JR	-	27602958	2016-10-25	Smoking pack-years	EFO_0006526, EFO_0005671, EFO_0004318	Discovery and replication	Additional file 1	DNA methylation	Smoking pack-years	Age, sex, ethnicity, cell type, EGFR mutation status and KRAS mutation status	M values	Pack-years	Illumina HumanMethylation450	Lung adenocarcinoma and lung squamous cell	-	511	1	66.8	Both	European,African,Other	cg16364152	chr20:5591818	20	5591818	RP5-1022P6.2	Island	0.20113236	0.0364	0.0000000325	-	27602958_smoking_packyears_discovery_and_replication
Freeman JR	-	27602958	2016-10-25	Smoking pack-years	EFO_0006526, EFO_0005671, EFO_0004318	Replication	Additional file 1	DNA methylation	Smoking pack-years	Age, sex, ethnicity, cell type, EGFR mutation status and KRAS mutation status	M values	Pack-years	Illumina HumanMethylation450	Lung adenocarcinoma and lung squamous cell	-	185	1	66.4	Both	European,African,Other	cg00032419	chr17:27895566	17	27895566	TP53I13	Island	-1.1430095	0.2068	0.0000000328	-	27602958_smoking_packyears_replication
Freeman JR	-	27602958	2016-10-25	Smoking pack-years	EFO_0006526, EFO_0005671, EFO_0004318	Discovery	Additional file 1	DNA methylation	Smoking pack-years	Age, sex, ethnicity, cell type, EGFR mutation status and KRAS mutation status	M values	Pack-years	Illumina HumanMethylation450	Lung adenocarcinoma and lung squamous cell	-	326	1	67	Both	European,African,Other	cg06818515	chr16:2944443	16	2944443	FLYWCH2	Island	0.6017076	0.1091	0.0000000347	-	27602958_smoking_packyears_discovery
Freeman JR	-	27602958	2016-10-25	Smoking pack-years	EFO_0006526, EFO_0005671, EFO_0004318	Lung squamous cell	Additional file 3	DNA methylation	Smoking pack-years	Age, sex, ethnicity, cell type, EGFR mutation status and KRAS mutation status	M values	Pack-years	Illumina HumanMethylation450	Lung squamous cell	-	511	1	66.8	Both	European,African,Other	cg04880618	chr17:74706567	17	74706567	MXRA7	Island	-1.4103677	0.2558	0.0000000352	-	27602958_smoking_packyears_lung_squamous_cell
Freeman JR	-	27602958	2016-10-25	Smoking pack-years	EFO_0006526, EFO_0005671, EFO_0004318	Discovery	Additional file 1	DNA methylation	Smoking pack-years	Age, sex, ethnicity, cell type, EGFR mutation status and KRAS mutation status	M values	Pack-years	Illumina HumanMethylation450	Lung adenocarcinoma and lung squamous cell	-	326	1	67	Both	European,African,Other	cg22409276	chr15:40763763	15	40763763	CHST14	Island	-0.8824168	0.1605	0.0000000381	-	27602958_smoking_packyears_discovery
Freeman JR	-	27602958	2016-10-25	Smoking pack-years	EFO_0006526, EFO_0005671, EFO_0004318	Discovery	Additional file 1	DNA methylation	Smoking pack-years	Age, sex, ethnicity, cell type, EGFR mutation status and KRAS mutation status	M values	Pack-years	Illumina HumanMethylation450	Lung adenocarcinoma and lung squamous cell	-	326	1	67	Both	European,African,Other	cg07243103	chr16:699355	16	699355	WDR90	Island	-0.381626	0.0695	0.0000000399	-	27602958_smoking_packyears_discovery
Freeman JR	-	27602958	2016-10-25	Smoking pack-years	EFO_0006526, EFO_0005671, EFO_0004318	Replication	Additional file 1	DNA methylation	Smoking pack-years	Age, sex, ethnicity, cell type, EGFR mutation status and KRAS mutation status	M values	Pack-years	Illumina HumanMethylation450	Lung adenocarcinoma and lung squamous cell	-	185	1	66.4	Both	European,African,Other	cg05933803	chr17:27895641	17	27895641	TP53I13	Island	-0.2289858	0.0418	0.0000000416	-	27602958_smoking_packyears_replication
Freeman JR	-	27602958	2016-10-25	Smoking pack-years	EFO_0006526, EFO_0005671, EFO_0004318	Discovery and replication	Additional file 1	DNA methylation	Smoking pack-years	Age, sex, ethnicity, cell type, EGFR mutation status and KRAS mutation status	M values	Pack-years	Illumina HumanMethylation450	Lung adenocarcinoma and lung squamous cell	-	511	1	66.8	Both	European,African,Other	cg11875268	chr12:54576025	12	54576025	SMUG1	Open sea	0.87479446	0.1597	0.0000000428	-	27602958_smoking_packyears_discovery_and_replication
Freeman JR	-	27602958	2016-10-25	Smoking pack-years	EFO_0006526, EFO_0005671, EFO_0004318	Discovery and replication	Additional file 1	DNA methylation	Smoking pack-years	Age, sex, ethnicity, cell type, EGFR mutation status and KRAS mutation status	M values	Pack-years	Illumina HumanMethylation450	Lung adenocarcinoma and lung squamous cell	-	511	1	66.8	Both	European,African,Other	cg12025027	chr17:1531232	17	1531232	SLC43A2	Island	-0.61329706	0.112	0.0000000435	-	27602958_smoking_packyears_discovery_and_replication
Freeman JR	-	27602958	2016-10-25	Smoking pack-years	EFO_0006526, EFO_0005671, EFO_0004318	Discovery	Additional file 1	DNA methylation	Smoking pack-years	Age, sex, ethnicity, cell type, EGFR mutation status and KRAS mutation status	M values	Pack-years	Illumina HumanMethylation450	Lung adenocarcinoma and lung squamous cell	-	326	1	67	Both	European,African,Other	cg05624510	chr15:41245527	15	41245527	CHAC1	Island	-0.8030989	0.1469	0.0000000457	-	27602958_smoking_packyears_discovery
Freeman JR	-	27602958	2016-10-25	Smoking pack-years	EFO_0006526, EFO_0005671, EFO_0004318	Lung squamous cell	Additional file 3	DNA methylation	Smoking pack-years	Age, sex, ethnicity, cell type, EGFR mutation status and KRAS mutation status	M values	Pack-years	Illumina HumanMethylation450	Lung squamous cell	-	511	1	66.8	Both	European,African,Other	cg13341720	chr19:6740888	19	6740888	TRIP10	Island	-0.8948788	0.1638	0.0000000468	-	27602958_smoking_packyears_lung_squamous_cell
Freeman JR	-	27602958	2016-10-25	Smoking pack-years	EFO_0006526, EFO_0005671, EFO_0004318	Discovery and replication	Additional file 1	DNA methylation	Smoking pack-years	Age, sex, ethnicity, cell type, EGFR mutation status and KRAS mutation status	M values	Pack-years	Illumina HumanMethylation450	Lung adenocarcinoma and lung squamous cell	-	511	1	66.8	Both	European,African,Other	cg04151290	chr11:2398500	11	2398500	CD81	Island	-0.29954992	0.0549	0.0000000474	-	27602958_smoking_packyears_discovery_and_replication
Freeman JR	-	27602958	2016-10-25	Smoking pack-years	EFO_0006526, EFO_0005671, EFO_0004318	Lung squamous cell	Additional file 3	DNA methylation	Smoking pack-years	Age, sex, ethnicity, cell type, EGFR mutation status and KRAS mutation status	M values	Pack-years	Illumina HumanMethylation450	Lung squamous cell	-	511	1	66.8	Both	European,African,Other	cg13264059	chr10:129705415	10	129705415	PTPRE	Island	-0.8498589	0.1558	0.0000000488	-	27602958_smoking_packyears_lung_squamous_cell
Freeman JR	-	27602958	2016-10-25	Smoking pack-years	EFO_0006526, EFO_0005671, EFO_0004318	Discovery and replication	Additional file 1	DNA methylation	Smoking pack-years	Age, sex, ethnicity, cell type, EGFR mutation status and KRAS mutation status	M values	Pack-years	Illumina HumanMethylation450	Lung adenocarcinoma and lung squamous cell	-	511	1	66.8	Both	European,African,Other	cg24823993	chr22:42085003	22	42085003	NHP2L1	Island	-0.35062232	0.0644	0.0000000513	-	27602958_smoking_packyears_discovery_and_replication
Freeman JR	-	27602958	2016-10-25	Smoking pack-years	EFO_0006526, EFO_0005671, EFO_0004318	Lung squamous cell	Additional file 3	DNA methylation	Smoking pack-years	Age, sex, ethnicity, cell type, EGFR mutation status and KRAS mutation status	M values	Pack-years	Illumina HumanMethylation450	Lung squamous cell	-	511	1	66.8	Both	European,African,Other	cg16364152	chr20:5591818	20	5591818	RP5-1022P6.2	Island	0.4529001	0.0833	0.0000000534	-	27602958_smoking_packyears_lung_squamous_cell
Freeman JR	-	27602958	2016-10-25	Smoking pack-years	EFO_0006526, EFO_0005671, EFO_0004318	Lung squamous cell	Additional file 3	DNA methylation	Smoking pack-years	Age, sex, ethnicity, cell type, EGFR mutation status and KRAS mutation status	M values	Pack-years	Illumina HumanMethylation450	Lung squamous cell	-	511	1	66.8	Both	European,African,Other	cg19916637	chr8:95961757	8	95961757	TP53INP1	Island	-0.9210253	0.1693	0.0000000536	-	27602958_smoking_packyears_lung_squamous_cell
Freeman JR	-	27602958	2016-10-25	Smoking pack-years	EFO_0006526, EFO_0005671, EFO_0004318	Discovery and replication	Additional file 1	DNA methylation	Smoking pack-years	Age, sex, ethnicity, cell type, EGFR mutation status and KRAS mutation status	M values	Pack-years	Illumina HumanMethylation450	Lung adenocarcinoma and lung squamous cell	-	511	1	66.8	Both	European,African,Other	cg11516830	chr17:75242950	17	75242950	-	Island	0.31938968	0.0588	0.0000000557	-	27602958_smoking_packyears_discovery_and_replication
Freeman JR	-	27602958	2016-10-25	Smoking pack-years	EFO_0006526, EFO_0005671, EFO_0004318	Lung squamous cell	Additional file 3	DNA methylation	Smoking pack-years	Age, sex, ethnicity, cell type, EGFR mutation status and KRAS mutation status	M values	Pack-years	Illumina HumanMethylation450	Lung squamous cell	-	511	1	66.8	Both	European,African,Other	cg06818515	chr16:2944443	16	2944443	FLYWCH2	Island	0.9242321	0.1703	0.0000000576	-	27602958_smoking_packyears_lung_squamous_cell
Freeman JR	-	27602958	2016-10-25	Smoking pack-years	EFO_0006526, EFO_0005671, EFO_0004318	Discovery and replication	Additional file 1	DNA methylation	Smoking pack-years	Age, sex, ethnicity, cell type, EGFR mutation status and KRAS mutation status	M values	Pack-years	Illumina HumanMethylation450	Lung adenocarcinoma and lung squamous cell	-	511	1	66.8	Both	European,African,Other	cg08843134	chr16:2301653	16	2301653	DCI	Island	0.44407324	0.082	0.0000000622	-	27602958_smoking_packyears_discovery_and_replication
Freeman JR	-	27602958	2016-10-25	Smoking pack-years	EFO_0006526, EFO_0005671, EFO_0004318	Replication	Additional file 1	DNA methylation	Smoking pack-years	Age, sex, ethnicity, cell type, EGFR mutation status and KRAS mutation status	M values	Pack-years	Illumina HumanMethylation450	Lung adenocarcinoma and lung squamous cell	-	185	1	66.4	Both	European,African,Other	cg13204512	chr17:29298184	17	29298184	RNF135	Island	-1.3060439	0.2414	0.0000000633	-	27602958_smoking_packyears_replication
Freeman JR	-	27602958	2016-10-25	Smoking pack-years	EFO_0006526, EFO_0005671, EFO_0004318	Lung squamous cell	Additional file 3	DNA methylation	Smoking pack-years	Age, sex, ethnicity, cell type, EGFR mutation status and KRAS mutation status	M values	Pack-years	Illumina HumanMethylation450	Lung squamous cell	-	511	1	66.8	Both	European,African,Other	cg14826215	chr7:139762483	7	139762483	PARP12	Island	-0.9405122	0.1741	0.0000000657	-	27602958_smoking_packyears_lung_squamous_cell
Freeman JR	-	27602958	2016-10-25	Smoking pack-years	EFO_0006526, EFO_0005671, EFO_0004318	Replication	Additional file 1	DNA methylation	Smoking pack-years	Age, sex, ethnicity, cell type, EGFR mutation status and KRAS mutation status	M values	Pack-years	Illumina HumanMethylation450	Lung adenocarcinoma and lung squamous cell	-	185	1	66.4	Both	European,African,Other	cg08135278	chr1:226070709	1	226070709	TMEM63A	Island	-1.271732	0.2367	0.0000000772	-	27602958_smoking_packyears_replication
Freeman JR	-	27602958	2016-10-25	Smoking pack-years	EFO_0006526, EFO_0005671, EFO_0004318	Lung squamous cell	Additional file 3	DNA methylation	Smoking pack-years	Age, sex, ethnicity, cell type, EGFR mutation status and KRAS mutation status	M values	Pack-years	Illumina HumanMethylation450	Lung squamous cell	-	511	1	66.8	Both	European,African,Other	cg07243103	chr16:699355	16	699355	WDR90	Island	-0.4260533	0.0793	0.0000000783	-	27602958_smoking_packyears_lung_squamous_cell
Freeman JR	-	27602958	2016-10-25	Smoking pack-years	EFO_0006526, EFO_0005671, EFO_0004318	Replication	Additional file 1	DNA methylation	Smoking pack-years	Age, sex, ethnicity, cell type, EGFR mutation status and KRAS mutation status	M values	Pack-years	Illumina HumanMethylation450	Lung adenocarcinoma and lung squamous cell	-	185	1	66.4	Both	European,African,Other	cg05624510	chr15:41245527	15	41245527	CHAC1	Island	-0.8130831	0.1517	0.0000000828	-	27602958_smoking_packyears_replication
Freeman JR	-	27602958	2016-10-25	Smoking pack-years	EFO_0006526, EFO_0005671, EFO_0004318	Discovery	Additional file 1	DNA methylation	Smoking pack-years	Age, sex, ethnicity, cell type, EGFR mutation status and KRAS mutation status	M values	Pack-years	Illumina HumanMethylation450	Lung adenocarcinoma and lung squamous cell	-	326	1	67	Both	European,African,Other	cg18496502	chr19:42880157	19	42880157	MEGF8	Island	0.9437453	0.1766	0.0000000907	-	27602958_smoking_packyears_discovery
Freeman JR	-	27602958	2016-10-25	Smoking pack-years	EFO_0006526, EFO_0005671, EFO_0004318	Lung adenocarcinoma	Additional file 2	DNA methylation	Smoking pack-years	Age, sex, ethnicity, cell type, EGFR mutation status and KRAS mutation status	M values	Pack-years	Illumina HumanMethylation450	Lung adenocarcinoma	-	511	1	66.8	Both	European,African,Other	cg16579555	chr17:29298352	17	29298352	RNF135	Island	-0.82032558	0.1535	0.0000000916	-	27602958_smoking_packyears_lung_adenocarcinoma
Freeman JR	-	27602958	2016-10-25	Smoking pack-years	EFO_0006526, EFO_0005671, EFO_0004318	Lung adenocarcinoma	Additional file 2	DNA methylation	Smoking pack-years	Age, sex, ethnicity, cell type, EGFR mutation status and KRAS mutation status	M values	Pack-years	Illumina HumanMethylation450	Lung adenocarcinoma	-	511	1	66.8	Both	European,African,Other	cg20480233	chr14:23451154	14	23451154	JUB	Island	-1.00264149	0.1882	0.0000000994	-	27602958_smoking_packyears_lung_adenocarcinoma
Freeman JR	-	27602958	2016-10-25	Smoking pack-years	EFO_0006526, EFO_0005671, EFO_0004318	Replication	Additional file 1	DNA methylation	Smoking pack-years	Age, sex, ethnicity, cell type, EGFR mutation status and KRAS mutation status	M values	Pack-years	Illumina HumanMethylation450	Lung adenocarcinoma and lung squamous cell	-	185	1	66.4	Both	European,African,Other	cg11345323	chr1:1981825	1	1981825	PRKCZ	Island	-0.9499692	0.1794	0.000000119	-	27602958_smoking_packyears_replication
Freeman JR	-	27602958	2016-10-25	Smoking pack-years	EFO_0006526, EFO_0005671, EFO_0004318	Lung squamous cell	Additional file 3	DNA methylation	Smoking pack-years	Age, sex, ethnicity, cell type, EGFR mutation status and KRAS mutation status	M values	Pack-years	Illumina HumanMethylation450	Lung squamous cell	-	511	1	66.8	Both	European,African,Other	cg09876101	chr16:699357	16	699357	WDR90	Island	-0.4483389	0.0847	0.000000119	-	27602958_smoking_packyears_lung_squamous_cell
Freeman JR	-	27602958	2016-10-25	Smoking pack-years	EFO_0006526, EFO_0005671, EFO_0004318	Lung adenocarcinoma	Additional file 2	DNA methylation	Smoking pack-years	Age, sex, ethnicity, cell type, EGFR mutation status and KRAS mutation status	M values	Pack-years	Illumina HumanMethylation450	Lung adenocarcinoma	-	511	1	66.8	Both	European,African,Other	cg16654732	chr5:170846517	5	170846517	FGF18	Island	-0.91980866	0.1738	0.000000121	-	27602958_smoking_packyears_lung_adenocarcinoma
Freeman JR	-	27602958	2016-10-25	Smoking pack-years	EFO_0006526, EFO_0005671, EFO_0004318	Lung squamous cell	Additional file 3	DNA methylation	Smoking pack-years	Age, sex, ethnicity, cell type, EGFR mutation status and KRAS mutation status	M values	Pack-years	Illumina HumanMethylation450	Lung squamous cell	-	511	1	66.8	Both	European,African,Other	cg19634213	chr10:89621792	10	89621792	PTEN;KILLIN	Island	-1.0996725	0.2082	0.000000129	-	27602958_smoking_packyears_lung_squamous_cell
Freeman JR	-	27602958	2016-10-25	Smoking pack-years	EFO_0006526, EFO_0005671, EFO_0004318	Lung squamous cell	Additional file 3	DNA methylation	Smoking pack-years	Age, sex, ethnicity, cell type, EGFR mutation status and KRAS mutation status	M values	Pack-years	Illumina HumanMethylation450	Lung squamous cell	-	511	1	66.8	Both	European,African,Other	cg21273098	chr6:109762418	6	109762418	SMPD2;PPIL6	Island	-0.3352546	0.0635	0.00000013	-	27602958_smoking_packyears_lung_squamous_cell
Freeman JR	-	27602958	2016-10-25	Smoking pack-years	EFO_0006526, EFO_0005671, EFO_0004318	Discovery and replication	Additional file 1	DNA methylation	Smoking pack-years	Age, sex, ethnicity, cell type, EGFR mutation status and KRAS mutation status	M values	Pack-years	Illumina HumanMethylation450	Lung adenocarcinoma and lung squamous cell	-	511	1	66.8	Both	European,African,Other	cg02232531	chr16:699316	16	699316	WDR90	Island	-0.34147637	0.0647	0.000000131	-	27602958_smoking_packyears_discovery_and_replication
Freeman JR	-	27602958	2016-10-25	Smoking pack-years	EFO_0006526, EFO_0005671, EFO_0004318	Lung squamous cell	Additional file 3	DNA methylation	Smoking pack-years	Age, sex, ethnicity, cell type, EGFR mutation status and KRAS mutation status	M values	Pack-years	Illumina HumanMethylation450	Lung squamous cell	-	511	1	66.8	Both	European,African,Other	cg16142707	chr3:156544075	3	156544075	LEKR1	Island	-1.5944131	0.3028	0.00000014	-	27602958_smoking_packyears_lung_squamous_cell
Freeman JR	-	27602958	2016-10-25	Smoking pack-years	EFO_0006526, EFO_0005671, EFO_0004318	Discovery and replication	Additional file 1	DNA methylation	Smoking pack-years	Age, sex, ethnicity, cell type, EGFR mutation status and KRAS mutation status	M values	Pack-years	Illumina HumanMethylation450	Lung adenocarcinoma and lung squamous cell	-	511	1	66.8	Both	European,African,Other	cg18873530	chr19:49315663	19	49315663	BCAT2	Island	-0.44602756	0.0849	0.000000147	-	27602958_smoking_packyears_discovery_and_replication
Freeman JR	-	27602958	2016-10-25	Smoking pack-years	EFO_0006526, EFO_0005671, EFO_0004318	Lung squamous cell	Additional file 3	DNA methylation	Smoking pack-years	Age, sex, ethnicity, cell type, EGFR mutation status and KRAS mutation status	M values	Pack-years	Illumina HumanMethylation450	Lung squamous cell	-	511	1	66.8	Both	European,African,Other	cg05288071	chr19:7712539	19	7712539	STXBP2	South shore	1.2005325	0.2284	0.000000148	-	27602958_smoking_packyears_lung_squamous_cell
Freeman JR	-	27602958	2016-10-25	Smoking pack-years	EFO_0006526, EFO_0005671, EFO_0004318	Lung adenocarcinoma	Additional file 2	DNA methylation	Smoking pack-years	Age, sex, ethnicity, cell type, EGFR mutation status and KRAS mutation status	M values	Pack-years	Illumina HumanMethylation450	Lung adenocarcinoma	-	511	1	66.8	Both	European,African,Other	cg00032419	chr17:27895566	17	27895566	TP53I13	Island	-0.8185973	0.156	0.000000153	-	27602958_smoking_packyears_lung_adenocarcinoma
Freeman JR	-	27602958	2016-10-25	Smoking pack-years	EFO_0006526, EFO_0005671, EFO_0004318	Lung adenocarcinoma	Additional file 2	DNA methylation	Smoking pack-years	Age, sex, ethnicity, cell type, EGFR mutation status and KRAS mutation status	M values	Pack-years	Illumina HumanMethylation450	Lung adenocarcinoma	-	511	1	66.8	Both	European,African,Other	cg01014490	chr1:714177	1	714177	-	Island	-0.87370565	0.1669	0.000000164	-	27602958_smoking_packyears_lung_adenocarcinoma
Freeman JR	-	27602958	2016-10-25	Smoking pack-years	EFO_0006526, EFO_0005671, EFO_0004318	Lung squamous cell	Additional file 3	DNA methylation	Smoking pack-years	Age, sex, ethnicity, cell type, EGFR mutation status and KRAS mutation status	M values	Pack-years	Illumina HumanMethylation450	Lung squamous cell	-	511	1	66.8	Both	European,African,Other	cg03705926	chr19:6740952	19	6740952	TRIP10	Island	-1.056621	0.2019	0.000000167	-	27602958_smoking_packyears_lung_squamous_cell
Freeman JR	-	27602958	2016-10-25	Smoking pack-years	EFO_0006526, EFO_0005671, EFO_0004318	Discovery	Additional file 1	DNA methylation	Smoking pack-years	Age, sex, ethnicity, cell type, EGFR mutation status and KRAS mutation status	M values	Pack-years	Illumina HumanMethylation450	Lung adenocarcinoma and lung squamous cell	-	326	1	67	Both	European,African,Other	cg25144930	chr11:2398505	11	2398505	CD81	Island	-0.8020162	0.1534	0.000000171	-	27602958_smoking_packyears_discovery
Freeman JR	-	27602958	2016-10-25	Smoking pack-years	EFO_0006526, EFO_0005671, EFO_0004318	Discovery and replication	Additional file 1	DNA methylation	Smoking pack-years	Age, sex, ethnicity, cell type, EGFR mutation status and KRAS mutation status	M values	Pack-years	Illumina HumanMethylation450	Lung adenocarcinoma and lung squamous cell	-	511	1	66.8	Both	European,African,Other	cg10729325	chr3:10206413	3	10206413	IRAK2	North shore	-0.48565517	0.0929	0.000000172	-	27602958_smoking_packyears_discovery_and_replication
Freeman JR	-	27602958	2016-10-25	Smoking pack-years	EFO_0006526, EFO_0005671, EFO_0004318	Replication	Additional file 1	DNA methylation	Smoking pack-years	Age, sex, ethnicity, cell type, EGFR mutation status and KRAS mutation status	M values	Pack-years	Illumina HumanMethylation450	Lung adenocarcinoma and lung squamous cell	-	185	1	66.4	Both	European,African,Other	cg00265578	chr17:27895564	17	27895564	TP53I13	Island	-0.9645883	0.1847	0.000000176	-	27602958_smoking_packyears_replication
Freeman JR	-	27602958	2016-10-25	Smoking pack-years	EFO_0006526, EFO_0005671, EFO_0004318	Replication	Additional file 1	DNA methylation	Smoking pack-years	Age, sex, ethnicity, cell type, EGFR mutation status and KRAS mutation status	M values	Pack-years	Illumina HumanMethylation450	Lung adenocarcinoma and lung squamous cell	-	185	1	66.4	Both	European,African,Other	cg20215367	chr8:143808432	8	143808432	C8orf55	Island	-0.7605804	0.1458	0.000000182	-	27602958_smoking_packyears_replication
Freeman JR	-	27602958	2016-10-25	Smoking pack-years	EFO_0006526, EFO_0005671, EFO_0004318	Discovery	Additional file 1	DNA methylation	Smoking pack-years	Age, sex, ethnicity, cell type, EGFR mutation status and KRAS mutation status	M values	Pack-years	Illumina HumanMethylation450	Lung adenocarcinoma and lung squamous cell	-	326	1	67	Both	European,African,Other	cg04029055	chr17:37213281	17	37213281	-	Open sea	-0.5554169	0.1067	0.000000194	-	27602958_smoking_packyears_discovery
Freeman JR	-	27602958	2016-10-25	Smoking pack-years	EFO_0006526, EFO_0005671, EFO_0004318	Discovery	Additional file 1	DNA methylation	Smoking pack-years	Age, sex, ethnicity, cell type, EGFR mutation status and KRAS mutation status	M values	Pack-years	Illumina HumanMethylation450	Lung adenocarcinoma and lung squamous cell	-	326	1	67	Both	European,African,Other	cg18699112	chr17:81009351	17	81009351	B3GNTL1	Island	-0.5529258	0.1063	0.0000002	-	27602958_smoking_packyears_discovery
Freeman JR	-	27602958	2016-10-25	Smoking pack-years	EFO_0006526, EFO_0005671, EFO_0004318	Lung squamous cell	Additional file 3	DNA methylation	Smoking pack-years	Age, sex, ethnicity, cell type, EGFR mutation status and KRAS mutation status	M values	Pack-years	Illumina HumanMethylation450	Lung squamous cell	-	511	1	66.8	Both	European,African,Other	cg10729325	chr3:10206413	3	10206413	IRAK2	North shore	-1.0815609	0.2085	0.000000213	-	27602958_smoking_packyears_lung_squamous_cell
Freeman JR	-	27602958	2016-10-25	Smoking pack-years	EFO_0006526, EFO_0005671, EFO_0004318	Lung squamous cell	Additional file 3	DNA methylation	Smoking pack-years	Age, sex, ethnicity, cell type, EGFR mutation status and KRAS mutation status	M values	Pack-years	Illumina HumanMethylation450	Lung squamous cell	-	511	1	66.8	Both	European,African,Other	cg08118159	chr19:41055208	19	41055208	SPTBN4	Island	-0.6001919	0.1157	0.000000215	-	27602958_smoking_packyears_lung_squamous_cell
Freeman JR	-	27602958	2016-10-25	Smoking pack-years	EFO_0006526, EFO_0005671, EFO_0004318	Lung adenocarcinoma	Additional file 2	DNA methylation	Smoking pack-years	Age, sex, ethnicity, cell type, EGFR mutation status and KRAS mutation status	M values	Pack-years	Illumina HumanMethylation450	Lung adenocarcinoma	-	511	1	66.8	Both	European,African,Other	cg21273098	chr6:109762418	6	109762418	SMPD2;PPIL6	Island	-0.27825929	0.0538	0.000000237	-	27602958_smoking_packyears_lung_adenocarcinoma
Freeman JR	-	27602958	2016-10-25	Smoking pack-years	EFO_0006526, EFO_0005671, EFO_0004318	Lung squamous cell	Additional file 3	DNA methylation	Smoking pack-years	Age, sex, ethnicity, cell type, EGFR mutation status and KRAS mutation status	M values	Pack-years	Illumina HumanMethylation450	Lung squamous cell	-	511	1	66.8	Both	European,African,Other	cg02112681	chr7:1120141	7	1120141	C7orf50	Island	1.1958111	0.2324	0.000000268	-	27602958_smoking_packyears_lung_squamous_cell
Freeman JR	-	27602958	2016-10-25	Smoking pack-years	EFO_0006526, EFO_0005671, EFO_0004318	Lung squamous cell	Additional file 3	DNA methylation	Smoking pack-years	Age, sex, ethnicity, cell type, EGFR mutation status and KRAS mutation status	M values	Pack-years	Illumina HumanMethylation450	Lung squamous cell	-	511	1	66.8	Both	European,African,Other	cg17323383	chr3:182896670	3	182896670	MCF2L2	North shore	-1.3779499	0.2681	0.000000275	-	27602958_smoking_packyears_lung_squamous_cell
Freeman JR	-	27602958	2016-10-25	Smoking pack-years	EFO_0006526, EFO_0005671, EFO_0004318	Discovery	Additional file 1	DNA methylation	Smoking pack-years	Age, sex, ethnicity, cell type, EGFR mutation status and KRAS mutation status	M values	Pack-years	Illumina HumanMethylation450	Lung adenocarcinoma and lung squamous cell	-	326	1	67	Both	European,African,Other	cg19168961	chr15:41245649	15	41245649	CHAC1	Island	-0.4792784	0.0934	0.000000286	-	27602958_smoking_packyears_discovery
Freeman JR	-	27602958	2016-10-25	Smoking pack-years	EFO_0006526, EFO_0005671, EFO_0004318	Discovery	Additional file 1	DNA methylation	Smoking pack-years	Age, sex, ethnicity, cell type, EGFR mutation status and KRAS mutation status	M values	Pack-years	Illumina HumanMethylation450	Lung adenocarcinoma and lung squamous cell	-	326	1	67	Both	European,African,Other	cg26569144	chr5:170846504	5	170846504	FGF18	Island	-0.7941544	0.1559	0.000000349	-	27602958_smoking_packyears_discovery
Freeman JR	-	27602958	2016-10-25	Smoking pack-years	EFO_0006526, EFO_0005671, EFO_0004318	Lung adenocarcinoma	Additional file 2	DNA methylation	Smoking pack-years	Age, sex, ethnicity, cell type, EGFR mutation status and KRAS mutation status	M values	Pack-years	Illumina HumanMethylation450	Lung adenocarcinoma	-	511	1	66.8	Both	European,African,Other	cg04029055	chr17:37213281	17	37213281	-	Open sea	-0.41800533	0.0821	0.000000356	-	27602958_smoking_packyears_lung_adenocarcinoma
Freeman JR	-	27602958	2016-10-25	Smoking pack-years	EFO_0006526, EFO_0005671, EFO_0004318	Discovery	Additional file 1	DNA methylation	Smoking pack-years	Age, sex, ethnicity, cell type, EGFR mutation status and KRAS mutation status	M values	Pack-years	Illumina HumanMethylation450	Lung adenocarcinoma and lung squamous cell	-	326	1	67	Both	European,African,Other	cg03586437	chr1:226070052	1	226070052	TMEM63A	Island	-0.6666502	0.1313	0.000000379	-	27602958_smoking_packyears_discovery
Freeman JR	-	27602958	2016-10-25	Smoking pack-years	EFO_0006526, EFO_0005671, EFO_0004318	Replication	Additional file 1	DNA methylation	Smoking pack-years	Age, sex, ethnicity, cell type, EGFR mutation status and KRAS mutation status	M values	Pack-years	Illumina HumanMethylation450	Lung adenocarcinoma and lung squamous cell	-	185	1	66.4	Both	European,African,Other	cg24948990	chr8:143820828	8	143820828	-	Island	-0.9949825	0.1962	0.000000393	-	27602958_smoking_packyears_replication
Freeman JR	-	27602958	2016-10-25	Smoking pack-years	EFO_0006526, EFO_0005671, EFO_0004318	Discovery	Additional file 1	DNA methylation	Smoking pack-years	Age, sex, ethnicity, cell type, EGFR mutation status and KRAS mutation status	M values	Pack-years	Illumina HumanMethylation450	Lung adenocarcinoma and lung squamous cell	-	326	1	67	Both	European,African,Other	cg22296620	chr15:45315419	15	45315419	SORD	Island	0.2949919	0.0583	0.000000423	-	27602958_smoking_packyears_discovery
Freeman JR	-	27602958	2016-10-25	Smoking pack-years	EFO_0006526, EFO_0005671, EFO_0004318	Discovery	Additional file 1	DNA methylation	Smoking pack-years	Age, sex, ethnicity, cell type, EGFR mutation status and KRAS mutation status	M values	Pack-years	Illumina HumanMethylation450	Lung adenocarcinoma and lung squamous cell	-	326	1	67	Both	European,African,Other	cg02456708	chr17:27895477	17	27895477	ABHD15;TP53I13	Island	-0.6200905	0.1226	0.000000425	-	27602958_smoking_packyears_discovery
Freeman JR	-	27602958	2016-10-25	Smoking pack-years	EFO_0006526, EFO_0005671, EFO_0004318	Replication	Additional file 1	DNA methylation	Smoking pack-years	Age, sex, ethnicity, cell type, EGFR mutation status and KRAS mutation status	M values	Pack-years	Illumina HumanMethylation450	Lung adenocarcinoma and lung squamous cell	-	185	1	66.4	Both	European,African,Other	cg07766672	chr8:143808440	8	143808440	C8orf55	Island	-0.817114	0.1616	0.000000426	-	27602958_smoking_packyears_replication
Freeman JR	-	27602958	2016-10-25	Smoking pack-years	EFO_0006526, EFO_0005671, EFO_0004318	Discovery	Additional file 1	DNA methylation	Smoking pack-years	Age, sex, ethnicity, cell type, EGFR mutation status and KRAS mutation status	M values	Pack-years	Illumina HumanMethylation450	Lung adenocarcinoma and lung squamous cell	-	326	1	67	Both	European,African,Other	cg07766672	chr8:143808440	8	143808440	C8orf55	Island	-0.6987398	0.1385	0.000000449	-	27602958_smoking_packyears_discovery
Freeman JR	-	27602958	2016-10-25	Smoking pack-years	EFO_0006526, EFO_0005671, EFO_0004318	Lung adenocarcinoma	Additional file 2	DNA methylation	Smoking pack-years	Age, sex, ethnicity, cell type, EGFR mutation status and KRAS mutation status	M values	Pack-years	Illumina HumanMethylation450	Lung adenocarcinoma	-	511	1	66.8	Both	European,African,Other	cg20849378	chr7:1516084	7	1516084	INTS1	Island	0.4969423	0.0985	0.000000454	-	27602958_smoking_packyears_lung_adenocarcinoma
Freeman JR	-	27602958	2016-10-25	Smoking pack-years	EFO_0006526, EFO_0005671, EFO_0004318	Discovery	Additional file 1	DNA methylation	Smoking pack-years	Age, sex, ethnicity, cell type, EGFR mutation status and KRAS mutation status	M values	Pack-years	Illumina HumanMethylation450	Lung adenocarcinoma and lung squamous cell	-	326	1	67	Both	European,African,Other	cg03705926	chr19:6740952	19	6740952	TRIP10	Island	-0.7763861	0.1542	0.000000475	-	27602958_smoking_packyears_discovery
Freeman JR	-	27602958	2016-10-25	Smoking pack-years	EFO_0006526, EFO_0005671, EFO_0004318	Discovery	Additional file 1	DNA methylation	Smoking pack-years	Age, sex, ethnicity, cell type, EGFR mutation status and KRAS mutation status	M values	Pack-years	Illumina HumanMethylation450	Lung adenocarcinoma and lung squamous cell	-	326	1	67	Both	European,African,Other	cg01725199	chr9:101569990	9	101569990	GALNT12	Island	-0.4685475	0.0931	0.000000478	-	27602958_smoking_packyears_discovery
Freeman JR	-	27602958	2016-10-25	Smoking pack-years	EFO_0006526, EFO_0005671, EFO_0004318	Replication	Additional file 1	DNA methylation	Smoking pack-years	Age, sex, ethnicity, cell type, EGFR mutation status and KRAS mutation status	M values	Pack-years	Illumina HumanMethylation450	Lung adenocarcinoma and lung squamous cell	-	185	1	66.4	Both	European,African,Other	cg21273098	chr6:109762418	6	109762418	SMPD2;PPIL6	Island	-0.2472666	0.0491	0.000000484	-	27602958_smoking_packyears_replication
Freeman JR	-	27602958	2016-10-25	Smoking pack-years	EFO_0006526, EFO_0005671, EFO_0004318	Discovery	Additional file 1	DNA methylation	Smoking pack-years	Age, sex, ethnicity, cell type, EGFR mutation status and KRAS mutation status	M values	Pack-years	Illumina HumanMethylation450	Lung adenocarcinoma and lung squamous cell	-	326	1	67	Both	European,African,Other	cg20737072	chr19:5785252	19	5785252	PRR22;DUS3L	North shore	0.6762013	0.1344	0.000000491	-	27602958_smoking_packyears_discovery
Freeman JR	-	27602958	2016-10-25	Smoking pack-years	EFO_0006526, EFO_0005671, EFO_0004318	Lung adenocarcinoma	Additional file 2	DNA methylation	Smoking pack-years	Age, sex, ethnicity, cell type, EGFR mutation status and KRAS mutation status	M values	Pack-years	Illumina HumanMethylation450	Lung adenocarcinoma	-	511	1	66.8	Both	European,African,Other	cg21919790	chr17:72926781	17	72926781	OTOP2	Open sea	-0.58603085	0.1166	0.000000506	-	27602958_smoking_packyears_lung_adenocarcinoma
Freeman JR	-	27602958	2016-10-25	Smoking pack-years	EFO_0006526, EFO_0005671, EFO_0004318	Lung squamous cell	Additional file 3	DNA methylation	Smoking pack-years	Age, sex, ethnicity, cell type, EGFR mutation status and KRAS mutation status	M values	Pack-years	Illumina HumanMethylation450	Lung squamous cell	-	511	1	66.8	Both	European,African,Other	cg23423230	chr21:43327978	21	43327978	C2CD2	Island	0.8944704	0.1781	0.000000509	-	27602958_smoking_packyears_lung_squamous_cell
Freeman JR	-	27602958	2016-10-25	Smoking pack-years	EFO_0006526, EFO_0005671, EFO_0004318	Discovery	Additional file 1	DNA methylation	Smoking pack-years	Age, sex, ethnicity, cell type, EGFR mutation status and KRAS mutation status	M values	Pack-years	Illumina HumanMethylation450	Lung adenocarcinoma and lung squamous cell	-	326	1	67	Both	European,African,Other	cg24198953	chr19:18451444	19	18451444	PGPEP1	Island	-0.8622414	0.1718	0.000000517	-	27602958_smoking_packyears_discovery
Freeman JR	-	27602958	2016-10-25	Smoking pack-years	EFO_0006526, EFO_0005671, EFO_0004318	Replication	Additional file 1	DNA methylation	Smoking pack-years	Age, sex, ethnicity, cell type, EGFR mutation status and KRAS mutation status	M values	Pack-years	Illumina HumanMethylation450	Lung adenocarcinoma and lung squamous cell	-	185	1	66.4	Both	European,African,Other	cg24599345	chr2:85645863	2	85645863	-	Island	-0.4443563	0.0888	0.000000566	-	27602958_smoking_packyears_replication
Freeman JR	-	27602958	2016-10-25	Smoking pack-years	EFO_0006526, EFO_0005671, EFO_0004318	Discovery	Additional file 1	DNA methylation	Smoking pack-years	Age, sex, ethnicity, cell type, EGFR mutation status and KRAS mutation status	M values	Pack-years	Illumina HumanMethylation450	Lung adenocarcinoma and lung squamous cell	-	326	1	67	Both	European,African,Other	cg06788803	chr1:45805948	1	45805948	MUTYH;TOE1	Island	-0.3411394	0.0682	0.000000573	-	27602958_smoking_packyears_discovery
Freeman JR	-	27602958	2016-10-25	Smoking pack-years	EFO_0006526, EFO_0005671, EFO_0004318	Replication	Additional file 1	DNA methylation	Smoking pack-years	Age, sex, ethnicity, cell type, EGFR mutation status and KRAS mutation status	M values	Pack-years	Illumina HumanMethylation450	Lung adenocarcinoma and lung squamous cell	-	185	1	66.4	Both	European,African,Other	cg18699112	chr17:81009351	17	81009351	B3GNTL1	Island	-0.7579261	0.1518	0.000000593	-	27602958_smoking_packyears_replication
Freeman JR	-	27602958	2016-10-25	Smoking pack-years	EFO_0006526, EFO_0005671, EFO_0004318	Lung squamous cell	Additional file 3	DNA methylation	Smoking pack-years	Age, sex, ethnicity, cell type, EGFR mutation status and KRAS mutation status	M values	Pack-years	Illumina HumanMethylation450	Lung squamous cell	-	511	1	66.8	Both	European,African,Other	cg09025960	chr1:226070808	1	226070808	TMEM63A	Island	-1.0309648	0.2069	0.000000625	-	27602958_smoking_packyears_lung_squamous_cell
Freeman JR	-	27602958	2016-10-25	Smoking pack-years	EFO_0006526, EFO_0005671, EFO_0004318	Replication	Additional file 1	DNA methylation	Smoking pack-years	Age, sex, ethnicity, cell type, EGFR mutation status and KRAS mutation status	M values	Pack-years	Illumina HumanMethylation450	Lung adenocarcinoma and lung squamous cell	-	185	1	66.4	Both	European,African,Other	cg18617333	chr8:143808383	8	143808383	C8orf55	Island	-0.7939026	0.1595	0.000000646	-	27602958_smoking_packyears_replication
Freeman JR	-	27602958	2016-10-25	Smoking pack-years	EFO_0006526, EFO_0005671, EFO_0004318	Discovery	Additional file 1	DNA methylation	Smoking pack-years	Age, sex, ethnicity, cell type, EGFR mutation status and KRAS mutation status	M values	Pack-years	Illumina HumanMethylation450	Lung adenocarcinoma and lung squamous cell	-	326	1	67	Both	European,African,Other	cg05288071	chr19:7712539	19	7712539	STXBP2	South shore	0.8637106	0.1735	0.000000647	-	27602958_smoking_packyears_discovery
Freeman JR	-	27602958	2016-10-25	Smoking pack-years	EFO_0006526, EFO_0005671, EFO_0004318	Discovery	Additional file 1	DNA methylation	Smoking pack-years	Age, sex, ethnicity, cell type, EGFR mutation status and KRAS mutation status	M values	Pack-years	Illumina HumanMethylation450	Lung adenocarcinoma and lung squamous cell	-	326	1	67	Both	European,African,Other	cg16200496	chr19:13107141	19	13107141	NFIX	Island	-0.6336856	0.1275	0.000000671	-	27602958_smoking_packyears_discovery
Freeman JR	-	27602958	2016-10-25	Smoking pack-years	EFO_0006526, EFO_0005671, EFO_0004318	Lung squamous cell	Additional file 3	DNA methylation	Smoking pack-years	Age, sex, ethnicity, cell type, EGFR mutation status and KRAS mutation status	M values	Pack-years	Illumina HumanMethylation450	Lung squamous cell	-	511	1	66.8	Both	European,African,Other	cg20737072	chr19:5785252	19	5785252	PRR22;DUS3L	North shore	0.8998624	0.1812	0.000000682	-	27602958_smoking_packyears_lung_squamous_cell
Freeman JR	-	27602958	2016-10-25	Smoking pack-years	EFO_0006526, EFO_0005671, EFO_0004318	Lung squamous cell	Additional file 3	DNA methylation	Smoking pack-years	Age, sex, ethnicity, cell type, EGFR mutation status and KRAS mutation status	M values	Pack-years	Illumina HumanMethylation450	Lung squamous cell	-	511	1	66.8	Both	European,African,Other	cg08806263	chr16:699293	16	699293	WDR90	Island	-0.4364309	0.088	0.000000708	-	27602958_smoking_packyears_lung_squamous_cell
Freeman JR	-	27602958	2016-10-25	Smoking pack-years	EFO_0006526, EFO_0005671, EFO_0004318	Discovery	Additional file 1	DNA methylation	Smoking pack-years	Age, sex, ethnicity, cell type, EGFR mutation status and KRAS mutation status	M values	Pack-years	Illumina HumanMethylation450	Lung adenocarcinoma and lung squamous cell	-	326	1	67	Both	European,African,Other	cg09876101	chr16:699357	16	699357	WDR90	Island	-0.3429947	0.0692	0.000000709	-	27602958_smoking_packyears_discovery
Freeman JR	-	27602958	2016-10-25	Smoking pack-years	EFO_0006526, EFO_0005671, EFO_0004318	Discovery	Additional file 1	DNA methylation	Smoking pack-years	Age, sex, ethnicity, cell type, EGFR mutation status and KRAS mutation status	M values	Pack-years	Illumina HumanMethylation450	Lung adenocarcinoma and lung squamous cell	-	326	1	67	Both	European,African,Other	cg00106446	chr1:247242130	1	247242130	ZNF670	Island	0.1535691	0.0311	0.000000794	-	27602958_smoking_packyears_discovery
Freeman JR	-	27602958	2016-10-25	Smoking pack-years	EFO_0006526, EFO_0005671, EFO_0004318	Lung squamous cell	Additional file 3	DNA methylation	Smoking pack-years	Age, sex, ethnicity, cell type, EGFR mutation status and KRAS mutation status	M values	Pack-years	Illumina HumanMethylation450	Lung squamous cell	-	511	1	66.8	Both	European,African,Other	cg02232531	chr16:699316	16	699316	WDR90	Island	-0.654024	0.1325	0.000000794	-	27602958_smoking_packyears_lung_squamous_cell
Freeman JR	-	27602958	2016-10-25	Smoking pack-years	EFO_0006526, EFO_0005671, EFO_0004318	Replication	Additional file 1	DNA methylation	Smoking pack-years	Age, sex, ethnicity, cell type, EGFR mutation status and KRAS mutation status	M values	Pack-years	Illumina HumanMethylation450	Lung adenocarcinoma and lung squamous cell	-	185	1	66.4	Both	European,African,Other	cg26369667	chr11:101981789	11	101981789	YAP1	Island	-0.8829717	0.1789	0.0000008	-	27602958_smoking_packyears_replication
Freeman JR	-	27602958	2016-10-25	Smoking pack-years	EFO_0006526, EFO_0005671, EFO_0004318	Replication	Additional file 1	DNA methylation	Smoking pack-years	Age, sex, ethnicity, cell type, EGFR mutation status and KRAS mutation status	M values	Pack-years	Illumina HumanMethylation450	Lung adenocarcinoma and lung squamous cell	-	185	1	66.4	Both	European,African,Other	cg21701395	chr8:95961492	8	95961492	TP53INP1	Island	-1.0438272	0.2116	0.000000812	-	27602958_smoking_packyears_replication
Freeman JR	-	27602958	2016-10-25	Smoking pack-years	EFO_0006526, EFO_0005671, EFO_0004318	Lung adenocarcinoma	Additional file 2	DNA methylation	Smoking pack-years	Age, sex, ethnicity, cell type, EGFR mutation status and KRAS mutation status	M values	Pack-years	Illumina HumanMethylation450	Lung adenocarcinoma	-	511	1	66.8	Both	European,African,Other	cg18496502	chr19:42880157	19	42880157	MEGF8	Island	0.37508201	0.0761	0.000000836	-	27602958_smoking_packyears_lung_adenocarcinoma
Freeman JR	-	27602958	2016-10-25	Smoking pack-years	EFO_0006526, EFO_0005671, EFO_0004318	Replication	Additional file 1	DNA methylation	Smoking pack-years	Age, sex, ethnicity, cell type, EGFR mutation status and KRAS mutation status	M values	Pack-years	Illumina HumanMethylation450	Lung adenocarcinoma and lung squamous cell	-	185	1	66.4	Both	European,African,Other	cg19508701	chr8:9008170	8	9008170	PPP1R3B	Island	-0.9824254	0.1995	0.000000848	-	27602958_smoking_packyears_replication
Freeman JR	-	27602958	2016-10-25	Smoking pack-years	EFO_0006526, EFO_0005671, EFO_0004318	Lung squamous cell	Additional file 3	DNA methylation	Smoking pack-years	Age, sex, ethnicity, cell type, EGFR mutation status and KRAS mutation status	M values	Pack-years	Illumina HumanMethylation450	Lung squamous cell	-	511	1	66.8	Both	European,African,Other	cg06788803	chr1:45805948	1	45805948	MUTYH;TOE1	Island	-0.390781	0.0794	0.000000849	-	27602958_smoking_packyears_lung_squamous_cell
Freeman JR	-	27602958	2016-10-25	Smoking pack-years	EFO_0006526, EFO_0005671, EFO_0004318	Discovery	Additional file 1	DNA methylation	Smoking pack-years	Age, sex, ethnicity, cell type, EGFR mutation status and KRAS mutation status	M values	Pack-years	Illumina HumanMethylation450	Lung adenocarcinoma and lung squamous cell	-	326	1	67	Both	European,African,Other	cg16726667	chr16:68002228	16	68002228	SLC12A4	Island	-0.7807993	0.1586	0.00000085	-	27602958_smoking_packyears_discovery
Freeman JR	-	27602958	2016-10-25	Smoking pack-years	EFO_0006526, EFO_0005671, EFO_0004318	Discovery	Additional file 1	DNA methylation	Smoking pack-years	Age, sex, ethnicity, cell type, EGFR mutation status and KRAS mutation status	M values	Pack-years	Illumina HumanMethylation450	Lung adenocarcinoma and lung squamous cell	-	326	1	67	Both	European,African,Other	cg18617333	chr8:143808383	8	143808383	C8orf55	Island	-0.6748327	0.1377	0.000000959	-	27602958_smoking_packyears_discovery
Freeman JR	-	27602958	2016-10-25	Smoking pack-years	EFO_0006526, EFO_0005671, EFO_0004318	Lung adenocarcinoma	Additional file 2	DNA methylation	Smoking pack-years	Age, sex, ethnicity, cell type, EGFR mutation status and KRAS mutation status	M values	Pack-years	Illumina HumanMethylation450	Lung adenocarcinoma	-	511	1	66.8	Both	European,African,Other	cg06818515	chr16:2944443	16	2944443	FLYWCH2	Island	0.43354707	0.0885	0.000000962	-	27602958_smoking_packyears_lung_adenocarcinoma
Freeman JR	-	27602958	2016-10-25	Smoking pack-years	EFO_0006526, EFO_0005671, EFO_0004318	Replication	Additional file 1	DNA methylation	Smoking pack-years	Age, sex, ethnicity, cell type, EGFR mutation status and KRAS mutation status	M values	Pack-years	Illumina HumanMethylation450	Lung adenocarcinoma and lung squamous cell	-	185	1	66.4	Both	European,African,Other	cg24843246	chr19:7621952	19	7621952	PNPLA6	Island	0.8932538	0.1826	0.00000101	-	27602958_smoking_packyears_replication
Freeman JR	-	27602958	2016-10-25	Smoking pack-years	EFO_0006526, EFO_0005671, EFO_0004318	Lung squamous cell	Additional file 3	DNA methylation	Smoking pack-years	Age, sex, ethnicity, cell type, EGFR mutation status and KRAS mutation status	M values	Pack-years	Illumina HumanMethylation450	Lung squamous cell	-	511	1	66.8	Both	European,African,Other	cg24198953	chr19:18451444	19	18451444	PGPEP1	Island	-1.3053627	0.2676	0.00000107	-	27602958_smoking_packyears_lung_squamous_cell
Freeman JR	-	27602958	2016-10-25	Smoking pack-years	EFO_0006526, EFO_0005671, EFO_0004318	Replication	Additional file 1	DNA methylation	Smoking pack-years	Age, sex, ethnicity, cell type, EGFR mutation status and KRAS mutation status	M values	Pack-years	Illumina HumanMethylation450	Lung adenocarcinoma and lung squamous cell	-	185	1	66.4	Both	European,African,Other	cg22865720	chr1:1981816	1	1981816	PRKCZ	Island	-0.8235049	0.1689	0.00000108	-	27602958_smoking_packyears_replication
Freeman JR	-	27602958	2016-10-25	Smoking pack-years	EFO_0006526, EFO_0005671, EFO_0004318	Lung squamous cell	Additional file 3	DNA methylation	Smoking pack-years	Age, sex, ethnicity, cell type, EGFR mutation status and KRAS mutation status	M values	Pack-years	Illumina HumanMethylation450	Lung squamous cell	-	511	1	66.8	Both	European,African,Other	cg13426839	chr19:539489	19	539489	CDC34	Island	1.2931081	0.2657	0.00000114	-	27602958_smoking_packyears_lung_squamous_cell
Freeman JR	-	27602958	2016-10-25	Smoking pack-years	EFO_0006526, EFO_0005671, EFO_0004318	Discovery	Additional file 1	DNA methylation	Smoking pack-years	Age, sex, ethnicity, cell type, EGFR mutation status and KRAS mutation status	M values	Pack-years	Illumina HumanMethylation450	Lung adenocarcinoma and lung squamous cell	-	326	1	67	Both	European,African,Other	cg13620366	chr9:138839624	9	138839624	UBAC1	Open sea	0.7526127	0.1548	0.00000117	-	27602958_smoking_packyears_discovery
Freeman JR	-	27602958	2016-10-25	Smoking pack-years	EFO_0006526, EFO_0005671, EFO_0004318	Lung adenocarcinoma	Additional file 2	DNA methylation	Smoking pack-years	Age, sex, ethnicity, cell type, EGFR mutation status and KRAS mutation status	M values	Pack-years	Illumina HumanMethylation450	Lung adenocarcinoma	-	511	1	66.8	Both	European,African,Other	cg13620366	chr9:138839624	9	138839624	UBAC1	Open sea	0.63119216	0.1299	0.00000117	-	27602958_smoking_packyears_lung_adenocarcinoma
Freeman JR	-	27602958	2016-10-25	Smoking pack-years	EFO_0006526, EFO_0005671, EFO_0004318	Discovery	Additional file 1	DNA methylation	Smoking pack-years	Age, sex, ethnicity, cell type, EGFR mutation status and KRAS mutation status	M values	Pack-years	Illumina HumanMethylation450	Lung adenocarcinoma and lung squamous cell	-	326	1	67	Both	European,African,Other	cg16364152	chr20:5591818	20	5591818	RP5-1022P6.2	Island	0.1475078	0.0303	0.00000117	-	27602958_smoking_packyears_discovery
Freeman JR	-	27602958	2016-10-25	Smoking pack-years	EFO_0006526, EFO_0005671, EFO_0004318	Lung squamous cell	Additional file 3	DNA methylation	Smoking pack-years	Age, sex, ethnicity, cell type, EGFR mutation status and KRAS mutation status	M values	Pack-years	Illumina HumanMethylation450	Lung squamous cell	-	511	1	66.8	Both	European,African,Other	cg09923107	chr20:30193892	20	30193892	ID1	Island	-0.9211749	0.1899	0.00000123	-	27602958_smoking_packyears_lung_squamous_cell
Freeman JR	-	27602958	2016-10-25	Smoking pack-years	EFO_0006526, EFO_0005671, EFO_0004318	Lung adenocarcinoma	Additional file 2	DNA methylation	Smoking pack-years	Age, sex, ethnicity, cell type, EGFR mutation status and KRAS mutation status	M values	Pack-years	Illumina HumanMethylation450	Lung adenocarcinoma	-	511	1	66.8	Both	European,African,Other	cg24198953	chr19:18451444	19	18451444	PGPEP1	Island	-0.61239748	0.1267	0.00000133	-	27602958_smoking_packyears_lung_adenocarcinoma
Freeman JR	-	27602958	2016-10-25	Smoking pack-years	EFO_0006526, EFO_0005671, EFO_0004318	Discovery	Additional file 1	DNA methylation	Smoking pack-years	Age, sex, ethnicity, cell type, EGFR mutation status and KRAS mutation status	M values	Pack-years	Illumina HumanMethylation450	Lung adenocarcinoma and lung squamous cell	-	326	1	67	Both	European,African,Other	cg06839820	chr22:43485161	22	43485161	TTLL1	Island	-0.5673653	0.1177	0.00000143	-	27602958_smoking_packyears_discovery
Freeman JR	-	27602958	2016-10-25	Smoking pack-years	EFO_0006526, EFO_0005671, EFO_0004318	Lung adenocarcinoma	Additional file 2	DNA methylation	Smoking pack-years	Age, sex, ethnicity, cell type, EGFR mutation status and KRAS mutation status	M values	Pack-years	Illumina HumanMethylation450	Lung adenocarcinoma	-	511	1	66.8	Both	European,African,Other	cg24599345	chr2:85645863	2	85645863	-	Island	-0.56336946	0.1172	0.00000153	-	27602958_smoking_packyears_lung_adenocarcinoma
Freeman JR	-	27602958	2016-10-25	Smoking pack-years	EFO_0006526, EFO_0005671, EFO_0004318	Replication	Additional file 1	DNA methylation	Smoking pack-years	Age, sex, ethnicity, cell type, EGFR mutation status and KRAS mutation status	M values	Pack-years	Illumina HumanMethylation450	Lung adenocarcinoma and lung squamous cell	-	185	1	66.4	Both	European,African,Other	cg06818515	chr16:2944443	16	2944443	FLYWCH2	Island	0.6989127	0.1454	0.00000153	-	27602958_smoking_packyears_replication
Freeman JR	-	27602958	2016-10-25	Smoking pack-years	EFO_0006526, EFO_0005671, EFO_0004318	Discovery	Additional file 1	DNA methylation	Smoking pack-years	Age, sex, ethnicity, cell type, EGFR mutation status and KRAS mutation status	M values	Pack-years	Illumina HumanMethylation450	Lung adenocarcinoma and lung squamous cell	-	326	1	67	Both	European,African,Other	cg06370133	chr2:113914844	2	113914844	-	Island	-0.5927435	0.1234	0.00000156	-	27602958_smoking_packyears_discovery
Freeman JR	-	27602958	2016-10-25	Smoking pack-years	EFO_0006526, EFO_0005671, EFO_0004318	Discovery	Additional file 1	DNA methylation	Smoking pack-years	Age, sex, ethnicity, cell type, EGFR mutation status and KRAS mutation status	M values	Pack-years	Illumina HumanMethylation450	Lung adenocarcinoma and lung squamous cell	-	326	1	67	Both	European,African,Other	cg25975165	chr1:2444426	1	2444426	PANK4	North shore	0.7474419	0.1559	0.00000162	-	27602958_smoking_packyears_discovery
Freeman JR	-	27602958	2016-10-25	Smoking pack-years	EFO_0006526, EFO_0005671, EFO_0004318	Discovery	Additional file 1	DNA methylation	Smoking pack-years	Age, sex, ethnicity, cell type, EGFR mutation status and KRAS mutation status	M values	Pack-years	Illumina HumanMethylation450	Lung adenocarcinoma and lung squamous cell	-	326	1	67	Both	European,African,Other	cg22515201	chr22:38577827	22	38577827	PLA2G6	Island	-0.9289604	0.1938	0.00000164	-	27602958_smoking_packyears_discovery
Freeman JR	-	27602958	2016-10-25	Smoking pack-years	EFO_0006526, EFO_0005671, EFO_0004318	Lung squamous cell	Additional file 3	DNA methylation	Smoking pack-years	Age, sex, ethnicity, cell type, EGFR mutation status and KRAS mutation status	M values	Pack-years	Illumina HumanMethylation450	Lung squamous cell	-	511	1	66.8	Both	European,African,Other	cg03779431	chr21:27543124	21	27543124	APP	Island	-0.3998807	0.0834	0.00000165	-	27602958_smoking_packyears_lung_squamous_cell
Freeman JR	-	27602958	2016-10-25	Smoking pack-years	EFO_0006526, EFO_0005671, EFO_0004318	Replication	Additional file 1	DNA methylation	Smoking pack-years	Age, sex, ethnicity, cell type, EGFR mutation status and KRAS mutation status	M values	Pack-years	Illumina HumanMethylation450	Lung adenocarcinoma and lung squamous cell	-	185	1	66.4	Both	European,African,Other	cg25144930	chr11:2398505	11	2398505	CD81	Island	-0.9125574	0.1907	0.00000171	-	27602958_smoking_packyears_replication
Freeman JR	-	27602958	2016-10-25	Smoking pack-years	EFO_0006526, EFO_0005671, EFO_0004318	Discovery	Additional file 1	DNA methylation	Smoking pack-years	Age, sex, ethnicity, cell type, EGFR mutation status and KRAS mutation status	M values	Pack-years	Illumina HumanMethylation450	Lung adenocarcinoma and lung squamous cell	-	326	1	67	Both	European,African,Other	cg11345323	chr1:1981825	1	1981825	PRKCZ	Island	-0.6449169	0.1349	0.00000174	-	27602958_smoking_packyears_discovery
Freeman JR	-	27602958	2016-10-25	Smoking pack-years	EFO_0006526, EFO_0005671, EFO_0004318	Replication	Additional file 1	DNA methylation	Smoking pack-years	Age, sex, ethnicity, cell type, EGFR mutation status and KRAS mutation status	M values	Pack-years	Illumina HumanMethylation450	Lung adenocarcinoma and lung squamous cell	-	185	1	66.4	Both	European,African,Other	cg03586437	chr1:226070052	1	226070052	TMEM63A	Island	-0.7881258	0.1652	0.00000183	-	27602958_smoking_packyears_replication
Freeman JR	-	27602958	2016-10-25	Smoking pack-years	EFO_0006526, EFO_0005671, EFO_0004318	Discovery	Additional file 1	DNA methylation	Smoking pack-years	Age, sex, ethnicity, cell type, EGFR mutation status and KRAS mutation status	M values	Pack-years	Illumina HumanMethylation450	Lung adenocarcinoma and lung squamous cell	-	326	1	67	Both	European,African,Other	cg09378497	chr16:1525169	16	1525169	CLCN7	Island	-0.6486034	0.1363	0.00000193	-	27602958_smoking_packyears_discovery
Freeman JR	-	27602958	2016-10-25	Smoking pack-years	EFO_0006526, EFO_0005671, EFO_0004318	Discovery	Additional file 1	DNA methylation	Smoking pack-years	Age, sex, ethnicity, cell type, EGFR mutation status and KRAS mutation status	M values	Pack-years	Illumina HumanMethylation450	Lung adenocarcinoma and lung squamous cell	-	326	1	67	Both	European,African,Other	cg03779431	chr21:27543124	21	27543124	APP	Island	-0.3650518	0.0767	0.00000195	-	27602958_smoking_packyears_discovery
Freeman JR	-	27602958	2016-10-25	Smoking pack-years	EFO_0006526, EFO_0005671, EFO_0004318	Replication	Additional file 1	DNA methylation	Smoking pack-years	Age, sex, ethnicity, cell type, EGFR mutation status and KRAS mutation status	M values	Pack-years	Illumina HumanMethylation450	Lung adenocarcinoma and lung squamous cell	-	185	1	66.4	Both	European,African,Other	cg06370133	chr2:113914844	2	113914844	-	Island	-0.7442867	0.1564	0.00000196	-	27602958_smoking_packyears_replication
Freeman JR	-	27602958	2016-10-25	Smoking pack-years	EFO_0006526, EFO_0005671, EFO_0004318	Replication	Additional file 1	DNA methylation	Smoking pack-years	Age, sex, ethnicity, cell type, EGFR mutation status and KRAS mutation status	M values	Pack-years	Illumina HumanMethylation450	Lung adenocarcinoma and lung squamous cell	-	185	1	66.4	Both	European,African,Other	cg09025960	chr1:226070808	1	226070808	TMEM63A	Island	-0.7902514	0.1664	0.00000204	-	27602958_smoking_packyears_replication
Freeman JR	-	27602958	2016-10-25	Smoking pack-years	EFO_0006526, EFO_0005671, EFO_0004318	Discovery	Additional file 1	DNA methylation	Smoking pack-years	Age, sex, ethnicity, cell type, EGFR mutation status and KRAS mutation status	M values	Pack-years	Illumina HumanMethylation450	Lung adenocarcinoma and lung squamous cell	-	326	1	67	Both	European,African,Other	cg11004501	chr13:77461056	13	77461056	KCTD12	Island	-0.5551632	0.117	0.00000208	-	27602958_smoking_packyears_discovery
Freeman JR	-	27602958	2016-10-25	Smoking pack-years	EFO_0006526, EFO_0005671, EFO_0004318	Discovery	Additional file 1	DNA methylation	Smoking pack-years	Age, sex, ethnicity, cell type, EGFR mutation status and KRAS mutation status	M values	Pack-years	Illumina HumanMethylation450	Lung adenocarcinoma and lung squamous cell	-	326	1	67	Both	European,African,Other	cg22005634	chr20:62152128	20	62152128	PPDPF	Island	-0.4661092	0.0983	0.00000212	-	27602958_smoking_packyears_discovery
Freeman JR	-	27602958	2016-10-25	Smoking pack-years	EFO_0006526, EFO_0005671, EFO_0004318	Discovery	Additional file 1	DNA methylation	Smoking pack-years	Age, sex, ethnicity, cell type, EGFR mutation status and KRAS mutation status	M values	Pack-years	Illumina HumanMethylation450	Lung adenocarcinoma and lung squamous cell	-	326	1	67	Both	European,African,Other	cg19916637	chr8:95961757	8	95961757	TP53INP1	Island	-0.6496862	0.1372	0.0000022	-	27602958_smoking_packyears_discovery
Freeman JR	-	27602958	2016-10-25	Smoking pack-years	EFO_0006526, EFO_0005671, EFO_0004318	Lung adenocarcinoma	Additional file 2	DNA methylation	Smoking pack-years	Age, sex, ethnicity, cell type, EGFR mutation status and KRAS mutation status	M values	Pack-years	Illumina HumanMethylation450	Lung adenocarcinoma	-	511	1	66.8	Both	European,African,Other	cg22515201	chr22:38577827	22	38577827	PLA2G6	Island	-0.87192453	0.1843	0.00000223	-	27602958_smoking_packyears_lung_adenocarcinoma
Freeman JR	-	27602958	2016-10-25	Smoking pack-years	EFO_0006526, EFO_0005671, EFO_0004318	Replication	Additional file 1	DNA methylation	Smoking pack-years	Age, sex, ethnicity, cell type, EGFR mutation status and KRAS mutation status	M values	Pack-years	Illumina HumanMethylation450	Lung adenocarcinoma and lung squamous cell	-	185	1	66.4	Both	European,African,Other	cg16200496	chr19:13107141	19	13107141	NFIX	Island	-0.8780391	0.1857	0.00000227	-	27602958_smoking_packyears_replication
Freeman JR	-	27602958	2016-10-25	Smoking pack-years	EFO_0006526, EFO_0005671, EFO_0004318	Discovery	Additional file 1	DNA methylation	Smoking pack-years	Age, sex, ethnicity, cell type, EGFR mutation status and KRAS mutation status	M values	Pack-years	Illumina HumanMethylation450	Lung adenocarcinoma and lung squamous cell	-	326	1	67	Both	European,African,Other	cg13426839	chr19:539489	19	539489	CDC34	Island	0.7645422	0.1623	0.00000245	-	27602958_smoking_packyears_discovery
Freeman JR	-	27602958	2016-10-25	Smoking pack-years	EFO_0006526, EFO_0005671, EFO_0004318	Replication	Additional file 1	DNA methylation	Smoking pack-years	Age, sex, ethnicity, cell type, EGFR mutation status and KRAS mutation status	M values	Pack-years	Illumina HumanMethylation450	Lung adenocarcinoma and lung squamous cell	-	185	1	66.4	Both	European,African,Other	cg09378497	chr16:1525169	16	1525169	CLCN7	Island	-0.5773869	0.1227	0.00000251	-	27602958_smoking_packyears_replication
Freeman JR	-	27602958	2016-10-25	Smoking pack-years	EFO_0006526, EFO_0005671, EFO_0004318	Discovery	Additional file 1	DNA methylation	Smoking pack-years	Age, sex, ethnicity, cell type, EGFR mutation status and KRAS mutation status	M values	Pack-years	Illumina HumanMethylation450	Lung adenocarcinoma and lung squamous cell	-	326	1	67	Both	European,African,Other	cg25924823	chr8:145113480	8	145113480	OPLAH	Island	0.5943884	0.1264	0.00000259	-	27602958_smoking_packyears_discovery
Freeman JR	-	27602958	2016-10-25	Smoking pack-years	EFO_0006526, EFO_0005671, EFO_0004318	Lung squamous cell	Additional file 3	DNA methylation	Smoking pack-years	Age, sex, ethnicity, cell type, EGFR mutation status and KRAS mutation status	M values	Pack-years	Illumina HumanMethylation450	Lung squamous cell	-	511	1	66.8	Both	European,African,Other	cg11004501	chr13:77461056	13	77461056	KCTD12	Island	-0.6931877	0.1475	0.00000261	-	27602958_smoking_packyears_lung_squamous_cell
Freeman JR	-	27602958	2016-10-25	Smoking pack-years	EFO_0006526, EFO_0005671, EFO_0004318	Discovery	Additional file 1	DNA methylation	Smoking pack-years	Age, sex, ethnicity, cell type, EGFR mutation status and KRAS mutation status	M values	Pack-years	Illumina HumanMethylation450	Lung adenocarcinoma and lung squamous cell	-	326	1	67	Both	European,African,Other	cg23790326	chr15:41245406	15	41245406	CHAC1	Island	-0.6145027	0.1309	0.00000269	-	27602958_smoking_packyears_discovery
Freeman JR	-	27602958	2016-10-25	Smoking pack-years	EFO_0006526, EFO_0005671, EFO_0004318	Lung squamous cell	Additional file 3	DNA methylation	Smoking pack-years	Age, sex, ethnicity, cell type, EGFR mutation status and KRAS mutation status	M values	Pack-years	Illumina HumanMethylation450	Lung squamous cell	-	511	1	66.8	Both	European,African,Other	cg18873530	chr19:49315663	19	49315663	BCAT2	Island	-0.8089827	0.1727	0.0000028	-	27602958_smoking_packyears_lung_squamous_cell
Freeman JR	-	27602958	2016-10-25	Smoking pack-years	EFO_0006526, EFO_0005671, EFO_0004318	Lung adenocarcinoma	Additional file 2	DNA methylation	Smoking pack-years	Age, sex, ethnicity, cell type, EGFR mutation status and KRAS mutation status	M values	Pack-years	Illumina HumanMethylation450	Lung adenocarcinoma	-	511	1	66.8	Both	European,African,Other	cg00265578	chr17:27895564	17	27895564	TP53I13	Island	-0.65294652	0.1401	0.00000314	-	27602958_smoking_packyears_lung_adenocarcinoma
Freeman JR	-	27602958	2016-10-25	Smoking pack-years	EFO_0006526, EFO_0005671, EFO_0004318	Replication	Additional file 1	DNA methylation	Smoking pack-years	Age, sex, ethnicity, cell type, EGFR mutation status and KRAS mutation status	M values	Pack-years	Illumina HumanMethylation450	Lung adenocarcinoma and lung squamous cell	-	185	1	66.4	Both	European,African,Other	cg02456708	chr17:27895477	17	27895477	ABHD15;TP53I13	Island	-0.4558489	0.0982	0.00000344	-	27602958_smoking_packyears_replication
Freeman JR	-	27602958	2016-10-25	Smoking pack-years	EFO_0006526, EFO_0005671, EFO_0004318	Replication	Additional file 1	DNA methylation	Smoking pack-years	Age, sex, ethnicity, cell type, EGFR mutation status and KRAS mutation status	M values	Pack-years	Illumina HumanMethylation450	Lung adenocarcinoma and lung squamous cell	-	185	1	66.4	Both	European,African,Other	cg26569144	chr5:170846504	5	170846504	FGF18	Island	-0.9635831	0.2076	0.00000346	-	27602958_smoking_packyears_replication
Freeman JR	-	27602958	2016-10-25	Smoking pack-years	EFO_0006526, EFO_0005671, EFO_0004318	Replication	Additional file 1	DNA methylation	Smoking pack-years	Age, sex, ethnicity, cell type, EGFR mutation status and KRAS mutation status	M values	Pack-years	Illumina HumanMethylation450	Lung adenocarcinoma and lung squamous cell	-	185	1	66.4	Both	European,African,Other	cg01014490	chr1:714177	1	714177	-	Island	-0.9814672	0.2116	0.00000353	-	27602958_smoking_packyears_replication
Freeman JR	-	27602958	2016-10-25	Smoking pack-years	EFO_0006526, EFO_0005671, EFO_0004318	Replication	Additional file 1	DNA methylation	Smoking pack-years	Age, sex, ethnicity, cell type, EGFR mutation status and KRAS mutation status	M values	Pack-years	Illumina HumanMethylation450	Lung adenocarcinoma and lung squamous cell	-	185	1	66.4	Both	European,African,Other	cg23326811	chr10:11865525	10	11865525	C10orf47	Island	-0.8253493	0.1792	0.00000411	-	27602958_smoking_packyears_replication
Freeman JR	-	27602958	2016-10-25	Smoking pack-years	EFO_0006526, EFO_0005671, EFO_0004318	Replication	Additional file 1	DNA methylation	Smoking pack-years	Age, sex, ethnicity, cell type, EGFR mutation status and KRAS mutation status	M values	Pack-years	Illumina HumanMethylation450	Lung adenocarcinoma and lung squamous cell	-	185	1	66.4	Both	European,African,Other	cg23087239	chr3:134080574	3	134080574	AMOTL2	Island	0.7851794	0.1706	0.00000417	-	27602958_smoking_packyears_replication
Freeman JR	-	27602958	2016-10-25	Smoking pack-years	EFO_0006526, EFO_0005671, EFO_0004318	Discovery	Additional file 1	DNA methylation	Smoking pack-years	Age, sex, ethnicity, cell type, EGFR mutation status and KRAS mutation status	M values	Pack-years	Illumina HumanMethylation450	Lung adenocarcinoma and lung squamous cell	-	326	1	67	Both	European,African,Other	cg05933803	chr17:27895641	17	27895641	TP53I13	Island	-0.1519198	0.033	0.00000419	-	27602958_smoking_packyears_discovery
Freeman JR	-	27602958	2016-10-25	Smoking pack-years	EFO_0006526, EFO_0005671, EFO_0004318	Discovery	Additional file 1	DNA methylation	Smoking pack-years	Age, sex, ethnicity, cell type, EGFR mutation status and KRAS mutation status	M values	Pack-years	Illumina HumanMethylation450	Lung adenocarcinoma and lung squamous cell	-	326	1	67	Both	European,African,Other	cg21701395	chr8:95961492	8	95961492	TP53INP1	Island	-0.6431522	0.1399	0.00000428	-	27602958_smoking_packyears_discovery
Freeman JR	-	27602958	2016-10-25	Smoking pack-years	EFO_0006526, EFO_0005671, EFO_0004318	Discovery	Additional file 1	DNA methylation	Smoking pack-years	Age, sex, ethnicity, cell type, EGFR mutation status and KRAS mutation status	M values	Pack-years	Illumina HumanMethylation450	Lung adenocarcinoma and lung squamous cell	-	326	1	67	Both	European,African,Other	cg24948990	chr8:143820828	8	143820828	-	Island	-0.7104795	0.1556	0.00000494	-	27602958_smoking_packyears_discovery
Freeman JR	-	27602958	2016-10-25	Smoking pack-years	EFO_0006526, EFO_0005671, EFO_0004318	Discovery	Additional file 1	DNA methylation	Smoking pack-years	Age, sex, ethnicity, cell type, EGFR mutation status and KRAS mutation status	M values	Pack-years	Illumina HumanMethylation450	Lung adenocarcinoma and lung squamous cell	-	326	1	67	Both	European,African,Other	cg04880618	chr17:74706567	17	74706567	MXRA7	Island	-1.0022516	0.2195	0.00000496	-	27602958_smoking_packyears_discovery
Freeman JR	-	27602958	2016-10-25	Smoking pack-years	EFO_0006526, EFO_0005671, EFO_0004318	Lung squamous cell	Additional file 3	DNA methylation	Smoking pack-years	Age, sex, ethnicity, cell type, EGFR mutation status and KRAS mutation status	M values	Pack-years	Illumina HumanMethylation450	Lung squamous cell	-	511	1	66.8	Both	European,African,Other	cg11875268	chr12:54576025	12	54576025	SMUG1	Open sea	1.6562172	0.3628	0.000005	-	27602958_smoking_packyears_lung_squamous_cell
Freeman JR	-	27602958	2016-10-25	Smoking pack-years	EFO_0006526, EFO_0005671, EFO_0004318	Replication	Additional file 1	DNA methylation	Smoking pack-years	Age, sex, ethnicity, cell type, EGFR mutation status and KRAS mutation status	M values	Pack-years	Illumina HumanMethylation450	Lung adenocarcinoma and lung squamous cell	-	185	1	66.4	Both	European,African,Other	cg18496502	chr19:42880157	19	42880157	MEGF8	Island	0.7935839	0.1739	0.00000502	-	27602958_smoking_packyears_replication
Freeman JR	-	27602958	2016-10-25	Smoking pack-years	EFO_0006526, EFO_0005671, EFO_0004318	Replication	Additional file 1	DNA methylation	Smoking pack-years	Age, sex, ethnicity, cell type, EGFR mutation status and KRAS mutation status	M values	Pack-years	Illumina HumanMethylation450	Lung adenocarcinoma and lung squamous cell	-	185	1	66.4	Both	European,African,Other	cg01725199	chr9:101569990	9	101569990	GALNT12	Island	-0.6520189	0.1429	0.00000503	-	27602958_smoking_packyears_replication
Freeman JR	-	27602958	2016-10-25	Smoking pack-years	EFO_0006526, EFO_0005671, EFO_0004318	Discovery	Additional file 1	DNA methylation	Smoking pack-years	Age, sex, ethnicity, cell type, EGFR mutation status and KRAS mutation status	M values	Pack-years	Illumina HumanMethylation450	Lung adenocarcinoma and lung squamous cell	-	326	1	67	Both	European,African,Other	cg23087239	chr3:134080574	3	134080574	AMOTL2	Island	0.6788629	0.1488	0.00000509	-	27602958_smoking_packyears_discovery
Freeman JR	-	27602958	2016-10-25	Smoking pack-years	EFO_0006526, EFO_0005671, EFO_0004318	Discovery	Additional file 1	DNA methylation	Smoking pack-years	Age, sex, ethnicity, cell type, EGFR mutation status and KRAS mutation status	M values	Pack-years	Illumina HumanMethylation450	Lung adenocarcinoma and lung squamous cell	-	326	1	67	Both	European,African,Other	cg15469014	chr19:11032172	19	11032172	CARM1	Island	0.5210553	0.1143	0.00000511	-	27602958_smoking_packyears_discovery
Freeman JR	-	27602958	2016-10-25	Smoking pack-years	EFO_0006526, EFO_0005671, EFO_0004318	Replication	Additional file 1	DNA methylation	Smoking pack-years	Age, sex, ethnicity, cell type, EGFR mutation status and KRAS mutation status	M values	Pack-years	Illumina HumanMethylation450	Lung adenocarcinoma and lung squamous cell	-	185	1	66.4	Both	European,African,Other	cg13341720	chr19:6740888	19	6740888	TRIP10	Island	-0.6601515	0.1448	0.00000515	-	27602958_smoking_packyears_replication
Freeman JR	-	27602958	2016-10-25	Smoking pack-years	EFO_0006526, EFO_0005671, EFO_0004318	Replication	Additional file 1	DNA methylation	Smoking pack-years	Age, sex, ethnicity, cell type, EGFR mutation status and KRAS mutation status	M values	Pack-years	Illumina HumanMethylation450	Lung adenocarcinoma and lung squamous cell	-	185	1	66.4	Both	European,African,Other	cg19168961	chr15:41245649	15	41245649	CHAC1	Island	-0.5396224	0.1189	0.00000564	-	27602958_smoking_packyears_replication
Freeman JR	-	27602958	2016-10-25	Smoking pack-years	EFO_0006526, EFO_0005671, EFO_0004318	Lung adenocarcinoma	Additional file 2	DNA methylation	Smoking pack-years	Age, sex, ethnicity, cell type, EGFR mutation status and KRAS mutation status	M values	Pack-years	Illumina HumanMethylation450	Lung adenocarcinoma	-	511	1	66.8	Both	European,African,Other	cg19634213	chr10:89621792	10	89621792	PTEN;KILLIN	Island	-0.78463685	0.173	0.00000575	-	27602958_smoking_packyears_lung_adenocarcinoma
Freeman JR	-	27602958	2016-10-25	Smoking pack-years	EFO_0006526, EFO_0005671, EFO_0004318	Discovery	Additional file 1	DNA methylation	Smoking pack-years	Age, sex, ethnicity, cell type, EGFR mutation status and KRAS mutation status	M values	Pack-years	Illumina HumanMethylation450	Lung adenocarcinoma and lung squamous cell	-	326	1	67	Both	European,African,Other	cg13341720	chr19:6740888	19	6740888	TRIP10	Island	-0.4975973	0.1098	0.00000587	-	27602958_smoking_packyears_discovery
Freeman JR	-	27602958	2016-10-25	Smoking pack-years	EFO_0006526, EFO_0005671, EFO_0004318	Discovery	Additional file 1	DNA methylation	Smoking pack-years	Age, sex, ethnicity, cell type, EGFR mutation status and KRAS mutation status	M values	Pack-years	Illumina HumanMethylation450	Lung adenocarcinoma and lung squamous cell	-	326	1	67	Both	European,African,Other	cg22865720	chr1:1981816	1	1981816	PRKCZ	Island	-0.5329098	0.1176	0.00000591	-	27602958_smoking_packyears_discovery
Freeman JR	-	27602958	2016-10-25	Smoking pack-years	EFO_0006526, EFO_0005671, EFO_0004318	Lung adenocarcinoma	Additional file 2	DNA methylation	Smoking pack-years	Age, sex, ethnicity, cell type, EGFR mutation status and KRAS mutation status	M values	Pack-years	Illumina HumanMethylation450	Lung adenocarcinoma	-	511	1	66.8	Both	European,African,Other	cg24823993	chr22:42085003	22	42085003	NHP2L1	Island	-0.34889161	0.0771	0.00000603	-	27602958_smoking_packyears_lung_adenocarcinoma
Freeman JR	-	27602958	2016-10-25	Smoking pack-years	EFO_0006526, EFO_0005671, EFO_0004318	Discovery	Additional file 1	DNA methylation	Smoking pack-years	Age, sex, ethnicity, cell type, EGFR mutation status and KRAS mutation status	M values	Pack-years	Illumina HumanMethylation450	Lung adenocarcinoma and lung squamous cell	-	326	1	67	Both	European,African,Other	cg11516830	chr17:75242950	17	75242950	-	Island	0.3402058	0.0754	0.00000637	-	27602958_smoking_packyears_discovery
Freeman JR	-	27602958	2016-10-25	Smoking pack-years	EFO_0006526, EFO_0005671, EFO_0004318	Replication	Additional file 1	DNA methylation	Smoking pack-years	Age, sex, ethnicity, cell type, EGFR mutation status and KRAS mutation status	M values	Pack-years	Illumina HumanMethylation450	Lung adenocarcinoma and lung squamous cell	-	185	1	66.4	Both	European,African,Other	cg24823993	chr22:42085003	22	42085003	NHP2L1	Island	-0.2438715	0.0541	0.00000652	-	27602958_smoking_packyears_replication
Freeman JR	-	27602958	2016-10-25	Smoking pack-years	EFO_0006526, EFO_0005671, EFO_0004318	Lung adenocarcinoma	Additional file 2	DNA methylation	Smoking pack-years	Age, sex, ethnicity, cell type, EGFR mutation status and KRAS mutation status	M values	Pack-years	Illumina HumanMethylation450	Lung adenocarcinoma	-	511	1	66.8	Both	European,African,Other	cg08135278	chr1:226070709	1	226070709	TMEM63A	Island	-0.65276408	0.1451	0.00000687	-	27602958_smoking_packyears_lung_adenocarcinoma
Freeman JR	-	27602958	2016-10-25	Smoking pack-years	EFO_0006526, EFO_0005671, EFO_0004318	Lung adenocarcinoma	Additional file 2	DNA methylation	Smoking pack-years	Age, sex, ethnicity, cell type, EGFR mutation status and KRAS mutation status	M values	Pack-years	Illumina HumanMethylation450	Lung adenocarcinoma	-	511	1	66.8	Both	European,African,Other	cg20737072	chr19:5785252	19	5785252	PRR22;DUS3L	North shore	0.43694872	0.0973	0.0000071	-	27602958_smoking_packyears_lung_adenocarcinoma
Freeman JR	-	27602958	2016-10-25	Smoking pack-years	EFO_0006526, EFO_0005671, EFO_0004318	Lung adenocarcinoma	Additional file 2	DNA methylation	Smoking pack-years	Age, sex, ethnicity, cell type, EGFR mutation status and KRAS mutation status	M values	Pack-years	Illumina HumanMethylation450	Lung adenocarcinoma	-	511	1	66.8	Both	European,African,Other	cg19390357	chr16:12211186	16	12211186	SNX29	Island	0.71496551	0.1592	0.00000713	-	27602958_smoking_packyears_lung_adenocarcinoma
Freeman JR	-	27602958	2016-10-25	Smoking pack-years	EFO_0006526, EFO_0005671, EFO_0004318	Discovery	Additional file 1	DNA methylation	Smoking pack-years	Age, sex, ethnicity, cell type, EGFR mutation status and KRAS mutation status	M values	Pack-years	Illumina HumanMethylation450	Lung adenocarcinoma and lung squamous cell	-	326	1	67	Both	European,African,Other	cg02112681	chr7:1120141	7	1120141	C7orf50	Island	0.6535378	0.1456	0.00000716	-	27602958_smoking_packyears_discovery
Freeman JR	-	27602958	2016-10-25	Smoking pack-years	EFO_0006526, EFO_0005671, EFO_0004318	Lung adenocarcinoma	Additional file 2	DNA methylation	Smoking pack-years	Age, sex, ethnicity, cell type, EGFR mutation status and KRAS mutation status	M values	Pack-years	Illumina HumanMethylation450	Lung adenocarcinoma	-	511	1	66.8	Both	European,African,Other	cg13426839	chr19:539489	19	539489	CDC34	Island	0.41143101	0.0917	0.00000723	-	27602958_smoking_packyears_lung_adenocarcinoma
Freeman JR	-	27602958	2016-10-25	Smoking pack-years	EFO_0006526, EFO_0005671, EFO_0004318	Replication	Additional file 1	DNA methylation	Smoking pack-years	Age, sex, ethnicity, cell type, EGFR mutation status and KRAS mutation status	M values	Pack-years	Illumina HumanMethylation450	Lung adenocarcinoma and lung squamous cell	-	185	1	66.4	Both	European,African,Other	cg20480233	chr14:23451154	14	23451154	JUB	Island	-0.8052719	0.1798	0.00000747	-	27602958_smoking_packyears_replication
Freeman JR	-	27602958	2016-10-25	Smoking pack-years	EFO_0006526, EFO_0005671, EFO_0004318	Lung adenocarcinoma	Additional file 2	DNA methylation	Smoking pack-years	Age, sex, ethnicity, cell type, EGFR mutation status and KRAS mutation status	M values	Pack-years	Illumina HumanMethylation450	Lung adenocarcinoma	-	511	1	66.8	Both	European,African,Other	cg09939831	chr14:55596647	14	55596647	LGALS3	Island	-0.6686604	0.1493	0.00000752	-	27602958_smoking_packyears_lung_adenocarcinoma
Freeman JR	-	27602958	2016-10-25	Smoking pack-years	EFO_0006526, EFO_0005671, EFO_0004318	Replication	Additional file 1	DNA methylation	Smoking pack-years	Age, sex, ethnicity, cell type, EGFR mutation status and KRAS mutation status	M values	Pack-years	Illumina HumanMethylation450	Lung adenocarcinoma and lung squamous cell	-	185	1	66.4	Both	European,African,Other	cg06788803	chr1:45805948	1	45805948	MUTYH;TOE1	Island	-0.2256358	0.0505	0.00000781	-	27602958_smoking_packyears_replication
Freeman JR	-	27602958	2016-10-25	Smoking pack-years	EFO_0006526, EFO_0005671, EFO_0004318	Lung adenocarcinoma	Additional file 2	DNA methylation	Smoking pack-years	Age, sex, ethnicity, cell type, EGFR mutation status and KRAS mutation status	M values	Pack-years	Illumina HumanMethylation450	Lung adenocarcinoma	-	511	1	66.8	Both	European,African,Other	cg06839820	chr22:43485161	22	43485161	TTLL1	Island	-0.4944276	0.1107	0.00000803	-	27602958_smoking_packyears_lung_adenocarcinoma
Freeman JR	-	27602958	2016-10-25	Smoking pack-years	EFO_0006526, EFO_0005671, EFO_0004318	Lung adenocarcinoma	Additional file 2	DNA methylation	Smoking pack-years	Age, sex, ethnicity, cell type, EGFR mutation status and KRAS mutation status	M values	Pack-years	Illumina HumanMethylation450	Lung adenocarcinoma	-	511	1	66.8	Both	European,African,Other	cg07243103	chr16:699355	16	699355	WDR90	Island	-0.34535423	0.0774	0.0000082	-	27602958_smoking_packyears_lung_adenocarcinoma
Freeman JR	-	27602958	2016-10-25	Smoking pack-years	EFO_0006526, EFO_0005671, EFO_0004318	Lung adenocarcinoma	Additional file 2	DNA methylation	Smoking pack-years	Age, sex, ethnicity, cell type, EGFR mutation status and KRAS mutation status	M values	Pack-years	Illumina HumanMethylation450	Lung adenocarcinoma	-	511	1	66.8	Both	European,African,Other	cg05288071	chr19:7712539	19	7712539	STXBP2	South shore	0.69762267	0.157	0.0000089	-	27602958_smoking_packyears_lung_adenocarcinoma
Freeman JR	-	27602958	2016-10-25	Smoking pack-years	EFO_0006526, EFO_0005671, EFO_0004318	Discovery	Additional file 1	DNA methylation	Smoking pack-years	Age, sex, ethnicity, cell type, EGFR mutation status and KRAS mutation status	M values	Pack-years	Illumina HumanMethylation450	Lung adenocarcinoma and lung squamous cell	-	326	1	67	Both	European,African,Other	cg23326811	chr10:11865525	10	11865525	C10orf47	Island	-0.5904602	0.133	0.00000896	-	27602958_smoking_packyears_discovery
Freeman JR	-	27602958	2016-10-25	Smoking pack-years	EFO_0006526, EFO_0005671, EFO_0004318	Discovery	Additional file 1	DNA methylation	Smoking pack-years	Age, sex, ethnicity, cell type, EGFR mutation status and KRAS mutation status	M values	Pack-years	Illumina HumanMethylation450	Lung adenocarcinoma and lung squamous cell	-	326	1	67	Both	European,African,Other	cg02250553	chr10:134511404	10	134511404	INPP5A	Open sea	0.509141	0.115	0.00000959	-	27602958_smoking_packyears_discovery
Freeman JR	-	27602958	2016-10-25	Smoking pack-years	EFO_0006526, EFO_0005671, EFO_0004318	Discovery	Additional file 1	DNA methylation	Smoking pack-years	Age, sex, ethnicity, cell type, EGFR mutation status and KRAS mutation status	M values	Pack-years	Illumina HumanMethylation450	Lung adenocarcinoma and lung squamous cell	-	326	1	67	Both	European,African,Other	cg17323383	chr3:182896670	3	182896670	MCF2L2	North shore	-0.784142	0.1772	0.00000967	-	27602958_smoking_packyears_discovery
Freeman JR	-	27602958	2016-10-25	Smoking pack-years	EFO_0006526, EFO_0005671, EFO_0004318	Discovery	Additional file 1	DNA methylation	Smoking pack-years	Age, sex, ethnicity, cell type, EGFR mutation status and KRAS mutation status	M values	Pack-years	Illumina HumanMethylation450	Lung adenocarcinoma and lung squamous cell	-	326	1	67	Both	European,African,Other	cg02232531	chr16:699316	16	699316	WDR90	Island	-0.2671127	0.0604	0.00000973	-	27602958_smoking_packyears_discovery
Freeman JR	-	27602958	2016-10-25	Smoking pack-years	EFO_0006526, EFO_0005671, EFO_0004318	Replication	Additional file 1	DNA methylation	Smoking pack-years	Age, sex, ethnicity, cell type, EGFR mutation status and KRAS mutation status	M values	Pack-years	Illumina HumanMethylation450	Lung adenocarcinoma and lung squamous cell	-	185	1	66.4	Both	European,African,Other	cg02250553	chr10:134511404	10	134511404	INPP5A	Open sea	0.4427942	0.1003	0.0000101	-	27602958_smoking_packyears_replication
Freeman JR	-	27602958	2016-10-25	Smoking pack-years	EFO_0006526, EFO_0005671, EFO_0004318	Discovery	Additional file 1	DNA methylation	Smoking pack-years	Age, sex, ethnicity, cell type, EGFR mutation status and KRAS mutation status	M values	Pack-years	Illumina HumanMethylation450	Lung adenocarcinoma and lung squamous cell	-	326	1	67	Both	European,African,Other	cg23423230	chr21:43327978	21	43327978	C2CD2	Island	0.4367492	0.0993	0.0000108	-	27602958_smoking_packyears_discovery
Freeman JR	-	27602958	2016-10-25	Smoking pack-years	EFO_0006526, EFO_0005671, EFO_0004318	Discovery	Additional file 1	DNA methylation	Smoking pack-years	Age, sex, ethnicity, cell type, EGFR mutation status and KRAS mutation status	M values	Pack-years	Illumina HumanMethylation450	Lung adenocarcinoma and lung squamous cell	-	326	1	67	Both	European,African,Other	cg07469408	chr14:75894384	14	75894384	JDP2	Island	-0.4312961	0.0982	0.0000111	-	27602958_smoking_packyears_discovery
Freeman JR	-	27602958	2016-10-25	Smoking pack-years	EFO_0006526, EFO_0005671, EFO_0004318	Replication	Additional file 1	DNA methylation	Smoking pack-years	Age, sex, ethnicity, cell type, EGFR mutation status and KRAS mutation status	M values	Pack-years	Illumina HumanMethylation450	Lung adenocarcinoma and lung squamous cell	-	185	1	66.4	Both	European,African,Other	cg23790326	chr15:41245406	15	41245406	CHAC1	Island	-0.6234848	0.1423	0.0000118	-	27602958_smoking_packyears_replication
Freeman JR	-	27602958	2016-10-25	Smoking pack-years	EFO_0006526, EFO_0005671, EFO_0004318	Replication	Additional file 1	DNA methylation	Smoking pack-years	Age, sex, ethnicity, cell type, EGFR mutation status and KRAS mutation status	M values	Pack-years	Illumina HumanMethylation450	Lung adenocarcinoma and lung squamous cell	-	185	1	66.4	Both	European,African,Other	cg20737072	chr19:5785252	19	5785252	PRR22;DUS3L	North shore	0.4418865	0.1008	0.0000118	-	27602958_smoking_packyears_replication
Freeman JR	-	27602958	2016-10-25	Smoking pack-years	EFO_0006526, EFO_0005671, EFO_0004318	Lung squamous cell	Additional file 3	DNA methylation	Smoking pack-years	Age, sex, ethnicity, cell type, EGFR mutation status and KRAS mutation status	M values	Pack-years	Illumina HumanMethylation450	Lung squamous cell	-	511	1	66.8	Both	European,African,Other	cg06839820	chr22:43485161	22	43485161	TTLL1	Island	-0.685074	0.1564	0.0000119	-	27602958_smoking_packyears_lung_squamous_cell
Freeman JR	-	27602958	2016-10-25	Smoking pack-years	EFO_0006526, EFO_0005671, EFO_0004318	Replication	Additional file 1	DNA methylation	Smoking pack-years	Age, sex, ethnicity, cell type, EGFR mutation status and KRAS mutation status	M values	Pack-years	Illumina HumanMethylation450	Lung adenocarcinoma and lung squamous cell	-	185	1	66.4	Both	European,African,Other	cg14826215	chr7:139762483	7	139762483	PARP12	Island	-0.7622945	0.1741	0.000012	-	27602958_smoking_packyears_replication
Freeman JR	-	27602958	2016-10-25	Smoking pack-years	EFO_0006526, EFO_0005671, EFO_0004318	Lung adenocarcinoma	Additional file 2	DNA methylation	Smoking pack-years	Age, sex, ethnicity, cell type, EGFR mutation status and KRAS mutation status	M values	Pack-years	Illumina HumanMethylation450	Lung adenocarcinoma	-	511	1	66.8	Both	European,African,Other	cg11875268	chr12:54576025	12	54576025	SMUG1	Open sea	0.47276903	0.108	0.000012	-	27602958_smoking_packyears_lung_adenocarcinoma
Freeman JR	-	27602958	2016-10-25	Smoking pack-years	EFO_0006526, EFO_0005671, EFO_0004318	Discovery	Additional file 1	DNA methylation	Smoking pack-years	Age, sex, ethnicity, cell type, EGFR mutation status and KRAS mutation status	M values	Pack-years	Illumina HumanMethylation450	Lung adenocarcinoma and lung squamous cell	-	326	1	67	Both	European,African,Other	cg10729325	chr3:10206413	3	10206413	IRAK2	North shore	-0.5872971	0.1343	0.0000123	-	27602958_smoking_packyears_discovery
Freeman JR	-	27602958	2016-10-25	Smoking pack-years	EFO_0006526, EFO_0005671, EFO_0004318	Discovery	Additional file 1	DNA methylation	Smoking pack-years	Age, sex, ethnicity, cell type, EGFR mutation status and KRAS mutation status	M values	Pack-years	Illumina HumanMethylation450	Lung adenocarcinoma and lung squamous cell	-	326	1	67	Both	European,African,Other	cg08843134	chr16:2301653	16	2301653	DCI	Island	0.4885532	0.1119	0.0000127	-	27602958_smoking_packyears_discovery
Freeman JR	-	27602958	2016-10-25	Smoking pack-years	EFO_0006526, EFO_0005671, EFO_0004318	Replication	Additional file 1	DNA methylation	Smoking pack-years	Age, sex, ethnicity, cell type, EGFR mutation status and KRAS mutation status	M values	Pack-years	Illumina HumanMethylation450	Lung adenocarcinoma and lung squamous cell	-	185	1	66.4	Both	European,African,Other	cg03779431	chr21:27543124	21	27543124	APP	Island	-0.390123	0.0897	0.0000138	-	27602958_smoking_packyears_replication
Freeman JR	-	27602958	2016-10-25	Smoking pack-years	EFO_0006526, EFO_0005671, EFO_0004318	Lung adenocarcinoma	Additional file 2	DNA methylation	Smoking pack-years	Age, sex, ethnicity, cell type, EGFR mutation status and KRAS mutation status	M values	Pack-years	Illumina HumanMethylation450	Lung adenocarcinoma	-	511	1	66.8	Both	European,African,Other	cg05624510	chr15:41245527	15	41245527	CHAC1	Island	-0.57819991	0.1332	0.0000142	-	27602958_smoking_packyears_lung_adenocarcinoma
Freeman JR	-	27602958	2016-10-25	Smoking pack-years	EFO_0006526, EFO_0005671, EFO_0004318	Replication	Additional file 1	DNA methylation	Smoking pack-years	Age, sex, ethnicity, cell type, EGFR mutation status and KRAS mutation status	M values	Pack-years	Illumina HumanMethylation450	Lung adenocarcinoma and lung squamous cell	-	185	1	66.4	Both	European,African,Other	cg09939831	chr14:55596647	14	55596647	LGALS3	Island	-0.8538753	0.1968	0.0000143	-	27602958_smoking_packyears_replication
Freeman JR	-	27602958	2016-10-25	Smoking pack-years	EFO_0006526, EFO_0005671, EFO_0004318	Discovery	Additional file 1	DNA methylation	Smoking pack-years	Age, sex, ethnicity, cell type, EGFR mutation status and KRAS mutation status	M values	Pack-years	Illumina HumanMethylation450	Lung adenocarcinoma and lung squamous cell	-	326	1	67	Both	European,African,Other	cg25771041	chr3:149376042	3	149376042	WWTR1	Island	-0.3525423	0.0814	0.0000148	-	27602958_smoking_packyears_discovery
Freeman JR	-	27602958	2016-10-25	Smoking pack-years	EFO_0006526, EFO_0005671, EFO_0004318	Lung adenocarcinoma	Additional file 2	DNA methylation	Smoking pack-years	Age, sex, ethnicity, cell type, EGFR mutation status and KRAS mutation status	M values	Pack-years	Illumina HumanMethylation450	Lung adenocarcinoma	-	511	1	66.8	Both	European,African,Other	cg25144930	chr11:2398505	11	2398505	CD81	Island	-0.69236913	0.1601	0.0000153	-	27602958_smoking_packyears_lung_adenocarcinoma
Freeman JR	-	27602958	2016-10-25	Smoking pack-years	EFO_0006526, EFO_0005671, EFO_0004318	Lung adenocarcinoma	Additional file 2	DNA methylation	Smoking pack-years	Age, sex, ethnicity, cell type, EGFR mutation status and KRAS mutation status	M values	Pack-years	Illumina HumanMethylation450	Lung adenocarcinoma	-	511	1	66.8	Both	European,African,Other	cg03779431	chr21:27543124	21	27543124	APP	Island	-0.35109102	0.0813	0.0000158	-	27602958_smoking_packyears_lung_adenocarcinoma
Freeman JR	-	27602958	2016-10-25	Smoking pack-years	EFO_0006526, EFO_0005671, EFO_0004318	Discovery	Additional file 1	DNA methylation	Smoking pack-years	Age, sex, ethnicity, cell type, EGFR mutation status and KRAS mutation status	M values	Pack-years	Illumina HumanMethylation450	Lung adenocarcinoma and lung squamous cell	-	326	1	67	Both	European,African,Other	cg07556403	chr20:62152146	20	62152146	PPDPF	Island	-0.4610195	0.1069	0.0000162	-	27602958_smoking_packyears_discovery
Freeman JR	-	27602958	2016-10-25	Smoking pack-years	EFO_0006526, EFO_0005671, EFO_0004318	Discovery	Additional file 1	DNA methylation	Smoking pack-years	Age, sex, ethnicity, cell type, EGFR mutation status and KRAS mutation status	M values	Pack-years	Illumina HumanMethylation450	Lung adenocarcinoma and lung squamous cell	-	326	1	67	Both	European,African,Other	cg13128305	chr8:95961759	8	95961759	TP53INP1	Island	-0.4685586	0.1088	0.0000166	-	27602958_smoking_packyears_discovery
Freeman JR	-	27602958	2016-10-25	Smoking pack-years	EFO_0006526, EFO_0005671, EFO_0004318	Discovery	Additional file 1	DNA methylation	Smoking pack-years	Age, sex, ethnicity, cell type, EGFR mutation status and KRAS mutation status	M values	Pack-years	Illumina HumanMethylation450	Lung adenocarcinoma and lung squamous cell	-	326	1	67	Both	European,African,Other	cg20215367	chr8:143808432	8	143808432	C8orf55	Island	-0.5260664	0.1223	0.0000169	-	27602958_smoking_packyears_discovery
Freeman JR	-	27602958	2016-10-25	Smoking pack-years	EFO_0006526, EFO_0005671, EFO_0004318	Discovery	Additional file 1	DNA methylation	Smoking pack-years	Age, sex, ethnicity, cell type, EGFR mutation status and KRAS mutation status	M values	Pack-years	Illumina HumanMethylation450	Lung adenocarcinoma and lung squamous cell	-	326	1	67	Both	European,African,Other	cg26185554	chr17:1391406	17	1391406	MYO1C	Island	-0.5893289	0.1371	0.0000172	-	27602958_smoking_packyears_discovery
Freeman JR	-	27602958	2016-10-25	Smoking pack-years	EFO_0006526, EFO_0005671, EFO_0004318	Replication	Additional file 1	DNA methylation	Smoking pack-years	Age, sex, ethnicity, cell type, EGFR mutation status and KRAS mutation status	M values	Pack-years	Illumina HumanMethylation450	Lung adenocarcinoma and lung squamous cell	-	185	1	66.4	Both	European,African,Other	cg02516388	chr17:48503634	17	48503634	ACSF2	Island	-0.2506612	0.0583	0.0000173	-	27602958_smoking_packyears_replication
Freeman JR	-	27602958	2016-10-25	Smoking pack-years	EFO_0006526, EFO_0005671, EFO_0004318	Discovery	Additional file 1	DNA methylation	Smoking pack-years	Age, sex, ethnicity, cell type, EGFR mutation status and KRAS mutation status	M values	Pack-years	Illumina HumanMethylation450	Lung adenocarcinoma and lung squamous cell	-	326	1	67	Both	European,African,Other	cg08118159	chr19:41055208	19	41055208	SPTBN4	Island	-0.3635134	0.0846	0.0000174	-	27602958_smoking_packyears_discovery
Freeman JR	-	27602958	2016-10-25	Smoking pack-years	EFO_0006526, EFO_0005671, EFO_0004318	Discovery	Additional file 1	DNA methylation	Smoking pack-years	Age, sex, ethnicity, cell type, EGFR mutation status and KRAS mutation status	M values	Pack-years	Illumina HumanMethylation450	Lung adenocarcinoma and lung squamous cell	-	326	1	67	Both	European,African,Other	cg08806263	chr16:699293	16	699293	WDR90	Island	-0.2433563	0.0567	0.0000177	-	27602958_smoking_packyears_discovery
Freeman JR	-	27602958	2016-10-25	Smoking pack-years	EFO_0006526, EFO_0005671, EFO_0004318	Discovery	Additional file 1	DNA methylation	Smoking pack-years	Age, sex, ethnicity, cell type, EGFR mutation status and KRAS mutation status	M values	Pack-years	Illumina HumanMethylation450	Lung adenocarcinoma and lung squamous cell	-	326	1	67	Both	European,African,Other	cg02516388	chr17:48503634	17	48503634	ACSF2	Island	-0.2633854	0.0615	0.0000183	-	27602958_smoking_packyears_discovery
Freeman JR	-	27602958	2016-10-25	Smoking pack-years	EFO_0006526, EFO_0005671, EFO_0004318	Replication	Additional file 1	DNA methylation	Smoking pack-years	Age, sex, ethnicity, cell type, EGFR mutation status and KRAS mutation status	M values	Pack-years	Illumina HumanMethylation450	Lung adenocarcinoma and lung squamous cell	-	185	1	66.4	Both	European,African,Other	cg13264059	chr10:129705415	10	129705415	PTPRE	Island	-0.6092323	0.1424	0.0000188	-	27602958_smoking_packyears_replication
Freeman JR	-	27602958	2016-10-25	Smoking pack-years	EFO_0006526, EFO_0005671, EFO_0004318	Discovery	Additional file 1	DNA methylation	Smoking pack-years	Age, sex, ethnicity, cell type, EGFR mutation status and KRAS mutation status	M values	Pack-years	Illumina HumanMethylation450	Lung adenocarcinoma and lung squamous cell	-	326	1	67	Both	European,African,Other	cg08874430	chr8:11659970	8	11659970	FDFT1	Island	-0.4066875	0.0951	0.000019	-	27602958_smoking_packyears_discovery
Freeman JR	-	27602958	2016-10-25	Smoking pack-years	EFO_0006526, EFO_0005671, EFO_0004318	Lung adenocarcinoma	Additional file 2	DNA methylation	Smoking pack-years	Age, sex, ethnicity, cell type, EGFR mutation status and KRAS mutation status	M values	Pack-years	Illumina HumanMethylation450	Lung adenocarcinoma	-	511	1	66.8	Both	European,African,Other	cg12025027	chr17:1531232	17	1531232	SLC43A2	Island	-0.47260217	0.1108	0.0000199	-	27602958_smoking_packyears_lung_adenocarcinoma
Freeman JR	-	27602958	2016-10-25	Smoking pack-years	EFO_0006526, EFO_0005671, EFO_0004318	Lung squamous cell	Additional file 3	DNA methylation	Smoking pack-years	Age, sex, ethnicity, cell type, EGFR mutation status and KRAS mutation status	M values	Pack-years	Illumina HumanMethylation450	Lung squamous cell	-	511	1	66.8	Both	European,African,Other	cg04029055	chr17:37213281	17	37213281	-	Open sea	-0.8446499	0.1982	0.0000203	-	27602958_smoking_packyears_lung_squamous_cell
Freeman JR	-	27602958	2016-10-25	Smoking pack-years	EFO_0006526, EFO_0005671, EFO_0004318	Lung squamous cell	Additional file 3	DNA methylation	Smoking pack-years	Age, sex, ethnicity, cell type, EGFR mutation status and KRAS mutation status	M values	Pack-years	Illumina HumanMethylation450	Lung squamous cell	-	511	1	66.8	Both	European,African,Other	cg08843134	chr16:2301653	16	2301653	DCI	Island	0.7304948	0.1715	0.0000206	-	27602958_smoking_packyears_lung_squamous_cell
Freeman JR	-	27602958	2016-10-25	Smoking pack-years	EFO_0006526, EFO_0005671, EFO_0004318	Lung squamous cell	Additional file 3	DNA methylation	Smoking pack-years	Age, sex, ethnicity, cell type, EGFR mutation status and KRAS mutation status	M values	Pack-years	Illumina HumanMethylation450	Lung squamous cell	-	511	1	66.8	Both	European,African,Other	cg13620366	chr9:138839624	9	138839624	UBAC1	Open sea	0.8290719	0.1948	0.0000208	-	27602958_smoking_packyears_lung_squamous_cell
Freeman JR	-	27602958	2016-10-25	Smoking pack-years	EFO_0006526, EFO_0005671, EFO_0004318	Lung adenocarcinoma	Additional file 2	DNA methylation	Smoking pack-years	Age, sex, ethnicity, cell type, EGFR mutation status and KRAS mutation status	M values	Pack-years	Illumina HumanMethylation450	Lung adenocarcinoma	-	511	1	66.8	Both	European,African,Other	cg06788803	chr1:45805948	1	45805948	MUTYH;TOE1	Island	-0.24944161	0.0587	0.0000217	-	27602958_smoking_packyears_lung_adenocarcinoma
Freeman JR	-	27602958	2016-10-25	Smoking pack-years	EFO_0006526, EFO_0005671, EFO_0004318	Lung squamous cell	Additional file 3	DNA methylation	Smoking pack-years	Age, sex, ethnicity, cell type, EGFR mutation status and KRAS mutation status	M values	Pack-years	Illumina HumanMethylation450	Lung squamous cell	-	511	1	66.8	Both	European,African,Other	cg04151290	chr11:2398500	11	2398500	CD81	Island	-0.3433595	0.0809	0.0000217	-	27602958_smoking_packyears_lung_squamous_cell
Freeman JR	-	27602958	2016-10-25	Smoking pack-years	EFO_0006526, EFO_0005671, EFO_0004318	Lung adenocarcinoma	Additional file 2	DNA methylation	Smoking pack-years	Age, sex, ethnicity, cell type, EGFR mutation status and KRAS mutation status	M values	Pack-years	Illumina HumanMethylation450	Lung adenocarcinoma	-	511	1	66.8	Both	European,African,Other	cg26369667	chr11:101981789	11	101981789	YAP1	Island	-0.58003559	0.1369	0.0000226	-	27602958_smoking_packyears_lung_adenocarcinoma
Freeman JR	-	27602958	2016-10-25	Smoking pack-years	EFO_0006526, EFO_0005671, EFO_0004318	Discovery	Additional file 1	DNA methylation	Smoking pack-years	Age, sex, ethnicity, cell type, EGFR mutation status and KRAS mutation status	M values	Pack-years	Illumina HumanMethylation450	Lung adenocarcinoma and lung squamous cell	-	326	1	67	Both	European,African,Other	cg14716208	chr3:52089752	3	52089752	DUSP7	Island	-0.7785429	0.184	0.0000233	-	27602958_smoking_packyears_discovery
Freeman JR	-	27602958	2016-10-25	Smoking pack-years	EFO_0006526, EFO_0005671, EFO_0004318	Discovery	Additional file 1	DNA methylation	Smoking pack-years	Age, sex, ethnicity, cell type, EGFR mutation status and KRAS mutation status	M values	Pack-years	Illumina HumanMethylation450	Lung adenocarcinoma and lung squamous cell	-	326	1	67	Both	European,African,Other	cg09923107	chr20:30193892	20	30193892	ID1	Island	-0.7803923	0.1846	0.0000236	-	27602958_smoking_packyears_discovery
Freeman JR	-	27602958	2016-10-25	Smoking pack-years	EFO_0006526, EFO_0005671, EFO_0004318	Lung squamous cell	Additional file 3	DNA methylation	Smoking pack-years	Age, sex, ethnicity, cell type, EGFR mutation status and KRAS mutation status	M values	Pack-years	Illumina HumanMethylation450	Lung squamous cell	-	511	1	66.8	Both	European,African,Other	cg08874430	chr8:11659970	8	11659970	FDFT1	Island	-0.5175883	0.123	0.0000256	-	27602958_smoking_packyears_lung_squamous_cell
Freeman JR	-	27602958	2016-10-25	Smoking pack-years	EFO_0006526, EFO_0005671, EFO_0004318	Lung adenocarcinoma	Additional file 2	DNA methylation	Smoking pack-years	Age, sex, ethnicity, cell type, EGFR mutation status and KRAS mutation status	M values	Pack-years	Illumina HumanMethylation450	Lung adenocarcinoma	-	511	1	66.8	Both	European,African,Other	cg13204512	chr17:29298184	17	29298184	RNF135	Island	-0.55731932	0.1324	0.0000258	-	27602958_smoking_packyears_lung_adenocarcinoma
Freeman JR	-	27602958	2016-10-25	Smoking pack-years	EFO_0006526, EFO_0005671, EFO_0004318	Lung adenocarcinoma	Additional file 2	DNA methylation	Smoking pack-years	Age, sex, ethnicity, cell type, EGFR mutation status and KRAS mutation status	M values	Pack-years	Illumina HumanMethylation450	Lung adenocarcinoma	-	511	1	66.8	Both	European,African,Other	cg23087239	chr3:134080574	3	134080574	AMOTL2	Island	0.52296357	0.1244	0.0000262	-	27602958_smoking_packyears_lung_adenocarcinoma
Freeman JR	-	27602958	2016-10-25	Smoking pack-years	EFO_0006526, EFO_0005671, EFO_0004318	Replication	Additional file 1	DNA methylation	Smoking pack-years	Age, sex, ethnicity, cell type, EGFR mutation status and KRAS mutation status	M values	Pack-years	Illumina HumanMethylation450	Lung adenocarcinoma and lung squamous cell	-	185	1	66.4	Both	European,African,Other	cg25924823	chr8:145113480	8	145113480	OPLAH	Island	0.5565748	0.1325	0.0000265	-	27602958_smoking_packyears_replication
Freeman JR	-	27602958	2016-10-25	Smoking pack-years	EFO_0006526, EFO_0005671, EFO_0004318	Replication	Additional file 1	DNA methylation	Smoking pack-years	Age, sex, ethnicity, cell type, EGFR mutation status and KRAS mutation status	M values	Pack-years	Illumina HumanMethylation450	Lung adenocarcinoma and lung squamous cell	-	185	1	66.4	Both	European,African,Other	cg26185554	chr17:1391406	17	1391406	MYO1C	Island	-0.6724396	0.1603	0.0000274	-	27602958_smoking_packyears_replication
Freeman JR	-	27602958	2016-10-25	Smoking pack-years	EFO_0006526, EFO_0005671, EFO_0004318	Replication	Additional file 1	DNA methylation	Smoking pack-years	Age, sex, ethnicity, cell type, EGFR mutation status and KRAS mutation status	M values	Pack-years	Illumina HumanMethylation450	Lung adenocarcinoma and lung squamous cell	-	185	1	66.4	Both	European,African,Other	cg21919790	chr17:72926781	17	72926781	OTOP2	Open sea	-0.6623381	0.1583	0.0000286	-	27602958_smoking_packyears_replication
Freeman JR	-	27602958	2016-10-25	Smoking pack-years	EFO_0006526, EFO_0005671, EFO_0004318	Discovery	Additional file 1	DNA methylation	Smoking pack-years	Age, sex, ethnicity, cell type, EGFR mutation status and KRAS mutation status	M values	Pack-years	Illumina HumanMethylation450	Lung adenocarcinoma and lung squamous cell	-	326	1	67	Both	European,African,Other	cg16142707	chr3:156544075	3	156544075	LEKR1	Island	-0.7261296	0.1737	0.000029	-	27602958_smoking_packyears_discovery
Freeman JR	-	27602958	2016-10-25	Smoking pack-years	EFO_0006526, EFO_0005671, EFO_0004318	Discovery	Additional file 1	DNA methylation	Smoking pack-years	Age, sex, ethnicity, cell type, EGFR mutation status and KRAS mutation status	M values	Pack-years	Illumina HumanMethylation450	Lung adenocarcinoma and lung squamous cell	-	326	1	67	Both	European,African,Other	cg11875268	chr12:54576025	12	54576025	SMUG1	Open sea	0.8492834	0.2032	0.0000292	-	27602958_smoking_packyears_discovery
Freeman JR	-	27602958	2016-10-25	Smoking pack-years	EFO_0006526, EFO_0005671, EFO_0004318	Replication	Additional file 1	DNA methylation	Smoking pack-years	Age, sex, ethnicity, cell type, EGFR mutation status and KRAS mutation status	M values	Pack-years	Illumina HumanMethylation450	Lung adenocarcinoma and lung squamous cell	-	185	1	66.4	Both	European,African,Other	cg03705926	chr19:6740952	19	6740952	TRIP10	Island	-0.5918695	0.1416	0.0000292	-	27602958_smoking_packyears_replication
Freeman JR	-	27602958	2016-10-25	Smoking pack-years	EFO_0006526, EFO_0005671, EFO_0004318	Discovery	Additional file 1	DNA methylation	Smoking pack-years	Age, sex, ethnicity, cell type, EGFR mutation status and KRAS mutation status	M values	Pack-years	Illumina HumanMethylation450	Lung adenocarcinoma and lung squamous cell	-	326	1	67	Both	European,African,Other	cg18873530	chr19:49315663	19	49315663	BCAT2	Island	-0.4734784	0.1133	0.0000292	-	27602958_smoking_packyears_discovery
Freeman JR	-	27602958	2016-10-25	Smoking pack-years	EFO_0006526, EFO_0005671, EFO_0004318	Discovery	Additional file 1	DNA methylation	Smoking pack-years	Age, sex, ethnicity, cell type, EGFR mutation status and KRAS mutation status	M values	Pack-years	Illumina HumanMethylation450	Lung adenocarcinoma and lung squamous cell	-	326	1	67	Both	European,African,Other	cg14826215	chr7:139762483	7	139762483	PARP12	Island	-0.4821179	0.1154	0.0000295	-	27602958_smoking_packyears_discovery
Freeman JR	-	27602958	2016-10-25	Smoking pack-years	EFO_0006526, EFO_0005671, EFO_0004318	Discovery	Additional file 1	DNA methylation	Smoking pack-years	Age, sex, ethnicity, cell type, EGFR mutation status and KRAS mutation status	M values	Pack-years	Illumina HumanMethylation450	Lung adenocarcinoma and lung squamous cell	-	326	1	67	Both	European,African,Other	cg09025960	chr1:226070808	1	226070808	TMEM63A	Island	-0.5620065	0.1347	0.0000301	-	27602958_smoking_packyears_discovery
Freeman JR	-	27602958	2016-10-25	Smoking pack-years	EFO_0006526, EFO_0005671, EFO_0004318	Discovery	Additional file 1	DNA methylation	Smoking pack-years	Age, sex, ethnicity, cell type, EGFR mutation status and KRAS mutation status	M values	Pack-years	Illumina HumanMethylation450	Lung adenocarcinoma and lung squamous cell	-	326	1	67	Both	European,African,Other	cg19390357	chr16:12211186	16	12211186	SNX29	Island	0.6096117	0.1461	0.0000301	-	27602958_smoking_packyears_discovery
Freeman JR	-	27602958	2016-10-25	Smoking pack-years	EFO_0006526, EFO_0005671, EFO_0004318	Replication	Additional file 1	DNA methylation	Smoking pack-years	Age, sex, ethnicity, cell type, EGFR mutation status and KRAS mutation status	M values	Pack-years	Illumina HumanMethylation450	Lung adenocarcinoma and lung squamous cell	-	185	1	66.4	Both	European,African,Other	cg19634213	chr10:89621792	10	89621792	PTEN;KILLIN	Island	-0.7861763	0.1892	0.0000323	-	27602958_smoking_packyears_replication
Freeman JR	-	27602958	2016-10-25	Smoking pack-years	EFO_0006526, EFO_0005671, EFO_0004318	Discovery	Additional file 1	DNA methylation	Smoking pack-years	Age, sex, ethnicity, cell type, EGFR mutation status and KRAS mutation status	M values	Pack-years	Illumina HumanMethylation450	Lung adenocarcinoma and lung squamous cell	-	326	1	67	Both	European,African,Other	cg13264059	chr10:129705415	10	129705415	PTPRE	Island	-0.4928484	0.1186	0.0000327	-	27602958_smoking_packyears_discovery
Freeman JR	-	27602958	2016-10-25	Smoking pack-years	EFO_0006526, EFO_0005671, EFO_0004318	Lung adenocarcinoma	Additional file 2	DNA methylation	Smoking pack-years	Age, sex, ethnicity, cell type, EGFR mutation status and KRAS mutation status	M values	Pack-years	Illumina HumanMethylation450	Lung adenocarcinoma	-	511	1	66.8	Both	European,African,Other	cg18617333	chr8:143808383	8	143808383	C8orf55	Island	-0.52278151	0.1259	0.0000329	-	27602958_smoking_packyears_lung_adenocarcinoma
Freeman JR	-	27602958	2016-10-25	Smoking pack-years	EFO_0006526, EFO_0005671, EFO_0004318	Discovery	Additional file 1	DNA methylation	Smoking pack-years	Age, sex, ethnicity, cell type, EGFR mutation status and KRAS mutation status	M values	Pack-years	Illumina HumanMethylation450	Lung adenocarcinoma and lung squamous cell	-	326	1	67	Both	European,African,Other	cg21919790	chr17:72926781	17	72926781	OTOP2	Open sea	-0.4925651	0.1187	0.0000334	-	27602958_smoking_packyears_discovery
Freeman JR	-	27602958	2016-10-25	Smoking pack-years	EFO_0006526, EFO_0005671, EFO_0004318	Discovery	Additional file 1	DNA methylation	Smoking pack-years	Age, sex, ethnicity, cell type, EGFR mutation status and KRAS mutation status	M values	Pack-years	Illumina HumanMethylation450	Lung adenocarcinoma and lung squamous cell	-	326	1	67	Both	European,African,Other	cg24823993	chr22:42085003	22	42085003	NHP2L1	Island	-0.4057208	0.0979	0.0000342	-	27602958_smoking_packyears_discovery
Freeman JR	-	27602958	2016-10-25	Smoking pack-years	EFO_0006526, EFO_0005671, EFO_0004318	Lung adenocarcinoma	Additional file 2	DNA methylation	Smoking pack-years	Age, sex, ethnicity, cell type, EGFR mutation status and KRAS mutation status	M values	Pack-years	Illumina HumanMethylation450	Lung adenocarcinoma	-	511	1	66.8	Both	European,African,Other	cg03705926	chr19:6740952	19	6740952	TRIP10	Island	-0.512185	0.1243	0.0000379	-	27602958_smoking_packyears_lung_adenocarcinoma
Freeman JR	-	27602958	2016-10-25	Smoking pack-years	EFO_0006526, EFO_0005671, EFO_0004318	Discovery	Additional file 1	DNA methylation	Smoking pack-years	Age, sex, ethnicity, cell type, EGFR mutation status and KRAS mutation status	M values	Pack-years	Illumina HumanMethylation450	Lung adenocarcinoma and lung squamous cell	-	326	1	67	Both	European,African,Other	cg04151290	chr11:2398500	11	2398500	CD81	Island	-0.2960229	0.0719	0.0000387	-	27602958_smoking_packyears_discovery
Freeman JR	-	27602958	2016-10-25	Smoking pack-years	EFO_0006526, EFO_0005671, EFO_0004318	Discovery	Additional file 1	DNA methylation	Smoking pack-years	Age, sex, ethnicity, cell type, EGFR mutation status and KRAS mutation status	M values	Pack-years	Illumina HumanMethylation450	Lung adenocarcinoma and lung squamous cell	-	326	1	67	Both	European,African,Other	cg12025027	chr17:1531232	17	1531232	SLC43A2	Island	-0.5753039	0.14	0.0000398	-	27602958_smoking_packyears_discovery
Freeman JR	-	27602958	2016-10-25	Smoking pack-years	EFO_0006526, EFO_0005671, EFO_0004318	Replication	Additional file 1	DNA methylation	Smoking pack-years	Age, sex, ethnicity, cell type, EGFR mutation status and KRAS mutation status	M values	Pack-years	Illumina HumanMethylation450	Lung adenocarcinoma and lung squamous cell	-	185	1	66.4	Both	European,African,Other	cg05288071	chr19:7712539	19	7712539	STXBP2	South shore	0.8111323	0.1984	0.0000433	-	27602958_smoking_packyears_replication
Freeman JR	-	27602958	2016-10-25	Smoking pack-years	EFO_0006526, EFO_0005671, EFO_0004318	Replication	Additional file 1	DNA methylation	Smoking pack-years	Age, sex, ethnicity, cell type, EGFR mutation status and KRAS mutation status	M values	Pack-years	Illumina HumanMethylation450	Lung adenocarcinoma and lung squamous cell	-	185	1	66.4	Both	European,African,Other	cg16726667	chr16:68002228	16	68002228	SLC12A4	Island	-0.6532922	0.1606	0.0000474	-	27602958_smoking_packyears_replication
Freeman JR	-	27602958	2016-10-25	Smoking pack-years	EFO_0006526, EFO_0005671, EFO_0004318	Replication	Additional file 1	DNA methylation	Smoking pack-years	Age, sex, ethnicity, cell type, EGFR mutation status and KRAS mutation status	M values	Pack-years	Illumina HumanMethylation450	Lung adenocarcinoma and lung squamous cell	-	185	1	66.4	Both	European,African,Other	cg13620366	chr9:138839624	9	138839624	UBAC1	Open sea	0.532507	0.131	0.0000478	-	27602958_smoking_packyears_replication
Freeman JR	-	27602958	2016-10-25	Smoking pack-years	EFO_0006526, EFO_0005671, EFO_0004318	Replication	Additional file 1	DNA methylation	Smoking pack-years	Age, sex, ethnicity, cell type, EGFR mutation status and KRAS mutation status	M values	Pack-years	Illumina HumanMethylation450	Lung adenocarcinoma and lung squamous cell	-	185	1	66.4	Both	European,African,Other	cg22005634	chr20:62152128	20	62152128	PPDPF	Island	-0.5137732	0.1264	0.0000478	-	27602958_smoking_packyears_replication
Freeman JR	-	27602958	2016-10-25	Smoking pack-years	EFO_0006526, EFO_0005671, EFO_0004318	Lung squamous cell	Additional file 3	DNA methylation	Smoking pack-years	Age, sex, ethnicity, cell type, EGFR mutation status and KRAS mutation status	M values	Pack-years	Illumina HumanMethylation450	Lung squamous cell	-	511	1	66.8	Both	European,African,Other	cg12025027	chr17:1531232	17	1531232	SLC43A2	Island	-0.9167797	0.2269	0.0000535	-	27602958_smoking_packyears_lung_squamous_cell
Freeman JR	-	27602958	2016-10-25	Smoking pack-years	EFO_0006526, EFO_0005671, EFO_0004318	Lung adenocarcinoma	Additional file 2	DNA methylation	Smoking pack-years	Age, sex, ethnicity, cell type, EGFR mutation status and KRAS mutation status	M values	Pack-years	Illumina HumanMethylation450	Lung adenocarcinoma	-	511	1	66.8	Both	European,African,Other	cg19508701	chr8:9008170	8	9008170	PPP1R3B	Island	-0.56602268	0.1403	0.0000546	-	27602958_smoking_packyears_lung_adenocarcinoma
Freeman JR	-	27602958	2016-10-25	Smoking pack-years	EFO_0006526, EFO_0005671, EFO_0004318	Lung adenocarcinoma	Additional file 2	DNA methylation	Smoking pack-years	Age, sex, ethnicity, cell type, EGFR mutation status and KRAS mutation status	M values	Pack-years	Illumina HumanMethylation450	Lung adenocarcinoma	-	511	1	66.8	Both	European,African,Other	cg21701395	chr8:95961492	8	95961492	TP53INP1	Island	-0.64806506	0.1614	0.0000592	-	27602958_smoking_packyears_lung_adenocarcinoma
Freeman JR	-	27602958	2016-10-25	Smoking pack-years	EFO_0006526, EFO_0005671, EFO_0004318	Replication	Additional file 1	DNA methylation	Smoking pack-years	Age, sex, ethnicity, cell type, EGFR mutation status and KRAS mutation status	M values	Pack-years	Illumina HumanMethylation450	Lung adenocarcinoma and lung squamous cell	-	185	1	66.4	Both	European,African,Other	cg19916637	chr8:95961757	8	95961757	TP53INP1	Island	-0.6528627	0.1626	0.0000593	-	27602958_smoking_packyears_replication
Freeman JR	-	27602958	2016-10-25	Smoking pack-years	EFO_0006526, EFO_0005671, EFO_0004318	Replication	Additional file 1	DNA methylation	Smoking pack-years	Age, sex, ethnicity, cell type, EGFR mutation status and KRAS mutation status	M values	Pack-years	Illumina HumanMethylation450	Lung adenocarcinoma and lung squamous cell	-	185	1	66.4	Both	European,African,Other	cg24198953	chr19:18451444	19	18451444	PGPEP1	Island	-0.8512737	0.2123	0.0000608	-	27602958_smoking_packyears_replication
Freeman JR	-	27602958	2016-10-25	Smoking pack-years	EFO_0006526, EFO_0005671, EFO_0004318	Lung adenocarcinoma	Additional file 2	DNA methylation	Smoking pack-years	Age, sex, ethnicity, cell type, EGFR mutation status and KRAS mutation status	M values	Pack-years	Illumina HumanMethylation450	Lung adenocarcinoma	-	511	1	66.8	Both	European,African,Other	cg09876101	chr16:699357	16	699357	WDR90	Island	-0.24712457	0.0618	0.0000631	-	27602958_smoking_packyears_lung_adenocarcinoma
Freeman JR	-	27602958	2016-10-25	Smoking pack-years	EFO_0006526, EFO_0005671, EFO_0004318	Lung adenocarcinoma	Additional file 2	DNA methylation	Smoking pack-years	Age, sex, ethnicity, cell type, EGFR mutation status and KRAS mutation status	M values	Pack-years	Illumina HumanMethylation450	Lung adenocarcinoma	-	511	1	66.8	Both	European,African,Other	cg22409276	chr15:40763763	15	40763763	CHST14	Island	-0.52929264	0.1324	0.0000636	-	27602958_smoking_packyears_lung_adenocarcinoma
Freeman JR	-	27602958	2016-10-25	Smoking pack-years	EFO_0006526, EFO_0005671, EFO_0004318	Lung adenocarcinoma	Additional file 2	DNA methylation	Smoking pack-years	Age, sex, ethnicity, cell type, EGFR mutation status and KRAS mutation status	M values	Pack-years	Illumina HumanMethylation450	Lung adenocarcinoma	-	511	1	66.8	Both	European,African,Other	cg23423230	chr21:43327978	21	43327978	C2CD2	Island	0.25079012	0.0627	0.0000637	-	27602958_smoking_packyears_lung_adenocarcinoma
Freeman JR	-	27602958	2016-10-25	Smoking pack-years	EFO_0006526, EFO_0005671, EFO_0004318	Lung adenocarcinoma	Additional file 2	DNA methylation	Smoking pack-years	Age, sex, ethnicity, cell type, EGFR mutation status and KRAS mutation status	M values	Pack-years	Illumina HumanMethylation450	Lung adenocarcinoma	-	511	1	66.8	Both	European,African,Other	cg08843134	chr16:2301653	16	2301653	DCI	Island	0.30486934	0.0764	0.000066	-	27602958_smoking_packyears_lung_adenocarcinoma
Freeman JR	-	27602958	2016-10-25	Smoking pack-years	EFO_0006526, EFO_0005671, EFO_0004318	Replication	Additional file 1	DNA methylation	Smoking pack-years	Age, sex, ethnicity, cell type, EGFR mutation status and KRAS mutation status	M values	Pack-years	Illumina HumanMethylation450	Lung adenocarcinoma and lung squamous cell	-	185	1	66.4	Both	European,African,Other	cg11122493	chr17:74706551	17	74706551	MXRA7	Island	-0.8718122	0.2188	0.0000678	-	27602958_smoking_packyears_replication
Freeman JR	-	27602958	2016-10-25	Smoking pack-years	EFO_0006526, EFO_0005671, EFO_0004318	Replication	Additional file 1	DNA methylation	Smoking pack-years	Age, sex, ethnicity, cell type, EGFR mutation status and KRAS mutation status	M values	Pack-years	Illumina HumanMethylation450	Lung adenocarcinoma and lung squamous cell	-	185	1	66.4	Both	European,African,Other	cg22409276	chr15:40763763	15	40763763	CHST14	Island	-0.7143654	0.1802	0.0000739	-	27602958_smoking_packyears_replication
Freeman JR	-	27602958	2016-10-25	Smoking pack-years	EFO_0006526, EFO_0005671, EFO_0004318	Replication	Additional file 1	DNA methylation	Smoking pack-years	Age, sex, ethnicity, cell type, EGFR mutation status and KRAS mutation status	M values	Pack-years	Illumina HumanMethylation450	Lung adenocarcinoma and lung squamous cell	-	185	1	66.4	Both	European,African,Other	cg07556403	chr20:62152146	20	62152146	PPDPF	Island	-0.5956797	0.1508	0.0000778	-	27602958_smoking_packyears_replication
Freeman JR	-	27602958	2016-10-25	Smoking pack-years	EFO_0006526, EFO_0005671, EFO_0004318	Replication	Additional file 1	DNA methylation	Smoking pack-years	Age, sex, ethnicity, cell type, EGFR mutation status and KRAS mutation status	M values	Pack-years	Illumina HumanMethylation450	Lung adenocarcinoma and lung squamous cell	-	185	1	66.4	Both	European,African,Other	cg17323383	chr3:182896670	3	182896670	MCF2L2	North shore	-0.9006774	0.2285	0.0000807	-	27602958_smoking_packyears_replication
Freeman JR	-	27602958	2016-10-25	Smoking pack-years	EFO_0006526, EFO_0005671, EFO_0004318	Lung adenocarcinoma	Additional file 2	DNA methylation	Smoking pack-years	Age, sex, ethnicity, cell type, EGFR mutation status and KRAS mutation status	M values	Pack-years	Illumina HumanMethylation450	Lung adenocarcinoma	-	511	1	66.8	Both	European,African,Other	cg19168961	chr15:41245649	15	41245649	CHAC1	Island	-0.3045452	0.0773	0.0000823	-	27602958_smoking_packyears_lung_adenocarcinoma
Freeman JR	-	27602958	2016-10-25	Smoking pack-years	EFO_0006526, EFO_0005671, EFO_0004318	Replication	Additional file 1	DNA methylation	Smoking pack-years	Age, sex, ethnicity, cell type, EGFR mutation status and KRAS mutation status	M values	Pack-years	Illumina HumanMethylation450	Lung adenocarcinoma and lung squamous cell	-	185	1	66.4	Both	European,African,Other	cg07243103	chr16:699355	16	699355	WDR90	Island	-0.3674247	0.0933	0.0000827	-	27602958_smoking_packyears_replication
Freeman JR	-	27602958	2016-10-25	Smoking pack-years	EFO_0006526, EFO_0005671, EFO_0004318	Replication	Additional file 1	DNA methylation	Smoking pack-years	Age, sex, ethnicity, cell type, EGFR mutation status and KRAS mutation status	M values	Pack-years	Illumina HumanMethylation450	Lung adenocarcinoma and lung squamous cell	-	185	1	66.4	Both	European,African,Other	cg25771041	chr3:149376042	3	149376042	WWTR1	Island	-0.4626843	0.1175	0.0000828	-	27602958_smoking_packyears_replication
Freeman JR	-	27602958	2016-10-25	Smoking pack-years	EFO_0006526, EFO_0005671, EFO_0004318	Lung adenocarcinoma	Additional file 2	DNA methylation	Smoking pack-years	Age, sex, ethnicity, cell type, EGFR mutation status and KRAS mutation status	M values	Pack-years	Illumina HumanMethylation450	Lung adenocarcinoma	-	511	1	66.8	Both	European,African,Other	cg07766672	chr8:143808440	8	143808440	C8orf55	Island	-0.49242066	0.1254	0.0000858	-	27602958_smoking_packyears_lung_adenocarcinoma
Freeman JR	-	27602958	2016-10-25	Smoking pack-years	EFO_0006526, EFO_0005671, EFO_0004318	Lung adenocarcinoma	Additional file 2	DNA methylation	Smoking pack-years	Age, sex, ethnicity, cell type, EGFR mutation status and KRAS mutation status	M values	Pack-years	Illumina HumanMethylation450	Lung adenocarcinoma	-	511	1	66.8	Both	European,African,Other	cg06370133	chr2:113914844	2	113914844	-	Island	-0.38594459	0.0985	0.0000897	-	27602958_smoking_packyears_lung_adenocarcinoma
Freeman JR	-	27602958	2016-10-25	Smoking pack-years	EFO_0006526, EFO_0005671, EFO_0004318	Replication	Additional file 1	DNA methylation	Smoking pack-years	Age, sex, ethnicity, cell type, EGFR mutation status and KRAS mutation status	M values	Pack-years	Illumina HumanMethylation450	Lung adenocarcinoma and lung squamous cell	-	185	1	66.4	Both	European,African,Other	cg07469408	chr14:75894384	14	75894384	JDP2	Island	-0.3946719	0.1009	0.0000919	-	27602958_smoking_packyears_replication
Freeman JR	-	27602958	2016-10-25	Smoking pack-years	EFO_0006526, EFO_0005671, EFO_0004318	Lung adenocarcinoma	Additional file 2	DNA methylation	Smoking pack-years	Age, sex, ethnicity, cell type, EGFR mutation status and KRAS mutation status	M values	Pack-years	Illumina HumanMethylation450	Lung adenocarcinoma	-	511	1	66.8	Both	European,African,Other	cg18699112	chr17:81009351	17	81009351	B3GNTL1	Island	-0.32630088	0.0838	0.000099	-	27602958_smoking_packyears_lung_adenocarcinoma